Common structural traits across pathogenic mutants of the human prion protein and their implications for familial prion diseases

Journal of Molecular Biology

Volumn 411, Issue 3, 2011, Pages 700-712

  Rossetti, Giulia ^a,b,c,d   Cong, Xiaojing ^a,b,c   Caliandro, Rocco ^e   Legname, Giuseppe ^a,c,f   Carloni, Paolo ^a,b,c,d  

^a SISSA   (Italy)

^b DEMOCRITOS NATIONAL SIMULATION CENTER   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e CNR   (Italy)

^f SINCROTRONE TRIESTE   (Italy)

Author keywords

ADI; angular dispersion index; disease linked mutation; DLM; GD; globular domain; HB; HuPrP(E219K 129M); HuPrP(PP); hydrogen bond; MD; molecular dynamics; prion protein; PrP; RMSF; root mean square fluctuation; salt bridge; SB; wild type; WT

Indexed keywords

MUTANT PROTEIN; PRION PROTEIN;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; POINT MUTATION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN VARIANT; SCRAPIE; WILD TYPE;

EID: 79960904305     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.06.008     Document Type: Article

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