Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin

Fertility and Sterility

Volumn 88, Issue 1, 2007, Pages 125-130

  Guido, Maurizio ^a   Romualdi, Daniela ^a   De Marinis, Laura ^a   Porcelli, Teresa ^a   Giuliani, Maddalena ^a   Costantini, Barbara ^a   Lanzone, Antonio ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

GH; ghrelin; insulin; obesity; PCOS

Indexed keywords

CLINALFA; GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; INSULIN BLOOD LEVEL; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; BLOOD GLUCOSE; FEMALE; GROWTH HORMONE; HUMANS; INSULIN; OBESITY; PEPTIDE HORMONES; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES;

EID: 34347270206     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.11.067     Document Type: Article

References (42)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 9 (1999) 656-660
2. Ariyasu H., Takaya K., Tagami T., Ogawa Y., Hosoda K., Akamizu T., et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86 (2001) 4753-4758
3. Arvat E., Di Vito L., Broglio F., Papotti M., Muccioli G., Dieguez C., et al. Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23 (2000) 493-495
4. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri S., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (2000) 4325-4328
5. Arvat E., Maccario M., Di Vito L., Broglio F., Benso A., Gottero C., et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86 (2001) 1169-1174
6. Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276 (2000) 905-908
7. De Ambrogi M., Volpe S., and Tamanini C. Ghrelin: central and peripheral effects of a novel peptydil hormone. Med Sci Monit 9 (2003) RA217-RA224
8. van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25 (2004) 426-457
9. Arosio M., Ronchi C.L., Beck-Peccoz P., Gebbia C., Giavoli C., Cappiello V., et al. Effects of modified sham feeding on ghrelin levels in healthy human subjects. J Clin Endocrinol Metab 89 (2004) 5101-5104
10. Tanaka M., Nakahara T., Kojima S., Nakano T., Muranaga T., Nagai N., et al. Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa. Regul Pept 122 (2004) 163-168
11. Marzullo P., Verti B., Savia G., Walker G.E., Guzzaloni G., Tagliaferri M., et al. The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab 89 (2004) 936-939
12. Broglio F., Arvat E., Benso A., Gottero C., Muccioli G., Papotti M., et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86 (2001) 5083-5086
13. Ciampelli M., and Lanzone A. Insulin and polycystic ovary syndrome: a new look at an old subject. Gynecol Endocrinol 12 (1998) 277-292
14. Lanzone A., Villa P., Fulghesu A.M., Pavone V., Caruso A., and Mancuso S. The growth hormone response to growth hormone-releasing hormone is blunted in polycystic ovary syndrome: relationship with obesity and hyperinsulinaemia. Hum Reprod 10 (1995) 1653-1657
15. Villa P., Soranna L., Mancini A., De Marinis L., Valle D., Mancuso S., et al. Effect of feeding on growth hormone response to growth hormone-releasing hormone in polycystic ovarian syndrome: relation with body weight and hyperinsulinism. Hum Reprod 16 (2001) 430-434
16. Comim F.V., and Spritzer P.M. Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. Fertil Steril 81 (2004) 108-113
17. Guido M., Romualdi D., Mancini A., Lattanzi F., Villa P., Barini A., et al. Effect of the opioid blockade on the feeding-induced growth hormone response to growth hormone-releasing hormone in women with polycystic ovary syndrome. Fertil Steril 78 (2002) 994-1000
18. Schofl C., Horn R., Schill T., Schlosser H.W., Muller M.J., and Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 4607-4610
19. Pagotto U., Gambineri A., Vicennati V., Heiman M.L., Tschop M., and Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 87 (2002) 5625-5629
20. Moran L.J., Noakes M., Clifton P.M., Wittert G.A., Tomlinson L., Galletly C., et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 89 (2004) 3337-3344
21. Orio Jr. F., Lucidi P., Palomba S., Tauchmanova L., Cascella T., Russo T., et al. Circulating ghrelin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab 88 (2003) 942-945
22. Wasko R., Komarowska H., Warenik-Szymankiewicz A., and Sowinski J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res 36 (2004) 170-173
23. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. 2004 Rotterdam 1: revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
24. Fulghesu A.M., Ciampelli M., Belosi C., Apa R., Pavone V., and Lanzone A. A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio. Fertil Steril 76 (2001) 326-331
25. Belosi C., Selvaggi L., Apa R., Guido M., Romualdi D., Fulghesu A.M., et al. Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma?. Hum Reprod 21 (2006) 3108-3115
26. Ferriman D., and Gallwey J.D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21 (1961) 1440-1447
27. New M.I., Lorenzen F., Lerner A.J., Kohn B., Oberfield S.E., Pollack M.S., et al. Genotyping steroid 21-hydroxylase deficiency: hormonal reference data. J Clin Endocrinol Metab 57 (1983) 320-326
28. Petersenn S. Growth hormone secretagogues and ghrelin: an update on physiology and clinical relevance. Horm Res 58 Suppl 3 (2002) 56-61
29. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., et al. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
30. Carrel A.L., and Allen D.B. Effects of growth hormone on body composition and bone metabolism. Endocrine 12 (2000) 163-172
31. Bevers M.M., and Izadyar F. Role of growth hormone and growth hormone receptor in oocyte maturation. Mol Cell Endocrinol 197 (2002) 173-178
32. Apa R., Lanzone A., Miceli F., Mastrandrea M., Caruso A., Mancuso S., et al. Growth hormone induces in vitro maturation of follicle- and cumulus-enclosed rat oocytes. Mol Cell Endocrinol 106 (1994) 207-212
33. Kazer R.R., Unterman T.G., and Glick R.P. An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 71 (1990) 958-962
34. Jaatinen T.A., Anttila L., Erkkola R., Koskinen P., Laippala P., Ruutiainen K., et al. Hormonal responses to physical exercise in patients with polycystic ovarian syndrome. Fertil Steril 60 (1993) 262-267
35. Orio Jr. F., Palomba S., Colao A., Russo T., Dentico C., Tauchmanova L., et al. GH release after GHRH plus arginine administration in obese and overweight women with polycystic ovary syndrome. J Endocrinol Invest 26 (2003) 117-122
36. Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2 (2001) 551-560
37. Takaya K., Ariyasu H., Kanamoto N., Iwakura H., Yoshimoto A., Harada M., et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85 (2000) 4908-4911
38. Micic D., Kendereski A., Popovic V., Sumarac M., Zoric S., Macut D., et al. Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome. Clin Endocrinol (Oxf) 45 (1996) 385-390
39. Ghigo E., Broglio F., Me E., Prodam F., and Ragazzoni F. Ghrelin: more than a new frontier in neuroendocrinology. J Endocrinol Invest 27 Suppl 6 (2004) 101-104
40. Hansen T.K., Dall R., Hosoda H., Kojima M., Kangawa K., Christiansen J.S., et al. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) 56 (2002) 203-206
41. Saad M.F., Bernaba B., Hwu C.M., Jinagouda S., Fahmi S., Kogosov E., et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87 (2002) 3997-4000
42. Volante M., Allia E., Gugliotta P., Funaro A., Broglio F., Deghenghi R., et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 87 (2002) 1300-1308