Modulation of airway inflammation by passive transfer of allergen- specific Th1 and Th2 cells in a mouse model of asthma

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 2375-2383

  Randolph, David A ^a   Carruthers, Cynthia J L ^a   Szabo, Susanne J ^a   Murphy, Kenneth M ^a   Chaplin, David D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HELPER CELL; LUNG LAVAGE; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ASTHMA; CELL MOVEMENT; DISEASE MODELS, ANIMAL; FEMALE; IMMUNIZATION; INJECTIONS, INTRAPERITONEAL; LUNG; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; TH1 CELLS; TH2 CELLS;

EID: 0033557718     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Holtzman, M. J., D. Sampath, M. Castro, D. C. Look, and S. Jayaraman. 1996. The one-two of T helper cells: does interferon-γ knock out the Th2 hypothesis for asthma? Am. J. Respir. Cell Mol. Biol. 14:316.
2. Boushey, H. A., and J. V. Fahy. 1995. Basic mechanisms of asthma. Environ. Health Perspect. 103(Suppl. 6)1:229.
3. Kline, J. N., and G. W. Hunninghake. 1994. T-lymphocyte dysregulation in asthma. Proc. Soc. Exp. Biol. Med. 207:243.
4. Kay, A. B. 1997. T cells as orchestrators of the asthmatic response. Ciba Found. Symp. 206:56.
5. Krug, N., and A. J. Frew. 1997. The Th2 cell in asthma: initial expectations yet to be realized. Clin. Exp. Allergy 27:142.
6. Borish, L., and L. Rosenwasser 1997. TH1/TH2 lymphocytes: doubt some more. J. Allergy Clin. Immunol. 99:161.
7. Wilson, J. W., R. Djukanovic, P. H. Howarth, and S. T. Holgate. 1992. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am. Rev. Respir. Dis. 145:958.
8. Bentley, A. M., Q. Meng, D. S. Robinson, Q. Hamid, A. B. Kay, and S. R. Durham. 1993. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am. J. Respir. Cell Mol. Biol. 8:35.
9. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
10. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
11. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system Proc. Natl. Acad. Sci. USA 89: 6065.
12. Cookson, W. O., and M. F. Moffatt. 1997. Asthma: an epidemic in the absence of infection? Science 275:41.
13. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
14. Shirakawa, T., T. Enomoto, S. Shimazu, and J. M. Hopkin. 1997. The inverse association between tuberculin responses and atopic disorder. Science 275:77.
15. Coyle, A. J., G. Le Gros, C. Bertrand, S. Tsuyuki, C. H. Heusser, M. Kopf, and G. P. Anderson. 1995. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Resp. Cell Mol. Biol. 13:54.
16. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195.
17. Corry, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109.
18. Brusselle, G. G., J. C. Kips, J. H. Tavernier, J. G. van der Heyden, C. A. Cuvelier, R. A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 24:73.
19. Kips, J. C., G. G. Brusselle, G. F. Joos, R. A. Peleman, R. R. Devos, J. H. Tavernier, and R. A. Pauwels. 1995. Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice. Int. Arch. Allergy Immunol. 107:115.
20. Coyle, A. J., S. Tsuyuki, C. Bertrand, S. Huang, M. Aguet, S. S. Alkan, and G. P. Anderson. 1996. Mice lacking the IFN-γ receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J. Immunol. 156:2680.
21. Gavett, S. H., D. J. O'Hearn, X. Li, S. K. Huang, F. D. Finkelman, and M. Wills-Karp. 1995. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182:1527.
22. Lack, G., K. L. Bradley, E. Hamelmann, H. Renz, J. Loader, D. Y. Leung, G. Larsen, and E. W. Gelfand. 1996. Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J. Immunol. 157:1432.
23. Krug, N., J. Madden, A. E. Redington, P. Lackie, R. Djukanovic, U. Schauer, S. T. Holgate, A. J. Frew, and P. H. Howarth. 1996. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am. J. Resp. Cell Mol. Biol. 14:319.
24. Krouwels, F. H., B. E. Hol, B. Bruinier, R. Lutter, H. M. Jansen, and T. A. Out. 1996. Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy subjects. Eur. Respir. J. Suppl. 22:95s.
25. Busse, W. W., J. E. Gern, and E. C. Dick. 1997. The role of respiratory viruses in asthma. Ciba Found Symp. 206:208.
26. Io thymocytes in vivo. Science 250: 1720.
27. Kung, T. T., H. Jones, G. K. Adams, S. P. Umland, W. Kreutner, R. W. Egan, R. W. Chapman, and A. S. Watnick. 1994. Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105:83.
28. Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181:713.
29. Korsgren, M., J. S. Erjefalt, O. Korsgren, F. Sundler, and C. G. Persson. 1997. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J. Exp. Med. 185:885.
30. Cohn, L., R. J. Homer, A. Marinov, J. Rankin, and K. Bottomly. 1997. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186:1737.
31. Tripp, C. S., O. Kanagawa, and E. R. Unanue. 1995. Secondary response to Listeria infection requires IFN-γ but is partially independent of IL-12. J. Immunol. 155:3427.