Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: Impact on prognosis and therapy

Indian Journal of Cancer

Volumn 43, Issue 4, 2006, Pages 163-168

  Mohammad, A Mohammad ^a   Abdel, H A ^a   Abdel, W ^a   Ahmed, A M ^a   Wael, T ^a   Eiman, G ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Breast cancer; Cox 2; estrogen receptor; Her 2 neu; Lipoxygenase 12; Progesterone receptor

Indexed keywords

EID: 33846225642     PISSN: 0019509X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0019-509X.29421     Document Type: Article

References (30)

1. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and -2. J Biol Chem 1996;271:33157-60.
2. Williams CS, DuBois RN. Prostaglandin endoperoxide synthase: Why two isofoms? Am J Physiol 1996;270:G393-400.
3. Herschman HR. Prostaglandin synthase 2. Biochem Biophys Acta 1996;1299:125-40.
4. Wu KK. Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles. J Lab Clin Med 1996;128:242-5.
5. O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993;330:156-60.
6. Bennett A, Charlier EM, McDonald AM, Simpson JS, Stamford IF, Zebro T. Postaglandins and breast cancer. Lancet 1977;2:624-6.
7. Parrett ML, Harris RE, Joarder FS, Ross MS, Clausen KP, Robertson FM. Cyclooxygenase-2 gene expression in human breast cancer. Int J Oncol 1997;10:503-7.
8. Subbaramaiah K, Dannenberg AJ. Resveratrol inhibits the expression of cyclooxygenase-2 in mammary epithelialcells. Adv Exp Med Biol 2001;492:147-57.
9. Davies G, Salter J, Hills M, Martin LA, Sacks N, Dowsett M. Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. Clin Cancer Res 2003;9:2651-6.
10. Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY, Lin JK. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett 2001;496:12-8.
11. Singh B, Berry JA, Shoher A, Ramakrishnan V, Lucci A. COX-2 overexpression increases motility and invasion of breast cancer cells. Int J Oncol 2005;26:1393-9.
12. Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci 1997;94:3336-40.
13. Larkins TL, Nowell M, Singh S, Sanford GL. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer 2006;6:181.
14. Liu XH, Connolly JM, Rose DP. Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line. Clin Exp Metast 1996;14:145-52.
15. Honn KV, Timar J, Rozhin J, Bazaz R, Sameni M, Ziegler G, et al. A lipoxygenase metabolite, 12-(s)-HETE, stimulates protein-kinase C-mediated release of cathepsin-B from malignant-cells. Exp Cell Res 1994;214:120-30.
16. Connolly JM, Rose DP. Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice. Cancer Lett 1998;132:107-12.
17. Nie D, Hillman GG, Geddes T, Tang K, Pierson C, Grignon DJ, et al. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. Cancer Res 1998;58:4047-51.
18. Sweeney CJ, Marshall MS, Barnard DS, Heilman DK, Billings SD, Cheng L, et al. Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. Cancer Detect Prev 2002;26:238-44.
19. Singh B, Lucci A. Role of cyclooxygenase-2 in breast cancer. J Surg Res 2002;108:173-9.
20. Jiang WG, Douglas-Jones A, Mansel RE. Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. Prostaglandins Leukot. Essent Fatty Acids 2003;69:275-81.
21. Soslow RA, Dannenberg AJ, Rush D, Woerner BM, Khan KN, Masferrer J, et al. COX-2 is expressed in human pulmonary, colonic and mammary tumors. Cancer 2000;89:2637-45.
22. Ristimaki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 2002;62:632-5.
23. Spizzo G, Gastl G, Wolf D, Gunsilius E, Steurer M, Fong D, et al. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. Br J Cancer 2003;88:574-8.
24. Marshall SF, Bernstein L, Anton-Culver H, Deapen D, Horn-Ross PL, Mohrenweiser H, et al. Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. J Natl Cancer Inst 2005;97:805-12.
25. Sucic M, Boban D, Markovic-Glamocak M, Jakic-Razumovic J, Vrbanec D, Ries S, et al. Expression of cyclooxygenase-2 in fineneedle aspirates from breast carcinoma and benign breast diseases. Breast 2003;12:51-7.
26. Subbaramaiah K, Norton L, Gerald W, Dannenberg AJ. Cyclooxygenase-2 is overexpressed in HER 2/neu-positive breast cancer: Evidence for involvement of AP-1 and PEA3. J Biol Chem 2002;277:18649-57.
27. Howe LR, Subbaramaiah K, Brown AM, Dannenberg AJ. Cyclooxygenase-2: A target for the prevention and treatment of breast cancer. Endocr Relat Cancer 2001;8:97-114.
28. Howe LR, Chang SH, Tolle KC, Dillon R, Young LJ, Cardiff RD, et al. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res 2005;65:10113-9.
29. Natarajan R, Esworthy R, Bai W, Gu JL, Wilczynski S, Nadler J. Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor. J Clin Endocrinol Metab 1997;82:1790-8.
30. Liu B, Marnett LJ, Chaudhary A, Ji C, Blair IA, Johnson CR, et al. Biosynthesis of 12(s) hydroxyeicosatetraenoic acid by B16 amelanoic cells is a determinant of their metastatic potential. Lab Invest 1994;70:314-23.