Synthetic mammalian prions

Science

Volumn 305, Issue 5684, 2004, Pages 673-676

  Legname, Giuseppe ^a,b   Baskakov, Ilia V ^a,b,d   Nguyen, Hoang Oanh B ^a   Riesner, Detlev ^c   Cohen, Fred E ^a,b   DeArmond, Stephen J ^a,b   Prusiner, Stanley B ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; ESCHERICHIA COLI; NEUROLOGY; PATHOLOGY; POLYMERIZATION;

INFECTIOUS PROTEINS; INOCULATION; NEUROLOGICAL DYSFUNCTIONS;

PROTEINS;

AMYLOID; BRAIN EXTRACT; PRION PROTEIN; RECOMBINANT PROTEIN; BIOPOLYMER; TISSUE EXTRACT;

BIOLOGY; MAMMAL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; ESCHERICHIA COLI; GLIOSIS; INCUBATION TIME; INOCULATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRION; PRIORITY JOURNAL; SURVIVAL TIME; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN; BRAIN LEVEL; CELL VACUOLE; CHEMISTRY; DISEASE TRANSMISSION; FEMALE; GENETICS; GLYCOSYLATION; MALE; METABOLISM; PATHOGENICITY; PATHOLOGY; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN FOLDING; SENILE PLAQUE; TIME;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA; MAMMALIAN PRIONS; MUS MUSCULUS;

AMYLOID; ANIMALS; BIOPOLYMERS; BRAIN; BRAIN CHEMISTRY; ESCHERICHIA COLI; FEMALE; GLYCOSYLATION; MALE; MICE; MICE, TRANSGENIC; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; PRPSC PROTEINS; RECOMBINANT PROTEINS; SENILE PLAQUES; TIME FACTORS; TISSUE EXTRACTS; VACUOLES;

EID: 3442889359     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1100195     Document Type: Article

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44. We thank P. Culhane, K. Giles, P. Lessard, M. Scott, S. Supattapone, and the staff at the Hunters Point Animal Facility, Supported by NIH grants AG02132, AG10770, and AG021601, the G. Harold and Leila Y. Mathers Charitable Foundation, the Dana Foundation, and the Sherman Fairchild Foundation. G.L., D.R., F.E.C., S.J.D., and S.B.P. have a financial interest in InPro Biotechnology, which applies research on prions and prion diseases to promote human health.