메뉴 건너뛰기




Volumn 77, Issue , 2007, Pages 13-30

Biochemistry of Ghrelin Precursor Peptides

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; PROTEIN PRECURSOR;

EID: 35648957666     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(06)77002-9     Document Type: Review
Times cited : (26)

References (76)
  • 4
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • Banks W.A., Tschop M., Robinson S.M., and Heiman M.L. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J. Pharmacol. Exp. Ther. 302 (2002) 822-827
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschop, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 7
    • 3843070931 scopus 로고    scopus 로고
    • Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: Effect of maternal fasting
    • Chanoine J.P., and Wong A.C. Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: Effect of maternal fasting. Endocrinology 145 (2004) 3813-3820
    • (2004) Endocrinology , vol.145 , pp. 3813-3820
    • Chanoine, J.P.1    Wong, A.C.2
  • 8
    • 33746336541 scopus 로고    scopus 로고
    • Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas
    • Chanoine J.P., Wong A.C., and Barrios V. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Horm. Res. 66 (2006) 81-88
    • (2006) Horm. Res. , vol.66 , pp. 81-88
    • Chanoine, J.P.1    Wong, A.C.2    Barrios, V.3
  • 11
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000) 4255-4261
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 14
    • 0019352579 scopus 로고
    • A rapid and potent natriuretic response to intravenous injection of atrial myocyte extract in rats
    • De Bold A.J., Borenstein H.B., Veress A.T., and Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocyte extract in rats. Life Sci. 28 (1979) 89-94
    • (1979) Life Sci. , vol.28 , pp. 89-94
    • De Bold, A.J.1    Borenstein, H.B.2    Veress, A.T.3    Sonnenberg, H.4
  • 16
    • 31544452274 scopus 로고    scopus 로고
    • Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
    • Delhanty P.J., van der Eerden B.C., van der Velde M., Gauna C., Pols H.A., Jahr H., Chiba H., van der Lely A.J., and van Leeuwen J.P. Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. J. Endocrinol. 188 (2006) 37-47
    • (2006) J. Endocrinol. , vol.188 , pp. 37-47
    • Delhanty, P.J.1    van der Eerden, B.C.2    van der Velde, M.3    Gauna, C.4    Pols, H.A.5    Jahr, H.6    Chiba, H.7    van der Lely, A.J.8    van Leeuwen, J.P.9
  • 17
    • 0037068005 scopus 로고    scopus 로고
    • Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta
    • Galas L., Chartrel N., Kojima M., Kangawa K., and Vaudry H. Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta. J. Comp. Neurol. 450 (2002) 34-44
    • (2002) J. Comp. Neurol. , vol.450 , pp. 34-44
    • Galas, L.1    Chartrel, N.2    Kojima, M.3    Kangawa, K.4    Vaudry, H.5
  • 20
    • 33751019166 scopus 로고    scopus 로고
    • Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signalling in rodents
    • Gourcerol G., Million M., Adelson D.W., Wang Y., Wang L., Rivier J., St-Pierre D.H., and Tache Y. Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signalling in rodents. Peptides 27 (2006) 2811-2819
    • (2006) Peptides , vol.27 , pp. 2811-2819
    • Gourcerol, G.1    Million, M.2    Adelson, D.W.3    Wang, Y.4    Wang, L.5    Rivier, J.6    St-Pierre, D.H.7    Tache, Y.8
  • 22
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H., Kojima M., Matsuo H., and Kangawa K. Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem. Biophys. Res. Commun. 279 (2000) 909-913
    • (2000) Biochem. Biophys. Res. Commun. , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 23
    • 0034698072 scopus 로고    scopus 로고
    • Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
    • Hosoda H., Kojima M., Matsuo H., and Kangawa K. Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J. Biol. Chem. 275 (2000) 21995-22000
    • (2000) J. Biol. Chem. , vol.275 , pp. 21995-22000
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 24
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by posttranslational processing
    • Hosoda H., Kojima M., Mizushima T., Shimizu S., and Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by posttranslational processing. J. Biol. Chem. 278 (2003) 64-70
    • (2003) J. Biol. Chem. , vol.278 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3    Shimizu, S.4    Kangawa, K.5
  • 27
    • 33744466554 scopus 로고    scopus 로고
    • GPR39 receptor expression in the mouse brain
    • Jackson V.R., Hothacker H.P., and Civelli O. GPR39 receptor expression in the mouse brain. Neuroreport 17 (2006) 813-816
    • (2006) Neuroreport , vol.17 , pp. 813-816
    • Jackson, V.R.1    Hothacker, H.P.2    Civelli, O.3
  • 28
    • 11144228935 scopus 로고    scopus 로고
    • Expression of the Ghrelin axis in the mouse; an exon 4-delected mouse proghrelin variant encodes a novel C-terminal peptide
    • Jeffrey P.L., Duncan R.P., Yeh A.H., Jaskolski R.A., Hammond D.S., Herington A.C., and Chopin L.K. Expression of the Ghrelin axis in the mouse; an exon 4-delected mouse proghrelin variant encodes a novel C-terminal peptide. Endocrinology 146 (2005) 432-440
    • (2005) Endocrinology , vol.146 , pp. 432-440
    • Jeffrey, P.L.1    Duncan, R.P.2    Yeh, A.H.3    Jaskolski, R.A.4    Hammond, D.S.5    Herington, A.C.6    Chopin, L.K.7
  • 32
    • 0345688712 scopus 로고    scopus 로고
    • Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout
    • Kaiya H., Kojima M., Hosoda H., Moriyama S., Takahashi A., Kawauchi H., and Kangawa K. Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. Endocrinology 144 (2003) 5215-5226
    • (2003) Endocrinology , vol.144 , pp. 5215-5226
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Moriyama, S.4    Takahashi, A.5    Kawauchi, H.6    Kangawa, K.7
  • 33
    • 0037357065 scopus 로고    scopus 로고
    • Amidated fish ghrelin: Purification, cDNA cloning in the Japanese eel and its biological activity
    • Kaiya H., Kojima M., Hosoda H., Riley L.G., Hirano T., Grau E.G., and Kangawa K. Amidated fish ghrelin: Purification, cDNA cloning in the Japanese eel and its biological activity. J. Endocrinol. 176 (2003) 415-423
    • (2003) J. Endocrinol. , vol.176 , pp. 415-423
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Riley, L.G.4    Hirano, T.5    Grau, E.G.6    Kangawa, K.7
  • 35
    • 1842634405 scopus 로고    scopus 로고
    • Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach
    • Kamegai J., Tamura H., Shimizu T., Ishii S., Sugihara H., and Oikawa S. Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regul. Pept. 119 (2004) 77-81
    • (2004) Regul. Pept. , vol.119 , pp. 77-81
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Oikawa, S.6
  • 38
    • 29144466031 scopus 로고    scopus 로고
    • Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
    • Kleinz M.J., Maguire J.J., Skepper J.N., and Davenport A.P. Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man. Cardiovasc. Res. 69 (2006) 227-235
    • (2006) Cardiovasc. Res. , vol.69 , pp. 227-235
    • Kleinz, M.J.1    Maguire, J.J.2    Skepper, J.N.3    Davenport, A.P.4
  • 39
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M., and Kangawa K. Ghrelin: Structure and function. Physiol. Rev. 85 (2005) 495-522
    • (2005) Physiol. Rev. , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 40
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 44
    • 0031573862 scopus 로고    scopus 로고
    • Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors
    • McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., and Van der Ploeg L.H. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics 46 (1997) 426-434
    • (1997) Genomics , vol.46 , pp. 426-434
    • McKee, K.K.1    Tan, C.P.2    Palyha, O.C.3    Liu, J.4    Feighner, S.D.5    Hreniuk, D.L.6    Smith, R.G.7    Howard, A.D.8    Van der Ploeg, L.H.9
  • 47
    • 4344569717 scopus 로고    scopus 로고
    • Identification of promoter region of ghrelin gene in human medullary thyroid carcinoma cell line
    • Nakai N., Kaneko M., Nakao N., Fujikawa T., Nakashima K., Ogata M., and Tanaka M. Identification of promoter region of ghrelin gene in human medullary thyroid carcinoma cell line. Life Sci. 75 (2004) 2193-2201
    • (2004) Life Sci. , vol.75 , pp. 2193-2201
    • Nakai, N.1    Kaneko, M.2    Nakao, N.3    Fujikawa, T.4    Nakashima, K.5    Ogata, M.6    Tanaka, M.7
  • 49
    • 33645420927 scopus 로고    scopus 로고
    • Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin
    • Pan W., Tu H., and Kastin A.J. Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin. Peptides 27 (2006) 911-916
    • (2006) Peptides , vol.27 , pp. 911-916
    • Pan, W.1    Tu, H.2    Kastin, A.J.3
  • 55
    • 0036171253 scopus 로고    scopus 로고
    • Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract
    • Sakata I., Nakamura K., Yamazaki M., Matsubara M., Hayashi Y., Kangawa K., and Sakai T. Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 23 (2002) 531-536
    • (2002) Peptides , vol.23 , pp. 531-536
    • Sakata, I.1    Nakamura, K.2    Yamazaki, M.3    Matsubara, M.4    Hayashi, Y.5    Kangawa, K.6    Sakai, T.7
  • 60
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Sun Y., Ahmed S., and Smith R.G. Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 23 (2003) 7973-7981
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 61
    • 0034912651 scopus 로고    scopus 로고
    • Organization of the mouse ghrelin gene and promoter: Occurrence of a short noncoding first exon
    • Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., and Nakashima K. Organization of the mouse ghrelin gene and promoter: Occurrence of a short noncoding first exon. Endocrinology 142 (2001) 3697-3700
    • (2001) Endocrinology , vol.142 , pp. 3697-3700
    • Tanaka, M.1    Hayashida, Y.2    Iguchi, T.3    Nakao, N.4    Nakai, N.5    Nakashima, K.6
  • 62
    • 0035846447 scopus 로고    scopus 로고
    • Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse
    • Tanaka M., Hayashida Y., Nakao N., Nakai N., and Nakashima K. Testis-specific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim. Biophys. Acta 1522 (2001) 62-65
    • (2001) Biochim. Biophys. Acta , vol.1522 , pp. 62-65
    • Tanaka, M.1    Hayashida, Y.2    Nakao, N.3    Nakai, N.4    Nakashima, K.5
  • 63
    • 19444379510 scopus 로고    scopus 로고
    • Distribution of ghrelin-immunoreactive cells in human gastric mucosa: Comparison with that of parietal cells
    • Tanaka-Shintani M., and Watanabe M. Distribution of ghrelin-immunoreactive cells in human gastric mucosa: Comparison with that of parietal cells. J. Gastroenterol. 40 (2005) 345-349
    • (2005) J. Gastroenterol. , vol.40 , pp. 345-349
    • Tanaka-Shintani, M.1    Watanabe, M.2
  • 65
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor
    • Thompson N.M., Gill D.A., Davies R., Loveridge N., Houston P.A., Robinson I.C., and Wells T. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 145 (2004) 234-242
    • (2004) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3    Loveridge, N.4    Houston, P.A.5    Robinson, I.C.6    Wells, T.7
  • 67
    • 0036772802 scopus 로고    scopus 로고
    • Goldfish ghrelin: Molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake
    • Unniappan S., Lin X., Cervini L., Rivier J., Kaiya H., Kangawa K., and Peter R.E. Goldfish ghrelin: Molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake. Endocrinology 143 (2002) 4143-4146
    • (2002) Endocrinology , vol.143 , pp. 4143-4146
    • Unniappan, S.1    Lin, X.2    Cervini, L.3    Rivier, J.4    Kaiya, H.5    Kangawa, K.6    Peter, R.E.7
  • 68
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological and pharmacological aspects of ghrelin
    • van der Lely A., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological and pharmacological aspects of ghrelin. Endocr. Rev. 25 (2004) 426-457
    • (2004) Endocr. Rev. , vol.25 , pp. 426-457
    • van der Lely, A.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 69
    • 14244254694 scopus 로고    scopus 로고
    • Characterization and regulation of the rat and human ghrelin promoters
    • Wei W., Wang G., Qi X., Englander E.W., and Greeley Jr. G.H. Characterization and regulation of the rat and human ghrelin promoters. Endocrinology 146 (2005) 1611-1625
    • (2005) Endocrinology , vol.146 , pp. 1611-1625
    • Wei, W.1    Wang, G.2    Qi, X.3    Englander, E.W.4    Greeley Jr., G.H.5
  • 72
    • 20544444427 scopus 로고    scopus 로고
    • Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks
    • Yamato M., Sakata I., Wada R., Kaiya H., and Sakai T. Exogenous administration of octanoic acid accelerates octanoylated ghrelin production in the proventriculus of neonatal chicks. Biochem. Biophys. Res. Commun. 333 (2005) 583-589
    • (2005) Biochem. Biophys. Res. Commun. , vol.333 , pp. 583-589
    • Yamato, M.1    Sakata, I.2    Wada, R.3    Kaiya, H.4    Sakai, T.5
  • 73
    • 0034682466 scopus 로고    scopus 로고
    • Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme
    • Yan W., Wu F., Morser J., and Wu Q. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. Proc. Natl. Acad. Sci. USA 97 (2000) 8525-8529
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8525-8529
    • Yan, W.1    Wu, F.2    Morser, J.3    Wu, Q.4
  • 75
  • 76
    • 33846024377 scopus 로고    scopus 로고
    • On the processing of proghrelin to ghrelin
    • Zhu X., Cao Y., Voodg K., and Steiner D.F. On the processing of proghrelin to ghrelin. J. Biol. Chem. 281 50 (2006) 38867-38870
    • (2006) J. Biol. Chem. , vol.281 , Issue.50 , pp. 38867-38870
    • Zhu, X.1    Cao, Y.2    Voodg, K.3    Steiner, D.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.