Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats

Psychopharmacology

Volumn 206, Issue 2, 2009, Pages 223-232

  Sink, K S ^a,c   Segovia, K N ^a   Nunes, E J ^a   Collins, L E ^a   Vemuri, V K ^b   Thakur, G ^b   Makriyannis, A ^b   Salamone, J D ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Appetite; Brain; Feeding; Food intake; Motivation; Rimonabant

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; AM 411; AM 4113; ANOREXIGENIC AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEEDING BEHAVIOR; FOREBRAIN; HYPOTHALAMUS; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REINFORCEMENT; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG INTERACTIONS; EATING; FOOD DEPRIVATION; INJECTIONS, INTRAVENTRICULAR; MALE; MOTOR ACTIVITY; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE;

EID: 69549109976     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1602-8     Document Type: Article

References (58)

1. 7TM Pharma. 7TM Pharma announces the selection of a new pre-clinical development candidate, TM38837, for treatment of obesity and Type 2 diabetes. http://www.7tm.com/News.aspx?M=News&PID=42&NewsID=33 Accessed September 20, 2008
2. EL Abel 1971 Effects of marihuana on the solution of anagrams, memory and appetite Nature 231 260 261
3. WC Anderson-Baker CL McLaughlin CA Baile 1979 Oral and hypothalamic injections of barbiturates, benzodiazepines and cannabinoids and food intake in rats Pharmacol Biochem Behav 11 487 491
4. M Bensaid M Gary-Bobo A Esclangon JP Maffrand G Le Fur F Oury-Donat P Soubrie 2003 The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells Mol Pharmacol 63 908 914
5. JE Blevins MW Schwartz DG Baskin 2004 Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size Am J Physiol Regul Integr Comp Physiol 287 R87 96
6. JE Brown M Kassouny JK Cross 1977 Kinetic studies of food intake and sucrose solution preference by rats treated with low doses of delta9-tetrahydrocannabinol Behav Biol 20 104 110
7. G Burdyga S Lal A Varro R Dimaline DG Thompson GJ Dockray 2004 Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin J Neurosci 24 2708 2715
8. G Burdyga A Varro R Dimaline DG Thompson GJ Dockray 2006 Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance Am J Physiol Gastrointest Liver Physiol 290 G1289 97
9. AP Chambers KA Sharkey HS Koopmans 2004 Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat Physiol Behav 82 863 869
10. AP Chambers VK Vemuri Y Peng JT Wood T Olzewska QJ Pittman A Makriyannis K Sharkey 2007 A neutral CB1 receptor antagonist reduces weight gain in rat Am J Physiol Regul Integr Comp Physiol 293 R2185 2193
11. RZ Chen RR Huang CP Shen DJ MacNeil TM Fong 2004 Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice Brain Res 999 227 230
12. RZ Chen A Frassetto JZ Lao RR Huang JC Xiao MJ Clements TF Walsh JJ Hale J Wang X Tong TM Fong 2008 Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor Eur J Pharmacol 584 338 342
13. R Christensen PK Kristensen EM Bartels H Bliddal A Astrup 2007 Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials Lancet 370 1706 1713
14. G Colombo R Agabio G Diaz C Lobina R Reali GL Gessa 1998 Appetite suppression and weight loss after the cannabinoid antagonist SR 141716 Life Sci 63 PL113 PL117
15. D Cota G Marsicano M Tschop Y Grubler C Flachskamm M Schubert D Auer A Yassouridis C Thone-Reineke S Ortmann F Tomassoni C Cervino E Nisoli AC Linthorst R Pasquali B Lutz GK Stalla U Pagotto 2003 The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis J Clin Invest 112 423 431
16. C Curioni C Andre 2006 Rimonabant for overweight or obesity Cochrane Database Syst Rev 4 CD006162
17. JP Despres A Golay L Sjostrom Rimonabant in Obesity-Lipids Study Group 2005 Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia N Engl J Med 353 2121 2134
18. NV DiPatrizio KJ Simansky 2008 Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats J Neurosci 28 9702 9709
19. W Fan KL Ellacott IG Halatchev K Takahashi P Yu RD Cone 2004 Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system Nat Neurosci 7 335 336
20. RW Foltin JV Brady MW Fischman 1986 Behavioral analysis of marijuana effects on food intake in humans Pharmacol Biochem Behav 25 577 582
21. A Gardner PE Mallet 2006 Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist' Eur J Pharmacol 530 103 106
22. SJ Gatley AN Gifford ND Volkow R Lan A Makriyannis 1996 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors Eur J Pharmacol 307 331 338
23. R Gomez M Navarro B Ferrer JM Trigo A Bilbao I Del Arco A Cippitelli F Nava D Piomelli F Rodriguez de Fonseca 2002 A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding J Neurosci 22 9612 9617
24. N Hajos C Ledent TF Freund 2001 Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus Neuroscience 106 1 4
25. J Haller N Bakos M Szirmay C Ledent TF Freund 2002 The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety Eur J Neurosci 16 1395 1398
26. J Haller B Varga C Ledent TF Freund 2004 CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents Behav Pharmacol 15 299 304
27. AW Herling S Kilp R Elvert G Haschke W Kramer 2008 Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed Wistar rats Endocrinology 149 2557 2566
28. LE Hollister 1971 Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine Clin Pharmacol Ther 12 44 49
29. N Jamshidi DA Taylor 2001 Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats Br J Pharmacol 134 1151 1154
30. O Jbilo C Ravinet-Trillou M Arnone I Buisson E Bribes A Peleraux G Penarier P Soubrie G Le Fur S Galiegue P Casellas 2005 The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance FASEB J 19 1567 1569
31. Keppel G (1982) Design and analysis: a researcher's handbook. Prentice-Hall, Englewood Cliffs
32. JE Lauckner JB Jensen HY Chen HC Lu B Hille K Mackie 2008 GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current Proc Natl Acad Sci U S A 105 2699 2704
33. RD Mattes K Engelman LM Shaw MA Elsohly 1994 Cannabinoids and appetite stimulation Pharmacol Biochem Behav 49 187 195
34. PJ McLaughlin K Winston L Swezey A Wisniecki J Aberman DJ Tardif AJ Betz K Ishiwari A Makriyannis JD Salamone 2003 The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats Behav Pharmacol 14 583 588
35. PJ McLaughlin KM Winston CL Limebeer LA Parker A Makriyannis JD Salamone 2005 The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats Psychopharmacology (Berl) 180 286 293
36. PJ McLaughlin L Qian JT Wood A Wisniecki KM Winston LA Swezey K Ishiwari AJ Betz L Pandarinathan W Xu A Makriyannis JD Salamone 2006 Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387 Pharmacol Biochem Behav 83 396 402
37. D Osei-Hyiaman M DePetrillo P Pacher J Liu S Radaeva S Batkai J Harvey-White K Mackie L Offertaler L Wang G Kunos 2005 Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity J Clin Invest 115 1298 1305
38. ER Partosoedarso TP Abrahams RT Scullion JM Moerschbaecher PJ Hornby 2003 Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets J Physiol 550 149 158
39. FJ Pavon A Bilbao L Hernandez-Folgado A Cippitelli N Jagerovic G Abellan MA Rodriguez-Franco A Serrano M Macias R Gomez M Navarro P Goya F Rodriguez de Fonseca 2006 Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-3-hexyl-1H-1, 2, 4-triazole-LH 21 Neuropharmacology 51 358 366
40. FJ Pavón A Serrano V Pérez-Valero N Jagerovic L Hernández-Folgado FJ Bermúdez-Silva M Macías P Goya FR de Fonseca 2008 Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats J Neuroendocrinol 20 suppl 1 116 123
41. FX Pi-Sunyer LJ Aronne HM Heshmati J Devin J Rosenstock RIO-North America Study Group 2006 Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial JAMA 295 761 775
42. C Ravinet Trillou M Arnone C Delgorge N Gonalons P Keane JP Maffrand P Soubrie 2003 Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice Am J Physiol Regul Integr Comp Physiol 284 R345 53
43. E Ryberg N Larsson S Sjogren S Hjorth NO Hermansson J Leonova T Elebring K Nilsson T Drmota PJ Greasley 2007 The orphan receptor GPR55 is a novel cannabinoid receptor Br J Pharmacol 152 1092 1101
44. JD Salamone PJ McLaughlin K Sink A Makriyannis LA Parker 2007 Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions Physiol Behav 91 383 388
45. Salamone JD, Randall P, Hosmer S, Sink KS, Segovia KN, Stopper CM, Port RG, Vemuri VK, Wood J, Thakur G, Makriyannis A (2009) Central vs. peripheral effects of cannabinoid CB1 antagonists/inverse agonists on food-reinforced operant responding: Effects of the peripherally active CB1 antagonist AM6545. 2009 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2009. (in press)
46. MC Sanudo-Pena JM Walker 1998 A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia Ann N Y Acad Sci 860 475 479
47. MC Sanudo-Pena K Tsou JM Walker 1999 Motor actions of cannabinoids in the basal ganglia output nuclei Life Sci 65 703 713
48. LP Shearman KM Rosko R Fleischer J Wang S Xu XS Tong BA Rocha 2003 Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice Behav Pharmacol 14 573 582
49. KS Sink PJ McLaughlin JA Wood C Brown P Fan VK Vemuri Y Pang T Olzewska GA Thakur A Makriyannis LA Parker JD Salamone 2008 The novel cannabinoid CB(1) receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats Neuropsychopharmacology 33 946 966
50. KS Sink VK Vemuri J Wood A Makriyannis JD Salamone 2009 Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527: effects on food-reinforced behavior and comparisons with AM4113 Pharmacol Biochem Behav 91 303 306
51. E Soria-Gomez I Matias PE Rueda-Orozco M Cisneros S Petrosino L Navarro V Di Marzo O Prospero-Garcia 2007 Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-fos expression in the hypothalamus Br J Pharmacol 151 1109 1116
52. LF Van Gaal AM Rissanen AJ Scheen O Ziegler S Rossner RIO-Europe Study Group 2005 Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study Lancet 365 1389 1397 (Pubitemid 40523733)
53. AN Verty JR McFarlane IS McGregor PE Mallet 2004 Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake Neuropharmacology 47 593 603
54. AN Verty JR McFarlane IS McGregor PE Mallet 2004 Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake Endocrinology 145 3224 3231
55. AN Verty PE Mallet 2005 Paraventricular hypothalamic CB1 cannabinoid receptors are involved in the feeding stimulatory effects of delta9-tetrahydrocannabinol Neuropharmacology 49 1101 1109
56. NA Werner JE Koch 2003 Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in lewis rats Brain Res 967 290 292
57. CM Williams TC Kirkham 1999 Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors Psychopharmacology (Berl) 143 315 317
58. CM Williams TC Kirkham 2002 Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine Pharmacol Biochem Behav 71 333 340