메뉴 건너뛰기




Volumn 9, Issue 2, 2010, Pages 438-449

Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; MUTANT TEMPLATE MOUSE TELOMERASE RNA; SMALL INTERFERING RNA; TELOMERASE; UNCLASSIFIED DRUG; WILD TYPE MOUSE TELOMERASE RNA;

EID: 76649142740     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0682     Document Type: Article
Times cited : (13)

References (50)
  • 2
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989;337:331-7.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 3
  • 4
    • 33644777482 scopus 로고    scopus 로고
    • Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology
    • Meeker AK. Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology. Urol Oncol 2006;24:122-30.
    • (2006) Urol Oncol , vol.24 , pp. 122-130
    • Meeker, A.K.1
  • 5
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:87-791.
    • (1997) Eur J Cancer , vol.33 , pp. 87-791
    • Shay, J.W.1    Bacchetti, S.2
  • 6
    • 0036720448 scopus 로고    scopus 로고
    • Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors
    • Tomoda R, Seto M, Tsumuki H, et al. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer 2002;95: 1127-33.
    • (2002) Cancer , vol.95 , pp. 1127-1133
    • Tomoda, R.1    Seto, M.2    Tsumuki, H.3
  • 7
    • 24744446474 scopus 로고    scopus 로고
    • In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor
    • Dikmen ZG, Gellert GC, Jackson S, et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res 2005;65:7866-73.
    • (2005) Cancer Res , vol.65 , pp. 7866-7873
    • Dikmen, Z.G.1    Gellert, G.C.2    Jackson, S.3
  • 8
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999;5:1164-70.
    • (1999) Nat Med , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 9
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 1999;13:2388-99.
    • (1999) Genes Dev , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 10
    • 33745274487 scopus 로고    scopus 로고
    • Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells
    • Goldkorn A, Blackburn EH. Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res 2006;66:5763-71.
    • (2006) Cancer Res , vol.66 , pp. 5763-5771
    • Goldkorn, A.1    Blackburn, E.H.2
  • 11
    • 3142661809 scopus 로고    scopus 로고
    • Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    • Li S, Rosenberg JE, Donjacour AA, et al. Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res 2004;64:4833-40.
    • (2004) Cancer Res , vol.64 , pp. 4833-4840
    • Li, S.1    Rosenberg, J.E.2    Donjacour, A.A.3
  • 12
    • 33745679352 scopus 로고    scopus 로고
    • Telomerase therapeutics for cancer: Challenges and new directions
    • Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 2006;5:577-84.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 577-584
    • Shay, J.W.1    Wright, W.E.2
  • 13
    • 0036241599 scopus 로고    scopus 로고
    • A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
    • Gowan SM, Harrison JR, Patterson L, et al. A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol 2002;61: 1154-62.
    • (2002) Mol Pharmacol , vol.61 , pp. 1154-1162
    • Gowan, S.M.1    Harrison, J.R.2    Patterson, L.3
  • 14
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3
  • 17
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stemcell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stemcell biology to cancer. Nat Rev Cancer 2003;3:895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 19
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q, Rozengurt N, et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003;4:209-21.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3    Rozengurt, N.4
  • 20
    • 31944448885 scopus 로고    scopus 로고
    • Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
    • Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A 2006;103:1480-5.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1480-1485
    • Wang, S.1    Garcia, A.J.2    Wu, M.3    Lawson, D.A.4    Witte, O.N.5    Wu, H.6
  • 21
    • 34547632147 scopus 로고    scopus 로고
    • Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence
    • Liao CP, Zhong C, Saribekyan G, et al. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res 2007;67: 7525-33.
    • (2007) Cancer Res , vol.67 , pp. 7525-7533
    • Liao, C.P.1    Zhong, C.2    Saribekyan, G.3
  • 22
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272:263-7.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 23
    • 40649099368 scopus 로고    scopus 로고
    • Ramezani A, Hawley RG. Generation of HIV-1-based lentiviral vector particles. Curr Protoc Mol Biol 2002. Chapter 16: Unit 16.22.
    • Ramezani A, Hawley RG. Generation of HIV-1-based lentiviral vector particles. Curr Protoc Mol Biol 2002. Chapter 16: Unit 16.22.
  • 24
    • 34347249615 scopus 로고    scopus 로고
    • Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol
    • Herbert BS, Hochreiter AE, Wright WE, Shay JW. Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc 2006;1:1583-90.
    • (2006) Nat Protoc , vol.1 , pp. 1583-1590
    • Herbert, B.S.1    Hochreiter, A.E.2    Wright, W.E.3    Shay, J.W.4
  • 25
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-5.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 26
    • 84925570883 scopus 로고    scopus 로고
    • Mouse prostate cancer cell lines established from primary and post-castration recurrent tumors. Hormones & Cancer
    • In press
    • Liao C-P, Mengmeng Liang, Cohen MB, et al. Mouse prostate cancer cell lines established from primary and post-castration recurrent tumors. Hormones & Cancer. In press.
    • Liao, C.-P.1    Mengmeng Liang, C.M.B.2
  • 27
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005;19:2100-10.
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 28
    • 35349023061 scopus 로고    scopus 로고
    • Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres
    • Xu L, Blackburn EH. Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell 2007;28: 315-27.
    • (2007) Mol Cell , vol.28 , pp. 315-327
    • Xu, L.1    Blackburn, E.H.2
  • 31
    • 21244502260 scopus 로고    scopus 로고
    • Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
    • Li S, Crothers J, Haqq CM, Blackburn EH. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 2005;280:23709-17.
    • (2005) J Biol Chem , vol.280 , pp. 23709-23717
    • Li, S.1    Crothers, J.2    Haqq, C.M.3    Blackburn, E.H.4
  • 32
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu GL, Bradley JD, Attardi LD, Blackburn EH. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 1990;344:126-32.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 33
    • 1642423569 scopus 로고    scopus 로고
    • Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response
    • Lin J, Smith DL, Blackburn EH. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Mol Biol Cell 2004;15:1623-34.
    • (2004) Mol Biol Cell , vol.15 , pp. 1623-1634
    • Lin, J.1    Smith, D.L.2    Blackburn, E.H.3
  • 34
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995;269:1236-41.
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 35
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci C, Cerone MA, Bacchetti S. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene 2001;20:714-25.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 36
    • 1842339879 scopus 로고    scopus 로고
    • Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
    • Marusic L, Anton M, Tidy A, Wang P, Villeponteau B, Bacchetti S. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol 1997;17: 6394-401.
    • (1997) Mol Cell Biol , vol.17 , pp. 6394-6401
    • Marusic, L.1    Anton, M.2    Tidy, A.3    Wang, P.4    Villeponteau, B.5    Bacchetti, S.6
  • 37
    • 0035444984 scopus 로고    scopus 로고
    • Telomere maintenance by telomerase and by recombination can coexist in human cells
    • Cerone MA, Londono-Vallejo JA, Bacchetti S. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum Mol Genet 2001;10:1945-52.
    • (2001) Hum Mol Genet , vol.10 , pp. 1945-1952
    • Cerone, M.A.1    Londono-Vallejo, J.A.2    Bacchetti, S.3
  • 38
    • 0025100858 scopus 로고
    • Cell biology: Telomeres sans frontieres
    • Blackburn EH. Cell biology: telomeres sans frontieres. Nature 1990; 343:122.
    • (1990) Nature , vol.343 , pp. 122
    • Blackburn, E.H.1
  • 39
    • 0033455559 scopus 로고    scopus 로고
    • Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
    • Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A 1999;96:14276-81.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14276-14281
    • Herbert, B.1    Pitts, A.E.2    Baker, S.I.3
  • 40
    • 0030737882 scopus 로고    scopus 로고
    • Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
    • Zijlmans JM, Martens UM, Poon SS, et al. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A 1997;94:7423-8.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7423-7428
    • Zijlmans, J.M.1    Martens, U.M.2    Poon, S.S.3
  • 41
    • 0034669532 scopus 로고    scopus 로고
    • Wild-derived inbred mouse strains have short telomeres
    • Hemann MT, Greider CW. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res 2000;28:4474-8.
    • (2000) Nucleic Acids Res , vol.28 , pp. 4474-4478
    • Hemann, M.T.1    Greider, C.W.2
  • 42
    • 59549087180 scopus 로고    scopus 로고
    • Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA
    • Marie-Egyptienne DT, Brault ME, Nimmo GA, Londono-Vallejo JA, Autexier C. Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA. Cancer Lett 2009;275:266-76.
    • (2009) Cancer Lett , vol.275 , pp. 266-276
    • Marie-Egyptienne, D.T.1    Brault, M.E.2    Nimmo, G.A.3    Londono-Vallejo, J.A.4    Autexier, C.5
  • 43
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A 1995;92:4818-22.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 44
    • 0037089438 scopus 로고    scopus 로고
    • Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    • Samper E, Fernandez P, Eguia R, et al. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 2002;99:2767-75.
    • (2002) Blood , vol.99 , pp. 2767-2775
    • Samper, E.1    Fernandez, P.2    Eguia, R.3
  • 45
    • 0036362266 scopus 로고    scopus 로고
    • Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again
    • Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation 2002;69:188-97.
    • (2002) Differentiation , vol.69 , pp. 188-197
    • Forsyth, N.R.1    Wright, W.E.2    Shay, J.W.3
  • 46
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 2003;102: 517-20.
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 47
    • 4544256099 scopus 로고    scopus 로고
    • Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
    • Ferron S, Mira H, Franco S, et al. Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells. Development 2004;131:4059-70.
    • (2004) Development , vol.131 , pp. 4059-4070
    • Ferron, S.1    Mira, H.2    Franco, S.3
  • 48
    • 23844540299 scopus 로고    scopus 로고
    • Effects of telomerase and telomere length on epidermal stem cell behavior
    • Flores I, Cayuela ML, Blasco MA. Effects of telomerase and telomere length on epidermal stem cell behavior. Science 2005;309:1253-6.
    • (2005) Science , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 49
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E, Samper E, Ramirez A, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 2001;20:2619-30.
    • (2001) EMBO J , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3
  • 50
    • 33745847778 scopus 로고    scopus 로고
    • Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing
    • Davis T, Kipling D. Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing. Biogerontology 2005;6:371-85.
    • (2005) Biogerontology , vol.6 , pp. 371-385
    • Davis, T.1    Kipling, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.