Pathogenic Mutations in the Hydrophobic Core of the Human Prion Protein Can Promote Structural Instability and Misfolding

Journal of Molecular Biology

Volumn 404, Issue 4, 2010, Pages 732-748

  van der Kamp, Marc W ^a   Daggett, Valerie ^a  

^a University of Washington   (United States)

Author keywords

Creutzfeld Jakob disease; Familial prion disease; Gerstmann Str ussler Scheinker syndrome; Molecular dynamics

Indexed keywords

PRION PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CREUTZFELDT JAKOB DISEASE; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; HUMAN; HYDROPHOBICITY; MOLECULAR DYNAMICS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STABILITY;

EID: 78149417303     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.09.060     Document Type: Article

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