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Volumn 68, Issue 13, 2008, Pages 5309-5317

ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CAMPTOTHECIN; PROTEIN P53; RNA; TELOMERASE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TELOMERASE RNA; TUMOR SUPPRESSOR PROTEIN;

EID: 48549084245     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0504     Document Type: Article
Times cited : (33)

References (48)
  • 1
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. Telomere states and cell fates. Nature 2000;408:53-6.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 2
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005;19:2100-10.
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 4
    • 0038350026 scopus 로고    scopus 로고
    • Role of telomeres and telomerase in the pathogenesis of human cancer
    • Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer. J Clin Oncol 2003;21:2034-43.
    • (2003) J Clin Oncol , vol.21 , pp. 2034-2043
    • Hahn, W.C.1
  • 5
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    • Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 2004;14:501-13.
    • (2004) Mol Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.3    Chen, D.J.4    Sedivy, J.M.5
  • 6
    • 33745679352 scopus 로고    scopus 로고
    • Telomerase therapeutics for cancer: Challenges and new directions
    • Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 2006;5:577-84.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 577-584
    • Shay, J.W.1    Wright, W.E.2
  • 8
    • 25444522262 scopus 로고    scopus 로고
    • Telomerase and cancer: Kirk A. Landon - AACR prize for basic cancer research lecture
    • Blackburn EH. Telomerase and cancer: Kirk A. Landon - AACR prize for basic cancer research lecture. Mol Cancer Res 2005;3:477-82.
    • (2005) Mol Cancer Res , vol.3 , pp. 477-482
    • Blackburn, E.H.1
  • 9
    • 1842339879 scopus 로고    scopus 로고
    • Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
    • Marusic L, Anton M, Tidy A, Wang P, Villeponteau B, Bacchetti S. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol 1997;17:6394-401.
    • (1997) Mol Cell Biol , vol.17 , pp. 6394-6401
    • Marusic, L.1    Anton, M.2    Tidy, A.3    Wang, P.4    Villeponteau, B.5    Bacchetti, S.6
  • 10
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci C, Cerone MA, Bacchetti S. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene 2001;20:714-25.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 11
    • 10344235232 scopus 로고    scopus 로고
    • Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
    • Xu L, Blackburn EH. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 2004;167:819-30.
    • (2004) J Cell Biol , vol.167 , pp. 819-830
    • Xu, L.1    Blackburn, E.H.2
  • 12
    • 21244502260 scopus 로고    scopus 로고
    • Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
    • Li S, Crothers J, Haqq CM, Blackburn EH. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 2005;280:23709-17.
    • (2005) J Biol Chem , vol.280 , pp. 23709-23717
    • Li, S.1    Crothers, J.2    Haqq, C.M.3    Blackburn, E.H.4
  • 13
    • 3142661809 scopus 로고    scopus 로고
    • Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    • Li S, Rosenberg JE, Donjacour AA, et al. Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res 2004;64:4833-40.
    • (2004) Cancer Res , vol.64 , pp. 4833-4840
    • Li, S.1    Rosenberg, J.E.2    Donjacour, A.A.3
  • 14
    • 2442455288 scopus 로고    scopus 로고
    • Telomeres are double-strand DNA breaks hidden from DNA damage responses
    • Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol Cell 2004;14:420-1.
    • (2004) Mol Cell , vol.14 , pp. 420-421
    • Shay, J.W.1    Wright, W.E.2
  • 15
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 16
    • 34547813672 scopus 로고    scopus 로고
    • Goudsouzian LK, Tuzon CT, Zakian VA. S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 2006;24:603-10.
    • Goudsouzian LK, Tuzon CT, Zakian VA. S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 2006;24:603-10.
  • 17
    • 34548492016 scopus 로고    scopus 로고
    • MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control
    • Wu Y, Xiao S, Zhu XD. MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat Struct Mol Biol 2007;14:832-40.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 832-840
    • Wu, Y.1    Xiao, S.2    Zhu, X.D.3
  • 18
    • 0035928740 scopus 로고    scopus 로고
    • Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
    • Chan SW, Chang J, Prescott J, Blackburn EH. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol 2001;11:1240-50.
    • (2001) Curr Biol , vol.11 , pp. 1240-1250
    • Chan, S.W.1    Chang, J.2    Prescott, J.3    Blackburn, E.H.4
  • 19
    • 0037716757 scopus 로고    scopus 로고
    • Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    • Chan SW, Blackburn EH. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell 2003;11:1379-87.
    • (2003) Mol Cell , vol.11 , pp. 1379-1387
    • Chan, S.W.1    Blackburn, E.H.2
  • 20
    • 0029681361 scopus 로고    scopus 로고
    • Accelerated telomere shortening in ataxia telangiectasia
    • Metcalfe JA, Parkhill J, Campbell L, et al. Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 1996;13:350-3.
    • (1996) Nat Genet , vol.13 , pp. 350-353
    • Metcalfe, J.A.1    Parkhill, J.2    Campbell, L.3
  • 21
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 2007;448:1068-71.
    • (2007) Nature , vol.448 , pp. 1068-1071
    • Denchi, E.L.1    de Lange, T.2
  • 22
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007;316:1160-6.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3
  • 24
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • Hickson I, Zhao Y, Richardson CJ, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004;64:9152-9.
    • (2004) Cancer Res , vol.64 , pp. 9152-9159
    • Hickson, I.1    Zhao, Y.2    Richardson, C.J.3
  • 25
    • 0038011619 scopus 로고    scopus 로고
    • Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites
    • Fedier A, Schlamminger M, Schwarz VA, Haller U, Howell SB, Fink D. Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites. Ann Oncol 2003;14:938-45.
    • (2003) Ann Oncol , vol.14 , pp. 938-945
    • Fedier, A.1    Schlamminger, M.2    Schwarz, V.A.3    Haller, U.4    Howell, S.B.5    Fink, D.6
  • 26
    • 0037382008 scopus 로고    scopus 로고
    • Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
    • Collis SJ, Swartz MJ, Nelson WG, DeWeese TL. Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors. Cancer Res 2003;63:1550-4.
    • (2003) Cancer Res , vol.63 , pp. 1550-1554
    • Collis, S.J.1    Swartz, M.J.2    Nelson, W.G.3    DeWeese, T.L.4
  • 27
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003;13:1549-56.
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 28
    • 0033605145 scopus 로고    scopus 로고
    • p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999;283:1321-5.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    de Lange, T.5
  • 29
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997;15:871-5.
    • (1997) Nat Biotechnol , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 30
    • 15744386741 scopus 로고    scopus 로고
    • Regulation of CHK2 by DNA-dependent protein kinase
    • Li J, Stern DF. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem 2005;280:12041-50.
    • (2005) J Biol Chem , vol.280 , pp. 12041-12050
    • Li, J.1    Stern, D.F.2
  • 31
    • 4544222069 scopus 로고    scopus 로고
    • ATM-dependent CHK2 activation induced by anticancer agent, irofulven
    • Wang J, Wiltshire T, Wang Y, et al. ATM-dependent CHK2 activation induced by anticancer agent, irofulven. J Biol Chem 2004;279:39584-92.
    • (2004) J Biol Chem , vol.279 , pp. 39584-39592
    • Wang, J.1    Wiltshire, T.2    Wang, Y.3
  • 32
    • 35349023061 scopus 로고    scopus 로고
    • Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres
    • Xu L, Blackburn EH. Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell 2007;28:315-27.
    • (2007) Mol Cell , vol.28 , pp. 315-327
    • Xu, L.1    Blackburn, E.H.2
  • 33
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase I inhibitors: Camptothecins and beyond
    • Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 2006;6:789-802.
    • (2006) Nat Rev Cancer , vol.6 , pp. 789-802
    • Pommier, Y.1
  • 34
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-7.
    • (2003) Nat Biotechnol , vol.21 , pp. 635-637
    • Jackson, A.L.1    Bartz, S.R.2    Schelter, J.3
  • 35
    • 33745274487 scopus 로고    scopus 로고
    • Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells
    • Goldkorn A, Blackburn EH. Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res 2006;66:5763-71.
    • (2006) Cancer Res , vol.66 , pp. 5763-5771
    • Goldkorn, A.1    Blackburn, E.H.2
  • 36
    • 18344388668 scopus 로고    scopus 로고
    • Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
    • Lau A, Swinbank KM, Ahmed PS, et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol 2005;7:493-500.
    • (2005) Nat Cell Biol , vol.7 , pp. 493-500
    • Lau, A.1    Swinbank, K.M.2    Ahmed, P.S.3
  • 37
    • 34548269900 scopus 로고    scopus 로고
    • Tel1p preferentially associates with short telomeres to stimulate their elongation
    • Hector RE, Shtofman RL, Ray A, et al. Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell 2007;27:851-8.
    • (2007) Mol Cell , vol.27 , pp. 851-858
    • Hector, R.E.1    Shtofman, R.L.2    Ray, A.3
  • 38
    • 0028652646 scopus 로고
    • p53 mutations in bladder carcinoma cell lines
    • Cooper MJ, Haluschak JJ, Johnson D, et al. p53 mutations in bladder carcinoma cell lines. Oncol Res 1994;6:569-79.
    • (1994) Oncol Res , vol.6 , pp. 569-579
    • Cooper, M.J.1    Haluschak, J.J.2    Johnson, D.3
  • 40
    • 0031047642 scopus 로고    scopus 로고
    • Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH. Block in anaphase chromosome separation caused by a telomerase template mutation. Science 1997;275:1478-81.
    • Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH. Block in anaphase chromosome separation caused by a telomerase template mutation. Science 1997;275:1478-81.
  • 41
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: Role of telomeres and telomerase
    • Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005;26:867-74.
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 42
    • 33748173811 scopus 로고    scopus 로고
    • Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability
    • Jeggo PA, Lobrich M. Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair (Amst) 2006;5:1192-8.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 1192-1198
    • Jeggo, P.A.1    Lobrich, M.2
  • 43
    • 36248952723 scopus 로고    scopus 로고
    • Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
    • Guo X, Deng Y, Lin Y, et al. Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 2007;26:4709-19.
    • (2007) EMBO J , vol.26 , pp. 4709-4719
    • Guo, X.1    Deng, Y.2    Lin, Y.3
  • 44
    • 33745955860 scopus 로고    scopus 로고
    • Impact of genetic diagnostics on drug development strategy
    • Million RP. Impact of genetic diagnostics on drug development strategy. Nat Rev Drug Discov 2006;5:459-62.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 459-462
    • Million, R.P.1
  • 45
    • 23844507598 scopus 로고    scopus 로고
    • The ataxia-telangiectasia mutated gene and breast cancer: Gene expression profiles and sequence variants
    • Hall J. The ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants. Cancer Lett 2005;227:105-14.
    • (2005) Cancer Lett , vol.227 , pp. 105-114
    • Hall, J.1
  • 46
    • 0037627448 scopus 로고    scopus 로고
    • Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma
    • Fang NY, Greiner TC, Weisenburger DD, et al. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proc Natl Acad Sci U S A 2003;100:5372-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5372-5377
    • Fang, N.Y.1    Greiner, T.C.2    Weisenburger, D.D.3
  • 47
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu GL, Bradley JD, Attardi LD, Blackburn EH. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 1990;344:126-32.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 48
    • 1642423569 scopus 로고    scopus 로고
    • Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response
    • Lin J, Smith DL, Blackburn EH. Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Mol Biol Cell 2004;15:1623-34.
    • (2004) Mol Biol Cell , vol.15 , pp. 1623-1634
    • Lin, J.1    Smith, D.L.2    Blackburn, E.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.