Conformational diversity in prion protein variants influences intermolecular β-sheet formation

EMBO Journal

Volumn 29, Issue 1, 2010, Pages 251-262

  Lee, Seungjoo ^a   Antony, Lizamma ^b   Hartmann, Rune ^a,b   Knaus, Karen J ^b   Surewicz, Krystyna ^c   Surewicz, Witold K ^c   Yee, Vivien C ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Crystal structure; Prion proteins; Spongiform encephalopathies

Indexed keywords

DIMER; MONOMER; PRION PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BETA SHEET; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETIC VARIABILITY; GENETICS; IN VITRO STUDY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PATHOGENICITY; POINT MUTATION; PRION; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GENETIC VARIATION; HUMANS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POINT MUTATION; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PRPSC PROTEINS; RECOMBINANT PROTEINS;

EID: 75649120399     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.333     Document Type: Article

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