메뉴 건너뛰기




Volumn 54, Issue 1, 2005, Pages 18-24

Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; COCAINE; DESACYLGHRELIN; GHRELIN; GROWTH HORMONE SECRETAGOGUE; MOTILIN; NEUROPEPTIDE; PEPTIDE; UNCLASSIFIED DRUG;

EID: 10844287775     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.038737     Document Type: Article
Times cited : (423)

References (39)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 2
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelln: Two major forms or rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, et al. Ghrelin and des-acyl ghrelln: two major forms or rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000;279:909-13.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3
  • 3
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelln. Identification of multiple ghrelin-derived molecules produced by post-translational processing
    • Hosoda H, Kojima M, Mizushima T, et al. Structural divergence of human ghrelln. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 2003;278:64-70.
    • (2003) J Biol Chem , vol.278 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3
  • 4
    • 0035430665 scopus 로고    scopus 로고
    • Ghrelin: An orexigenic and somatotrophic signal from the stomach
    • Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2001;2:551-60.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 551-560
    • Inui, A.1
  • 5
    • 0036904031 scopus 로고    scopus 로고
    • Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract
    • Kojima M, Kangawa K. Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract. Curr Opin Pharmacol 2002;2:665-8.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 665-668
    • Kojima, M.1    Kangawa, K.2
  • 6
    • 0037592273 scopus 로고    scopus 로고
    • Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    • Fujino K, Inui A, Asakawa A, et al. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 2003;550:227-40.
    • (2003) J Physiol , vol.550 , pp. 227-240
    • Fujino, K.1    Inui, A.2    Asakawa, A.3
  • 7
    • 0037384111 scopus 로고    scopus 로고
    • Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure
    • Nagaya N, Kangawa K. Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure. Curr Opin Pharmacol 2003;3:146-51.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 146-151
    • Nagaya, N.1    Kangawa, K.2
  • 8
    • 0036930643 scopus 로고    scopus 로고
    • Ghrelin increases anxiety-like behavior and memory retention in rats
    • Carlini VP, Monzon ME, Varas MM, et al. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun 2002;299:739-43.
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 739-743
    • Carlini, V.P.1    Monzon, M.E.2    Varas, M.M.3
  • 9
    • 0037162116 scopus 로고    scopus 로고
    • Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    • Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002;346:1623-30.
    • (2002) N Engl J Med , vol.346 , pp. 1623-1630
    • Cummings, D.E.1    Weigle, D.S.2    Frayo, R.S.3
  • 10
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nofure 2000;407:908-13.
    • (2000) Nofure , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 11
    • 18644377203 scopus 로고    scopus 로고
    • Plasma ghrelin and desacyl ghrelin concentrations in renal failure
    • Yoshimoto A, Mori K, Sugawara A, et al. Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 2002;13:2748-52.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2748-2752
    • Yoshimoto, A.1    Mori, K.2    Sugawara, A.3
  • 12
    • 0030931678 scopus 로고    scopus 로고
    • Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice
    • Barrachina MD, Martinez V, Wang L, et al. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 1997;94:10455-60.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10455-10460
    • Barrachina, M.D.1    Martinez, V.2    Wang, L.3
  • 13
    • 0037847510 scopus 로고    scopus 로고
    • Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    • Asakawa A, Inui A, Yuzuriha H, et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 2003;124:1325-36.
    • (2003) Gastroenterology , vol.124 , pp. 1325-1336
    • Asakawa, A.1    Inui, A.2    Yuzuriha, H.3
  • 14
    • 1342346545 scopus 로고    scopus 로고
    • Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    • Roh J, Chang CL, Bhalla A, et al. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 2004;279:7264-74.
    • (2004) J Biol Chem , vol.279 , pp. 7264-7274
    • Roh, J.1    Chang, C.L.2    Bhalla, A.3
  • 15
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991;108:193-9.
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 16
    • 0015086341 scopus 로고
    • Chromatography of nucleic acid digests on thin layers of cellulose impregnated with polyethyleneimine
    • Southern EM, Mitchell AR. Chromatography of nucleic acid digests on thin layers of cellulose impregnated with polyethyleneimine. Biochem J 1971;123:613-17.
    • (1971) Biochem J , vol.123 , pp. 613-617
    • Southern, E.M.1    Mitchell, A.R.2
  • 17
    • 17944379112 scopus 로고    scopus 로고
    • Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    • Ariyasu H, Takaya K, Tagami T, et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001;86:4753-8.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4753-4758
    • Ariyasu, H.1    Takaya, K.2    Tagami, T.3
  • 18
    • 0036720528 scopus 로고    scopus 로고
    • Delayed short-term secretory regulation of ghrelin in obese animals: Evidenced by a specific RIA for the active form ofghrelin
    • Ariyasu H, Takaya K, Hosoda H, et al. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form ofghrelin. Endocrinology 2002;143:3341-50.
    • (2002) Endocrinology , vol.143 , pp. 3341-3350
    • Ariyasu, H.1    Takaya, K.2    Hosoda, H.3
  • 19
    • 0034048279 scopus 로고    scopus 로고
    • Transgenic approach to the study of body weight regulation
    • Inui A. Transgenic approach to the study of body weight regulation. Pharmacol Rev 2000;52:35-61.
    • (2000) Pharmacol Rev , vol.52 , pp. 35-61
    • Inui, A.1
  • 20
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001;104:531-43.
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 21
    • 0035654440 scopus 로고    scopus 로고
    • Hypathalamic peptides as drug targets for obesity
    • Dhillo WS, Bloom SR. Hypathalamic peptides as drug targets for obesity. Curr Opin Pharmacol 2001;1:651-5.
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 651-655
    • Dhillo, W.S.1    Bloom, S.R.2
  • 22
    • 0037423143 scopus 로고    scopus 로고
    • Cellular warriors at the battle of the bulge
    • Marx J. Cellular warriors at the battle of the bulge. Science 2003;299:846-9.
    • (2003) Science , vol.299 , pp. 846-849
    • Marx, J.1
  • 23
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
    • Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-45.
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 24
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 25
    • 0037388790 scopus 로고    scopus 로고
    • Ghrelin-induced food intake is mediated via the orexin pathway
    • Toshinai K, Date Y, Murakami N, et al. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 2003;144:1506-12.
    • (2003) Endocrinology , vol.144 , pp. 1506-1512
    • Toshinai, K.1    Date, Y.2    Murakami, N.3
  • 26
    • 0022585356 scopus 로고
    • Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions
    • Duggan JP, Booth DA. Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions. Science 1986;231:609-11.
    • (1986) Science , vol.231 , pp. 609-611
    • Duggan, J.P.1    Booth, D.A.2
  • 27
    • 0033567912 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Are neuropeptides the key?
    • Inui A. Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer Res 1999;59:4493-501.
    • (1999) Cancer Res , vol.59 , pp. 4493-4501
    • Inui, A.1
  • 28
    • 0036198117 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: Current issues in research and management
    • Inui A. Cancer anorexia-cachexia syndrome: Current issues in research and management. CA-Cancer J Clin 2002;52:72-91.
    • (2002) CA-Cancer J Clin , vol.52 , pp. 72-91
    • Inui, A.1
  • 29
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • Baldanzi G, Filigheddu N, Cutrupi S, et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 2002;159:1029-37.
    • (2002) J Cell Biol , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3
  • 30
    • 0142200403 scopus 로고    scopus 로고
    • Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-gnrelin
    • Bedendi I, Alloatti G, Marcantoni A, et al. Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-gnrelin. Eur J Pharmacol 2003;476:87-95.
    • (2003) Eur J Pharmacol , vol.476 , pp. 87-95
    • Bedendi, I.1    Alloatti, G.2    Marcantoni, A.3
  • 31
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • Asakawa A, Inui A, Kaga T, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003;52:947-52.
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 32
    • 1542343913 scopus 로고    scopus 로고
    • Ghrelin, appetite, and gastric motility: The emerging role of the stomach as an endocrine organ
    • Inui A, Asakawa A, Bowers CY, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J 2004;18:439-56.
    • (2004) FASEB J , vol.18 , pp. 439-456
    • Inui, A.1    Asakawa, A.2    Bowers, C.Y.3
  • 33
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • Lawrence CB, Snape AC, Baudoin FM, et al. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002;143:155-62.
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3
  • 34
    • 0035953173 scopus 로고    scopus 로고
    • Characterization of CART neurons in the rat and human hypothalamus
    • Elias CF, Lee CE, Kelly JF, et al. Characterization of CART neurons in the rat and human hypothalamus. J Comp Neurol 2001;432:1-19.
    • (2001) J Comp Neurol , vol.432 , pp. 1-19
    • Elias, C.F.1    Lee, C.E.2    Kelly, J.F.3
  • 36
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002;123:1120-8.
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3
  • 37
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • Banks WA, Tschop M, Robinson SM, et al. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 2002;302:822-7.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschop, M.2    Robinson, S.M.3
  • 38
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1 a growth hormone secretagogue receptor
    • Thompson NM, Gill DA, Davies R, et al. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1 a growth hormone secretagogue receptor. Endocrinology 2004;145:234-42.
    • (2004) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3
  • 39
    • 2342582164 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by ghrelin
    • Zhang W, Zhao L, Lin TR, et al. Inhibition of adipogenesis by ghrelin. Mol Biol Cell 2004;15:2484-91.
    • (2004) Mol Biol Cell , vol.15 , pp. 2484-2491
    • Zhang, W.1    Zhao, L.2    Lin, T.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.