MSI-1436 reduces acute food intake without affecting dopamine transporter activity

Pharmacology Biochemistry and Behavior

Volumn 97, Issue 1, 2010, Pages 138-143

  Roitman, Mitchell F ^a   Wescott, Seth ^a   Cone, Jackson J ^a   McLane, Michael P ^b   Wolfe, Henry R ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Genaera Corporation   (United States)

Author keywords

Motivation; Obesity; Reward; Striatum; Voltammetry

Indexed keywords

AMFEBUTAMONE; DOPAMINE TRANSPORTER; MSI 1436; NATURAL PRODUCT; SODIUM CHLORIDE; TRODUSQUEMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINE UPTAKE; DRUG EFFECT; ELECTROSTIMULATION; EVOKED RESPONSE; FOOD INTAKE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; VENTRAL TEGMENTUM;

ANIMALS; ANTI-OBESITY AGENTS; CHOLESTANES; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EATING; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPERMINE; TIME FACTORS;

RATTUS;

EID: 77957749253     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.05.010     Document Type: Article

References (48)

1. Ahima R.S., Patel H.R., Takahashi N., Qi Y., Hileman S.M., Zasloff M.A. Appetite suppression and weight reduction by a centrally active aminosterol. Diabetes 2002, 51:2099-2104.
2. Ahmad F., Azevedo J.L., Cortright R., Dohm G.L., Goldstein B.J. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J Clin Investig 1997, 100:449-458.
3. Baumann M.H., Ayestas M.A., Dersch C.M., Brockington A., Rice K.C., Rothman R.B. Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications. Synapse (New York, N.Y 2000, 36:102-113.
4. Berridge K.C., Robinson T.E. Parsing reward. Trends Neurosci 2003, 26:507-513.
5. Billes S.K., Cowley M.A. Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis. Neuropsychopharmacology 2008, 33:1287-1297.
6. Billes S.K., Cowley M.A. Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice. Neuropsychopharmacology 2007, 32:822-834.
7. Britt J.P., McGehee D.S. Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens. J Neurosci 2008, 28:1672-1681.
8. Cagniard B., Beeler J.A., Britt J.P., McGehee D.S., Marinelli M., Zhuang X. Dopamine scales performance in the absence of new learning. Neuron 2006, 51:541-547.
9. Cheer J.F., Wassum K.M., Heien M.L., Phillips P.E., Wightman R.M. Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J Neurosci 2004, 24:4393-4400.
10. Cheer J.F., Wassum K.M., Sombers L.A., Heien M.L., Ariansen J.L., Aragona B.J., et al. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. J Neurosci 2007, 27:791-795.
11. Colman E. Anorectics on trial: a half century of federal regulation of prescription appetite suppressants. Ann Intern Med 2005, 143:380-385.
12. Cooper S.J., van der Hoek G.A. Cocaine: a microstructural analysis of its effects on feeding and associated behaviour in the rat. Brain Res 1993, 608:45-51.
13. Cragg S.J., Rice M.E. DAncing past the DAT at a DA synapse. Trends Neurosci 2004, 27:270-277.
14. Day J.J., Roitman M.F., Wightman R.M., Carelli R.M. Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nat Neurosci 2007, 10:1020-1028.
15. Di Chiara G., Bassareo V. Reward system and addiction: what dopamine does and doesn't do. Curr Opin Pharmacol 2007, 7:69-76.
16. Di Paola R., Frittitta L., Miscio G., Bozzali M., Baratta R., Centra M., et al. A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet 2002, 70:806-812.
17. Finkelstein E.A., Fiebelkorn I.C., Wang G. State-level estimates of annual medical expenditures attributable to obesity. Obes Res 2004, 12:18-24.
18. Goldstein B.J., Bittner-Kowalczyk A., White M.F., Harbeck M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem 2000, 275:4283-4289.
19. Golozoubova V., Strauss F., Malmlof K. Locomotion is the major determinant of sibutramine-induced increase in energy expenditure. Pharmacol Biochem Behav 2006, 83:517-527.
20. Harto-Truax N., Stern W.C., Miller L.L., Sato T.L., Cato A.E. Effects of bupropion on body weight. J Clin Psychiatry 1983, 44:183-186.
21. Heien M.L., Johnson M.A., Wightman R.M. Resolving neurotransmitters detected by fast-scan cyclic voltammetry. Anal Chem 2004, 76:5697-5704.
22. Heien M.L., Khan A.S., Ariansen J.L., Cheer J.F., Phillips P.E., Wassum K.M., et al. Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proc Natl Acad Sci USA 2005.
23. John C.E., Jones S.R. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology 2007, 52:1596-1605.
24. Jones S.R., Gainetdinov R.R., Wightman R.M., Caron M.G. Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci 1998, 18:1979-1986.
25. Jones S.R., Joseph J.D., Barak L.S., Caron M.G., Wightman R.M. Dopamine neuronal transport kinetics and effects of amphetamine. J Neurochem 1999, 73:2406-2414.
26. Lantz K.A., Hart S.G., Planey S.L., Roitman M.F., Ruiz-White I.A., Wolfe H.R., McLane M.P. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring) 2010, 18:1516-1523.
27. Luscher C., Ungless M.A. The mechanistic classification of addictive drugs. PLoS Med 2006, 3:e437.
28. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1986, Academic Press Inc., San Diego, California.
29. Phillips P.E., Robinson D.L., Stuber G.D., Carelli R.M., Wightman R.M. Real-time measurements of phasic changes in extracellular dopamine concentration in freely moving rats by fast-scan cyclic voltammetry. Meth Mol Med 2003, 79:443-464.
30. Phillips P.E., Stuber G.D., Heien M.L., Wightman R.M., Carelli R.M. Subsecond dopamine release promotes cocaine seeking. Nature 2003, 422:614-618.
31. Pierce R.C., Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?. Neurosci Biobehav Rev 2006, 30:215-238.
32. Rao M.N., Shinnar A.E., Noecker L.A., Chao T.L., Feibush B., Snyder B., et al. Aminosterols from the dogfish shark Squalus acanthias. J Nat Prod 2000, 63:631-635.
33. Roitman M.F., Stuber G.D., Phillips P.E., Wightman R.M., Carelli R.M. Dopamine operates as a subsecond modulator of food seeking. J Neurosci 2004, 24:1265-1271.
34. Roitman M.F., van Dijk G., Thiele T.E., Bernstein I.L. Dopamine mediation of the feeding response to violations of spatial and temporal expectancies. Behav Brain Res 2001, 122:193-199.
35. Roitman M.F., Wheeler R.A., Carelli R.M. Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output. Neuron 2005, 45:587-597.
36. Roitman M.F., Wheeler R.A., Wightman R.M., Carelli R.M. Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli. Nat Neurosci 2008, 11:1376-1377.
37. Rowley H.L., Butler S.A., Prow M.R., Dykes S.G., Aspley S., Kilpatrick I.C., et al. Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats. Synapse (New York, N.Y 2000, 38:167-176.
38. Salahpour A., Ramsey A.J., Medvedev I.O., Kile B., Sotnikova T.D., Holmstrand E., et al. Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proc Natl Acad Sci USA 2008, 105:4405-4410.
39. Schultz W. Behavioral dopamine signals. Trends Neurosci 2007, 30:203-210.
40. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell 2001, 104:531-543.
41. Stamford J.A., Kruk Z.L., Millar J. Dissociation of the actions of uptake blockers upon dopamine overflow and uptake in the rat nucleus accumbens: in vivo voltammetric data. Neuropharmacology 1989, 28:1383-1388.
42. Stuber G.D., Roitman M.F., Phillips P.E., Carelli R.M., Wightman R.M. Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration. Neuropsychopharmacology 2005, 30:853-863.
43. Sulzer D., Sonders M.S., Poulsen N.W., Galli A. Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 2005, 75:406-433.
44. Szczypka M.S., Kwok K., Brot M.D., Marck B.T., Matsumoto A.M., Donahue B.A., et al. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 2001, 30:819-828.
45. van der Hoek G.A., Cooper S.J. The selective dopamine uptake inhibitor GBR 12909: its effects on the microstructure of feeding in rats. Pharmacol Biochem Behav 1994, 48:135-140.
46. Volkow N.D., Fowler J.S., Wang G.J., Swanson J.M., Telang F. Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Arch Neurol 2007, 64:1575-1579.
47. Wellman P.J. Modulation of eating by central catecholamine systems. Curr Drug Targets 2005, 6:191-199.
48. Zasloff M., Williams J.I., Chen Q., Anderson M., Maeder T., Holroyd K., et al. A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. Int J Obes Relat Metab Disord 2001, 25:689-697.