The nucleus tractus solitari (NTS) participates in peripheral ghrelin glucostatic hunger signalling mediated by insulin

Neuropeptides

Volumn 40, Issue 3, 2006, Pages 169-175

  Solomon, A ^a   De Fanti, B A ^a   Martinez J A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Appetite; Ghrelin; Glycemia; Hypothalamus; Nucleus tractus solitari

Indexed keywords

ANTIBODY; GHRELIN; GHRELIN ANTIBODY; GLUCOSE; INSULIN; PROTEIN C FOS; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HUNGER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SOLITARY TRACT NUCLEUS;

AMYGDALA; ANIMALS; BLOOD GLUCOSE; EATING; GHRELIN; HUNGER; INSULIN; MALE; PEPTIDE HORMONES; PROTO-ONCOGENE PROTEINS C-FOS; RAPHE NUCLEI; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SOLITARY NUCLEUS;

ANIMALIA;

EID: 33646436737     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2006.03.003     Document Type: Article

References (38)

1. Adachi A., and Kobashi M. Chemosensitive neurons within the area postrema of the rat. Neurosci. Lett. 55 (1985) 137-140
2. Andrews P.L., and Sanger G.J. Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction. Curr. Opin. Pharmacol. 2 (2002) 650-656
3. Badman M.K., and Flier J.S. The gut and energy balance: visceral allies in the obesity wars. Science 307 (2005) 1909-1914
4. Banks W.A., Tschop M., Robinson S.M., and Heiman M.L. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J. Pharmacol. Exp. Ther. 302 (2002) 822-827
5. Bray G.A. Afferent signals regulating food intake. Proc. Nutr. Soc. 59 (2000) 373-384
6. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J. Intern. Med. 258 (2005) 301-327
7. Brown R.E., Sergeeva O., Eriksson K.S., and Haas H.L. Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology 40 (2001) 457-459
8. Buller K., Xu Y., Dayas C., and Day T. Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1beta-induced hypothalamic pituitary adrenal axis responses. Neuroendocrinology 73 (2001) 129-138
9. Buller K.M., Dayas C.V., and Day T.A. Descending pathways from the paraventricular nucleus contribute to the recruitment of brainstem nuclei following a systemic immune challenge. Neuroscience 118 (2003) 189-203
10. Cai X.J., Evans M.L., Lister C.A., Leslie R.A., Arch J.R., Wilson S., and Williams G. Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 50 (2001) 105-112
11. Carlini V.P., Varas M.M., Cragnolini A.B., Schioth H.B., Scimonelli T.N., and de Barioglio S.R. Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochem. Biophys. Res. Commun. 313 (2004) 635-641
12. Currie P.J., Mirza A., Fuld R., Park D., and Vasselli J.R. Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (2005) R353-R358
13. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000) 4255-4261
14. Date Y., Murakami N., Toshinai K., Matsukura S., Niijima A., Matsuo H., Kangawa K., and Nakazato M. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123 (2002) 1120-1128
15. Emond M., Schwartz G.J., and Moran T.H. Meal-related stimuli differentially induce c-fos activation in the nucleus of the solitary tract. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R1315-R1321
16. Ganaraj B., and Jeganathan P.S. Involvement of basolateral nucleus and central nucleus of amygdala in the regulation of ingestive behaviour in rat. Indian J. Med. Res. 108 (1998) 98-103
17. Kalra S.P., and Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 (2004) 201-211
18. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
19. Korbonits M., and Grossman A.B. Ghrelin: update on a novel hormonal system. Eur. J. Endocrinol. 151 Suppl. 1 (2004) S67-S70
20. Lawrence C.B., Snape A.C., Baudoin F.M., and Luckman S.M. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143 (2002) 155-162
21. Loewy B., Marczynski G.T., Dingwall A., and Shapiro L. Regulatory interactions between phospholipid synthesis and DNA replication in Caulobacter crescentus. J. Bacteriol. 172 (1990) 5523-5530
22. Michl T., Jocic M., Heinemann A., Schuligoi R., and Holzer P. Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain. Pain 92 (2001) 19-27
23. Mitchell V., Bouret S., Beauvillain J.C., Schilling A., Perret M., Kordon C., and Epelbaum J. Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. J. Comp. Neurol. 429 (2001) 469-489
24. Olszewski P.K., Grace M.K., Billington C.J., and Levine A.S. Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-fos immunoreactivity. Peptides 24 (2003) 919-923
25. Olszewski P.K., Li D., Grace M.K., Billington C.J., Kotz C.M., and Levine A.S. Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides 24 (2003) 597-602
26. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1997), Academic Press, Sydney
27. Sainsbury A., Cooney G.J., and Herzog H. Hypothalamic regulation of energy homeostasis. Best Pract. Res. Clin. Endocrinol. Metab. 16 (2002) 623-637
28. Sajdyk T.J., Shekhar A., and Gehlert D.R. Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides 38 (2004) 225-234
29. Sekino A., Ohata H., Mano-Otagiri A., Arai K., and Shibasaki T. Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats. Psychopharmacology (Berl.) 176 (2004) 30-38
30. Shuto Y., Shibasaki T., Wada K., Parhar I., Kamegai J., Sugihara H., Oikawa S., and Wakabayashi I. Generation of polyclonal anti-serum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats. Life Sci. 68 (2001) 991-996
31. Small C.J., and Bloom S.R. Gut hormones and the control of appetite. Trend. Endocrinol. Metab. 15 (2004) 259-263
32. Smith G.P. Introduction to the reviews on peptides and the control of food intake and body weight. Neuropeptides 33 (1999) 323-328
33. Solomon A., De Fanti B.A., and Martínez J.A. Control del apetito y peso corporal: la ghrelina y la señalización orexigénica. Nutrición Clínica y Dietética Hospitalaria 55 (2004) 13-27
34. Ter Horst G.J., and Luiten P.G. Phaseolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat. Brain Res. Bull. 18 (1987) 191-203
35. Thorens B., and Larsen P.J. Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis. Curr. Opin. Clin. Nutr. Metab. Care. 7 (2004) 471-478
36. Ueno H., Yamaguchi H., Kangawa K., and Nakazato M. Ghrelin: a gastric peptide that regulates food intake and energy homeostasis. Regul. Pept. 126 (2005) 11-19
37. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri S., Kennedy A.R., Roberts G.H., Morgan D.G., Ghatei M.A., and Bloom S.R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (2000) 4325-4328
38. Wren A.M., Small C.J., Abbott C.R., Dhillo W.S., Seal L.J., Cohen M.A., Batterham R.L., Taheri S., Stanley S.A., Ghatei M.A., and Bloom S.R. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50 (2001) 2540-2547