Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

Oncogene

Volumn 22, Issue 3, 2003, Pages 370-380

  Bilsland, Alan E ^a   Anderson, Claire J ^a   Fletcher Monaghan, Aileen J ^a   McGregor, Fiona ^a   Evans, T R Jeffry ^a   Ganly, Ian ^a   Knox, Richard J ^b   Plumb, Jane A ^a   Keith, W Nicol ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Enact Pharma PLC   (United Kingdom)

Author keywords

Adenovirus; GDEPT; Gene therapy; HTERT; HTR; Nitroreductase; Telomerase

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ADENOVIRUS VECTOR; ALKYLATING AGENT; CYTOTOXIC AGENT; NITROREDUCTASE; PRODRUG; RNA DIRECTED DNA POLYMERASE; TELOMERASE; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; CANCER CELL; CANCER CELL CULTURE; DRUG ACTIVATION; DRUG EFFICACY; DRUG SENSITIZATION; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SUICIDE GENE THERAPY; VIRAL GENE THERAPY; WESTERN BLOTTING;

ADENOCARCINOMA; ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS; AZIRIDINES; BACTERIAL PROTEINS; BASE SEQUENCE; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE THERAPY; GENETIC VECTORS; HUMANS; MALE; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASMS; NITROREDUCTASES; OVARIAN NEOPLASMS; PROMOTER REGIONS (GENETICS); TELOMERASE; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

ADENOVIRIDAE; ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037461917     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206168     Document Type: Article

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