Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

Nature

Volumn 412, Issue 6848, 2001, Pages 739-743

  Peretz, David ^a   Williamson, R Anthony ^b   Kaneko, Kiotoshi ^a,c   Vergara, Julie ^a   Leclerc, Estelle ^b   Schmitt Ulms, Gerold ^a   Mehlhorn, Ingrid R ^a   Legname, Giuseppe ^a   Wormald, Mark R ^d   Rudd, Pauline M ^d   Dwek, Raymond A ^d   Burton, Dennis R ^b   Prusiner, Stanley B ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ANTIGENS; PROTEINS;

PATHOGENIC AGENTS;

ANTIBODIES;

ANTIBODY;

DISEASE;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SCRAPIE;

ANIMALS; ANTIBODY SPECIFICITY; BIOLOGICAL ASSAY; EPITOPES, B-LYMPHOCYTE; ESCHERICHIA COLI; IMMUNOGLOBULIN FRAGMENTS; MICE; PRIONS; PRPC PROTEINS; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA; BOVINAE;

EID: 0035899413     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35089090     Document Type: Article

References (29)

1. Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity
2. Prions
3. Circumventing tolerance in order to generate autologous monoclonal antibodies to the prion protein
4. A conformational transition at the N-terminus of the prion protein features in formation of the scrapie isoform
5. Mapping the prion protein using recombinant antibodies
6. Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form
7. Neural cell adhesion molecules in rodent brains isolated by monoclonal antibodies with cross-species reactivity
8. Scrapie-infected routine neuroblastoma cells produce protease-resistant prion proteins
9. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
10. Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence
11. Mimicking dominant negative inhibition of prion replication through structure-based drug design
12. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines
13. Elimination of prions by branched polyamines and implications for therapeutics
14. Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells
15. Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
16. Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein
17. Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
18. A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells
19. Species specificity in the cell-free conversion of prion protein to protease-resistant forms: A model for the scrapie species barrier
20. Efficient conversion of normal prion protein (PrP) by abnormal hamster PrP is determined by homology at amino acid residue 155
21. Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice
22. In vitro characterization of five humanized OKT3 effector function variant antibodies
23. Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc
24. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
25. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
26. Characterization of scrapie infection in mouse neuroblastoma cells
27. Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
28. Prion glycoprotein: Structure, dynamics, and roles for the sugars
29. A statistical analysis of N- and O-glycan linkage conformations from crystallographic data