Modulation of ghrelin o-acyltransferase expression in pancreatic islets

Cellular Physiology and Biochemistry

Volumn 26, Issue 4-5, 2010, Pages 707-716

  An, Wenjiao ^a   Li, Yin ^a   Xu, Geyang ^a   Zhao, Jing ^a   Xiang, Xinxin ^a   Ding, Li ^a   Li, Jing ^a   Guan, Youfei ^a   Wang, Xian ^a   Tang, Chaosu ^a   Li, Xiaoying ^c   Mulholland, Michael ^b   Zhang, Weizhen ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Ghrelin O acyltransferase; Insulin; Mammalian target of rapamycin; Pancreatic islet cells

Indexed keywords

GHRELIN; GHRELIN O ACYLTRANSFERASE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE ENZYME; MESSENGER RNA; PROTEIN; RAPAMYCIN; TSC1 PROTEIN; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME REGULATION; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MAMMALIA;

EID: 78149450776     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322338     Document Type: Article

References (38)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660.
2. Kojima M, Kangawa K: Ghrelin: Structure and function. Physiol Rev 2005;85:495-522.
3. Zhang W, Chen M, Chen X, Segura BJ, Mulholland MW: Inhibition of pancreatic protein secretion by ghrelin in the rat. J Physiol 2001;537:231-236.
4. Zhang W, Hu Y, Lin TR, Fan Y, Mulholland MW: Stimulation of neurogenesis in rat nucleus of the solitary tract by ghrelin. Peptides 2005;26:2280-2288.
5. Zhang W, Lin TR, Hu Y, Fan Y, Zhao L, Stuenkel EL, Mulholland MW: Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus. J Physiol 2004;559:729-737.
6. Zhang W, Zhao L, Lin TR, Chai B, Fan Y, Gantz I, Mulholland MW: Inhibition of adipogenesis by ghrelin. Mol Biol Cell 2004;15:2484-2491.
7. Zhang W, Zhao L, Mulholland MW: Ghrelin stimulates myocyte development. Cell Physiol Biochem 2007;20:659-664.
8. Sun Y, Asnicar M, Smith RG: Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 2007;86:215-228.
9. Zhang W, Chai B, Li J Y, Wang H, Mulholland MW: Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 2008;149:4710-4716.
10. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L: Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci \USA 2004;101:2924-2929.
11. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci \USA 2008;105:6320-6325.
12. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008;132:387-396.
13. Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco AP: Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 1987;43:725-730.
14. Janjic D, Asfari M: Effects of cytokines on rat insulinoma ins-1 cells. J Endocrinol 1992;132:67-76.
15. Waeber G, Thompson N, Waeber B, Brunner HR, Nicod P, Grouzmann E: Neuropeptide y expression and regulation in a differentiated rat insulin-secreting cell line. Endocrinology 1993;133:1061-1067.
16. Bollheimer LC, Wrede CE, Rockmann F, Ottinger I, Scholmerich J, Buettner R: Glucagon production of the rat insulinoma cell line ins-1-a quantitative comparison with primary rat pancreatic islets. Biochem Biophys Res Commun 2005;330:327-332.
17. Arumugam R, Fleenor D, Freemark M: Lactogenic and somatogenic hormones regulate the expression of neuropeptide y and cocaine- and amphetamine-regulated transcript in rat insulinoma (ins-1) cells: Interactions with glucose and glucocorticoids. Endocrinology 2007;148:258-267.
18. Xu G, Li Y, An W, Li S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W: Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 2009;150:3637-3644.
19. Inoki K, Li Y, Zhu T, Wu J, Guan KL: Tsc2 is phosphorylated and inhibited by akt and suppresses mtor signalling. Nat Cell Biol 2002;4:648-657.
20. Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML: Metabolic regulation by leucine of translation initiation through the mtor-signaling pathway by pancreatic beta-cells. Diabetes 2001;50:353-360.
21. Adeghate E, Ponery AS: Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. J Neuroendocrinol 2002;14:555-560.
22. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S: Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002;51:124-129.
23. Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J: Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 2002;146:241-244.
24. Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T: Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating ca2+ signaling in beta-cells: Implication in the glycemic control in rodents. Diabetes 2004;53:3142-3151.
25. Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK: Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005;115:3564-3572.
26. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG: Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 2006;3:379-386.
27. Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schurmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschop MH: Goat links dietary lipids with the endocrine control of energy balance. Nat Med 2009;15:741-745.
28. Gonzalez CR, Vazquez MJ, Lopez M, Dieguez C: Influence of chronic undernutrition and leptin on goat mrna levels in rat stomach mucosa. J Mol Endocrinol 2008;41:415-421.
29. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, Muccioli G, Ghigo E, Papotti M: Expression of ghrelin and of the gh secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002;87:1300-1308.
30. Kageyama H, Funahashi H, Hirayama M, Takenoya F, Kita T, Kato S, Sakurai J, Lee E Y, Inoue S, Date Y, Nakazato M, Kangawa K, Shioda S: Morphological analysis of ghrelin and its receptor distribution in the rat pancreas. Regul Pept 2005;126:67-71.
31. Nakashima K, Kanda Y, Hirokawa Y, Kawasaki F, Matsuki M, Kaku K: Min6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones. Endocr J 2009;56:45-53.
32. Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M: Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 2001;21:5050-5062.
33. Brunn GJ, Fadden P, Haystead TA, Lawrence JC Jr: The mammalian target of rapamycin phosphorylates sites having a (ser/thr)-pro motif and is activated by antibodies to a region near its cooh terminus. J Biol Chem 1997;272:32547-32550.
34. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G: Mammalian tor: A homeostatic atp sensor. Science 2001;294:1102-1105.
35. Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J: Interaction of foxo1 and tsc2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 s6k pathway. J Biol Chem 2006;281:40242-40251.
36. Mori H, Inoki K, Opland D, Muenzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski D, Macdougald OA, Myers Jr MG, Guan KL: Critical roles for the tsc-mtor pathway in beta-cell function. Am J Physiol Endocrinol Metab 2009; 297:1013-1022.
37. Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG: Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/src and mtor pathways. Circ Res 2008;103:813-824.
38. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang C Y, He X, MacDougald OA, You M, Williams BO, Guan KL: Tsc2 integrates wnt and energy signals via a coordinated phosphorylation by ampk and gsk3 to regulate cell growth. Cell 2006;126:955-968.