Discovery of a class of diketopiperazines as antiprion compounds

ChemMedChem

Volumn 5, Issue 8, 2010, Pages 1324-1334

  Bolognesi, Maria Laura ^a   Tran, Hoang Ngoc Ai ^b   Staderini, Matteo ^c   Monaco, Alessandra ^c   López Cobẽas, Alberto ^c   Bongarzone, Salvatore ^b,d   Biarnés, Xevi ^b,d   López Alvarado, Pilar ^c   Cabezas, Nieves ^c   Caramelli, Maria ^e   Carloni, Paolo ^b,d,f   Menéndez, J Carlos ^c   Legname, Giuseppe ^b,d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SISSA   (Italy)

^c Club of Madrid   (Spain)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^e Istituto Zooprofilattico Sperimentale Torino   (Italy)

^f RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Computational chemistry; Drug design; Fibrillation inhibitors; Prion diseases

Indexed keywords

3 (2' PYRIDYLMETHYL) 6 (2 'PYRIDYLMETHYLENE) PIPERAZINE 2,5 DIONE; 3 (2,4,5 DIMETHOXY 3 METHYLBENZYL) 6 (2,4,5 DIMETHOXY 3 METHYLBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3 (2,5 DIMETHOXYBENZYL) 6 (2,5 DIMETHOXYBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3 (3,4 DIMETHOXYBENZYL) 6 (3,4 DIMETHOXYBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3 [(1 METHYLINDOL 3 YL) METHYL] 6 [(1 METHYLINDOL 3 YL) METHYLENE) PIPERAZINE 2,5 DIONE; 3 [(1 TOSYL 1H INDOL 3 YL) METHYL] 6 [(1 TOSYL 1H INDOL 3 YL) METHYLENE] PIPERAZINE 2,5 DIONE; 3 [4 (HYDROXYMETHYL) BENZYL] 6 [4 (HYDROXYMETHYL) BENZYLIDENE] PIPERAZINE 2,5 DIONE; 3,6 BIS (1 B CARBOLINYLMETHYLENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2 FURYLMETHYLENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2 PYRIDYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2 QUINOLYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2 THIENYLMETHYLENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2,4,5 METHOXY 3 METHYLBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (2,5 DIMETHOXYBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (3 PYRIDYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (3 QUINOLYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (3,4 DIMETHOXYBENZYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (4 FORMYLPHENYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (4 PYRIDYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS (4 QUINOLYLMETHYLIDENE) PIPERAZINE 2,5 DIONE; 3,6 BIS [(1 METHYLINDOL 3 YL) METHYLENE] PIPERAZINE 2,5 DIONE; 3,6 BIS [(1 TOSYLINDOL 3 YL) METHYLENE] PIPERAZINE 2,5 DIONE; 3,6 DIBENZYLIDENEPIPERAZINE 2,5 DIONE; PIPERAZINEDIONE; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPRION ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRION; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

CELL LINE; DIKETOPIPERAZINES; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, MOLECULAR; PRION DISEASES; PRIONS; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 77955116733     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000133     Document Type: Article

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