Contribution of a putative salt bridge and backbone dynamics in the structural instability of human prion protein upon R208H mutation

Biochemical and Biophysical Research Communications

Volumn 364, Issue 4, 2007, Pages 719-724

  Bamdad, Kourosh ^a   Naderi Manesh, Hossein ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Backbone dynamics; Conformational rearrangement; Molecular dynamics; Mutation; Prion protein; R208H; Salt bridge

Indexed keywords

PRION PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CREUTZFELDT JAKOB DISEASE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS;

COMPUTER SIMULATION; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PRIONS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; SALTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36048995435     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.011     Document Type: Article

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