Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion

European Journal of Pharmacology

Volumn 481, Issue 1, 2003, Pages 1-14

  Konturek, Stanislaw J ^a   Zabielski, Romuald ^b   Konturek, Jan W ^c   Czarnecki, John ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^c Elbe Klinikum Stade GmbH   (Germany)

Author keywords

Cholecystokinin; Gastrin releasing peptide; Ghrelin; Leptin; Pancreas; Pancreatic polypeptide; Secretin

Indexed keywords

ACETYLCHOLINE; BICARBONATE; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CERULETIDE; CHLORIDE; CHOLECYSTOKININ; CHOLINERGIC RECEPTOR; CYCLIC AMP; ENKEPHALIN; GASTRIN RELEASING PEPTIDE; GHRELIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; LEPTIN; MUSCARINIC RECEPTOR; N(G) METHYLARGININE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE; PANCREAS ENZYME; PANCREAS POLYPEPTIDE; PEPTIDE HORMONE; PHOSPHOLIPASE A2; SECRETIN; SOMATOSTATIN;

ACINAR CELL; APPETITE; BRAIN; DIABETES MELLITUS; DOG; ENDOCRINE DISEASE; ENZYME ACTIVITY; ENZYME RELEASE; EXOCRINE SECRETION; HUMAN; HYPOTHALAMUS; INTESTINE; INTESTINE INNERVATION; INTESTINE MUCOSA; LANGERHANS CELL; NEUROENDOCRINOLOGY; NONHUMAN; PANCREAS; PANCREAS FUNCTION; PANCREAS JUICE; PANCREAS SECRETION; POSTPRANDIAL STATE; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; SWINE; VAGUS REFLEX;

EID: 0344153907     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.08.042     Document Type: Review

References (77)

1. Aihara T., Nakamura E., Amagase K., Tomita K., Fujishita T., Furutani K., Okabe S. Pharmacological control of gastric acid secretion for treatment of acid-related peptic disease: past, present and future. Pharmacol. Ther. 98:2003;109-127.
2. Bayliss W.M., Starling E.H. The mechanism of pancreatic secretion. J. Physiol. 28:1902;325.
3. Bernard C. Memoir on the Pancreas and on the Role of Pancreatic Juice in Digestive Processes, Particularly in the Digestion of Neutral Fat (1856). (J. Henderson, Trans.):1985;Academic Press, London.
4. Bilski J., Konturek J.W., Konturek S.J., Domschke W. The involvement of endogenous nitric oxide in vagal-cholinergic stimulation of exocrine and endocrine pancreas in dogs. Int. J. Pancreatol. 18:1995;41-49.
5. Blackshaw L.A., Grundy D. Effect of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre. J. Auton. Nerv. Syst. 31:1990;191-201.
6. Case R.M. Pancreatic exocrine secretion: mechanism and control. Berger H.G., Warshaw A.L., Buchler M.W., Carl Locke D.L., Neoptolemus J.P., Russel C., Sarr M.G. The Pancreas. 1998;63-100 Blackwell, Oxford.
7. 2 from canine pancreatic juice. Pancreas. 19:1999;401-405.
8. Chariot J., Nagain C., Huonet F., Tsocas A., Roze C. Control of interdigestive and intraduodenal meal-stimulated pancreatic secretion in rats. Am. J. Physiol. 259:1990;G198-G204.
9. Chey W.Y., Konturek S.J. Plasma secretin and pancreatic secretion in response to liver extract with varied pH and exogenous secretin in dog. J. Physiol. (Lond.). 324:1982;263-267.
10. Chey W.Y., Kim M.S., Lee K.Y. Effect of rabbit antisecretin serum on postprandial pancreatic secretion in dog. Gastroenterology. 77:1979;1268-1272.
11. Compos-Toimil M., Edwardson J.M., Thomas P. Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells. J. Physiol. 528:2000;317-326.
12. Cummings D.E., Foster K.E. Ghrelin-leptin tango in body weight regulation. Gastroenterology. 124:2003;1532-1544.
13. Debas H.T., Konturek S.J., Grossman M.I. Effect of extragastric and truncal vagotomy on pancreatic secretion in dogs. Am. J. Physiol. 228:1975;1172-1177.
14. Deng X., Guarita D.R., Pedroso M.R., Kreiss C., Wood P.G., Sved A.F., Whitcomb D.C. PYY inhibits CCK-stimulated pancreatic secretion through the area postrema in unanesthetized rats. Am. J. Physiol., Regul. Integr. Comp. Physiol. 281:2001;R645-R653.
15. Deng X., Guarita D.R., Pedroso M.R., Wood P.G., Kreiss C., Sved A.F., Whitcomb D.C. Area postrema lesions after the inhibitory effects of peripherally infused pancreatic polypeptides on pancreatic secretion. Brain Res. 902:2001;18-29.
16. Deng X., Guarita D.R., Wood P.G., Kriess C., Whitcomb D.C. PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG stimulated pathways in awake rats. Dig. Dis. Sci. 46:2001;156-165.
17. Dominguez-Munoz J.E., Pieramino O., Buchler M., Malferheiner P. Exocrine pancreatic function in the early phase of human acute pancreatitis. Scand. J. Gastroenterol. 30:1995;186-191.
18. Domschke S., Domschke W., Rosch W., Konturek S.J., Wunsch E., Demling L. Bicarbonate and cyclic AMP content in pure pancreatic juice in response to graded doses of synthetic secretin. Gastroenterology. 70:1976;533-536.
19. Edkins J.S. On the chemical mechanisms of gastric secretion. Proc. R. Soc. Lond., B Biol. Sci. 76:1905;376-390.
20. Fahrenkrug J., Schaffalitzky de Muckadell O.B., Rune S.J. pH threshold for release of secretin in normal subjects and in patients with duodenal ulcer and patients with chronic pancreatitis. Scand. J. Gastroenterol. 13:1978;177-183.
21. Fushiki T., Fukuoka S., Iwai K. Stimulatory effect of an endogenous peptide in rat pancreatic juice on pancreatic enzyme secretion in the presence of atropine: evidence for different mode of action of stimulation from exogenous trypsin inhibitors. Biochem. Biophys. Res. Commun. 118:1984;532-537.
22. Gabryelewicz A., Kulesza E., Konturek S.J. Comparison of loxiglumide, a cholecystokinin (CCK)-receptor antagonist, and atropine on hormonal and meal-stimulated pancreatic secretion in man. Scand. J. Gastroenterol. 25:1990;731-738.
23. Gorelick F.S., Jamieson J.D. The pancreatic acinar cells. Structure-function relationships. Johnson L.R., Chriestensen J., Jackson M.J., Jacobson E.D., Walsh J.H. Physiology of the Gastrointestinal Tract. 3rd ed. 1994;Raven Press, New York.
24. Gray M.A., Greenwell J.R., Aregent B.E. Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J. Membr. Biol. 105:1988;131-135.
25. Green G.M., Lyman R.L. Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc. Soc. Exp. Biol. Med. 140:1972;6-12.
26. Grossman M.I., Konturek S.J. Gastric acid does drive pancreatic bicarbonate secretion. Scand. J. Gastroenterol. 9:1974;299-302.
27. Guan D., Spannagel A., Ohta H., Nakano I., Chey W.Y., Green G.M. Role of secretin in basal and fat-stimulated pancreatic secretion in conscious rats. Endocrinology. 128:1991;979-982.
28. Hansen J.T., Koeppen B.M. Netter's Atlas of Human Physiology. 2002;Icon Learning Systems, Teternoro, NJ.
29. Herzig K.H., Schon I., Tatemoto K., Ohe Y., Li Y., Folsch U.R., Owyang C. Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine. Proc. Natl. Acad. Sci. U. S. A. 93:1996;7927-7932.
30. Jaworek J., Konturek S.J., Szlachcic A. The role of CGRP and afferent nerves in the modulation of pancreatic enzyme secretion in the rat. Int. J. Pancreatol. 22:1997;137-146.
31. Jaworek J., Bonior J., Leja-Szpak A., Nawrot K., Kot M., Tomaszewska R., Stachura J., Pawlik W.W., Konturek S.J. Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin. J. Physiol. Pharmacol. 53:2002;51-74.
32. Ji B., Bi Y., Simeone D., Mortensen R.M., Logsdon C.D. Human pancreatic acinar cells lack functional response to cholecystokinin and gastrin. Gastroenterology. 121:2001;1380-1390.
33. Kim S.J., Kim J.K., Pavenstadt H., Greger R., Hug M.J., Bleich M. Regulation of slowly activating potassium current by secretin in rats pancreatic acinar cells. J. Physiol. 535:2001;349-358.
34. Kirsner J.B. The Growth of Gastroenterologic Knowledge during the Twentieth Century. 1994;Lea and Febiger, Philadelphia.
35. Konturek S.J., Konturek P.C. Role of nitric oxide in the digestive system. Digestion. 56:1995;1-13.
36. Konturek S.J., Konturek J.W. Cephalic phase of pancreatic secretion. Appetite. 34:2000;197-205.
37. Konturek S.J., Tasler J., Obtulowicz W. Effect of atropine on pancreatic responses to endogenous and exogenous secretin. Dig. Dis. Sci. 16:1971;384-394.
38. Konturek S.J., Tasler J., Obtulowicz W. Effect of atropine on pancreatic responses to endogenous and exogenous cholecystokinin. Dig. Dis. Sci. 17:1972;911-917.
39. Konturek S.J., Tasler J., Obtulowicz W., Coy D.H., Schally A.V. Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J. Clin. Invest. 58:1976;1-6.
40. Konturek S.J., Tasler J., Cieszkowski M., Jaworek J., Coy D.H., Schally A.V. Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology. 74:1978;851-855.
41. Konturek S.J., Thor P., Bilski J., Bielanski W., Laskiewicz J. Relationships between duodenal motility and pancreatic secretion in fasted and fed dogs. Am. J. Physiol. 250:1986;G570-G574.
42. Konturek S.J., Konturek J.W., Domsche S., Domschke W., Varga L., Halter F. Effects of secretin antibody on gastric acid inhibition and pancreatic bicarbonate stimulation by acidified liver extract meal in dogs. Hepato-gastroenterology. 33:1986;170-175.
43. Konturek S.J., Bielanski W., Solomon T.E. Effects of an antral mucosectomy, L-364,718 and atropine on cephalic phase of gastric and pancreatic secretion in dogs. Gastroenterology. 98:1990;47-55.
44. Konturek S.J., Bilski J., Konturek P.C., Cieszkowski M., Pawlik W.W. Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow. Gastroenterology. 104:1993;896-902.
45. Konturek J.W., Hengst K., Kulesza E., Gabryelewicz A., Konturek S.J., Domschke W. Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion in humans. Gut. 40:1997;86-91.
46. Konturek P.Ch., Brzozowski T., Konturek S.J., Elia G., Wright N., Śliwowski Z., Thim L., Hahn E.G. Role of spasmolytic polypeptide in healing of stress-induced gastric lesions in rats. Regul. Pept. 68:1997;71-79.
47. Konturek J.W., Konturek S.J., Kwiecien N., Bielanski W., Pawlik T., Rembiasz K., Domschke W. Leptin in the control of gastric secretion and gut hormones in humans infected with Helicobacter pylori. Scand. J. Gastroenterol. 36:2001;1148-1154.
48. Konturek S.J., Pepera J., Zabielski K., Konturek P.C., Pawlik T., Szlaccic J., Hahn E.G. Brain-gut axis in pancreatic secretion and appetite control. J. Physiol. Pharmacol. 54:2003;293-317.
49. Laubitz D., Zabielski R., Wolinski J., Nieminuszczy J., Grzesiuk E. Physiological chemical characteristics of antibacterial activity of pancreatic juice. J. Physiol. Pharmacol. 54:2003;283-290.
50. Lee K.Y., Shiratori K., Chen Y.F., Chang T.-M., Chey W.Y. A hormonal mechanism for the interdigestive pancreatic secretion in dogs. Am. J. Physiol. 251:1986;G759-G764.
51. Li P., Louie D., Owyang C. A cholecystokinin releasing peptide mediates feedback regulation of pancreatic secretion. Am. J. Physiol. 256:1989;G305-G309.
52. Li P., Lee K.Y., Chang T.M., Chey W.Y. Mechanism of acid-induced release of secretin in rats. Presence of a secretin-releasing peptide. J. Clin. Invest. 86:1990;1474-1479.
53. Li P., Chang T.M., Chey W.Y. Neuronal regulation of the release and action of secretin-releasing peptide and secretin. Am. J. Physiol. 269:1995;G305-G312.
54. Li P., Song Y., Lee K.Y., Chang T.M., Chey W.Y. A secretin releasing peptide exists in dog pancreatic juice. Life Sci. 66:2000;1307-1316.
55. 2 from the small intestine is a secretin-releasing factor in the rat. Am. J. Physiol. 281:2001;26-532.
56. Li J.P., Lee K.Y., Chang T.-M., Chey W.Y. MEK inhibits secretin release and pancreatic secretion: roles of secretin-releasing peptide and somatostatin. Am. J. Physiol., Gastrointest. Liver Physiol. 280:2001;G890-G896.
57. Louie D.S., May D., Miller P., Owyang C. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am. J. Physiol. 250:1986;G252-G257.
58. 1-vagal-dependent mechanism in anaesthetized rats. Regul. Pept. 114:2003;15-20.
59. Meyer J.H., Way L.W., Grossman M.I. Pancreatic bicarbonate response to various acids in duodenum of the dog. Am. J. Physiol. 219:1970;964-970.
60. Miller L.J. Gastrointestinal hormones and receptors. Yamada T., Alpers D.H., Laine L., Owyang C., Powell D.W. Textbook of Gastroenterology. 1999;35-66 Lippincott Williams and Wilkins, Philadelphia.
61. Niebel W., Berlinger C., Singer M.V. Hormonal control of pancreatic secretion by intrajejunal HCl: studies in dogs with an autotransplanted entire jejunoileum. Pancreas. 6:1991;341-349.
62. Owyang C. Physiological mechanisms of cholecystokinin action on pancreatic secretion. Am. J. Physiol. 271:1996;G1-G7.
63. Pavlov I.P. The Work of the Digestive Glands. (W.H. Thompson, Trans.):1910;Charles Griffin and Company, London.
64. Richards W., Hillsley K., Eastwood C., Grundy D. Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat. J. Physiol. 497:1996;473-481.
65. Sarr M.G., Foley M.K., Winters R.C., Duentes J.A., DiMagno E.P. Role of extrinsic innervation in carbohydrate-induced ileal modulation of pancreatic secretion and upper gut function. Pancreas. 14:1996;166-173.
66. Song Y., Li P., Lee K.Y., Chey W.Y. Canine pancreatic juice stimulates the release of secretin and pancreatic secretion in the dog. Am. J. Physiol. 277:1999;G731-G735.
67. Spannagel A.W., Green G.M., Guan D., Liddle R.A., Faull K., Reeve J.R. Jr. Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion. Proc. Natl. Acad. Sci. U. S. A. 93:1996;4415-4420.
68. i oscillations and enzyme secretion in pancreatic acini. J. Biol. Chem. 268:1993;19769-19775.
69. Williams J.A. Intracellular signaling mechanisms activated by cholecystokinin regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. Annu. Rev. Physiol. 63:2001;77-97.
70. Williams J.A. Receptor biology and intracellular regulatory mechanisms in pancreatic acinar secretion. Curr. Opin. Gastroenterol. 18:2002;529-535.
71. Zabielski R., Naruse S. Neurohormonal regulation of the exocrine pancreas during postnatal development. Pierzynowski S.G., Zabielski R. Biology of the Pancreas in Growing Animals. 1999;151-192 Elsevier, Amsterdam.
72. Zabielski R., Onaga T., Mineo H., Pierzynowski S.G., Kato S. Local versus peripheral blood administration of cholecystokinin-8 and secretin on pancreatic secretion in calves. Exp. Physiol. 79:1994;301-311.
73. Zabielski R., Onaga R., Mineo H., Kato S., Pierzynowski S.G. Intraduodenal cholecystokinin octapeptide (CCK-8) can stimulate pancreatic secretion in the calf. Int. J. Pancreatol. 17:1995;271-278.
74. Zabielski R., Leśniewska V., Borlak J., Gregory P.C., Kiela P., Pierzynowski S.G., Barej W. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul. Pept. 78:1998;113-123.
75. Zabielski R., Morisset J., Podgurniak P., Romé V., Biernat M., Bernard C., Chayvialle J.A., Guilloteau P. Bovine pancreatic secretion in the first week of life; involvement of a CCK-A receptor. Regul. Pept. 103:2002;93-104.
76. Zhang W., Chen M., Chen X., Segura B.J., Mulholland M.W. Inhibition of pancreatic protein secretion by ghrelin in the rat. J. Physiol. 537:2001;231-236.
77. Zimmerman D.W., Sarr M.G., Smith C.D., Nicholson C.P., Dalton R.R., Barr D., Perkins J.D., DiMagno E.P. Cyclic interdigestive pancreatic exocrine secretion: is it mediated by neural or hormonal mechanisms? Gastroenterology. 102:1992;1378-1384.