메뉴 건너뛰기




Volumn 9, Issue 6, 2011, Pages 442-455

Telomerase targeted therapy in cancer and cancer stem cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; CANCER VACCINE; CAPECITABINE; GEMCITABINE; GRNVAC1; GUANINE QUADRUPLEX; IMETELSTAT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NITROREDUCTASE; OBP 301; OLIGONUCLEOTIDE; QUARFLOXIN; TELOMELYSIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TERTOMOTIDE; TRETAZICAR; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 79959966315     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (160)
  • 1
    • 0022402513 scopus 로고
    • Identifcation of a specifc telomere terminal transferase activity in Tetrahymena extracts
    • Greider CW, Blackburn EH. Identifcation of a specifc telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985;43:405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 2
    • 33748602112 scopus 로고    scopus 로고
    • Lasker Laurels for telomerase
    • de Lange T. Lasker Laurels for telomerase. Cell. 2006;126:1017-1020.
    • (2006) Cell , vol.126 , pp. 1017-1020
    • de Lange, T.1
  • 4
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Grifth JD, Comeau L, Rosenfeld S, et al. Mammalian telomeres end in a large duplex loop. Cell. 1999;97:503-514.
    • (1999) Cell , vol.97 , pp. 503-514
    • Grifth, J.D.1    Comeau, L.2    Rosenfeld, S.3
  • 6
    • 34250841785 scopus 로고    scopus 로고
    • Replication and protection of telomeres
    • Verdun RE, Karlseder J. Replication and protection of telomeres. Nature. 2007;447:924-931.
    • (2007) Nature , vol.447 , pp. 924-931
    • Verdun, R.E.1    Karlseder, J.2
  • 7
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fbroblasts
    • Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fbroblasts. Proc Natl Acad Sci USA. 1992;89:10114-10118.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1    Vaziri, H.2    Patterson, C.3
  • 8
    • 2042429168 scopus 로고    scopus 로고
    • Regulation of telomerase by telomeric proteins
    • Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem. 2004;73:177-208.
    • (2004) Annu Rev Biochem , vol.73 , pp. 177-208
    • Smogorzewska, A.1    de Lange, T.2
  • 9
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • Watson JD. Origin of concatemeric T7 DNA. Nat New Biol. 1972;239: 197-201.
    • (1972) Nat New Biol , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 10
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. Telomere states and cell fates. Nature. 2000;408:53-56.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 11
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fbroblasts
    • Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for immortalization of normal human diploid fbroblasts. Mol Cell Biol. 1989;9:3088-3092.
    • (1989) Mol Cell Biol , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 12
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19:2100-2110.
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 13
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Models, mechanisms and implications
    • Cesare AJ, Reddel RR. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet. 2010;11:319-330.
    • (2010) Nat Rev Genet , vol.11 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2
  • 14
    • 0035444984 scopus 로고    scopus 로고
    • Telomere maintenance by telomerase and by recombination can coexist in human cells
    • Cerone MA, Londono-Vallejo JA, Bacchetti S. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum Mol Genet. 2001;10:1945-1952.
    • (2001) Hum Mol Genet , vol.10 , pp. 1945-1952
    • Cerone, M.A.1    Londono-Vallejo, J.A.2    Bacchetti, S.3
  • 15
    • 77954858289 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells
    • Chen W, Xiao BK, Liu J P, Chen SM, Tao ZZ. Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. Cancer Sci. 2010;101: 1769-1776.
    • (2010) Cancer Sci , vol.101 , pp. 1769-1776
    • Chen, W.1    Xiao, B.K.2    Liu, J.P.3    Chen, S.M.4    Tao, Z.Z.5
  • 17
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetra-hymena telomerase required for telomere repeat synthesis
    • Greider C W, Blackburn EH. A telomeric sequence in the RNA of Tetra-hymena telomerase required for telomere repeat synthesis. Nature. 1989;337: 331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 18
    • 38849191137 scopus 로고    scopus 로고
    • Physiological assembly and activity of human telomerase complexes
    • Collins K. Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev. 2008;129:91-98.
    • (2008) Mech Ageing Dev , vol.129 , pp. 91-98
    • Collins, K.1
  • 19
    • 33745862398 scopus 로고    scopus 로고
    • The biogenesis and regulation of telomerase holoenzymes
    • Collins K. The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol. 2006;7:484-494.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 484-494
    • Collins, K.1
  • 20
    • 77952604818 scopus 로고    scopus 로고
    • Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo
    • Egan ED, Collins K. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Molecular and Cellular Biology. 2010;30:2775-2786.
    • (2010) Molecular and Cellular Biology , vol.30 , pp. 2775-2786
    • Egan, E.D.1    Collins, K.2
  • 21
    • 59149095154 scopus 로고    scopus 로고
    • A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    • Venteicher AS, Abreu EB, Meng Z, et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 2009;323:644-648.
    • (2009) Science , vol.323 , pp. 644-648
    • Venteicher, A.S.1    Abreu, E.B.2    Meng, Z.3
  • 22
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell JR, Wood E, Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 1999;402:551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 23
    • 38349144367 scopus 로고    scopus 로고
    • Dyskeratosis congenita: A genetic disorder of many faces
    • Kirwan M, Dokal I. Dyskeratosis congenita: a genetic disorder of many faces. Clin Genet. 2008;73:103-112.
    • (2008) Clin Genet , vol.73 , pp. 103-112
    • Kirwan, M.1    Dokal, I.2
  • 24
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay J W. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 1996;18:173-179.
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 25
    • 0036362266 scopus 로고    scopus 로고
    • Telomerase and differentiation in mul-ticellular organisms: Turn it of, turn it on, and turn it of again
    • Forsyth NR, Wright WE, Shay J W. Telomerase and differentiation in mul-ticellular organisms: turn it of, turn it on, and turn it of again. Diferentiation. 2002;69:188-197.
    • (2002) Diferentiation , vol.69 , pp. 188-197
    • Forsyth, N.R.1    Wright, W.E.2    Shay, J.W.3
  • 26
    • 0032887083 scopus 로고    scopus 로고
    • Telomerase activity and prognosis in primary breast cancers
    • Carey LA, Kim N W, Goodman S, et al. Telomerase activity and prognosis in primary breast cancers. J Clin Oncol. 1999;17:3075-3081.
    • (1999) J Clin Oncol , vol.17 , pp. 3075-3081
    • Carey, L.A.1    Kim, N.W.2    Goodman, S.3
  • 27
    • 0032054369 scopus 로고    scopus 로고
    • Alteration of telomerase activity associated with development and extension of epithelial ovarian cancer
    • Oishi T, Kigawa J, Minagawa Y, Shimada M, Takahashi M, Terakawa N. Alteration of telomerase activity associated with development and extension of epithelial ovarian cancer. Obstet Gynecol. 1998;91:568-571.
    • (1998) Obstet Gynecol , vol.91 , pp. 568-571
    • Oishi, T.1    Kigawa, J.2    Minagawa, Y.3    Shimada, M.4    Takahashi, M.5    Terakawa, N.6
  • 28
    • 0031700926 scopus 로고    scopus 로고
    • Telomerase activity signifcantly correlates with cell diferentiation, proliferation and lymph node metastasis in colorectal carcinomas
    • Okayasu I, Mitomi H, Yamashita K, et al. Telomerase activity signifcantly correlates with cell diferentiation, proliferation and lymph node metastasis in colorectal carcinomas. J Cancer Res Clin Oncol. 1998;124:444-449.
    • (1998) J Cancer Res Clin Oncol , vol.124 , pp. 444-449
    • Okayasu, I.1    Mitomi, H.2    Yamashita, K.3
  • 29
    • 0142025379 scopus 로고    scopus 로고
    • Chromosomal imbalances in primary and metastatic melanomas: Over-representation of essential telomerase genes
    • Pirker C, Holzmann K, Spiegl-Kreinecker S, et al. Chromosomal imbalances in primary and metastatic melanomas: over-representation of essential telomerase genes. Melanoma Res. 2003;13:483-492.
    • (2003) Melanoma Res , vol.13 , pp. 483-492
    • Pirker, C.1    Holzmann, K.2    Spiegl-Kreinecker, S.3
  • 30
    • 0036772604 scopus 로고    scopus 로고
    • Telomerase as a prognostic marker in breast cancer: High-throughput tissue microarray analysis of hTERT and hTR
    • Poremba C, Heine B, Diallo R, et al. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J Pathol. 2002;198:181-189.
    • (2002) J Pathol , vol.198 , pp. 181-189
    • Poremba, C.1    Heine, B.2    Diallo, R.3
  • 31
    • 0036720448 scopus 로고    scopus 로고
    • Telomerase activity and human telom-erase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors
    • Tomoda R, Seto M, Tsumuki H, et al. Telomerase activity and human telom-erase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer. 2002;95:1127-1133.
    • (2002) Cancer , vol.95 , pp. 1127-1133
    • Tomoda, R.1    Seto, M.2    Tsumuki, H.3
  • 32
    • 0032789719 scopus 로고    scopus 로고
    • Change in telomerase activity during human colorectal carcinogenesis
    • Yoshida R, Kiyozuka Y, Ichiyoshi H, et al. Change in telomerase activity during human colorectal carcinogenesis. Anticancer Res. 1999;19:2167-2172.
    • (1999) Anticancer Res , vol.19 , pp. 2167-2172
    • Yoshida, R.1    Kiyozuka, Y.2    Ichiyoshi, H.3
  • 34
    • 0242694739 scopus 로고    scopus 로고
    • Immortalization and transformation of human cells
    • Hahn WC. Immortalization and transformation of human cells. Mol Cells. 2002;13:351-361.
    • (2002) Mol Cells , vol.13 , pp. 351-361
    • Hahn, W.C.1
  • 35
    • 0029655485 scopus 로고    scopus 로고
    • Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
    • Strahl C, Blackburn EH. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol. 1996;16:53-65.
    • (1996) Mol Cell Biol , vol.16 , pp. 53-65
    • Strahl, C.1    Blackburn, E.H.2
  • 36
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med. 1999;5:1164-1170.
    • (1999) Nat Med , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 37
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 1999;13:2388-2399.
    • (1999) Genes Dev , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 38
    • 0042674370 scopus 로고    scopus 로고
    • A novel telomerase template antagonist (GRN163) as a potential anticancer agent
    • Asai A, Oshima Y, Yamamoto Y, et al. A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res. 2003;63:3931-3939.
    • (2003) Cancer Res , vol.63 , pp. 3931-3939
    • Asai, A.1    Oshima, Y.2    Yamamoto, Y.3
  • 39
    • 24744446474 scopus 로고    scopus 로고
    • In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor
    • Dikmen ZG, Gellert GC, Jackson S, et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res. 2005;65:7866-7873.
    • (2005) Cancer Res , vol.65 , pp. 7866-7873
    • Dikmen, Z.G.1    Gellert, G.C.2    Jackson, S.3
  • 40
    • 78449304076 scopus 로고    scopus 로고
    • Telomerase inhibition potentiates the efects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specifc manner
    • Tamakawa RA, Fleisig HB, Wong JM. Telomerase inhibition potentiates the efects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specifc manner. Cancer Res. 2010;70:8684-8694.
    • (2010) Cancer Res , vol.70 , pp. 8684-8694
    • Tamakawa, R.A.1    Fleisig, H.B.2    Wong, J.M.3
  • 41
    • 78549257138 scopus 로고    scopus 로고
    • The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines
    • Joseph I, Tressler R, Bassett E, et al. The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res. 2010;70:9494-9504.
    • (2010) Cancer Res , vol.70 , pp. 9494-9504
    • Joseph, I.1    Tressler, R.2    Bassett, E.3
  • 42
    • 79960014113 scopus 로고    scopus 로고
    • Phase I study of imetelstat (GRN163L) in combination with paclitaxel (P) and bevacizumab (B) in patients (pts) with locally recurrent or metastatic breast cancer (MBC)
    • ASCO Annual Meeting Abstracts, Abstract 2598
    • Kozlof M, Sledge G W, Benedetti FM, et al. Phase I study of imetelstat (GRN163L) in combination with paclitaxel (P) and bevacizumab (B) in patients (pts) with locally recurrent or metastatic breast cancer (MBC). J Clin Oncol (ASCO Annual Meeting Abstracts). 2010;28:Abstract 2598.
    • (2010) J Clin Oncol , vol.28
    • Kozlof, M.1    Sledge, G.W.2    Benedetti, F.M.3
  • 43
    • 84858246481 scopus 로고    scopus 로고
    • A phase I trial of GRN163L (GRN), a frst-in-class telomerase inhibitor, in advanced solid tumors
    • ASCO Annual Meeting Abstracts, Abstract 3581
    • Ratain MJ, Benedetti FM, Janisch L, et al. A phase I trial of GRN163L (GRN), a frst-in-class telomerase inhibitor, in advanced solid tumors. J Clin Oncol (ASCO Annual Meeting Abstracts). 2008;26:Abstract 3581.
    • (2008) J Clin Oncol , vol.26
    • Ratain, M.J.1    Benedetti, F.M.2    Janisch, L.3
  • 44
    • 0037148567 scopus 로고    scopus 로고
    • Oligonucleotide N3'-P5' phosphoramidates as efcient telomerase inhibitors
    • Herbert BS, Pongracz K, Shay J W, Gryaznov SM. Oligonucleotide N3'-P5' phosphoramidates as efcient telomerase inhibitors. Oncogene. 2002; 21:638-642.
    • (2002) Oncogene , vol.21 , pp. 638-642
    • Herbert, B.S.1    Pongracz, K.2    Shay, J.W.3    Gryaznov, S.M.4
  • 45
    • 47549118123 scopus 로고    scopus 로고
    • Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
    • Shammas MA, Koley H, Bertheau RC, et al. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia. 2008;22:1410-1418.
    • (2008) Leukemia , vol.22 , pp. 1410-1418
    • Shammas, M.A.1    Koley, H.2    Bertheau, R.C.3
  • 46
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu GL, Bradley JD, Attardi LD, Blackburn EH. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature. 1990;344:126-132.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 47
    • 0034933876 scopus 로고    scopus 로고
    • A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
    • Kim MM, Rivera MA, Botchkina IL, Shalaby R, Tor AD, Blackburn EH. A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci U S A. 2001;98:7982-7987.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7982-7987
    • Kim, M.M.1    Rivera, M.A.2    Botchkina, I.L.3    Shalaby, R.4    Tor, A.D.5    Blackburn, E.H.6
  • 48
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci C, Cerone MA, Bacchetti S. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene. 2001;20:714-725.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 49
    • 3142661809 scopus 로고    scopus 로고
    • Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telom-erase RNA and anti-telomerase short-interfering RNA
    • Li S, Rosenberg JE, Donjacour AA, et al. Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telom-erase RNA and anti-telomerase short-interfering RNA. Cancer Res. 2004;64: 4833-4840.
    • (2004) Cancer Res , vol.64 , pp. 4833-4840
    • Li, S.1    Rosenberg, J.E.2    Donjacour, A.A.3
  • 50
    • 33745274487 scopus 로고    scopus 로고
    • Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells
    • Goldkorn A, Blackburn EH. Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res. 2006;66:5763-5771.
    • (2006) Cancer Res , vol.66 , pp. 5763-5771
    • Goldkorn, A.1    Blackburn, E.H.2
  • 51
    • 59549087180 scopus 로고    scopus 로고
    • Growth defects in mouse telomerase RNA-defcient cells expressing a template-mutated mouse telomerase RNA
    • Marie-Egyptienne DT, Brault ME, Nimmo GA, Londono-Vallejo JA, Autexier C. Growth defects in mouse telomerase RNA-defcient cells expressing a template-mutated mouse telomerase RNA. Cancer Lett. 2009;275:266-276.
    • (2009) Cancer Lett , vol.275 , pp. 266-276
    • Marie-Egyptienne, D.T.1    Brault, M.E.2    Nimmo, G.A.3    Londono-Vallejo, J.A.4    Autexier, C.5
  • 52
    • 76649142740 scopus 로고    scopus 로고
    • Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo
    • Xu T, Xu Y, Liao C P, Lau R, Goldkorn A. Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo. Mol Cancer Ter. 2010;9:438-449.
    • (2010) Mol Cancer Ter , vol.9 , pp. 438-449
    • Xu, T.1    Xu, Y.2    Liao, C.P.3    Lau, R.4    Goldkorn, A.5
  • 53
    • 48549084245 scopus 로고    scopus 로고
    • ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
    • Stohr BA, Blackburn EH. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008;68:5309-5317.
    • (2008) Cancer Res , vol.68 , pp. 5309-5317
    • Stohr, B.A.1    Blackburn, E.H.2
  • 54
    • 77955744007 scopus 로고    scopus 로고
    • A cancer detection platform which measures telomerase activity from live circulating tumor cells captured on a microflter
    • Xu T, Lu B, Tai YC, Goldkorn A. A cancer detection platform which measures telomerase activity from live circulating tumor cells captured on a microflter. Cancer Res. 2010;70:6420-6426.
    • (2010) Cancer Res , vol.70 , pp. 6420-6426
    • Xu, T.1    Lu, B.2    Tai, Y.C.3    Goldkorn, A.4
  • 55
    • 24644468229 scopus 로고    scopus 로고
    • Potential of telomerase expression and activity in cervical specimens as a diagnostic tool
    • Bravaccini S, Sanchini MA, Amadori A, et al. Potential of telomerase expression and activity in cervical specimens as a diagnostic tool. J Clin Pathol. 2005;58:911-914.
    • (2005) J Clin Pathol , vol.58 , pp. 911-914
    • Bravaccini, S.1    Sanchini, M.A.2    Amadori, A.3
  • 56
    • 0034714384 scopus 로고    scopus 로고
    • Telomerase activity as a marker of breast carcinoma in fne-needle aspirated samples
    • Hiyama E, Saeki T, Hiyama K, et al. Telomerase activity as a marker of breast carcinoma in fne-needle aspirated samples. Cancer. 2000;90:235-238.
    • (2000) Cancer , vol.90 , pp. 235-238
    • Hiyama, E.1    Saeki, T.2    Hiyama, K.3
  • 57
    • 0032766423 scopus 로고    scopus 로고
    • Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer
    • Marchetti A, Bertacca G, Buttitta F, et al. Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer. Clin Cancer Res. 1999;5:2077-2081.
    • (1999) Clin Cancer Res , vol.5 , pp. 2077-2081
    • Marchetti, A.1    Bertacca, G.2    Buttitta, F.3
  • 58
    • 33644777482 scopus 로고    scopus 로고
    • Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology
    • Meeker AK. Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology. Urol Oncol. 2006;24:122-130.
    • (2006) Urol Oncol , vol.24 , pp. 122-130
    • Meeker, A.K.1
  • 59
    • 0032774031 scopus 로고    scopus 로고
    • Telomerase activity distinguishes between neuroblastomas with good and poor prognosis
    • Poremba C, Willenbring H, Hero B, et al. Telomerase activity distinguishes between neuroblastomas with good and poor prognosis. Ann Oncol. 1999;10: 715-721.
    • (1999) Ann Oncol , vol.10 , pp. 715-721
    • Poremba, C.1    Willenbring, H.2    Hero, B.3
  • 60
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer. 1997;33:787-791.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 62
    • 27244433839 scopus 로고    scopus 로고
    • Relevance of urine telomerase in the diagnosis of bladder cancer
    • Sanchini MA, Gunelli R, Nanni O, et al. Relevance of urine telomerase in the diagnosis of bladder cancer. JAMA. 2005;294:2052-2056.
    • (2005) JAMA , vol.294 , pp. 2052-2056
    • Sanchini, M.A.1    Gunelli, R.2    Nanni, O.3
  • 63
    • 0032009778 scopus 로고    scopus 로고
    • Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases
    • Hiyama K, Ishioka S, Shay JW, et al. Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases. Int J Mol Med. 1998;1:545-549.
    • (1998) Int J Mol Med , vol.1 , pp. 545-549
    • Hiyama, K.1    Ishioka, S.2    Shay, J.W.3
  • 64
    • 0034956843 scopus 로고    scopus 로고
    • A comparative study of telomerase activity in sputum, bronchial washing and biopsy specimens of lung cancer
    • Sen S, Reddy VG, Khanna N, Guleria R, Kapila K, Singh N. A comparative study of telomerase activity in sputum, bronchial washing and biopsy specimens of lung cancer. Lung Cancer. 2001;33:41-49.
    • (2001) Lung Cancer , vol.33 , pp. 41-49
    • Sen, S.1    Reddy, V.G.2    Khanna, N.3    Guleria, R.4    Kapila, K.5    Singh, N.6
  • 65
    • 0032490118 scopus 로고    scopus 로고
    • Telomerase activity in lung cancer cells obtained from bronchial washings
    • Yahata N, Ohyashiki K, Ohyashiki JH, et al. Telomerase activity in lung cancer cells obtained from bronchial washings. J Natl Cancer Inst. 1998;90:684-690.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 684-690
    • Yahata, N.1    Ohyashiki, K.2    Ohyashiki, J.H.3
  • 66
    • 41849110973 scopus 로고    scopus 로고
    • Telomer-ase activity in transthoracic fne needle biopsy aspirates as a marker of peripheral lung cancer
    • Targowski T, Jahnz-Rozyk K, Szkoda T, From S, Qandil N, Plusa T. Telomer-ase activity in transthoracic fne needle biopsy aspirates as a marker of peripheral lung cancer. Torax. 2008;63:342-344.
    • (2008) Torax , vol.63 , pp. 342-344
    • Targowski, T.1    Jahnz-Rozyk, K.2    Szkoda, T.3    From, S.4    Qandil, N.5    Plusa, T.6
  • 67
    • 0030715607 scopus 로고    scopus 로고
    • Telomerase activity for the preoperative diagnosis of pancreatic cancer
    • Iwao T, Hiyama E, Yokoyama T, et al. Telomerase activity for the preoperative diagnosis of pancreatic cancer. J Natl Cancer Inst. 1997;89:1621-1623.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1621-1623
    • Iwao, T.1    Hiyama, E.2    Yokoyama, T.3
  • 68
    • 0031710103 scopus 로고    scopus 로고
    • In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies
    • Morales C P, Burdick JS, Saboorian MH, Wright WE, Shay JW. In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies. Gastrointest Endosc. 1998;48:402-405.
    • (1998) Gastrointest Endosc , vol.48 , pp. 402-405
    • Morales, C.P.1    Burdick, J.S.2    Saboorian, M.H.3    Wright, W.E.4    Shay, J.W.5
  • 69
    • 0031418170 scopus 로고    scopus 로고
    • Telomerase activity in pancreatic juice diferentiates ductal carcinoma from adenoma and pancreatitis
    • Suehara N, Mizumoto K, Tanaka M, et al. Telomerase activity in pancreatic juice diferentiates ductal carcinoma from adenoma and pancreatitis. Clin Cancer Res. 1997;3:2479-2483.
    • (1997) Clin Cancer Res , vol.3 , pp. 2479-2483
    • Suehara, N.1    Mizumoto, K.2    Tanaka, M.3
  • 70
    • 41149127401 scopus 로고    scopus 로고
    • In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases
    • Uehara H, Nakaizumi A, Iishi H, et al. In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases. Pancreas. 2008;36:236-240.
    • (2008) Pancreas , vol.36 , pp. 236-240
    • Uehara, H.1    Nakaizumi, A.2    Iishi, H.3
  • 71
    • 37149034280 scopus 로고    scopus 로고
    • Development of a novel assay to quantify serum human telomerase reverse transcriptase messenger RNA and its signifcance as a tumor marker for hepatocellular carcinoma
    • Miura N, Maruyama S, Oyama K, et al. Development of a novel assay to quantify serum human telomerase reverse transcriptase messenger RNA and its signifcance as a tumor marker for hepatocellular carcinoma. Oncology. 2007;72 Suppl 1:45-51.
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 45-51
    • Miura, N.1    Maruyama, S.2    Oyama, K.3
  • 72
    • 34447288480 scopus 로고    scopus 로고
    • Clinical significance of telomerase activity in peritoneal lavage fuid from patients with gastric cancer and its relationship with cellular proliferation
    • Da MX, Wu XT, Guo TK, et al. Clinical significance of telomerase activity in peritoneal lavage fuid from patients with gastric cancer and its relationship with cellular proliferation. World J Gastroenterol. 2007;13:3122-3127.
    • (2007) World J Gastroenterol , vol.13 , pp. 3122-3127
    • Da, M.X.1    Wu, X.T.2    Guo, T.K.3
  • 73
    • 0031442702 scopus 로고    scopus 로고
    • Telomerase activity and survival of patients with node-positive breast cancer
    • Clark GM, Osborne CK, Levitt D, Wu F, Kim NW. Telomerase activity and survival of patients with node-positive breast cancer. J Natl Cancer Inst. 1997;89:1874-1881.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1874-1881
    • Clark, G.M.1    Osborne, C.K.2    Levitt, D.3    Wu, F.4    Kim, N.W.5
  • 74
    • 45549089511 scopus 로고    scopus 로고
    • Telomerase activity in transthoracic fne-needle biopsy aspirates from non-small cell lung cancer as prognostic factor of patients' survival
    • Targowski T, Jahnz-Rozyk K, Szkoda T, Plusa T, From S. Telomerase activity in transthoracic fne-needle biopsy aspirates from non-small cell lung cancer as prognostic factor of patients' survival. Lung Cancer. 2008;61:97-103.
    • (2008) Lung Cancer , vol.61 , pp. 97-103
    • Targowski, T.1    Jahnz-Rozyk, K.2    Szkoda, T.3    Plusa, T.4    From, S.5
  • 75
    • 0029131243 scopus 로고
    • Telomerase activity in gastric cancer
    • Hiyama E, Yokoyama T, Tatsumoto N, et al. Telomerase activity in gastric cancer. Cancer Res. 1995;55:3258-3262.
    • (1995) Cancer Res , vol.55 , pp. 3258-3262
    • Hiyama, E.1    Yokoyama, T.2    Tatsumoto, N.3
  • 76
    • 0033942071 scopus 로고    scopus 로고
    • High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer
    • Tatsumoto N, Hiyama E, Murakami Y, et al. High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clin Cancer Res. 2000;6:2696-2701.
    • (2000) Clin Cancer Res , vol.6 , pp. 2696-2701
    • Tatsumoto, N.1    Hiyama, E.2    Murakami, Y.3
  • 77
    • 42649141934 scopus 로고    scopus 로고
    • Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin
    • Soreide K, Gudlaugsson E, Skaland I, et al. Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin. Int J Colorectal Dis. 2008;23:389-400.
    • (2008) Int J Colorectal Dis , vol.23 , pp. 389-400
    • Soreide, K.1    Gudlaugsson, E.2    Skaland, I.3
  • 79
    • 0032926781 scopus 로고    scopus 로고
    • Molecular detection of telomerase-positive circulating epithelial cells in metastatic breast cancer patients
    • Soria JC, Gauthier LR, Raymond E, et al. Molecular detection of telomerase-positive circulating epithelial cells in metastatic breast cancer patients. Clin Cancer Res. 1999;5:971-975.
    • (1999) Clin Cancer Res , vol.5 , pp. 971-975
    • Soria, J.C.1    Gauthier, L.R.2    Raymond, E.3
  • 80
    • 33847635749 scopus 로고    scopus 로고
    • High detection rate of circulating tumor cells in blood of patients with prostate cancer using telomerase activity
    • Fizazi K, Morat L, Chauveinc L, et al. High detection rate of circulating tumor cells in blood of patients with prostate cancer using telomerase activity. Ann Oncol. 2007;18:518-521.
    • (2007) Ann Oncol , vol.18 , pp. 518-521
    • Fizazi, K.1    Morat, L.2    Chauveinc, L.3
  • 81
    • 79959982471 scopus 로고    scopus 로고
    • FDA. 510(k) #K050245 premarket notifcation of intent to market device. March 15 2005
    • FDA. 510(k) #K050245 premarket notifcation of intent to market device. March 15 2005.
  • 82
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCam protein expression in human carcinomas
    • Went PT, Lugli A, Meier S, et al. Frequent EpCam protein expression in human carcinomas. Hum Pathol. 2004;35:122-128.
    • (2004) Hum Pathol , vol.35 , pp. 122-128
    • Went, P.T.1    Lugli, A.2    Meier, S.3
  • 83
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 84
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcrip-tionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    • Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist transcrip-tionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res. 2007;67:1979-1987.
    • (2007) Cancer Res , vol.67 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.H.6
  • 85
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9: 265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 87
    • 33745638729 scopus 로고    scopus 로고
    • Telomerase peptide vaccination: A phase I/II study in patients with non-small cell lung cancer
    • Brunsvig P F, Aamdal S, Gjertsen MK, et al. Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer. Cancer Immunol Immunother. 2006;55:1553-1564.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1553-1564
    • Brunsvig, P.F.1    Aamdal, S.2    Gjertsen, M.K.3
  • 88
    • 33846879251 scopus 로고    scopus 로고
    • A phase I/II study of telom-erase peptide vaccination in combination with chemotherapy in patients with stage IV malignant melanoma
    • ASCO Annual Meeting Abstracts, Abstract 8031
    • Aamdal S, Dueland S, Engebraaten O, et al. A phase I/II study of telom-erase peptide vaccination in combination with chemotherapy in patients with stage IV malignant melanoma. J Clin Oncol (ASCO Annual Meeting Abstracts). 2006;24:Abstract 8031.
    • (2006) J Clin Oncol , vol.24
    • Aamdal, S.1    Dueland, S.2    Engebraaten, O.3
  • 89
    • 77953963578 scopus 로고    scopus 로고
    • A phase II open label trial evaluating safety and efcacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • Greten T F, Forner A, Korangy F, et al. A phase II open label trial evaluating safety and efcacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer. 2010;10:209.
    • (2010) BMC Cancer , vol.10 , pp. 209
    • Greten, T.F.1    Forner, A.2    Korangy, F.3
  • 90
    • 68649104725 scopus 로고    scopus 로고
    • A randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC)
    • ASCO Annual Meeting Abstracts, Abstract 4601
    • T. Buanes JM, W. Liauw, M. Hebbar, and J. Nemunaitis. A randomized phase III study of gemcitabine (G) versus GV1001 in sequential combination with G in patients with unresectable and metastatic pancreatic cancer (PC). J Clin Oncol (ASCO Annual Meeting Abstracts). 2009;27:Abstract 4601.
    • (2009) J Clin Oncol , vol.27
    • Buanes, J.M.T.1    Liauw, W.2    Hebbar, M.3    Nemunaitis, J.4
  • 91
    • 0033151591 scopus 로고    scopus 로고
    • The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cyto-toxic T lymphocytes
    • Vonderheide RH, Hahn WC, Schultze JL, Nadler LM. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cyto-toxic T lymphocytes. Immunity. 1999;10:673-679.
    • (1999) Immunity , vol.10 , pp. 673-679
    • Vonderheide, R.H.1    Hahn, W.C.2    Schultze, J.L.3    Nadler, L.M.4
  • 93
    • 10744221022 scopus 로고    scopus 로고
    • Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes
    • Vonderheide RH, Domchek SM, Schultze JL, et al. Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res. 2004;10:828-839.
    • (2004) Clin Cancer Res , vol.10 , pp. 828-839
    • Vonderheide, R.H.1    Domchek, S.M.2    Schultze, J.L.3
  • 94
    • 35948955903 scopus 로고    scopus 로고
    • Telomerase-specifc T-cell immunity in breast cancer: Efect of vaccination on tumor immunosurveillance
    • Domchek SM, Recio A, Mick R, et al. Telomerase-specifc T-cell immunity in breast cancer: efect of vaccination on tumor immunosurveillance. Cancer Res. 2007;67:10546-10555.
    • (2007) Cancer Res , vol.67 , pp. 10546-10555
    • Domchek, S.M.1    Recio, A.2    Mick, R.3
  • 95
    • 20144364773 scopus 로고    scopus 로고
    • Telomerase mRNA-transfected dendritic cells stimulate antigen-specifc CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    • Su Z, Dannull J, Yang BK, et al. Telomerase mRNA-transfected dendritic cells stimulate antigen-specifc CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. J Immunol. 2005;174:3798-3807.
    • (2005) J Immunol , vol.174 , pp. 3798-3807
    • Su, Z.1    Dannull, J.2    Yang, B.K.3
  • 96
    • 79959983096 scopus 로고    scopus 로고
    • Phase I study of transgenic B lymphocyte immunization (TLI) against telomerase in andro-gen-independent prostate cancer (PC)
    • ASCO Annual Meeting Abstracts, Abstract 257
    • Millard, F, Gerloni M, Darrah D, Monsurro V, Zanetti M. Phase I study of transgenic B lymphocyte immunization (TLI) against telomerase in andro-gen-independent prostate cancer (PC). J Clin Oncol (ASCO Annual Meeting Abstracts). 2005;23:Abstract 257.
    • (2005) J Clin Oncol , vol.23
    • Millard, F.1    Gerloni, M.2    Darrah, D.3    Monsurro, V.4    Zanetti, M.5
  • 97
    • 0035584117 scopus 로고    scopus 로고
    • Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    • Yi X, Shay J W, Wright WE. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res. 2001;29:4818-4825.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4818-4825
    • Yi, X.1    Shay, J.W.2    Wright, W.E.3
  • 98
    • 1442348829 scopus 로고    scopus 로고
    • Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity
    • Irving J, Wang Z, Powell S, et al. Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity. Cancer Gene Ter. 2004;11:174-185.
    • (2004) Cancer Gene Ter , vol.11 , pp. 174-185
    • Irving, J.1    Wang, Z.2    Powell, S.3
  • 99
    • 76349086193 scopus 로고    scopus 로고
    • A phase I study of telomerase-specifc replication competent oncolytic adenovirus (telomelysin) for various solid tumors
    • Nemunaitis J, Tong AW, Nemunaitis M, et al. A phase I study of telomerase-specifc replication competent oncolytic adenovirus (telomelysin) for various solid tumors. Mol Ter. 2010;18:429-434.
    • (2010) Mol Ter , vol.18 , pp. 429-434
    • Nemunaitis, J.1    Tong, A.W.2    Nemunaitis, M.3
  • 100
    • 0037461917 scopus 로고    scopus 로고
    • Selective ablation of human cancer cells by telomerase-specifc adenoviral suicide gene therapy vectors expressing bacterial nitroreductase
    • Bilsland AE, Anderson CJ, Fletcher-Monaghan AJ, et al. Selective ablation of human cancer cells by telomerase-specifc adenoviral suicide gene therapy vectors expressing bacterial nitroreductase. Oncogene. 2003;22:370-380.
    • (2003) Oncogene , vol.22 , pp. 370-380
    • Bilsland, A.E.1    Anderson, C.J.2    Fletcher-Monaghan, A.J.3
  • 101
    • 0026554887 scopus 로고
    • Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
    • Smith F W, Feigon J. Quadruplex structure of Oxytricha telomeric DNA oligonucleotides. Nature. 1992;356:164-168.
    • (1992) Nature , vol.356 , pp. 164-168
    • Smith, F.W.1    Feigon, J.2
  • 103
    • 58149359322 scopus 로고    scopus 로고
    • G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors
    • Leonetti C, Scarsella M, Riggio G, et al. G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors. Clin Cancer Res. 2008;14:7284-7291.
    • (2008) Clin Cancer Res , vol.14 , pp. 7284-7291
    • Leonetti, C.1    Scarsella, M.2    Riggio, G.3
  • 104
    • 13944272246 scopus 로고    scopus 로고
    • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
    • Burger AM, Dai F, Schultes CM, et al. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 2005;65:1489-1496.
    • (2005) Cancer Res , vol.65 , pp. 1489-1496
    • Burger, A.M.1    Dai, F.2    Schultes, C.M.3
  • 105
    • 0036241599 scopus 로고    scopus 로고
    • A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo anti-tumor activity
    • Gowan SM, Harrison JR, Patterson L, et al. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo anti-tumor activity. Mol Pharmacol. 2002;61:1154-1162.
    • (2002) Mol Pharmacol , vol.61 , pp. 1154-1162
    • Gowan, S.M.1    Harrison, J.R.2    Patterson, L.3
  • 106
    • 77954627511 scopus 로고    scopus 로고
    • Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development
    • Waki K, Anno K, Ono T, Ide T, Chayama K, Tahara H. Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. Cancer Sci. 2010;101:1678-1685.
    • (2010) Cancer Sci , vol.101 , pp. 1678-1685
    • Waki, K.1    Anno, K.2    Ono, T.3    Ide, T.4    Chayama, K.5    Tahara, H.6
  • 107
    • 78650758700 scopus 로고    scopus 로고
    • S-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor
    • Doi T, Shibata K, Yoshida M, et al. (S)-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor. Org Biomol Chem. 2011; 9:387-393.
    • (2011) Org Biomol Chem , vol.9 , pp. 387-393
    • Doi, T.1    Shibata, K.2    Yoshida, M.3
  • 108
    • 33645280314 scopus 로고    scopus 로고
    • G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells
    • Tahara H, Shin-Ya K, Seimiya H, Yamada H, Tsuruo T, Ide T. G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells. Oncogene. 2006;25:1955-1966.
    • (2006) Oncogene , vol.25 , pp. 1955-1966
    • Tahara, H.1    Shin-Ya, K.2    Seimiya, H.3    Yamada, H.4    Tsuruo, T.5    Ide, T.6
  • 109
    • 36049045013 scopus 로고    scopus 로고
    • Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
    • Salvati E, Leonetti C, Rizzo A, et al. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest. 2007;117: 3236-3247.
    • (2007) J Clin Invest , vol.117 , pp. 3236-3247
    • Salvati, E.1    Leonetti, C.2    Rizzo, A.3
  • 110
    • 33845994055 scopus 로고    scopus 로고
    • Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells
    • Gomez D, Wenner T, Brassart B, et al. Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. J Biol Chem. 2006;281:38721-38729.
    • (2006) J Biol Chem , vol.281 , pp. 38721-38729
    • Gomez, D.1    Wenner, T.2    Brassart, B.3
  • 111
    • 33746916385 scopus 로고    scopus 로고
    • The G-quadruplex ligand telo mestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
    • Gomez D, O'Donohue MF, Wenner T, et al. The G-quadruplex ligand telo mestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res. 2006;66: 6908-6912.
    • (2006) Cancer Res , vol.66 , pp. 6908-6912
    • Gomez, D.1    O'Donohue, M.F.2    Wenner, T.3
  • 112
    • 0037015078 scopus 로고    scopus 로고
    • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    • Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A. 2002;99:11593-11598.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11593-11598
    • Siddiqui-Jain, A.1    Grand, C.L.2    Bearss, D.J.3    Hurley, L.H.4
  • 113
    • 27244435211 scopus 로고    scopus 로고
    • Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents
    • Sun D, Guo K, Rusche JJ, Hurley LH. Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res. 2005;33:6070-6080.
    • (2005) Nucleic Acids Res , vol.33 , pp. 6070-6080
    • Sun, D.1    Guo, K.2    Rusche, J.J.3    Hurley, L.H.4
  • 114
    • 33748519569 scopus 로고    scopus 로고
    • Gene function correlates with potential for G4 DNA formation in the human genome
    • Eddy J, Maizels N. Gene function correlates with potential for G4 DNA formation in the human genome. Nucleic Acids Res. 2006;34:3887-3896.
    • (2006) Nucleic Acids Res , vol.34 , pp. 3887-3896
    • Eddy, J.1    Maizels, N.2
  • 115
    • 70350220557 scopus 로고    scopus 로고
    • Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesis
    • Drygin D, Siddiqui-Jain A, O'Brien S, et al. Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Res. 2009;69:7653-7661.
    • (2009) Cancer Res , vol.69 , pp. 7653-7661
    • Drygin, D.1    Siddiqui-Jain, A.2    O'Brien, S.3
  • 116
    • 0033575958 scopus 로고    scopus 로고
    • Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
    • Saretzki G, Sitte N, Merkel U, Wurm RE, von Zglinicki T. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene. 1999;18:5148-5158.
    • (1999) Oncogene , vol.18 , pp. 5148-5158
    • Saretzki, G.1    Sitte, N.2    Merkel, U.3    Wurm, R.E.4    von Zglinicki, T.5
  • 118
    • 34248184169 scopus 로고    scopus 로고
    • Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
    • Yaar M, Eller MS, Panova I, et al. Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res. 2007;9:R13.
    • (2007) Breast Cancer Res , vol.9
    • Yaar, M.1    Eller, M.S.2    Panova, I.3
  • 119
    • 34548497874 scopus 로고    scopus 로고
    • Telomere 3' overhang-specifc DNA oli-gonucleotides induce autophagy in malignant glioma cells
    • Aoki H, Iwado E, Eller MS, et al. Telomere 3' overhang-specifc DNA oli-gonucleotides induce autophagy in malignant glioma cells. FASEB J. Sep 2007; 21(11):2918-2930.
    • (2007) FASEB J , vol.21 , Issue.11 , pp. 2918-2930
    • Aoki, H.1    Iwado, E.2    Eller, M.S.3
  • 122
    • 67651031415 scopus 로고    scopus 로고
    • Cancer stem cells: A new paradigm for understanding tumor growth and progression and drug resistance
    • Gangemi R, Paleari L, Orengo AM, et al. Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance. Curr Med Chem. 2009;16:1688-1703.
    • (2009) Curr Med Chem , vol.16 , pp. 1688-1703
    • Gangemi, R.1    Paleari, L.2    Orengo, A.M.3
  • 123
    • 67649432387 scopus 로고    scopus 로고
    • Cancer stem cells - from initiation to elimination, how far have we reached? (Review)
    • Akhtar K, Bussen W, Scott S P. Cancer stem cells - from initiation to elimination, how far have we reached? (Review). Int J Oncol. 2009;34:1491-1503.
    • (2009) Int J Oncol , vol.34 , pp. 1491-1503
    • Akhtar, K.1    Bussen, W.2    Scott, S.P.3
  • 124
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park CY, Tseng D, Weissman IL. Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ter. 2009;17:219-230.
    • (2009) Mol Ter , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 125
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008;8:755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 126
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta PB, Chafer CL, Weinberg RA. Cancer stem cells: mirage or reality? Nat Med. 2009;15:1010-1012.
    • (2009) Nat Med , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chafer, C.L.2    Weinberg, R.A.3
  • 127
  • 128
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer. 2005;5:275-284.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 129
    • 58049195459 scopus 로고    scopus 로고
    • Quantitative mass spectrometry identifes drug targets in cancer stem cell-containing side population
    • Steiniger SC, Coppinger JA, Kruger JA, Yates J, Janda KD. Quantitative mass spectrometry identifes drug targets in cancer stem cell-containing side population. Stem Cells. 2008;26:3037-3046.
    • (2008) Stem Cells , vol.26 , pp. 3037-3046
    • Steiniger, S.C.1    Coppinger, J.A.2    Kruger, J.A.3    Yates, J.4    Janda, K.D.5
  • 130
    • 77955078486 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells
    • Chikazawa N, Tanaka H, Tasaka T, et al. Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Antican-cer Res. 2010;30:2041-2048.
    • (2010) Antican-cer Res , vol.30 , pp. 2041-2048
    • Chikazawa, N.1    Tanaka, H.2    Tasaka, T.3
  • 131
    • 77950862035 scopus 로고    scopus 로고
    • Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant
    • Hu L, McArthur C, Jafe RB. Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer. 2010;102:1276-1283.
    • (2010) Br J Cancer , vol.102 , pp. 1276-1283
    • Hu, L.1    McArthur, C.2    Jafe, R.B.3
  • 132
    • 77955488723 scopus 로고    scopus 로고
    • Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and che-moresistance phenotype
    • Singh A, Wu H, Zhang P, Happel C, Ma J, Biswal S. Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and che-moresistance phenotype. Mol Cancer Ter. Aug 2010;9(8):2365-2376.
    • (2010) Mol Cancer Ter , vol.9 , Issue.8 , pp. 2365-2376
    • Singh, A.1    Wu, H.2    Zhang, P.3    Happel, C.4    Ma, J.5    Biswal, S.6
  • 134
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: Stem cells in cancer
    • Polyak K, Hahn WC. Roots and stems: stem cells in cancer. Nat Med. 2006;12:296-300.
    • (2006) Nat Med , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 135
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fbroblasts by defned factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fbroblasts by defned factors. Cell. 2007;131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 136
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 139
    • 45749102020 scopus 로고    scopus 로고
    • CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    • Shmelkov SV, Butler JM, Hooper AT, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008;118:2111-2120.
    • (2008) J Clin Invest , vol.118 , pp. 2111-2120
    • Shmelkov, S.V.1    Butler, J.M.2    Hooper, A.T.3
  • 140
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • Sharma SV, Lee DY, Li B, et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell. 2010;141:69-80.
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1    Lee, D.Y.2    Li, B.3
  • 141
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell. 2010;141:583-594.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3
  • 142
    • 79959996627 scopus 로고    scopus 로고
    • Cancer cells cyclically lose and regain a drug-resistant highly-tumorigenic phenotype in culture and in tumor xenografts
    • 2011 Apr 25. [Epub ahead of print]
    • He K, Xu T, Goldkorn A. Cancer cells cyclically lose and regain a drug-resistant highly-tumorigenic phenotype in culture and in tumor xenografts. Mol Cancer Ter. 2011 Apr 25. [Epub ahead of print]
    • Mol Cancer Ter
    • He, K.1    Xu, T.2    Goldkorn, A.3
  • 143
    • 45549091414 scopus 로고    scopus 로고
    • Prostate cancer stem cells: A new target for therapy
    • Maitland NJ, Collins AT. Prostate cancer stem cells: a new target for therapy. J Clin Oncol. 2008;26:2862-2870.
    • (2008) J Clin Oncol , vol.26 , pp. 2862-2870
    • Maitland, N.J.1    Collins, A.T.2
  • 144
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 146
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison D, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature. 2005;436:1048-1052.
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3
  • 147
    • 34250315214 scopus 로고    scopus 로고
    • Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo
    • Gu G, Yuan J, Wills M, Kasper S. Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res. 2007;67: 4807-4815.
    • (2007) Cancer Res , vol.67 , pp. 4807-4815
    • Gu, G.1    Yuan, J.2    Wills, M.3    Kasper, S.4
  • 148
    • 18644373013 scopus 로고    scopus 로고
    • Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
    • Stewart SA, Hahn WC, O'Connor B F, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA. 2002;99:12606-12611.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12606-12611
    • Stewart, S.A.1    Hahn, W.C.2    O'Connor, B.F.3
  • 149
    • 80051664954 scopus 로고    scopus 로고
    • Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference
    • 2011 Feb 14. [Epub ahead of print]
    • Xu T, He K, Wang L, Goldkorn A. Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference. Prostate. 2011 Feb 14. [Epub ahead of print]
    • Prostate
    • Xu, T.1    He, K.2    Wang, L.3    Goldkorn, A.4
  • 150
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho MM, Ng AV, Lam S, Hung JY. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res. 2007;67:4827-4833.
    • (2007) Cancer Res , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 151
    • 78549274789 scopus 로고    scopus 로고
    • Tumor-initiating function of nucleostemin-enriched mammary tumor cells
    • Lin T, Meng L, Li Y, Tsai RY. Tumor-initiating function of nucleostemin-enriched mammary tumor cells. Cancer Res. 2010;70:9444-9452.
    • (2010) Cancer Res , vol.70 , pp. 9444-9452
    • Lin, T.1    Meng, L.2    Li, Y.3    Tsai, R.Y.4
  • 152
    • 74949143829 scopus 로고    scopus 로고
    • Te telomerase antagonist, ime-telstat, efciently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
    • Marian CO, Cho SK, McEllin BM, et al. Te telomerase antagonist, ime-telstat, efciently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin Cancer Res. 2010;16:154-163.
    • (2010) Clin Cancer Res , vol.16 , pp. 154-163
    • Marian, C.O.1    Cho, S.K.2    McEllin, B.M.3
  • 153
    • 77953699259 scopus 로고    scopus 로고
    • The efects of telomerase inhibition on prostate tumor-initiating cells
    • Marian CO, Wright WE, Shay JW. The efects of telomerase inhibition on prostate tumor-initiating cells. Int J Cancer. 2010;127:321-331.
    • (2010) Int J Cancer , vol.127 , pp. 321-331
    • Marian, C.O.1    Wright, W.E.2    Shay, J.W.3
  • 154
    • 84858246481 scopus 로고    scopus 로고
    • A phase I trial of GRN163L (GRN), a frst-in-class telomerase inhibitor, in advanced solid tumors
    • ASCO Annual Meeting Abstracts, Abstract 3581
    • Ratain MJ, Benedetti FM, Janisch L, et al. A phase I trial of GRN163L (GRN), a frst-in-class telomerase inhibitor, in advanced solid tumors. J Clin Oncol (ASCO Annual Meeting Abstracts). 2008;26:Abstract 3581.
    • (2008) J Clin Oncol , vol.26
    • Ratain, M.J.1    Benedetti, F.M.2    Janisch, L.3
  • 155
    • 3242690518 scopus 로고    scopus 로고
    • Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
    • Parkhurst MR, Riley J P, Igarashi T, Li Y, Robbins P F, Rosenberg SA. Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase. Clin Cancer Res. 2004;10:4688-4698.
    • (2004) Clin Cancer Res , vol.10 , pp. 4688-4698
    • Parkhurst, M.R.1    Riley, J.P.2    Igarashi, T.3    Li, Y.4    Robbins, P.F.5    Rosenberg, S.A.6
  • 156
    • 78751699860 scopus 로고    scopus 로고
    • Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination based on hTERT and survivin following ASCT for myeloma
    • Rapoport A P, Aqui NA, Stadtmauer EA, et al. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination based on hTERT and survivin following ASCT for myeloma. Blood. 2011;3:788-797.
    • (2011) Blood , vol.3 , pp. 788-797
    • Rapoport, A.P.1    Aqui, N.A.2    Stadtmauer, E.A.3
  • 157
    • 79959945388 scopus 로고    scopus 로고
    • Phase I study of anti-CD25 mab dacli-zumab to deplete regulatory T cells prior to telomerase/survivin peptide vaccination in patients (pts) with metastatic breast cancer (MBC)
    • ASCO Annual Meeting Abstracts, Abstract 2508
    • Rech AJ, Mick R, Recio A, et al. Phase I study of anti-CD25 mab dacli-zumab to deplete regulatory T cells prior to telomerase/survivin peptide vaccination in patients (pts) with metastatic breast cancer (MBC). J Clin Oncol (ASCO Annual Meeting Abstracts). 2010;28:Abstract 2508.
    • (2010) J Clin Oncol , vol.28
    • Rech, A.J.1    Mick, R.2    Recio, A.3
  • 158
    • 77957319524 scopus 로고    scopus 로고
    • Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: Results from a phase I/II trial
    • Trepiakas R, Berntsen A, Hadrup SR, et al. Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial. Cytotherapy. 2010;12:721-734.
    • (2010) Cytotherapy , vol.12 , pp. 721-734
    • Trepiakas, R.1    Berntsen, A.2    Hadrup, S.R.3
  • 159
    • 79959996313 scopus 로고    scopus 로고
    • Dendritic cell based vaccination in combination with IL-2 as a treatment for advanced renal cell carcinoma patients: Results from a phase I/II trial
    • ASCO Annual Meeting Abstracts, Abstract 2575
    • Berntsen A, Geertsen P, Trepiakas R, et al. Dendritic cell based vaccination in combination with IL-2 as a treatment for advanced renal cell carcinoma patients: results from a phase I/II trial. J Clin Oncol (ASCO Annual Meeting Abstracts). 2006;24:Abstract 2575.
    • (2006) J Clin Oncol , vol.24
    • Berntsen, A.1    Geertsen, P.2    Trepiakas, R.3
  • 160
    • 20144364773 scopus 로고    scopus 로고
    • Telomerase mRNA-transfected dendritic cells stimulate antigen-specifc CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    • Su Z, Dannull J, Yang BK, et al. Telomerase mRNA-transfected dendritic cells stimulate antigen-specifc CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. J Immunol. 2005;174:3798-3807.
    • (2005) J Immunol , vol.174 , pp. 3798-3807
    • Su, Z.1    Dannull, J.2    Yang, B.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.