Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6900-6908

  Deschamps, Joshua D ^a   Gautschi, Jeffrey T ^a   Whitman, Stephanie ^a   Johnson, Tyler A ^a   Gassner, Nadine C ^a   Crews, Phillip ^a   Holman, Theodore R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

mangostin; Dysidenin; High throughput; IC50; Kinetics; Lipoxygenase; Michellamine B; NCI; Neodysidenin

Indexed keywords

ALPHA MANGOSTIN; ANTIVIRUS AGENT; ARACHIDONATE 12 LIPOXYGENASE; CASPASE 3 INHIBITOR; MICHELLAMINE B; NATURAL PRODUCT; NEODYSIDENIN; NSC 125034; NSC 172033; NSC 20410; NSC 268879; NSC 292213; NSC 30552; NSC 321237; NSC 321239; NSC 617570; NSC 661755; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; ENZYME ASSAY; HEALTH CARE ORGANIZATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INHIBITION KINETICS; RETICULOCYTE; STEADY STATE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THROMBOCYTE;

ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BLOOD PLATELETS; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; HUMANS; ISOENZYMES; KINETICS; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548819617     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.015     Document Type: Article

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