Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors

Cancer

Volumn 95, Issue 5, 2002, Pages 1127-1133

  Tomoda, Ryota ^a   Seto, Masashi ^a   Tsumuki, Hideaki ^a   Iida, Koji ^a   Yamazaki, Takashi ^a   Sonoda, Jun ^a   Matsumine, Akihiko ^a   Uchida, Atsumasa ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Human telomerase reverse transcriptase; Metastasis; Recurrence; Soft tissue tumor; Telomerase activity

Indexed keywords

MESSENGER RNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CARCINOGENESIS; CLINICAL ARTICLE; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; FLUORESCENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOFT TISSUE TUMOR; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; POLYMERASE CHAIN REACTION; PROGNOSIS; RNA, MESSENGER; SARCOMA; SOFT TISSUE NEOPLASMS; TELOMERASE; TUMOR MARKERS, BIOLOGICAL;

EID: 0036720448     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10793     Document Type: Article

References (33)

1. n, present at the telomeres of human chromosomes
2. Structure and function of telomeres
3. Telomere reduction in human colorectal carcinoma and with aging
4. Telomerase activity in small-cell and non-small-cell lung cancers
5. A survey of telomerase activity in human cancer
6. The RNA component of human telomerase
7. Telomerase catalytic subunit homologs from fission yeast and human
8. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
9. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
10. A mammalian telomerase-associated protein
11. Specific association of human telomerase activity with immortal cells and cancer
12. Levels of telomerase catalytic subunit mRNA as a predictor of potential malignancy
13. Elevated levels of telomerase activity in malignant pheochromocytoma
14. Real time quantitative PCR
15. Genetic diagnostic test of hepatocellular carcinoma by telomerase catalytic subunit mRNA
16. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
18. Telomerase activity in human breast tumors
19. Telomerase activity in gastric cancer
20. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas
21. Telomerase activity is detected in pancreatic cancer but not in benign tumors
22. High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer
23. Telomeric lengths and telomerase activity in liposarcomas
24. Prognostic significance of telomerase activity in soft tissue sarcomas
25. Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: Correlation with grade, histology, and proliferative activity
26. Telomerase activity in soft-tissue and bone sarcomas
27. Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas
28. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium, and myometrium
29. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer
30. High telomerase activity and high HTRT mRNA expression differentiate pure myxoid and myxoid/round-cell liposarcomas
31. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells
32. Telomerase is controlled by protein kinase C alpha in human breast cancer cells
33. Presence of telomerase activity in different musculoskeletal tumor histotypes and correlation with aggressiveness