Effect of histaminergic manipulation on weight in obese adults: A randomized placebo controlled trial

International Journal of Obesity

Volumn 32, Issue 10, 2008, Pages 1559-1565

  Barak, N ^a   Greenway, F L ^b   Fujioka, K ^c   Aronne, L J ^d   Kushner, R F ^e  

^a Obecure Ltd   (Israel)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c SCRIPPS CLINIC   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Betahistine; Clinical study; Histamine; Weight loss

Indexed keywords

BETAHISTINE; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TOLERABILITY; ETHNICITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBESITY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; SEX DIFFERENCE; SKIN ALLERGY; URTICARIA; WEIGHT REDUCTION;

ADOLESCENT; ADULT; AGED; BETAHISTINE; DOUBLE-BLIND METHOD; DRUG ERUPTIONS; FEMALE; HEADACHE DISORDERS; HISTAMINE AGONISTS; HUMANS; MALE; MIDDLE AGED; OBESITY; SINGLE-BLIND METHOD; TREATMENT OUTCOME; WEIGHT LOSS; YOUNG ADULT;

EID: 53849090615     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.135     Document Type: Article

References (34)

1. Bugajski J, Gadek-Michalska A, Bugajski AJ. Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones. J Physiol Pharmacol 2004; 55: 679-703.
2. Lecklin A, Etu-Seppälä P, Stark H, Tuomisto L. Effects of intracerebroventricularly infused histamine and selective H1, H2 and H3 agonists on food and water intake and urine flow in Wistar rats. Brain Res 1998; 793: 279-288.
3. Passani MB, Lin JS, Hancock A, Crochet S, Blandina P. The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Trends Pharmacol Sci 2004; 25: 618-625.
4. Morimoto T, Yamamoto Y, Yamatodani A. Brain histamine and feeding behavior. Behav Brain Res 2001; 124: 145-150.
5. Parsons ME, Ganellin CR. Histamine and its receptors. Br J Pharmacol 2006; 147 (Suppl 1): S127-S135.
6. Attoub S, Moizo L, Sobhani I, Laigneau JP, Lewin MJ, Bado A. The H3 receptor is involved in cholecystokinin inhibition of food intake in rats. Life Sci 2001; 69: 469-478.
7. 1 receptor in the regulation of feeding rhythm and obesity. Diabetes 2004; 53: 2250-2260.
8. Wijtmans M, Leurs R, de Esch I. Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas. Expert Opin Investig Drugs 2007; 16: 967-985.
9. Clineschmidt BV, Lotti VJ. Histamine: intraventricular injection suppresses ingestive behavior of the cat. Arch Int Pharmacodyn Ther 1973; 206: 288-298.
10. Itowi N, Nagai K, Nakagawa H, Watanabe T, Wada H. Changes in the feeding behavior of rats elicited by histamine infusion. Physiol Behav 1988; 44: 221-226.
11. Orthen-Gambill N. Antihistaminic drugs increase feeding, while histidine suppresses feeding in rats. Pharmacol Biochem Behav 1988; 31: 81-86.
12. Sheiner JB, Morris P, Anderson GH. Food intake suppression by histidine. Pharmacol Biochem Behav 1985; 23: 721-726.
13. Vaziri P, Dang K, Anderson GH. Evidence for histamine involvement in the effect of histidine loads on food and water intake in rats. J Nutr 1997; 127: 1519-1526.
14. Lecklin A, Tuomisto L, MacDonald E. Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats. Methods Find Exp Clin Pharmacol 1995; 17: 47-52.
15. Lecklin A, Tuomisto L. The blockade of H 1 receptors attenuates the suppression of feeding and diuresis induced by inhibition of histamine catabolism. Pharmacol Biochem Behav 1998; 59: 753-758.
16. Doi T, Sakata T, Yoshimatsu H, Machidori H, Kurokawa M, Jayasekara LA et al. Hypothalamic neuronal histamine regulates feeding circadian rhythm in rats. Brain Res 1994; 641: 311-318.
17. Sakata T, Fukagawa K, Ookuma K, Fujimoto K, Yoshimatsu H, Yamatodani A et al. Hypothalamic neuronal histamine modulates ad libitum feeding by rats. Brain Res 1990; 537: 303-306.
18. Orthen-Gambill N, Salomon M. FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats. Physiol Behav 1992; 51: 891-893.
19. Ookuma K, Sakata T, Fukagawa K, Yoshimatsu H, Kurokawa M, Machidori H et al. Neuronal histamine in the hypothalamus suppresses food intake in rats. Brain Res 1993; 628: 235-242.
20. Canty P, Valentine J, Papworth SJ. Betahistine in peripheral vertigo: a double blind, placebo-controlled, cross-over study of Serc versus placebo. J Laryngol Otol 1981; 95: 687-692.
21. Fossati A, Barone D, Benvenuti C. Binding affinity profile of betahistine and its metabolites for central histamine receptors of rodents. Pharmacol Res 2001; 43: 389-392.
22. Arrang JM, Garbarg M, Quach TT, Dam Trung Tuong M, Yeramian E, Schwartz JC. Actions of betahistine at histamine receptors in the brain. Eur J Pharmacol 1985; 111: 73-84.
23. Jeck-Thole S, Wagner W. Betahistine: a retrospective synopsis of safety data. Drug Safety 2006; 29: 1049-1059.
24. Food and Nutrition Board. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients) National Academy Press: Washington DC, 2005.
25. Mercer LP, Kelley DS, Bufidranj HM, Haq AA, Humphries LL. Gender affects rat's central nervous system histaminergic responses to dietary manipulation. J Nutr 1996; 126: 3128-3135.
26. Kasaoka S, Kawahara Y, Inoue S, Tsuji M, Kato H, Tsuchiya T et al. Gender effects in dietary histidine-induced anorexia. Nutrition 2005; 21: 855-858.
27. Bajic D, Hoang QV, Nakajima S, Nakajima Y. Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects. J Neurosci Methods 2004; 132: 177-184.
28. Sakata T, Yoshimatsu H, Kurokawa M. Hypothalamic neuronal histamine: implications of its homeostatic control of energy metabolism. Nutrition 1997; 13: 403-411.
29. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS. Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem 2000; 275: 36124-36133.
30. Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T et al. Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. J Neurochem 2007; 103: 1102-1110.
31. Kow LM, Pfaff DW. Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system. Behav Brain Res 1998; 92: 169-180.
32. Zhou J, Lee AW, Devidze N, Zhang Q, Kow LM, Pfaff DW. Histamine-induced excitatory responses in mouse ventromedial hypothalamic neurons: ionic mechanisms and estrogenic regulation. J Neurophysiol 2007; 98: 3143-3152.
33. Yusuf S, Wittes J, Probstfield J, Tyroler HA. Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA 1991; 266: 93-98.
34. Lagakos SW. The challenge of subgroup analyses - reporting without distorting. N Engl J Med 2006; 354: 1667-1669.