Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling

Diabetes

Volumn 57, Issue 12, 2008, Pages 3205-3210

  Vestergaard, Esben Thyssen ^a   Gormsen, Lars Christian ^a   Jessen, Niels ^a   Lund, Sten ^a   Hansen, Troels Krarup ^a   Moller, Niels ^a   Jorgensen, Jens Otto Lunde ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GHRELIN; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HYDROCORTISONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN;

ADULT; ARTICLE; CALORIMETRY; CLINICAL TRIAL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE METABOLISM; GROWTH HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOLYSIS; MALE; MICRODIALYSIS; MUSCLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; BLOOD; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HYPOPITUITARISM; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PHYSIOLOGY; REFERENCE VALUE; SECRETION; SIGNAL TRANSDUCTION;

ADRENOCORTICOTROPIC HORMONE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GHRELIN; GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPOPITUITARISM; INFUSIONS, INTRAVENOUS; INSULIN RESISTANCE; LIPOLYSIS; MALE; MIDDLE AGED; REFERENCE VALUES; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 58149352421     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0025     Document Type: Article

References (24)

1. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K: Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908- 4911, 2000
2. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992-5995, 2001
3. Dornonville, dlC, Lindstrom E, Norlen P, Hakanson R: Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul. Pept. 120:23-32, 2004
4. Papotti M, Ghe C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, Muccioli G: Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85:3803-3807, 2000
5. Damjanovic SS, Lalic NM, Pesko PM, Petakov MS, Jotic A, Miljic D, Lalic KS, Lukic L, Djurovic M, Djukic VB: Acute Effects of Ghrelin on Insulin Secretion and Glucose Disposal Rate in Gastrectomized Patients. J Clin Endocrinol Metab 91:2574-2581, 2006
6. Vestergaard ET, Hansen TK, Gormsen LC, Jakobsen P, Moller N, Christiansen JS, Jorgensen JO: Constant intravenous ghrelin infusion in healthy young men: Clinical pharmacokinetics and metabolic effects. Am JPhysiol Endocrinol Metab 292:E1829-E1836, 2007
7. Lucidi P, Murdolo G, Di Loreto C, Parlanti N, De Cicco A, Fatone C, Taglioni C, Fanelli C, Broglio F, Ghigo E, Bolli GB, Santeusanio F, De Feo P: Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations. Nutr. Metab Cardiovasc. Dis. 15:410-417, 2005
8. Vestergaard ET, Djurhuus CB, Gjedsted J, Nielsen S, Moller N, Holst JJ, Jorgensen JOL, Schmitz O: Acute Effects of Ghrelin Administration on Glucose and Lipid Metabolism. J Clin Endocrinol Metab 93:438-444, 2008
9. Steele R: Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 82:420-430, 1959 10. Ferrannini E: The theoretical bases of indirect calorimetry: a review. Metabolism 37:287-301, 1988
10. Gravholt CH, Schmitz O, Simonsen L, Bulow J, Christiansen JS, Moller N: Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol 277:E848-E854, 1999
11. Espelund U, Hansen TK, Hojlund K, Beck-Nielsen H, Clausen JT, Hansen BS, Orskov H, Jorgensen JO, Frystyk J: Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab 90:741-746, 2005
12. Eriksson BM, Persson BA: Determination of catecholamines in rat heart tissue and plasma samples by liquid chromatography with electrochemical detection. J Chromatogr 228:143-154, 1982
13. Holst JJ: Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumours. Diabetologia 24:359-365, 1983
14. Wojtaszewski JF, Hansen BF, Urso B, Richter EA: Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle. J Appl. Physiol 81:1501-1509, 1996
15. Gauna C, Meyler FM, Janssen JA, Delhanty PJ, Abribat T, Van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, Van der Lely AJ: Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab 89:5035-5042, 2004
16. Kageyama H, Funahashi H, Hirayama M, Takenoya F, Kita T, Kato S, Sakurai J, Lee EY, Inoue S, Date Y, Nakazato M, Kangawa K, Shioda S: Morphological analysis of ghrelin and its receptor distribution in the rat pancreas. Regul. Pept. 126:67-71, 2005
17. Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T: Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 55:3486-3493, 2006
18. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG: Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3:379-386, 2006
19. Pfluger PT, Kirchner H, Gunnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschop MH: Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest. LiverPhysiol 2007
20. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP: The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981
21. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ: AMP-activated protein kinase plays a role in the control of food intake. J Biol. Chem. 279:12005-12008, 2004
22. Barazzoni R, Bosutti A, Stebel M, Cattin MR, Roder E, Visintin L, Cattin L, Biolo G, Zanetti M, Guarnieri G: Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. Am J Physiol Endocrinol Metab 288:E228-E235, 2005
23. Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB, Korbonits M: Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol. Chem. 2005
24. Hardie DG, Carling D, Carlson M: The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855, 1998