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Volumn 32, Issue 11, 2011, Pages 2309-2318

Ghrelin and glucose homeostasis

Author keywords

Diabetes; Ghrelin; Metabolism; Obesity

Indexed keywords

GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN;

EID: 79960333463     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.03.001     Document Type: Review
Times cited : (102)

References (143)
  • 1
    • 78149450776 scopus 로고    scopus 로고
    • Modulation of ghrelin O-acyltransferase expression in pancreatic islets
    • W. An, Y. Li, G. Xu, J. Zhao, X. Xiang, and L. Ding Modulation of ghrelin O-acyltransferase expression in pancreatic islets Cell Physiol. Biochem. 26 2010 707 716
    • (2010) Cell Physiol. Biochem. , vol.26 , pp. 707-716
    • An, W.1    Li, Y.2    Xu, G.3    Zhao, J.4    Xiang, X.5    Ding, L.6
  • 3
    • 10844287775 scopus 로고    scopus 로고
    • Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    • A. Asakawa, A. Inui, M. Fujimiya, R. Sakamaki, N. Shinfuku, and Y. Ueta Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin Gut 54 2005 18 24
    • (2005) Gut , vol.54 , pp. 18-24
    • Asakawa, A.1    Inui, A.2    Fujimiya, M.3    Sakamaki, R.4    Shinfuku, N.5    Ueta, Y.6
  • 4
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • A. Asakawa, A. Inui, T. Kaga, G. Katsuura, M. Fujimiya, and M.A. Fujino Antagonism of ghrelin receptor reduces food intake and body weight gain in mice Gut 52 2003 947 952
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6
  • 5
    • 0034060310 scopus 로고    scopus 로고
    • Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway
    • A.R. Bailey, N. Von Englehardt, G. Leng, R.G. Smith, and S.L. Dickson Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway J. Neuroendocrinol. 12 2000 191 197
    • (2000) J. Neuroendocrinol. , vol.12 , pp. 191-197
    • Bailey, A.R.1    Von Englehardt, N.2    Leng, G.3    Smith, R.G.4    Dickson, S.L.5
  • 6
    • 19944396453 scopus 로고    scopus 로고
    • Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution favoring triglyceride deposition in liver but not skeletal muscle
    • R. Barazzoni, A. Bosutti, M. Stebel, M.R. Cattin, E. Roder, and L. Visintin Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution favoring triglyceride deposition in liver but not skeletal muscle Am. J. Physiol. Endocrinol. Metab. 288 2005 E228 E235
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Barazzoni, R.1    Bosutti, A.2    Stebel, M.3    Cattin, M.R.4    Roder, E.5    Visintin, L.6
  • 8
    • 35348979155 scopus 로고    scopus 로고
    • Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome
    • R. Barazzoni, M. Zanetti, C. Ferreira, P. Vinci, A. Pirulli, and M. Mucci Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome J. Clin. Endocrinol. Metab. 92 2007 3935 3940
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 3935-3940
    • Barazzoni, R.1    Zanetti, M.2    Ferreira, C.3    Vinci, P.4    Pirulli, A.5    Mucci, M.6
  • 9
    • 78650304822 scopus 로고    scopus 로고
    • Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor
    • B.P. Barnett, Y. Hwang, M.S. Taylor, H. Kirchner, P.T. Pfluger, and V. Bernard Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor Science 330 2010 1689 1692
    • (2010) Science , vol.330 , pp. 1689-1692
    • Barnett, B.P.1    Hwang, Y.2    Taylor, M.S.3    Kirchner, H.4    Pfluger, P.T.5    Bernard, V.6
  • 11
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • M.A. Bednarek, S.D. Feighner, S.S. Pong, K.K. McKee, D.L. Hreniuk, and M.V. Silva Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a J. Med. Chem. 43 2000 4370 4376
    • (2000) J. Med. Chem. , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6
  • 12
    • 64649087039 scopus 로고    scopus 로고
    • Mice with hyperghrelinemia are hyperphagic, glucose intolerant and have reduced leptin sensitivity
    • G.A. Bewick, A. Kent, D. Campbell, M. Patterson, M.A. Ghatei, and S.R. Bloom Mice with hyperghrelinemia are hyperphagic, glucose intolerant and have reduced leptin sensitivity Diabetes 58 2009 840 846
    • (2009) Diabetes , vol.58 , pp. 840-846
    • Bewick, G.A.1    Kent, A.2    Campbell, D.3    Patterson, M.4    Ghatei, M.A.5    Bloom, S.R.6
  • 13
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • F. Broglio, E. Arvat, A. Benso, C. Gottero, G. Muccioli, and M. Papotti Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans J. Clin. Endocrinol. Metab. 86 2001 5083 5086
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3    Gottero, C.4    Muccioli, G.5    Papotti, M.6
  • 17
    • 2942666142 scopus 로고    scopus 로고
    • Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans
    • F. Broglio, C. Gottero, F. Prodam, C. Gauna, G. Muccioli, and M. Papotti Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans J. Clin. Endocrinol. Metab. 89 2004 3062 3065
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3062-3065
    • Broglio, F.1    Gottero, C.2    Prodam, F.3    Gauna, C.4    Muccioli, G.5    Papotti, M.6
  • 18
    • 77955678525 scopus 로고    scopus 로고
    • Unacylated ghrelin (UAG) enhances the early insulin response to meal, improves glucose metabolism and decrease free fatty acids levels in healthy volunteers
    • Toronto
    • F. Broglio, F. Prodam, F. Riganti, E. Gramaglia, A. Benso, and B. Lucatello Unacylated ghrelin (UAG) enhances the early insulin response to meal, improves glucose metabolism and decrease free fatty acids levels in healthy volunteers 89th Endocrine Society Meeting Toronto 2007
    • (2007) 89th Endocrine Society Meeting
    • Broglio, F.1    Prodam, F.2    Riganti, F.3    Gramaglia, E.4    Benso, A.5    Lucatello, B.6
  • 19
    • 56549124437 scopus 로고    scopus 로고
    • Hypothalamic control of hepatic glucose production and its potential role in insulin resistance
    • C. Buettner, and R.C. Camacho Hypothalamic control of hepatic glucose production and its potential role in insulin resistance Endocrinol. Metab. Clin. North Am. 37 2008 825 840
    • (2008) Endocrinol. Metab. Clin. North Am. , vol.37 , pp. 825-840
    • Buettner, C.1    Camacho, R.C.2
  • 20
    • 57449088632 scopus 로고    scopus 로고
    • Physiological functions of glucose-inhibited neurones
    • D. Burdakov, and J.A. Gonzalez Physiological functions of glucose-inhibited neurones Acta Physiol. (Oxf) 195 2009 71 78
    • (2009) Acta Physiol. (Oxf) , vol.195 , pp. 71-78
    • Burdakov, D.1    Gonzalez, J.A.2
  • 22
    • 9844226786 scopus 로고    scopus 로고
    • Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults
    • I.M. Chapman, O.H. Pescovitz, G. Murphy, T. Treep, K.A. Cerchio, and D. Krupa Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults J. Clin. Endocrinol. Metab. 82 1997 3455 3463
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 3455-3463
    • Chapman, I.M.1    Pescovitz, O.H.2    Murphy, G.3    Treep, T.4    Cerchio, K.A.5    Krupa, D.6
  • 23
  • 25
    • 0030967950 scopus 로고    scopus 로고
    • Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat
    • R.G. Clark, G.B. Thomas, D.L. Mortensen, W.B. Won, Y.H. Ma, and E.E. Tomlinson Growth hormone secretagogues stimulate the hypothalamic-pituitary- adrenal axis and are diabetogenic in the Zucker diabetic fatty rat Endocrinology 138 1997 4316 4323
    • (1997) Endocrinology , vol.138 , pp. 4316-4323
    • Clark, R.G.1    Thomas, G.B.2    Mortensen, D.L.3    Won, W.B.4    Ma, Y.H.5    Tomlinson, E.E.6
  • 26
    • 0042626304 scopus 로고    scopus 로고
    • Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets
    • M. Colombo, S. Gregersen, J. Xiao, and K. Hermansen Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets Pancreas 27 2003 161 166
    • (2003) Pancreas , vol.27 , pp. 161-166
    • Colombo, M.1    Gregersen, S.2    Xiao, J.3    Hermansen, K.4
  • 27
    • 77951627717 scopus 로고    scopus 로고
    • Hypoadiponectinemia - Cause or consequence of human "insulin resistance"?
    • J.R. Cook, and R.K. Semple Hypoadiponectinemia - cause or consequence of human "insulin resistance"? J. Clin. Endocrinol. Metab. 95 2010 1544 1554
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 1544-1554
    • Cook, J.R.1    Semple, R.K.2
  • 28
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • M.A. Cowley, R.G. Smith, S. Diano, M. Tschop, N. Pronchuk, and K.L. Grove The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6
  • 30
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Y. Date, M. Nakazato, S. Hashiguchi, K. Dezaki, M.S. Mondal, and H. Hosoda Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion Diabetes 51 2002 124 129
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3    Dezaki, K.4    Mondal, M.S.5    Hosoda, H.6
  • 34
    • 77955673240 scopus 로고    scopus 로고
    • Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice
    • P.J. Delhanty, Y. Sun, J.A. Visser, A. van Kerkwijk, M. Huisman, and W.F. van Ijcken Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice PLoS One 5 2010 e11749
    • (2010) PLoS One , vol.5 , pp. 11749
    • Delhanty, P.J.1    Sun, Y.2    Visser, J.A.3    Van Kerkwijk, A.4    Huisman, M.5    Van Ijcken, W.F.6
  • 35
    • 33646148717 scopus 로고    scopus 로고
    • The contractile effect of the ghrelin receptor antagonist, d-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors
    • I. Depoortere, T. Thijs, and T. Peeters The contractile effect of the ghrelin receptor antagonist, d-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors Eur. J. Pharmacol. 537 2006 160 165
    • (2006) Eur. J. Pharmacol. , vol.537 , pp. 160-165
    • Depoortere, I.1    Thijs, T.2    Peeters, T.3
  • 37
    • 34548436635 scopus 로고    scopus 로고
    • 2+ signaling and insulin release in islet beta-cells: Novel signal transduction of ghrelin
    • 2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin Diabetes 56 2007 2319 2327
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 38
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • K. Dezaki, H. Sone, M. Koizumi, M. Nakata, M. Kakei, and H. Nagai Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance Diabetes 55 2006 3486 3493
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6
  • 39
    • 43049170316 scopus 로고    scopus 로고
    • Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    • K. Dezaki, H. Sone, and T. Yada Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis Pharmacol. Ther. 118 2008 239 249
    • (2008) Pharmacol. Ther. , vol.118 , pp. 239-249
    • Dezaki, K.1    Sone, H.2    Yada, T.3
  • 42
    • 40149100521 scopus 로고    scopus 로고
    • Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome
    • A. Fusco, A. Bianchi, A. Mancini, D. Milardi, A. Giampietro, and V. Cimino Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome J. Endocrinol. Invest. 30 2007 948 956
    • (2007) J. Endocrinol. Invest. , vol.30 , pp. 948-956
    • Fusco, A.1    Bianchi, A.2    Mancini, A.3    Milardi, D.4    Giampietro, A.5    Cimino, V.6
  • 43
    • 33646582986 scopus 로고    scopus 로고
    • Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    • C. Gauna, P. Delhanty, M. van Aken, J. Janssen, A. Themmen, and L. Hofland Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor Mol. Cell Endocrinol. 251 2006 103 111
    • (2006) Mol. Cell Endocrinol. , vol.251 , pp. 103-111
    • Gauna, C.1    Delhanty, P.2    Van Aken, M.3    Janssen, J.4    Themmen, A.5    Hofland, L.6
  • 46
    • 6344291317 scopus 로고    scopus 로고
    • Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
    • C. Gauna, F.M. Meyler, J.A. Janssen, P.J. Delhanty, T. Abribat, and P. van Koetsveld Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity J. Clin. Endocrinol. Metab. 89 2004 5035 5042
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5035-5042
    • Gauna, C.1    Meyler, F.M.2    Janssen, J.A.3    Delhanty, P.J.4    Abribat, T.5    Van Koetsveld, P.6
  • 47
    • 35548973084 scopus 로고    scopus 로고
    • Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: A comparison between portal and peripheral concentrations in anesthetized rats
    • C. Gauna, P. Uitterlinden, P. Kramer, R.M. Kiewiet, J.A. Janssen, and P.J. Delhanty Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats Endocrinology 148 2007 5278 5287
    • (2007) Endocrinology , vol.148 , pp. 5278-5287
    • Gauna, C.1    Uitterlinden, P.2    Kramer, P.3    Kiewiet, R.M.4    Janssen, J.A.5    Delhanty, P.J.6
  • 48
    • 34547157499 scopus 로고    scopus 로고
    • Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
    • C. Gauna, B. van de Zande, A. van Kerkwijk, A.P. Themmen, A.J. van der Lely, and P.J. Delhanty Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R) Mol. Cell Endocrinol. 274 2007 30 34
    • (2007) Mol. Cell Endocrinol. , vol.274 , pp. 30-34
    • Gauna, C.1    Van De Zande, B.2    Van Kerkwijk, A.3    Themmen, A.P.4    Van Der Lely, A.J.5    Delhanty, P.J.6
  • 51
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: Involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • R. Granata, F. Settanni, L. Biancone, L. Trovato, R. Nano, and F. Bertuzzi Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling Endocrinology 148 2007 512 529
    • (2007) Endocrinology , vol.148 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5    Bertuzzi, F.6
  • 52
    • 77954749961 scopus 로고    scopus 로고
    • Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    • R. Granata, M. Volante, F. Settanni, C. Gauna, C. Ghe, and M. Annunziata Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats J. Mol. Endocrinol. 45 2010 9 17
    • (2010) J. Mol. Endocrinol. , vol.45 , pp. 9-17
    • Granata, R.1    Volante, M.2    Settanni, F.3    Gauna, C.4    Ghe, C.5    Annunziata, M.6
  • 54
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Mol. Brain Res. 48 1997 23 29
    • (1997) Mol. Brain Res. , vol.48 , pp. 23-29
    • Guan, X.M.1    Yu, H.2    Palyha, O.C.3    McKee, K.K.4    Feighner, S.D.5    Sirinathsinghji, D.J.6
  • 55
    • 34347270206 scopus 로고    scopus 로고
    • Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: Effects on plasma levels of growth hormone, glucose, and insulin
    • M. Guido, D. Romualdi, L. De Marinis, T. Porcelli, M. Giuliani, and B. Costantini Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin Fertil. Steril. 88 2007 125 130
    • (2007) Fertil. Steril. , vol.88 , pp. 125-130
    • Guido, M.1    Romualdi, D.2    De Marinis, L.3    Porcelli, T.4    Giuliani, M.5    Costantini, B.6
  • 57
    • 27344437877 scopus 로고    scopus 로고
    • A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    • H.A. Halem, J.E. Taylor, J.Z. Dong, Y. Shen, R. Datta, and A. Abizaid A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain Neuroendocrinology 81 2005 339 349
    • (2005) Neuroendocrinology , vol.81 , pp. 339-349
    • Halem, H.A.1    Taylor, J.E.2    Dong, J.Z.3    Shen, Y.4    Datta, R.5    Abizaid, A.6
  • 60
    • 0038540318 scopus 로고    scopus 로고
    • Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
    • E. Hermans Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors Pharmacol. Ther. 99 2003 25 44
    • (2003) Pharmacol. Ther. , vol.99 , pp. 25-44
    • Hermans, E.1
  • 61
    • 0037232337 scopus 로고    scopus 로고
    • The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis
    • R.I. Holt, H.L. Simpson, and P.H. Sonksen The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis Diabet. Med. 20 2003 3 15
    • (2003) Diabet. Med. , vol.20 , pp. 3-15
    • Holt, R.I.1    Simpson, H.L.2    Sonksen, P.H.3
  • 62
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelin, identification of multiple ghrelin-derived molecules produced by post-translational processing
    • H. Hosoda, M. Kojima, T. Mizushima, S. Shimizu, and K. Kangawa Structural divergence of human ghrelin, identification of multiple ghrelin-derived molecules produced by post-translational processing J. Biol. Chem. 278 2003 64 70
    • (2003) J. Biol. Chem. , vol.278 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3    Shimizu, S.4    Kangawa, K.5
  • 64
    • 0036896934 scopus 로고    scopus 로고
    • Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • A. Ikezaki, H. Hosoda, K. Ito, S. Iwama, N. Miura, and H. Matsuoka Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents Diabetes 51 2002 3408 3411
    • (2002) Diabetes , vol.51 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6
  • 65
    • 56149100976 scopus 로고    scopus 로고
    • Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats
    • T. Inhoff, H. Monnikes, S. Noetzel, A. Stengel, M. Goebel, and Q.T. Dinh Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats Peptides 29 2008 2159 2168
    • (2008) Peptides , vol.29 , pp. 2159-2168
    • Inhoff, T.1    Monnikes, H.2    Noetzel, S.3    Stengel, A.4    Goebel, M.5    Dinh, Q.T.6
  • 66
    • 20444364831 scopus 로고    scopus 로고
    • Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep
    • J. Iqbal, T.R. Manley, Q. Yue, M.R. Namavar, and I.J. Clarke Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep J. Neuroendocrinol. 17 2005 341 352
    • (2005) J. Neuroendocrinol. , vol.17 , pp. 341-352
    • Iqbal, J.1    Manley, T.R.2    Yue, Q.3    Namavar, M.R.4    Clarke, I.J.5
  • 67
    • 20244373352 scopus 로고    scopus 로고
    • Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice
    • H. Iwakura, K. Hosoda, C. Son, J. Fujikura, T. Tomita, and M. Noguchi Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice J. Biol. Chem. 280 2005 15247 15256
    • (2005) J. Biol. Chem. , vol.280 , pp. 15247-15256
    • Iwakura, H.1    Hosoda, K.2    Son, C.3    Fujikura, J.4    Tomita, T.5    Noguchi, M.6
  • 68
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    • H. Jiang, L. Betancourt, and R.G. Smith Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers Mol. Endocrinol. 20 2006 1772 1785
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 69
    • 77049093432 scopus 로고    scopus 로고
    • Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding
    • H. Kageyama, F. Takenoya, K. Shiba, and S. Shioda Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding Neuropeptides 44 2010 133 138
    • (2010) Neuropeptides , vol.44 , pp. 133-138
    • Kageyama, H.1    Takenoya, F.2    Shiba, K.3    Shioda, S.4
  • 70
    • 9444236184 scopus 로고    scopus 로고
    • Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus
    • A. Katsuki, H. Urakawa, E.C. Gabazza, S. Murashima, K. Nakatani, and K. Togashi Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus Eur. J. Endocrinol. 151 2004 573 577
    • (2004) Eur. J. Endocrinol. , vol.151 , pp. 573-577
    • Katsuki, A.1    Urakawa, H.2    Gabazza, E.C.3    Murashima, S.4    Nakatani, K.5    Togashi, K.6
  • 71
    • 81755186276 scopus 로고    scopus 로고
    • Acute effects of acylated and unacylated ghrelin on total and high molecular weight adiponectin in morbidly obese subjects
    • PMID: 20959720
    • R.M. Kiewiet, M.J. Hazell, M.O. van Aken, K. van der Weerd, J.A. Visser, and A.P. Themmen Acute effects of acylated and unacylated ghrelin on total and high molecular weight adiponectin in morbidly obese subjects J. Endocrinol. Invest. 2010 PMID: 20959720
    • (2010) J. Endocrinol. Invest.
    • Kiewiet, R.M.1    Hazell, M.J.2    Van Aken, M.O.3    Van Der Weerd, K.4    Visser, J.A.5    Themmen, A.P.6
  • 72
  • 73
    • 0042200265 scopus 로고    scopus 로고
    • Changes in ghrelin and ghrelin receptor expression according to feeding status
    • M.S. Kim, C.Y. Yoon, K.H. Park, C.S. Shin, K.S. Park, and S.Y. Kim Changes in ghrelin and ghrelin receptor expression according to feeding status Neuroreport 14 2003 1317 1320
    • (2003) Neuroreport , vol.14 , pp. 1317-1320
    • Kim, M.S.1    Yoon, C.Y.2    Park, K.H.3    Shin, C.S.4    Park, K.S.5    Kim, S.Y.6
  • 75
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 76
    • 35648962374 scopus 로고    scopus 로고
    • Structure of mammalian and nonmammalian ghrelins
    • M. Kojima, T. Ida, and T. Sato Structure of mammalian and nonmammalian ghrelins Vitam. Horm. 77 2008 31 46
    • (2008) Vitam. Horm. , vol.77 , pp. 31-46
    • Kojima, M.1    Ida, T.2    Sato, T.3
  • 77
    • 0344153907 scopus 로고    scopus 로고
    • Neuroendocrinology of the pancreas; Role of brain-gut axis in pancreatic secretion
    • S.J. Konturek, R. Zabielski, J.W. Konturek, and J. Czarnecki Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion Eur. J. Pharmacol. 481 2003 1 14
    • (2003) Eur. J. Pharmacol. , vol.481 , pp. 1-14
    • Konturek, S.J.1    Zabielski, R.2    Konturek, J.W.3    Czarnecki, J.4
  • 79
  • 81
    • 0036141195 scopus 로고    scopus 로고
    • Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine, and dietary manipulations
    • H.M. Lee, G. Wang, E.W. Englander, M. Kojima, and G.H. Greeley Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations Endocrinology 143 2002 185 190
    • (2002) Endocrinology , vol.143 , pp. 185-190
    • Lee, H.M.1    Wang, G.2    Englander, E.W.3    Kojima, M.4    Greeley, Jr.G.H.5
  • 83
    • 43249089526 scopus 로고    scopus 로고
    • Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men
    • J. Liu, C.E. Prudom, R. Nass, S.S. Pezzoli, M.C. Oliveri, and M.L. Johnson Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men J. Clin. Endocrinol. Metab. 93 2008 1980 1987
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1980-1987
    • Liu, J.1    Prudom, C.E.2    Nass, R.3    Pezzoli, S.S.4    Oliveri, M.C.5    Johnson, M.L.6
  • 87
    • 0032916182 scopus 로고    scopus 로고
    • Growth hormone (GH) response to GH-releasing peptide-6 and GH-releasing hormone in normal-weight and overweight patients with non-insulin-dependent diabetes mellitus
    • D. Micic, D. Macut, V. Popovic, A. Kendereski, M. Sumarac-Dumanovic, and S. Zoric Growth hormone (GH) response to GH-releasing peptide-6 and GH-releasing hormone in normal-weight and overweight patients with non-insulin-dependent diabetes mellitus Metabolism 48 1999 525 530
    • (1999) Metabolism , vol.48 , pp. 525-530
    • Micic, D.1    MacUt, D.2    Popovic, V.3    Kendereski, A.4    Sumarac-Dumanovic, M.5    Zoric, S.6
  • 88
    • 4444246201 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor
    • G. Muccioli, N. Pons, C. Ghe, F. Catapano, R. Granata, and E. Ghigo Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor Eur. J. Pharmacol. 498 2004 27 35
    • (2004) Eur. J. Pharmacol. , vol.498 , pp. 27-35
    • Muccioli, G.1    Pons, N.2    Ghe, C.3    Catapano, F.4    Granata, R.5    Ghigo, E.6
  • 91
    • 77952534454 scopus 로고    scopus 로고
    • In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis
    • H. Ni, K. De Waele, P. Walia, and J.P. Chanoine In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis Pediatr. Res. 67 2010 609 613
    • (2010) Pediatr. Res. , vol.67 , pp. 609-613
    • Ni, H.1    De Waele, K.2    Walia, P.3    Chanoine, J.P.4
  • 92
    • 4043159122 scopus 로고    scopus 로고
    • Effects of peripheral ghrelin on the carbohydrate and lipid metabolism of the tundra vole (Microtus oeconomus)
    • P. Nieminen, and A.M. Mustonen Effects of peripheral ghrelin on the carbohydrate and lipid metabolism of the tundra vole (Microtus oeconomus) Gen. Comp. Endocrinol. 138 2004 182 187
    • (2004) Gen. Comp. Endocrinol. , vol.138 , pp. 182-187
    • Nieminen, P.1    Mustonen, A.M.2
  • 93
    • 20244366719 scopus 로고    scopus 로고
    • Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
    • Y. Nishi, H. Hiejima, H. Hosoda, H. Kaiya, K. Mori, and Y. Fukue Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin Endocrinology 146 2005 2255 2264
    • (2005) Endocrinology , vol.146 , pp. 2255-2264
    • Nishi, Y.1    Hiejima, H.2    Hosoda, H.3    Kaiya, H.4    Mori, K.5    Fukue, Y.6
  • 94
    • 33751506108 scopus 로고    scopus 로고
    • Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    • K. Nonogaki, K. Nozue, and Y. Oka Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice Endocrinology 147 2006 5893 5900
    • (2006) Endocrinology , vol.147 , pp. 5893-5900
    • Nonogaki, K.1    Nozue, K.2    Oka, Y.3
  • 95
    • 72949115929 scopus 로고    scopus 로고
    • Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome
    • L. Pacifico, E. Poggiogalle, F. Costantino, C. Anania, F. Ferraro, and F. Chiarelli Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome Eur. J. Endocrinol. 161 2009 861 870
    • (2009) Eur. J. Endocrinol. , vol.161 , pp. 861-870
    • Pacifico, L.1    Poggiogalle, E.2    Costantino, F.3    Anania, C.4    Ferraro, F.5    Chiarelli, F.6
  • 97
    • 35648957666 scopus 로고    scopus 로고
    • Biochemistry of ghrelin precursor peptides
    • C.J. Pemberton, and A.M. Richards Biochemistry of ghrelin precursor peptides Vitam. Horm. 77 2008 13 30
    • (2008) Vitam. Horm. , vol.77 , pp. 13-30
    • Pemberton, C.J.1    Richards, A.M.2
  • 98
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • S.M. Poykko, E. Kellokoski, S. Horkko, H. Kauma, Y.A. Kesaniemi, and O. Ukkola Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes Diabetes 52 2003 2546 2553
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Poykko, S.M.1    Kellokoski, E.2    Horkko, S.3    Kauma, H.4    Kesaniemi, Y.A.5    Ukkola, O.6
  • 100
    • 0346101851 scopus 로고    scopus 로고
    • Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    • J.Q. Purnell, D.S. Weigle, P. Breen, and D.E. Cummings Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans J. Clin. Endocrinol. Metab. 88 2003 5747 5752
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 5747-5752
    • Purnell, J.Q.1    Weigle, D.S.2    Breen, P.3    Cummings, D.E.4
  • 101
    • 0032993995 scopus 로고    scopus 로고
    • The effect of chronic hexarelin administration on the pituitary-adrenal axis and prolactin
    • A. Rahim, P.A. O'Neill, and S.M. Shalet The effect of chronic hexarelin administration on the pituitary-adrenal axis and prolactin Clin. Endocrinol. (Oxf). 50 1999 77 84
    • (1999) Clin. Endocrinol. (Oxf). , vol.50 , pp. 77-84
    • Rahim, A.1    O'Neill, P.A.2    Shalet, S.M.3
  • 103
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • M.K. Reimer, G. Pacini, and B. Ahren Dose-dependent inhibition by ghrelin of insulin secretion in the mouse Endocrinology 144 2003 916 921
    • (2003) Endocrinology , vol.144 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahren, B.3
  • 105
    • 79958016808 scopus 로고    scopus 로고
    • Effect of ghrelin on glucose-insulin homeostasis: Therapeutic implications
    • S. Sangiao-Alvarellos, and F. Cordido Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications Int. J. Pept. 2010 2010
    • (2010) Int. J. Pept. , vol.2010
    • Sangiao-Alvarellos, S.1    Cordido, F.2
  • 106
    • 1642503857 scopus 로고    scopus 로고
    • Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats
    • N. Sato, S. Kanai, S. Takano, M. Kurosawa, A. Funakoshi, and K. Miyasaka Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats Jpn. J. Physiol. 53 2003 443 449
    • (2003) Jpn. J. Physiol. , vol.53 , pp. 443-449
    • Sato, N.1    Kanai, S.2    Takano, S.3    Kurosawa, M.4    Funakoshi, A.5    Miyasaka, K.6
  • 107
    • 77957266562 scopus 로고    scopus 로고
    • Identification and characterization of acyl-protein thioesterase 1/lysophospholipase i as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
    • M. Satou, Y. Nishi, J. Yoh, Y. Hattori, and H. Sugimoto Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium Endocrinology 151 2010 4765 4775
    • (2010) Endocrinology , vol.151 , pp. 4765-4775
    • Satou, M.1    Nishi, Y.2    Yoh, J.3    Hattori, Y.4    Sugimoto, H.5
  • 108
    • 33646436737 scopus 로고    scopus 로고
    • The nucleus tractus solitari (NTS) participates in peripheral ghrelin glucostatic hunger signalling mediated by insulin
    • A. Solomon, B.A. De Fanti, and J.A. Martinez The nucleus tractus solitari (NTS) participates in peripheral ghrelin glucostatic hunger signalling mediated by insulin Neuropeptides 40 2006 169 175
    • (2006) Neuropeptides , vol.40 , pp. 169-175
    • Solomon, A.1    De Fanti, B.A.2    Martinez, J.A.3
  • 109
    • 73649093422 scopus 로고    scopus 로고
    • Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development
    • J. Soyer, L. Flasse, W. Raffelsberger, A. Beucher, C. Orvain, and B. Peers Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development Development 137 2010 203 212
    • (2010) Development , vol.137 , pp. 203-212
    • Soyer, J.1    Flasse, L.2    Raffelsberger, W.3    Beucher, A.4    Orvain, C.5    Peers, B.6
  • 110
    • 79951703161 scopus 로고    scopus 로고
    • Twenty-four-hour profiles of acylated and total ghrelin: Relationship with glucose levels and impact of time of day and sleep
    • K. Spiegel, E. Tasali, R. Leproult, N. Scherberg, and E. Van Cauter Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep J. Clin. Endocrinol. Metab. 96 2010 486 493
    • (2010) J. Clin. Endocrinol. Metab. , vol.96 , pp. 486-493
    • Spiegel, K.1    Tasali, E.2    Leproult, R.3    Scherberg, N.4    Van Cauter, E.5
  • 111
    • 33846034095 scopus 로고    scopus 로고
    • Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women
    • D.H. St-Pierre, A.D. Karelis, L. Coderre, F. Malita, J. Fontaine, and D. Mignault Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women J. Clin. Endocrinol. Metab. 92 2007 264 269
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 264-269
    • St-Pierre, D.H.1    Karelis, A.D.2    Coderre, L.3    Malita, F.4    Fontaine, J.5    Mignault, D.6
  • 113
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Y. Sun, M. Asnicar, P.K. Saha, L. Chan, and R.G. Smith Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metab. 3 2006 379 386
    • (2006) Cell Metab. , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 114
    • 35948929766 scopus 로고    scopus 로고
    • Central and peripheral roles of ghrelin on glucose homeostasis
    • Y. Sun, M. Asnicar, and R.G. Smith Central and peripheral roles of ghrelin on glucose homeostasis Neuroendocrinology 86 2007 215 228
    • (2007) Neuroendocrinology , vol.86 , pp. 215-228
    • Sun, Y.1    Asnicar, M.2    Smith, R.G.3
  • 115
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    • Y. Sun, N.F. Butte, J.M. Garcia, and R.G. Smith Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance Endocrinology 149 2008 843 850
    • (2008) Endocrinology , vol.149 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 116
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc. Natl. Acad. Sci. U.S.A. 101 2004 4679 4684
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 117
    • 15644364105 scopus 로고    scopus 로고
    • Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure
    • J. Svensson, L. Lonn, J.O. Jansson, G. Murphy, D. Wyss, and D. Krupa Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure J. Clin. Endocrinol. Metab. 83 1998 362 369
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 362-369
    • Svensson, J.1    Lonn, L.2    Jansson, J.O.3    Murphy, G.4    Wyss, D.5    Krupa, D.6
  • 119
    • 66149117736 scopus 로고    scopus 로고
    • Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: Relationship with cholinesterase
    • E. Tham, J. Liu, S. Innis, D. Thompson, B.D. Gaylinn, and R. Bogarin Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase Am. J. Physiol. Endocrinol. Metab. 296 2009 E1093 E1100
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Tham, E.1    Liu, J.2    Innis, S.3    Thompson, D.4    Gaylinn, B.D.5    Bogarin, R.6
  • 120
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of GHS-R1a
    • N.M. Thompson, D.A. Gill, R. Davies, N. Loveridge, P.A. Houston, and I.C. Robinson Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of GHS-R1a Endocrinology 145 2004 234 242
    • (2004) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3    Loveridge, N.4    Houston, P.A.5    Robinson, I.C.6
  • 121
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • J. Tong, R.L. Prigeon, H.W. Davis, M. Bidlingmaier, S.E. Kahn, and D.E. Cummings Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans Diabetes 59 2010 2145 2151
    • (2010) Diabetes , vol.59 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3    Bidlingmaier, M.4    Kahn, S.E.5    Cummings, D.E.6
  • 122
    • 33645857375 scopus 로고    scopus 로고
    • Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    • K. Toshinai, H. Yamaguchi, Y. Sun, R.G. Smith, A. Yamanaka, and T. Sakurai Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor Endocrinology 147 2006 2306 2314
    • (2006) Endocrinology , vol.147 , pp. 2306-2314
    • Toshinai, K.1    Yamaguchi, H.2    Sun, Y.3    Smith, R.G.4    Yamanaka, A.5    Sakurai, T.6
  • 123
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschöp, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 124
    • 0030880740 scopus 로고    scopus 로고
    • Roles of circadian rhythmicity and sleep in human glucose regulation
    • E. Van Cauter, K.S. Polonsky, and A.J. Scheen Roles of circadian rhythmicity and sleep in human glucose regulation Endocr. Rev. 18 1997 716 738
    • (1997) Endocr. Rev. , vol.18 , pp. 716-738
    • Van Cauter, E.1    Polonsky, K.S.2    Scheen, A.J.3
  • 125
    • 58549091080 scopus 로고    scopus 로고
    • Ghrelin and new metabolic frontiers
    • A.J. van der Lely Ghrelin and new metabolic frontiers Horm. Res. 71 Suppl. 1 2009 129 133
    • (2009) Horm. Res. , vol.71 , Issue.SUPPL. 1 , pp. 129-133
    • Van Der Lely, A.J.1
  • 126
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • A.J. van der Lely, M. Tschöp, M.L. Heiman, and E. Ghigo Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin Endocr. Rev. 25 2004 426 457
    • (2004) Endocr. Rev. , vol.25 , pp. 426-457
    • Van Der Lely, A.J.1    Tschöp, M.2    Heiman, M.L.3    Ghigo, E.4
  • 129
    • 58149352421 scopus 로고    scopus 로고
    • Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling
    • E.T. Vestergaard, L.C. Gormsen, N. Jessen, S. Lund, T.K. Hansen, and N. Moller Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling Diabetes 57 2008 3205 3210
    • (2008) Diabetes , vol.57 , pp. 3205-3210
    • Vestergaard, E.T.1    Gormsen, L.C.2    Jessen, N.3    Lund, S.4    Hansen, T.K.5    Moller, N.6
  • 132
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    • M. Volante, E. Allia, P. Gugliotta, A. Funaro, F. Broglio, and R. Deghenghi Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors J. Clin. Endocrinol. Metab. 87 2002 1300 1308
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1300-1308
    • Volante, M.1    Allia, E.2    Gugliotta, P.3    Funaro, A.4    Broglio, F.5    Deghenghi, R.6
  • 133
    • 38149024823 scopus 로고    scopus 로고
    • Effects of ghrelin on glucose-sensing and gastric distension sensitive neurons in rat dorsal vagal complex
    • W.G. Wang, X. Chen, H. Jiang, and Z.Y. Jiang Effects of ghrelin on glucose-sensing and gastric distension sensitive neurons in rat dorsal vagal complex Regulat. Pept. 146 2008 169 175
    • (2008) Regulat. Pept. , vol.146 , pp. 169-175
    • Wang, W.G.1    Chen, X.2    Jiang, H.3    Jiang, Z.Y.4
  • 134
    • 1242318803 scopus 로고    scopus 로고
    • Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    • N. Wierup, S. Yang, R.J. McEvilly, H. Mulder, and F. Sundler Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells J. Histochem. Cytochem. 52 2004 301 310
    • (2004) J. Histochem. Cytochem. , vol.52 , pp. 301-310
    • Wierup, N.1    Yang, S.2    McEvilly, R.J.3    Mulder, H.4    Sundler, F.5
  • 135
    • 67651177691 scopus 로고    scopus 로고
    • Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake
    • G. Xu, Y. Li, W. An, S. Li, Y. Guan, and N. Wang Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake Endocrinology 150 2009 3637 3644
    • (2009) Endocrinology , vol.150 , pp. 3637-3644
    • Xu, G.1    Li, Y.2    An, W.3    Li, S.4    Guan, Y.5    Wang, N.6
  • 137
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • J. Yang, M.S. Brown, G. Liang, N.V. Grishin, and J.L. Goldstein Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone Cell 132 2008 387 396
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 138
    • 42149126035 scopus 로고    scopus 로고
    • A new variation in the promoter region, the -604 C > T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance
    • S. Zavarella, A. Petrone, S. Zampetti, M. Gueorguiev, M. Spoletini, and C.A. Mein A new variation in the promoter region, the -604 C > T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance Int. J. Obes. (Lond). 32 2008 663 668
    • (2008) Int. J. Obes. (Lond). , vol.32 , pp. 663-668
    • Zavarella, S.1    Petrone, A.2    Zampetti, S.3    Gueorguiev, M.4    Spoletini, M.5    Mein, C.A.6
  • 139
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • C.Y. Zhang, G. Baffy, P. Perret, S. Krauss, O. Peroni, and D. Grujic Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes Cell 105 2001 745 755
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3    Krauss, S.4    Peroni, O.5    Grujic, D.6
  • 140
    • 50449085374 scopus 로고    scopus 로고
    • Effect of des-acyl ghrelin on adiposity and glucose metabolism
    • W. Zhang, B. Chai, J.Y. Li, H. Wang, and M.W. Mulholland Effect of des-acyl ghrelin on adiposity and glucose metabolism Endocrinology 149 2008 4710 4716
    • (2008) Endocrinology , vol.149 , pp. 4710-4716
    • Zhang, W.1    Chai, B.2    Li, J.Y.3    Wang, H.4    Mulholland, M.W.5
  • 141
    • 77952165770 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    • T.J. Zhao, G. Liang, R.L. Li, X. Xie, M.W. Sleeman, and A.J. Murphy Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice Proc. Natl. Acad. Sci. U.S.A. 107 2010 7467 7472
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 7467-7472
    • Zhao, T.J.1    Liang, G.2    Li, R.L.3    Xie, X.4    Sleeman, M.W.5    Murphy, A.J.6
  • 142
    • 33846024377 scopus 로고    scopus 로고
    • On the processing of proghrelin to ghrelin
    • X. Zhu, Y. Cao, K. Voogd, and D.F. Steiner On the processing of proghrelin to ghrelin J. Biol. Chem. 281 2006 38867 38870
    • (2006) J. Biol. Chem. , vol.281 , pp. 38867-38870
    • Zhu, X.1    Cao, Y.2    Voogd, K.3    Steiner, D.F.4


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