Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 4295-4301

  Deschamps, Joshua D ^a   Kenyon, Victor A ^a   Holman, Theodore R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apigenin; Baicalein; Flavonoids; IC50; Kinetics; Lipoxygenase; Reductive inhibition

Indexed keywords

APIGENIN; BAICALEIN; CATECHOL; CELL ENZYME; FLAVONOID; IRON; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; THROMBOCYTE ENZYME;

ARTICLE; CELL ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BINDING; DRUG DETERMINATION; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; METAL BINDING; MOLECULAR MODEL; RETICULOCYTE; STEADY STATE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

APIGENIN; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BINDING SITES; BLOOD PLATELETS; FLAVANONES; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; RETICULOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646177187     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.057     Document Type: Article

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