메뉴 건너뛰기




Volumn 274, Issue 1-2, 2007, Pages 30-34

Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)

Author keywords

Antagonism; Ghrelin; GHS R

Indexed keywords

AEQUORIN; CALCIUM ION; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1A; UNACYLATED GHRELIN; UNCLASSIFIED DRUG;

EID: 34547157499     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.05.010     Document Type: Article
Times cited : (74)

References (26)
  • 2
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek M.A., Feighner S.D., Pong S.S., McKee K.K., Hreniuk D.L., Silva M.V., Warren V.A., Howard A.D., Van Der Ploeg L.H., and Heck J.V. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 43 (2000) 4370-4376
    • (2000) J. Med. Chem. , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6    Warren, V.A.7    Howard, A.D.8    Van Der Ploeg, L.H.9    Heck, J.V.10
  • 4
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • Cassoni P., Papotti M., Ghe C., Catapano F., Sapino A., Graziani A., Deghenghi R., Reissmann T., Ghigo E., and Muccioli G. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J. Clin. Endocrinol. Metab. 86 (2001) 1738-1745
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1738-1745
    • Cassoni, P.1    Papotti, M.2    Ghe, C.3    Catapano, F.4    Sapino, A.5    Graziani, A.6    Deghenghi, R.7    Reissmann, T.8    Ghigo, E.9    Muccioli, G.10
  • 5
    • 12144290080 scopus 로고    scopus 로고
    • Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines
    • Cassoni P., Ghe C., Marrocco T., Tarabra E., Allia E., Catapano F., Deghenghi R., Ghigo E., Papotti M., and Muccioli G. Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur. J. Endocrinol. 150 (2004) 173-184
    • (2004) Eur. J. Endocrinol. , vol.150 , pp. 173-184
    • Cassoni, P.1    Ghe, C.2    Marrocco, T.3    Tarabra, E.4    Allia, E.5    Catapano, F.6    Deghenghi, R.7    Ghigo, E.8    Papotti, M.9    Muccioli, G.10
  • 7
    • 0024412624 scopus 로고
    • The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture
    • Cheng K., Chan W., Barreto A.J., Convey E., and Smith R. The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology 124 (1989) 2791-2798
    • (1989) Endocrinology , vol.124 , pp. 2791-2798
    • Cheng, K.1    Chan, W.2    Barreto, A.J.3    Convey, E.4    Smith, R.5
  • 8
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • Dezaki K., Sone H., Koizumi M., Nakata M., Kakei M., Nagai H., Hosoda H., Kangawa K., and Yada T. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55 (2006) 3486-3493
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6    Hosoda, H.7    Kangawa, K.8    Yada, T.9
  • 11
    • 33646582986 scopus 로고    scopus 로고
    • Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    • Gauna C., Delhanty P., van Aken M., Janssen J., Themmen A., Hofland L., Culler M., Broglio F., Ghigo E., and van der Lely A. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol. Cell. Endocrinol. 251 (2006) 103-111
    • (2006) Mol. Cell. Endocrinol. , vol.251 , pp. 103-111
    • Gauna, C.1    Delhanty, P.2    van Aken, M.3    Janssen, J.4    Themmen, A.5    Hofland, L.6    Culler, M.7    Broglio, F.8    Ghigo, E.9    van der Lely, A.10
  • 13
    • 27344437877 scopus 로고    scopus 로고
    • A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    • Halem H.A., Taylor J.E., Dong J.Z., Shen Y., Datta R., Abizaid A., Diano S., Horvath T.L., and Culler M.D. A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology 81 (2005) 339-349
    • (2005) Neuroendocrinology , vol.81 , pp. 339-349
    • Halem, H.A.1    Taylor, J.E.2    Dong, J.Z.3    Shen, Y.4    Datta, R.5    Abizaid, A.6    Diano, S.7    Horvath, T.L.8    Culler, M.D.9
  • 14
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing
    • Hosoda H., Kojima M., Mizushima T., Shimizu S., and Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J. Biol. Chem. 278 (2003) 64-70
    • (2003) J. Biol. Chem. , vol.278 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3    Shimizu, S.4    Kangawa, K.5
  • 15
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: structure and function
    • Kojima M., and Kangawa K. Ghrelin: structure and function. Physiol. Rev. 85 (2005) 495-522
    • (2005) Physiol. Rev. , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 16
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 19
    • 4444246201 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor
    • Muccioli G., Pons N., Ghe C., Catapano F., Granata R., and Ghigo E. Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor. Eur. J. Pharmacol. 498 (2004) 27-35
    • (2004) Eur. J. Pharmacol. , vol.498 , pp. 27-35
    • Muccioli, G.1    Pons, N.2    Ghe, C.3    Catapano, F.4    Granata, R.5    Ghigo, E.6
  • 20
  • 21
    • 27144468685 scopus 로고    scopus 로고
    • Developments in ghrelin biology and potential clinical relevance
    • Smith R.G., Jiang H., and Sun Y. Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol. Metab. 16 (2005) 436-442
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 436-442
    • Smith, R.G.1    Jiang, H.2    Sun, Y.3
  • 23
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directlyin vivo by a mechanism independent of GHS-R1a
    • Thompson N.M., Gill D.A., Davies R., Loveridge N., Houston P.A., Robinson I.C., and Wells T. Ghrelin and des-octanoyl ghrelin promote adipogenesis directlyin vivo by a mechanism independent of GHS-R1a. Endocrinology 145 (2003) 234-242
    • (2003) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3    Loveridge, N.4    Houston, P.A.5    Robinson, I.C.6    Wells, T.7
  • 24
    • 33645857375 scopus 로고    scopus 로고
    • Toshinai, K., Yamaguchi, H., Sun, Y., Smith, R.G., Yamanaka, A., Sakurai, T., Date, Y., Mondal, M.S., Shimbara, T., Kawagoe, T., Murakami, N., Miyazato, M., Kangawa, K., Nakazato, M., 2006. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology.
  • 25
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 25 (2004) 426-457
    • (2004) Endocr. Rev. , vol.25 , pp. 426-457
    • van der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.