-
1
-
-
33644991496
-
Global epidemiology of tuberculosis
-
Dye C: Global epidemiology of tuberculosis. Lancet 367(9514), 938-940 (2006
-
(2006)
Lancet
, vol.367
, Issue.9514
, pp. 938-940
-
-
Dye, C.1
-
2
-
-
11144250804
-
Tuberculosis - Metabolism and respiration in the absence of growth
-
DOI 10.1038/nrmicro1065
-
Boshoff HI, Barry CE 3rd: Tuberculosis - metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 3(1), 70-80 (2005 (Pubitemid 40028470)
-
(2005)
Nature Reviews Microbiology
, vol.3
, Issue.1
, pp. 70-80
-
-
Boshoff, H.I.M.1
Barry III, C.E.2
-
3
-
-
0842346271
-
The immunological aspects of latency in tuberculosis
-
DOI 10.1016/S1521-6616(03)00210-9
-
Chan J, Flynn J: The immunological aspects of latency in tuberculosis. Clin. Immunol. 110(1), 2-12 (2004 (Pubitemid 38177416)
-
(2004)
Clinical Immunology
, vol.110
, Issue.1
, pp. 2-12
-
-
Chan, J.1
Flynn, J.2
-
4
-
-
0347091999
-
M. tuberculosis persistence, latency, and drug tolerance
-
DOI 10.1016/j.tube.2003.08.003
-
Gomez JE, McKinney JD: M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis 84(1-2), 29-44 (2004 (Pubitemid 38082931)
-
(2004)
Tuberculosis
, vol.84
, Issue.1-2
, pp. 29-44
-
-
Gomez, J.E.1
McKinney, J.D.2
-
5
-
-
0036630033
-
Impact of tuberculosis on HIV-1 replication, diversity, and disease progression
-
Collins KR, Quinones-Mateu ME, Toossi Z, Arts EJ: Impact of tuberculosis on HIV-1 replication, diversity, and disease progression. AIDS Rev. 4(3), 165-176 (2002 (Pubitemid 35251994)
-
(2002)
AIDS Reviews
, vol.4
, Issue.3
, pp. 165-176
-
-
Collins, K.R.1
Quinones-Mateu, M.E.2
Toossi, Z.3
Arts, E.J.4
-
6
-
-
71549126811
-
Tuberculosis and diabetes mellitus: Convergence of two epidemics
-
Dooley KE, Chaisson RE: Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect. Dis. 9(12), 737-746 (2009
-
(2009)
Lancet Infect. Dis.
, vol.9
, Issue.12
, pp. 737-746
-
-
Dooley, K.E.1
Chaisson, R.E.2
-
7
-
-
35148847322
-
Diabetes and the risk of tuberculosis: A neglected threat to public health?
-
DOI 10.1177/1742395307081502
-
Stevenson CR, Critchley JA, Forouhi NG et al.: Diabetes and the risk of tuberculosis: a neglected threat to public health? Chronic Illn. 3(3), 228-245 (2007 (Pubitemid 351927860)
-
(2007)
Chronic lllness
, vol.3
, Issue.3
, pp. 228-245
-
-
Stevenson, C.R.1
Critchley, J.A.2
Forouhi, N.G.3
Roglic, G.4
Williams, B.G.5
Dye, C.6
Unwin, N.C.7
-
8
-
-
35148854758
-
Diabetes and tuberculosis: The impact of the diabetes epidemic on tuberculosis incidence
-
Stevenson CR, Forouhi NG, Roglic G et al.: Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health 7, 234 (2007
-
(2007)
BMC Public Health
, vol.7
, pp. 234
-
-
Stevenson, C.R.1
Forouhi, N.G.2
Roglic, G.3
-
9
-
-
77952366279
-
Development of new anti-tuberculosis drug candidates
-
Shi R, Sugawara I: Development of new anti-tuberculosis drug candidates. Tohoku J. Exp. Med. 221(2), 97-106 (2010
-
(2010)
Tohoku J. Exp. Med.
, vol.221
, Issue.2
, pp. 97-106
-
-
Shi, R.1
Sugawara, I.2
-
10
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
DOI 10.1126/science.1106753
-
Andries K, Verhasselt P, Guillemont J et al.: A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307(5707), 223-227 (2005 (Pubitemid 40116230)
-
(2005)
Science
, vol.307
, Issue.5707
, pp. 223-227
-
-
Andries, K.1
Verhasselt, P.2
Guillemont, J.3
Gohlmann, H.W.H.4
Neefs, J.-M.5
Winkler, H.6
Van Gestel, J.7
Timmerman, P.8
Zhu, M.9
Lee, E.10
Williams, P.11
De Chaffoy, D.12
Huitric, E.13
Hoffner, S.14
Cambau, E.15
Truffot-Pernot, C.16
Lounis, N.17
Jarlier, V.18
-
11
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
DOI 10.1038/nchembio884, PII NCHEMBIO884
-
Koul A, Dendouga N, Vergauwen K et al.: Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat. Chem. Biol. 3(6), 323-324 (2007 (Pubitemid 46789271)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.6
, pp. 323-324
-
-
Koul, A.1
Dendouga, N.2
Vergauwen, K.3
Molenberghs, B.4
Vranckx, L.5
Willebrords, R.6
Ristic, Z.7
Lill, H.8
Dorange, I.9
Guillemont, J.10
Bald, D.11
Andries, K.12
-
12
-
-
77149123917
-
Rates and mechanisms of resistance development in mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor
-
Huitric E, Verhasselt P, Koul A, Andries K, Hoffner S, Andersson DI: Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor. Antimicrob. Agents Chemother. 54(3), 1022-1028 (2010
-
(2010)
Antimicrob. Agents Chemother
, vol.54
, Issue.3
, pp. 1022-1028
-
-
Huitric, E.1
Verhasselt, P.2
Koul, A.3
Andries, K.4
Hoffner, S.5
Andersson, D.I.6
-
13
-
-
54449084104
-
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
-
Koul A, Vranckx L, Dendouga N et al.: Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J. Biol. Chem. 283(37), 25273-25280 (2008
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.37
, pp. 25273-25280
-
-
Koul, A.1
Vranckx, L.2
Dendouga, N.3
-
14
-
-
50149113470
-
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic nonreplicating mycobacterium tuberculosis
-
USA
-
Rao SP, Alonso S, Rand L, Dick T, Pethe K: The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 105(33), 11945-11950 (2008
-
(2008)
Proc. Natl Acad. Sci.
, vol.105
, Issue.33
, pp. 11945-11950
-
-
Rao, S.P.1
Alonso, S.2
Rand, L.3
Dick, T.4
Pethe, K.5
-
15
-
-
77957375205
-
Simple model for testing drugs against nonreplicating mycobacterium tuberculosis
-
Sala C, Dhar N, Hartkoorn RC et al.: Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 54(10), 4150-4158 (2010
-
(2010)
Antimicrob. Agents Chemother
, vol.54
, Issue.10
, pp. 4150-4158
-
-
Sala, C.1
Dhar, N.2
Hartkoorn, R.C.3
-
16
-
-
35948964746
-
Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by R207910
-
DOI 10.1128/AAC.00276-07
-
Lenaerts AJ, Hoff D, Aly S et al.: Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by r207910. Antimicrob. Agents Chemother. 51(9), 3338-3345 (2007 (Pubitemid 350067549)
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, Issue.9
, pp. 3338-3345
-
-
Lenaerts, A.J.1
Hoff, D.2
Aly, S.3
Ehlers, S.4
Andries, K.5
Cantarero, L.6
Orme, I.M.7
Basaraba, R.J.8
-
17
-
-
78650653480
-
The activity of TMC 207 rifampin and pyrazinamide against mycobacterium tuberculosis infection in guinea pigs
-
Shang S, Shanley CA, Caraway ML et al.: The activity of TMC 207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs. Antimicrob. Agents Chemother. 55(1), 124-131 (2011
-
(2011)
Antimicrob. Agents Chemother
, vol.55
, Issue.1
, pp. 124-131
-
-
Shang, S.1
Shanley, C.A.2
Caraway, M.L.3
-
18
-
-
70349093099
-
The diarylquinoline R207910 is bactericidal against mycobacterium leprae in mice at low dose and administered intermittently
-
Gelber R, Andries K, Paredes RM, Andaya CE, Burgos J: The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently. Antimicrob. Agents Chemother. 53(9), 3989-3991 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, Issue.9
, pp. 3989-3991
-
-
Gelber, R.1
Andries, K.2
Paredes, R.M.3
Andaya, C.E.4
Burgos, J.5
-
19
-
-
66649090346
-
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
-
Diacon AH, Pym A, Grobusch M et al.: The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360(23), 2397-2405 (2009
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.23
, pp. 2397-2405
-
-
Diacon, A.H.1
Pym, A.2
Grobusch, M.3
-
20
-
-
48749120676
-
Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
-
Rustomjee R, Diacon AH, Allen J et al.: Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis. Antimicrob. Agents Chemother. 52(8), 2831-2835 (2008
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, Issue.8
, pp. 2831-2835
-
-
Rustomjee, R.1
Diacon, A.H.2
Allen, J.3
-
21
-
-
0034702247
-
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
-
DOI 10.1038/35016103
-
Stover CK, Warrener P, VanDevanter DR et al.: A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 405(6789), 962-966 (2000 (Pubitemid 30435054)
-
(2000)
Nature
, vol.405
, Issue.6789
, pp. 962-966
-
-
Stover, C.K.1
Warrener, P.2
VanDevanter, D.R.3
Sherman, D.R.4
Arain, T.M.5
Langhorne, M.H.6
Anderson, S.W.7
Towell, J.A.8
Yuan, Y.9
McMurray, D.N.10
Kreiswirth, B.N.11
Barry, C.E.12
Baker, W.R.13
-
22
-
-
33749513414
-
Mycobacterium leprae is naturally resistant to PA-824
-
DOI 10.1128/AAC.00488-06
-
Manjunatha UH, Lahiri R, Randhawa B, Dowd CS, Krahenbuhl JL, Barry CE 3rd: Mycobacterium leprae is naturally resistant to PA-824. Antimicrob. Agents Chemother. 50(10), 3350-3354 (2006 (Pubitemid 44527509)
-
(2006)
Antimicrobial Agents and Chemotherapy
, vol.50
, Issue.10
, pp. 3350-3354
-
-
Manjunatha, U.H.1
Lahiri, R.2
Randhawa, B.3
Dowd, C.S.4
Krahenbuhl, J.L.5
Barry III, C.E.6
-
23
-
-
4644371358
-
Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis
-
DOI 10.2174/1381612043383214
-
Barry CE 3rd, Boshoff HI, Dowd CS: Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis. Curr. Pharm. Des. 10(26), 3239-3262 (2004 (Pubitemid 39276613)
-
(2004)
Current Pharmaceutical Design
, vol.10
, Issue.26
, pp. 3239-3262
-
-
Barry III, C.E.1
Boshoff, H.I.M.2
Dowd, C.S.3
-
24
-
-
31044452898
-
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
-
DOI 10.1073/pnas.0508392103
-
Manjunatha UH, Boshoff H, Dowd CS et al.: Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 103(2), 431-436 (2006 (Pubitemid 43122418)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.2
, pp. 431-436
-
-
Manjunatha, U.H.1
Boshoff, H.2
Dowd, C.S.3
Zhang, L.4
Albert, T.J.5
Norton, J.E.6
Daniels, L.7
Dick, T.8
Pang, S.S.9
Barry III, C.E.10
-
25
-
-
77951298792
-
The mechanism of action of PA-824: Novel insights from transcriptional profiling
-
Manjunatha U, Boshoff HI, Barry CE: The mechanism of action of PA-824: novel insights from transcriptional profiling. Commun. Integr. Biol. 2(3), 215-218 (2009
-
(2009)
Commun. Integr. Biol.
, vol.2
, Issue.3
, pp. 215-218
-
-
Manjunatha, U.1
Boshoff, H.I.2
Barry, C.E.3
-
26
-
-
57149099588
-
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
-
DOI 10.1126/science.1164571
-
Singh R, Manjunatha U, Boshoff HI et al.: PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science 322(5906), 1392-1395 (2008 (Pubitemid 352775253)
-
(2008)
Science
, vol.322
, Issue.5906
, pp. 1392-1395
-
-
Singh, R.1
Manjunatha, U.2
Boshoff, H.I.M.3
Young, H.H.4
Niyomrattanakit, P.5
Ledwidge, R.6
Dowd, C.S.7
Ill, Y.L.8
Kim, P.9
Zhang, L.10
Kang, S.11
Keller, T.H.12
Jiricek, J.13
Barry III, C.E.14
-
27
-
-
77955350759
-
Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients
-
Diacon AH, Dawson R, Hanekom M et al.: Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients. Antimicrob. Agents Chemother. 54(8), 3402-3407 (2010
-
(2010)
Antimicrob. Agents Chemother
, vol.54
, Issue.8
, pp. 3402-3407
-
-
Diacon, A.H.1
Dawson, R.2
Hanekom, M.3
-
28
-
-
70349105953
-
Safety tolerability and pharmacokinetics of PA-824 in healthy subjects
-
Ginsberg AM, Laurenzi MW, Rouse DJ, Whitney KD, Spigelman MK: Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects. Antimicrob. Agents Chemother. 53(9), 3720-3725 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, Issue.9
, pp. 3720-3725
-
-
Ginsberg, A.M.1
Laurenzi, M.W.2
Rouse, D.J.3
Whitney, K.D.4
Spigelman, M.K.5
-
29
-
-
33845323336
-
OPC-67683 a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
-
Matsumoto M, Hashizume H, Tomishige T et al.: OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 3(11), E466 (2006
-
(2006)
PLoS Med.
, vol.3
, Issue.11
-
-
Matsumoto, M.1
Hashizume, H.2
Tomishige, T.3
-
30
-
-
33845947982
-
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles
-
DOI 10.1021/jm060957y
-
Sasaki H, Haraguchi Y, Itotani M et al.: Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3- dihydroimidazo[2,1- b]oxazoles. J. Med. Chem. 49(26), 7854-7860 (2006 (Pubitemid 46033674)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.26
, pp. 7854-7860
-
-
Sasaki, H.1
Haraguchi, Y.2
Itotani, M.3
Kuroda, H.4
Hashizume, H.5
Tomishige, T.6
Kawasaki, M.7
Matsumoto, M.8
Komatsu, M.9
Tsubouchi, H.10
-
31
-
-
47549119545
-
Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosis
-
DOI 10.1378/chest.07-1988
-
Condos R, Hadgiangelis N, Leibert E, Jacquette G, Harkin T, Rom WN: Case series report of a linezolid-containing regimen for extensively drug-resistant tuberculosis. Chest 134(1), 187-192 (2008 (Pubitemid 352008783)
-
(2008)
Chest
, vol.134
, Issue.1
, pp. 187-192
-
-
Condos, R.1
Hadgiangelis, N.2
Leibert, E.3
Jacquette, G.4
Harkin, T.5
Rom, W.N.6
-
32
-
-
13344284628
-
Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
-
DOI 10.1021/jm950956y
-
Barbachyn MR, Hutchinson DK, Brickner SJ et al.: Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J. Med. Chem. 39(3), 680-685 (1996 (Pubitemid 26069690)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.3
, pp. 680-685
-
-
Barbachyn, M.R.1
Hutchinson, D.K.2
Brickner, S.J.3
Cynamon, M.H.4
Kilburn, J.O.5
Klemens, S.P.6
Glickman, S.E.7
Grega, K.C.8
Hendges, S.K.9
Toops, D.S.10
Ford, C.W.11
Zurenko, G.E.12
-
33
-
-
65649089528
-
Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model
-
Williams KN, Stover CK, Zhu T et al.: Promising antituberculosis activity of the oxazolidinone PNU-100480 relative to that of linezolid in a murine model. Antimicrob. Agents Chemother. 53(4), 1314-1319 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, Issue.4
, pp. 1314-1319
-
-
Williams, K.N.1
Stover, C.K.2
Zhu, T.3
-
34
-
-
0032846686
-
Mechanism of action of the oxazolidinone antibacterial agents
-
DOI 10.1517/13543784.8.8.1195
-
Shinabarger D: Mechanism of action of the oxazolidinone antibacterial agents. Expert Opin. Investig. Drugs 8(8), 1195-1202 (1999 (Pubitemid 29410576)
-
(1999)
Expert Opinion on Investigational Drugs
, vol.8
, Issue.8
, pp. 1195-1202
-
-
Shinabarger, D.1
-
35
-
-
45749089015
-
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit
-
DOI 10.1021/jm800379d
-
Ippolito JA, Kanyo ZF, Wang D et al.: Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit. J. Med. Chem. 51(12), 3353-3356 (2008 (Pubitemid 351874992)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.12
, pp. 3353-3356
-
-
Ippolito, J.A.1
Kanyo, Z.F.2
Wang, D.3
Franceschi, F.J.4
Moore, P.B.5
Steitz, T.A.6
Duffy, E.M.7
-
36
-
-
77955706291
-
Pharmacokinetics and whole-blood bactericidal activity against mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers
-
Wallis RS, Jakubiec WM, Kumar V et al.: Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. J. Infect. Dis. 202(5), 745-751 (2010
-
(2010)
J. Infect. Dis.
, vol.202
, Issue.5
, pp. 745-751
-
-
Wallis, R.S.1
Jakubiec, W.M.2
Kumar, V.3
-
37
-
-
78449274705
-
Drugs in development for tuberculosis
-
Ginsberg AM: Drugs in development for tuberculosis. Drugs 70(17), 2201-2214 (2010
-
(2010)
Drugs
, vol.70
, Issue.17
, pp. 2201-2214
-
-
Ginsberg, A.M.1
-
38
-
-
77955980346
-
New antituberculous drugs in development
-
Lalloo UG, Ambaram A: New antituberculous drugs in development. Curr. HIV/AIDS Rep. 7(3), 143-151 (2010
-
(2010)
Curr. HIV/AIDS Rep.
, vol.7
, Issue.3
, pp. 143-151
-
-
Lalloo, U.G.1
Ambaram, A.2
-
39
-
-
27744496465
-
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
-
DOI 10.1093/jac/dki319
-
Protopopova M, Hanrahan C, Nikonenko B et al.: Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines. J. Antimicrob. Chemother. 56(5), 968-974 (2005 (Pubitemid 41631930)
-
(2005)
Journal of Antimicrobial Chemotherapy
, vol.56
, Issue.5
, pp. 968-974
-
-
Protopopova, M.1
Hanrahan, C.2
Nikonenko, B.3
Samala, R.4
Chen, P.5
Gearhart, J.6
Einck, L.7
Nacy, C.A.8
-
40
-
-
34247127876
-
Drug therapy of experimental tuberculosis (TB): Improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs
-
DOI 10.1128/AAC.01326-06
-
Nikonenko BV, Protopopova M, Samala R, Einck L, Nacy CA: Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs. Antimicrob. Agents Chemother. 51(4), 1563-1565 (2007 (Pubitemid 46586854)
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, Issue.4
, pp. 1563-1565
-
-
Nikonenko, B.V.1
Protopopova, M.2
Samala, R.3
Einck, L.4
Nacy, C.A.5
-
41
-
-
13244283085
-
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug
-
DOI 10.1038/sj.bjp.0705984
-
Jia L, Tomaszewski JE, Hanrahan C et al.: Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug. Br. J. Pharmacol. 144(1), 80-87 (2005 (Pubitemid 40192564)
-
(2005)
British Journal of Pharmacology
, vol.144
, Issue.1
, pp. 80-87
-
-
Jia, L.1
Tomaszewski, J.E.2
Hanrahan, C.3
Coward, L.4
Noker, P.5
Gorman, G.6
Nikonenko, B.7
Protopopova, M.8
-
42
-
-
68949144774
-
Synthesis of novel 1 2-diamines with antituberculosis activity
-
Meng Q, Luo H, Chen Y, Wang T, Yao Q: Synthesis of novel [1,2]-diamines with antituberculosis activity. Bioorg. Med. Chem. Lett. 19(18), 5372-5375 (2009
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.18
, pp. 5372-5375
-
-
Meng, Q.1
Luo, H.2
Chen, Y.3
Wang, T.4
Yao, Q.5
-
43
-
-
77949488600
-
Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates
-
Onajole OK, Govender P, van Helden PD et al.: Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates. Eur. J. Med. Chem. 45(5), 2075-2079 (2010
-
(2010)
Eur. J. Med. Chem.
, vol.45
, Issue.5
, pp. 2075-2079
-
-
Onajole, O.K.1
Govender, P.2
Van Helden, P.D.3
-
44
-
-
65649096556
-
Benzothiazinones kill mycobacterium tuberculosis by blocking arabinan synthesis
-
Makarov V, Manina G, Mikusova K et al.: Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324(5928), 801-804 (2009
-
(2009)
Science
, vol.324
, Issue.5928
, pp. 801-804
-
-
Makarov, V.1
Manina, G.2
Mikusova, K.3
-
45
-
-
77950141431
-
Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones
-
Pasca MR, Degiacomi G, Ribeiro AL et al.: Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones. Antimicrob. Agents Chemother. 54(4), 1616-1618 (2010
-
(2010)
Antimicrob. Agents Chemother
, vol.54
, Issue.4
, pp. 1616-1618
-
-
Pasca, M.R.1
Degiacomi, G.2
Ribeiro, A.L.3
-
46
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors
-
Christophe T, Jackson M, Jeon HK et al.: High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5(10), E1000645 (2009
-
(2009)
PLoS Pathog.
, vol.5
, Issue.10
-
-
Christophe, T.1
Jackson, M.2
Jeon, H.K.3
-
47
-
-
78049483746
-
Leads for antitubercular compounds from kinase inhibitor library screens
-
Magnet S, Hartkoorn RC, Szekely R et al.: Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis 90(6), 354-360 (2010
-
(2010)
Tuberculosis
, vol.90
, Issue.6
, pp. 354-360
-
-
Magnet, S.1
Hartkoorn, R.C.2
Szekely, R.3
-
48
-
-
77957310736
-
Benzothiazinones: Prodrugs that covalently modify the decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of mycobacterium tuberculosis
-
Trefzer C, Rengifo-Gonzalez M, Hinner MJ et al.: Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis. J. Am. Chem. Soc. 132(39), 13663-13665 (2010
-
(2010)
J. Am. Chem. Soc.
, vol.132
, Issue.39
, pp. 13663-13665
-
-
Trefzer, C.1
Rengifo-Gonzalez, M.2
Hinner, M.J.3
-
49
-
-
0026049801
-
Serine β-lactamases and penicillin-binding proteins
-
Ghuysen JM: Serine β-lactamases and penicillin-binding proteins. Annu. Rev. Microbiol. 45, 37-67 (1991
-
(1991)
Annu. Rev. Microbiol.
, vol.45
, pp. 37-67
-
-
Ghuysen, J.M.1
-
50
-
-
0028912001
-
Distribution and characterization of beta-lactamases of mycobacteria and related organisms
-
Kwon HH, Tomioka H, Saito H: Distribution and characterization of beta-lactamases of mycobacteria and related organisms. Tuber. Lung Dis. 76(2), 141-148 (1995
-
(1995)
Tuber. Lung Dis.
, vol.76
, Issue.2
, pp. 141-148
-
-
Kwon, H.H.1
Tomioka, H.2
Saito, H.3
-
51
-
-
0028859485
-
Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis
-
Chambers HF, Moreau D, Yajko D et al.: Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? Antimicrob. Agents Chemother. 39(12), 2620-2624 (1995
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, Issue.12
, pp. 2620-2624
-
-
Chambers, H.F.1
Moreau, D.2
Yajko, D.3
-
52
-
-
77950534682
-
The mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
-
Gupta R, Lavollay M, Mainardi JL, Arthur M, Bishai WR, Lamichhane G: The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin. Nat. Med. 16(4), 466-469 (2010
-
(2010)
Nat. Med.
, vol.16
, Issue.4
, pp. 466-469
-
-
Gupta, R.1
Lavollay, M.2
Mainardi, J.L.3
Arthur, M.4
Bishai, W.R.5
Lamichhane, G.6
-
53
-
-
44949093590
-
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation
-
DOI 10.1128/JB.00239-08
-
Lavollay M, Arthur M, Fourgeaud M et al.: The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by l,d-transpeptidation. J. Bacteriol. 190(12), 4360-4366 (2008 (Pubitemid 351812884)
-
(2008)
Journal of Bacteriology
, vol.190
, Issue.12
, pp. 4360-4366
-
-
Lavollay, M.1
Arthur, M.2
Fourgeaud, M.3
Dubost, L.4
Marie, A.5
Veziris, N.6
Blanot, D.7
Gutmann, L.8
Mainardi, J.-L.9
-
54
-
-
61349183785
-
Meropenem-clavulanate is effective against extensively drug-resistant mycobacterium tuberculosis
-
Hugonnet JE, Tremblay LW, Boshoff HI, Barry CE 3rd, Blanchard JS: Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 323(5918), 1215-1218 (2009
-
(2009)
Science
, vol.323
, Issue.5918
, pp. 1215-1218
-
-
Hugonnet, J.E.1
Tremblay, L.W.2
Boshoff, H.I.3
Barry III, C.E.4
Blanchard, J.S.5
-
55
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65(1-2), 55-63 (1983 (Pubitemid 14203433)
-
(1983)
Journal of Immunological Methods
, vol.65
, Issue.1-2
, pp. 55-63
-
-
Mosmann, T.1
-
56
-
-
0036246226
-
Tetrazolium microplate assay as a rapid and inexpensive colorimetric method for determination of antibiotic susceptibility of Mycobacterium tuberculosis
-
DOI 10.1128/JCM.40.5.1873-1874.2002
-
Caviedes L, Delgado J, Gilman RH: Tetrazolium microplate assay as a rapid and inexpensive colorimetric method for determination of antibiotic susceptibility of Mycobacterium tuberculosis. J. Clin. Microbiol. 40(5), 1873-1874 (2002 (Pubitemid 34493180)
-
(2002)
Journal of Clinical Microbiology
, vol.40
, Issue.5
, pp. 1873-1874
-
-
Caviedes, L.1
Delgado, J.2
Gilman, R.H.3
-
57
-
-
0035089404
-
Comparison of two rapid colorimetric methods for determining resistance of Mycobacterium tuberculosis to rifampin, isoniazid, and streptomycin in liquid medium
-
De Logu A, Uda P, Pellerano ML, Pusceddu MC, Saddi B, Schivo ML: Comparison of two rapid colorimetric methods for determining resistance of Mycobacterium tuberculosis to rifampin, isoniazid, and streptomycin in liquid medium. Eur. J. Clin. Microbiol. Infect. Dis. 20(1), 33-39 (2001 (Pubitemid 32200359)
-
(2001)
European Journal of Clinical Microbiology and Infectious Diseases
, vol.20
, Issue.1
, pp. 33-39
-
-
De Logu, A.1
Uda, P.2
Pellerano, M.L.3
Pusceddu, M.C.4
Saddi, B.5
Schivo, M.L.6
-
58
-
-
0031959047
-
Use of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide for rapid detection of rifampin-resistant: Mycobacterium tuberculosis
-
Mshana RN, Tadesse G, Abate G, Miorner H: Use of 3-(4,5-dimethylthiazol- 2- yl)-2,5-diphenyl tetrazolium bromide for rapid detection of rifampin-resistant Mycobacterium tuberculosis. J. Clin. Microbiol. 36(5), 1214-1219 (1998 (Pubitemid 28208001)
-
(1998)
Journal of Clinical Microbiology
, vol.36
, Issue.5
, pp. 1214-1219
-
-
Mshana, R.N.1
Tadesse, G.2
Abate, G.3
Miorner, H.4
-
59
-
-
0344443250
-
Improved Green Fluorescent Protein Reporter Gene-Based Microplate Screening for Antituberculosis Compounds by Utilizing an Acetamidase Promoter
-
DOI 10.1128/AAC.47.12.3682-3687.2003
-
Changsen C, Franzblau SG, Palittapongarnpim P: Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter. Antimicrob. Agents Chemother. 47(12), 3682-3687 (2003 (Pubitemid 37484971)
-
(2003)
Antimicrobial Agents and Chemotherapy
, vol.47
, Issue.12
, pp. 3682-3687
-
-
Changsen, C.1
Franzblau, S.G.2
Palittapongarnpim, P.3
-
60
-
-
34247143197
-
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis
-
DOI 10.1128/AAC.00055-06
-
Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG: Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51(4), 1380-1385 (2007 (Pubitemid 46586820)
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, Issue.4
, pp. 1380-1385
-
-
Cho, S.H.1
Warit, S.2
Wan, B.3
Hwang, C.H.4
Pauli, G.F.5
Franzblau, S.G.6
-
61
-
-
0031941004
-
Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis
-
Collins LA, Torrero MN, Franzblau SG: Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 42(2), 344-347 (1998 (Pubitemid 28114442)
-
(1998)
Antimicrobial Agents and Chemotherapy
, vol.42
, Issue.2
, pp. 344-347
-
-
Collins, L.A.1
Torrero, M.N.2
Franzblau, S.G.3
-
62
-
-
70350765485
-
High-throughput screening for inhibitors of mycobacterium tuberculosis H37Rv
-
Ananthan S, Faaleolea ER, Goldman RC et al.: High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis 89(5), 334-353 (2009
-
(2009)
Tuberculosis
, vol.89
, Issue.5
, pp. 334-353
-
-
Ananthan, S.1
Faaleolea, E.R.2
Goldman, R.C.3
-
63
-
-
70449108128
-
Antituberculosis activity of the molecular libraries screening center network library
-
Maddry JA, Ananthan S, Goldman RC et al.: Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis 89(5), 354-363 (2009
-
(2009)
Tuberculosis
, vol.89
, Issue.5
, pp. 354-363
-
-
Maddry, J.A.1
Ananthan, S.2
Goldman, R.C.3
-
64
-
-
70350570382
-
New anti-tuberculosis agents amongst known drugs
-
Lougheed KE, Taylor DL, Osborne SA, Bryans JS, Buxton RS: New anti-tuberculosis agents amongst known drugs. Tuberculosis 89(5), 364-370 (2009
-
(2009)
Tuberculosis
, vol.89
, Issue.5
, pp. 364-370
-
-
Lougheed, K.E.1
Taylor, D.L.2
Osborne, S.A.3
Bryans, J.S.4
Buxton, R.S.5
-
65
-
-
0028603583
-
Dormancy of mycobacterium tuberculosis and latency of disease
-
Wayne LG: Dormancy of Mycobacterium tuberculosis and latency of disease. Eur. J. Clin. Microbiol. Infect. Dis. 13(11), 908-914 (1994
-
(1994)
Eur. J. Clin. Microbiol. Infect. Dis.
, vol.13
, Issue.11
, pp. 908-914
-
-
Wayne, L.G.1
-
66
-
-
0029976980
-
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
-
Wayne LG, Hayes LG: An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64(6), 2062-2069 (1996 (Pubitemid 26165667)
-
(1996)
Infection and Immunity
, vol.64
, Issue.6
, pp. 2062-2069
-
-
Wayne, L.G.1
Hayes, L.G.2
-
67
-
-
0034780485
-
Nonreplicating persistence of Mycobacterium tuberculosis
-
DOI 10.1146/annurev.micro.55.1.139
-
Wayne LG, Sohaskey CD: Nonreplicating persistence of Mycobacterium tuberculosis. Annu. Rev. Microbiol. 55, 139-163 (2001 (Pubitemid 32978103)
-
(2001)
Annual Review of Microbiology
, vol.55
, pp. 139-163
-
-
Wayne, L.G.1
Sohaskey, C.D.2
-
68
-
-
0028024035
-
Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis
-
Wayne LG, Sramek HA: Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38(9), 2054-2058 (1994 (Pubitemid 24278800)
-
(1994)
Antimicrobial Agents and Chemotherapy
, vol.38
, Issue.9
, pp. 2054-2058
-
-
Wayne, L.G.1
Sramek, H.A.2
-
69
-
-
0033764350
-
Detection of mRNA transcripts and active transcription in persistent mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide
-
Hu Y, Mangan JA, Dhillon J et al.: Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide. J. Bacteriol. 182(22), 6358-6365 (2000
-
(2000)
J. Bacteriol.
, vol.182
, Issue.22
, pp. 6358-6365
-
-
Hu, Y.1
Mangan, J.A.2
Dhillon, J.3
-
70
-
-
67650655950
-
A novel in vitro multiple-stress dormancy model for mycobacterium tuberculosis generates a lipid-loaded drug-tolerant dormant pathogen
-
Deb C, Lee CM, Dubey VS et al.: A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. PLoS ONE 4(6), E6077 (2009
-
(2009)
Plos One
, vol.4
, Issue.6
-
-
Deb, C.1
Lee, C.M.2
Dubey, V.S.3
-
71
-
-
59749096131
-
In vitro model of mycobacterial growth arrest using nitric oxide with limited air
-
Hussain S, Malik M, Shi L, Gennaro ML, Drlica K: In vitro model of mycobacterial growth arrest using nitric oxide with limited air. Antimicrob. Agents Chemother. 53(1), 157-161 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, Issue.1
, pp. 157-161
-
-
Hussain, S.1
Malik, M.2
Shi, L.3
Gennaro, M.L.4
Drlica, K.5
-
72
-
-
0036270739
-
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
-
DOI 10.1046/j.1365-2958.2002.02779.x
-
Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K: Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43(3), 717-731 (2002 (Pubitemid 34597265)
-
(2002)
Molecular Microbiology
, vol.43
, Issue.3
, pp. 717-731
-
-
Betts, J.C.1
Lukey, P.T.2
Robb, L.C.3
McAdam, R.A.4
Duncan, K.5
-
73
-
-
34250716965
-
M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells
-
DOI 10.1016/j.cell.2007.05.059, PII S0092867407007829
-
van der Wel N, Hava D, Houben D et al.: M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129(7), 1287-1298 (2007 (Pubitemid 46962098)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1287-1298
-
-
Van Der Wel, N.1
Hava, D.2
Houben, D.3
Fluitsma, D.4
Van Zon, M.5
Pierson, J.6
Brenner, M.7
Peters, P.J.8
-
74
-
-
34047261091
-
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein
-
DOI 10.1016/j.tube.2006.12.001, PII S1472979206001211
-
Hartkoorn RC, Chandler B, Owen A et al.: Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein. Tuberculosis 87(3), 248-255 (2007 (Pubitemid 46551848)
-
(2007)
Tuberculosis
, vol.87
, Issue.3
, pp. 248-255
-
-
Hartkoorn, R.C.1
Chandler, B.2
Owen, A.3
Ward, S.A.4
Bertel Squire, S.5
Back, D.J.6
Khoo, S.H.7
-
75
-
-
79251537963
-
A chemical genetic screen in mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
-
Pethe K, Sequeira PC, Agarwalla S et al.: A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy. Nat. Commun. 1(5), 1-8 (2010
-
(2010)
Nat. Commun.
, vol.1
, Issue.5
, pp. 1-8
-
-
Pethe, K.1
Sequeira, P.C.2
Agarwalla, S.3
-
76
-
-
0028156861
-
InhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
-
Banerjee A, Dubnau E, Quemard A et al.: inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263(5144), 227-230 (1994 (Pubitemid 24067929)
-
(1994)
Science
, vol.263
, Issue.5144
, pp. 227-230
-
-
Banerjee, A.1
Dubnau, E.2
Quemard, A.3
Balasubramanian, V.4
Um, K.S.5
Wilson, T.6
Collins, D.7
De Lisle, G.8
Jacobs Jr., W.R.9
-
77
-
-
33748469322
-
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
-
DOI 10.1038/nm1466, PII NM1466
-
Vilcheze C, Wang F, Arai M et al.: Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat. Med. 12(9), 1027-1029 (2006 (Pubitemid 44353383)
-
(2006)
Nature Medicine
, vol.12
, Issue.9
, pp. 1027-1029
-
-
Vilcheze, C.1
Wang, F.2
Arai, M.3
Hazbon, M.H.4
Colangeli, R.5
Kremer, L.6
Weisbrod, T.R.7
Alland, D.8
Sacchettini, J.C.9
Jacobs Jr., W.R.10
-
78
-
-
0029908204
-
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol
-
DOI 10.1073/pnas.93.21.11919
-
Belanger AE, Besra GS, Ford ME et al.: The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc. Natl Acad. Sci. USA 93(21), 11919-11924 (1996 (Pubitemid 26347224)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.21
, pp. 11919-11924
-
-
Belanger, A.E.1
Besra, G.S.2
Ford, M.E.3
Mikusova, K.4
Belisle, J.T.5
Brennan, P.J.6
Inamine, J.M.7
-
79
-
-
4544312369
-
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. Novel insights into drug mechanisms of action
-
DOI 10.1074/jbc.M406796200
-
Boshoff HI, Myers TG, Copp BR, McNeil MR, Wilson MA, Barry CE 3rd: The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J. Biol. Chem. 279(38), 40174-40184 (2004 (Pubitemid 39258293)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 40174-40184
-
-
Boshoff, H.I.M.1
Myers, T.G.2
Copp, B.R.3
McNeil, M.R.4
Wilson, M.A.5
Barry III, C.E.6
-
80
-
-
0032508046
-
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence
-
DOI 10.1038/31159
-
Cole ST, Brosch R, Parkhill J et al.: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393(6685), 537-544 (1998 (Pubitemid 28319235)
-
(1998)
Nature
, vol.393
, Issue.6685
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry III, C.E.10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.-A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
81
-
-
63249121217
-
Application of next-generation sequencing technologies to microbial genetics
-
MacLean D, Jones JD, Studholme DJ: Application of 'next-generation' sequencing technologies to microbial genetics. Nat. Rev. Microbiol. 7(4), 287-296 (2009
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, Issue.4
, pp. 287-296
-
-
MacLean, D.1
Jones, J.D.2
Studholme, D.J.3
-
82
-
-
0030884810
-
Development and use of a conditional antisense mutagenesis system in mycobacteria
-
DOI 10.1016/S0378-1097(97)00317-0, PII S0378109797003170
-
Parish T, Stoker NG: Development and use of a conditional antisense mutagenesis system in mycobacteria. FEMS Microbiol. Lett. 154(1), 151-157 (1997 (Pubitemid 27376750)
-
(1997)
FEMS Microbiology Letters
, vol.154
, Issue.1
, pp. 151-157
-
-
Parish, T.1
Stoker, N.G.2
-
84
-
-
19744383611
-
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor
-
Ehrt S, Guo XV, Hickey CM et al.: Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res. 33(2), E21 (2005
-
(2005)
Nucleic Acids Res.
, vol.33
, Issue.2
-
-
Ehrt, S.1
Guo, X.V.2
Hickey, C.M.3
-
85
-
-
0042268512
-
Gene regulation by tetracyclines: Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes
-
DOI 10.1046/j.1432-1033.2003.03694.x
-
Berens C, Hillen W: Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur. J. Biochem. 270(15), 3109-3121 (2003 (Pubitemid 36930176)
-
(2003)
European Journal of Biochemistry
, vol.270
, Issue.15
, pp. 3109-3121
-
-
Berens, C.1
Hillen, W.2
-
86
-
-
0027237298
-
Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells
-
Gossen M, Bujard H: Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells. Nucleic Acids Res. 21(18), 4411-4412 (1993 (Pubitemid 23279051)
-
(1993)
Nucleic Acids Research
, vol.21
, Issue.18
, pp. 4411-4412
-
-
Gossen, M.1
Bujard, H.2
-
87
-
-
77953105101
-
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for mycobacterium tuberculosis to establish and maintain infection
-
USA
-
Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S: Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proc. Natl Acad. Sci. USA 107(21), 9819-9824 (2010
-
(2010)
Proc. Natl Acad. Sci.
, vol.107
, Issue.21
, pp. 9819-9824
-
-
Marrero, J.1
Rhee, K.Y.2
Schnappinger, D.3
Pethe, K.4
Ehrt, S.5
-
88
-
-
34347402468
-
Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors
-
DOI 10.1128/JB.00216-07
-
Guo XV, Monteleone M, Klotzsche M et al.: Silencing Mycobacterium smegmatis by using tetracycline repressors. J. Bacteriol. 189(13), 4614-4623 (2007 (Pubitemid 47025573)
-
(2007)
Journal of Bacteriology
, vol.189
, Issue.13
, pp. 4614-4623
-
-
Guo, X.V.1
Monteleone, M.2
Klotzsche, M.3
Kamionka, A.4
Hillen, W.5
Braunstein, M.6
Ehrt, S.7
Schnappinger, D.8
-
89
-
-
36849063886
-
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
-
DOI 10.1038/nm1683, PII NM1683
-
Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S: In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nat. Med. 13(12), 1515-1520 (2007 (Pubitemid 350224249)
-
(2007)
Nature Medicine
, vol.13
, Issue.12
, pp. 1515-1520
-
-
Gandotra, S.1
Schnappinger, D.2
Monteleone, M.3
Hillen, W.4
Ehrt, S.5
-
90
-
-
62849091862
-
Pristinamycin-inducible gene regulation in mycobacteria
-
Forti F, Crosta A, Ghisotti D: Pristinamycin-inducible gene regulation in mycobacteria. J. Biotechnol. 140(3-4), 270-277 (2009
-
(2009)
J. Biotechnol.
, vol.140
, Issue.3-4
, pp. 270-277
-
-
Forti, F.1
Crosta, A.2
Ghisotti, D.3
-
91
-
-
0028785412
-
Unusual regulatory mechanism for a streptomyces multidrug resistance gene ptr involving three homologous protein-binding sites overlapping the promoter region
-
Salah-Bey K, Thompson CJ: Unusual regulatory mechanism for a Streptomyces multidrug resistance gene, ptr, involving three homologous protein-binding sites overlapping the promoter region. Mol. Microbiol. 17(6), 1109-1119 (1995
-
(1995)
Mol. Microbiol.
, vol.17
, Issue.6
, pp. 1109-1119
-
-
Salah-Bey, K.1
Thompson, C.J.2
-
92
-
-
77955074030
-
Development of a repressible mycobacterial promoter system based on two transcriptional repressors
-
Boldrin F, Casonato S, Dainese E et al.: Development of a repressible mycobacterial promoter system based on two transcriptional repressors. Nucleic Acids Res. 38(12), E134 (2010
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.12
-
-
Boldrin, F.1
Casonato, S.2
Dainese, E.3
-
93
-
-
79953701962
-
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase
-
Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D: Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Res. 39(6), 2210-2220 (2010
-
(2010)
Nucleic Acids Res.
, vol.39
, Issue.6
, pp. 2210-2220
-
-
Kim, J.H.1
Wei, J.R.2
Wallach, J.B.3
Robbins, R.S.4
Rubin, E.J.5
Schnappinger, D.6
-
94
-
-
53849117142
-
Biology of trans-translation
-
Keiler KC: Biology of trans-translation. Annu. Rev. Microbiol. 62, 133-151 (2008
-
(2008)
Annu. Rev. Microbiol.
, vol.62
, pp. 133-151
-
-
Keiler, K.C.1
-
95
-
-
0034730496
-
A specificity-enhancing factor for the ClpXP degradation machine
-
Levchenko I, Seidel M, Sauer RT, Baker TA: A specificity-enhancing factor for the ClpXP degradation machine. Science 289(5488), 2354-2356 (2000
-
(2000)
Science
, vol.289
, Issue.5488
, pp. 2354-2356
-
-
Levchenko, I.1
Seidel, M.2
Sauer, R.T.3
Baker, T.A.4
-
96
-
-
0014347979
-
Interaction of rifamycin with bacterial RNA polymerase
-
USA
-
Wehrli W, Knusel F, Schmid K, Staehelin M: Interaction of rifamycin with bacterial RNA polymerase. Proc. Natl Acad. Sci. USA 61(2), 667-673 (1968
-
(1968)
Proc. Natl Acad. Sci.
, vol.61
, Issue.2
, pp. 667-673
-
-
Wehrli, W.1
Knusel, F.2
Schmid, K.3
Staehelin, M.4
-
97
-
-
0014431046
-
Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria
-
Wehrli W, Knusel F, Staehelin M: Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria. Biochem. Biophys. Res. Commun. 32(2), 284-288 (1968
-
(1968)
Biochem. Biophys. Res. Commun.
, vol.32
, Issue.2
, pp. 284-288
-
-
Wehrli, W.1
Knusel, F.2
Staehelin, M.3
-
98
-
-
20944450448
-
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
-
DOI 10.1038/nm1252
-
Munoz-Elias EJ, McKinney JD: Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat. Med. 11(6), 638-644 (2005 (Pubitemid 40868304)
-
(2005)
Nature Medicine
, vol.11
, Issue.6
, pp. 638-644
-
-
Munoz-Elias, E.J.1
McKinney, J.D.2
-
99
-
-
67649660560
-
CarD is an essential regulator of rRNA transcription required for mycobacterium tuberculosis persistence
-
Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS: CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell 138(1), 146-159 (2009
-
(2009)
Cell
, vol.138
, Issue.1
, pp. 146-159
-
-
Stallings, C.L.1
Stephanou, N.C.2
Chu, L.3
Hochschild, A.4
Nickels, B.E.5
Glickman, M.S.6
-
100
-
-
70349658267
-
Inhibitors selective for mycobacterial versus human proteasomes
-
Lin G, Li D, de Carvalho LP et al.: Inhibitors selective for mycobacterial versus human proteasomes. Nature 461(7264), 621-626 (2009
-
(2009)
Nature
, vol.461
, Issue.7264
, pp. 621-626
-
-
Lin, G.1
Li, D.2
De Carvalho, L.P.3
-
101
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
DOI 10.1046/j.1365-2958.2003.03425.x
-
Sassetti CM, Boyd DH, Rubin EJ: Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48(1), 77-84 (2003 (Pubitemid 36411469)
-
(2003)
Molecular Microbiology
, vol.48
, Issue.1
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
103
-
-
0035931926
-
Massive gene decay in the leprosy bacillus
-
DOI 10.1038/35059006
-
Cole ST, Eiglmeier K, Parkhill J et al.: Massive gene decay in the leprosy bacillus. Nature 409(6823), 1007-1011 (2001 (Pubitemid 32204045)
-
(2001)
Nature
, vol.409
, Issue.6823
, pp. 1007-1011
-
-
Cole, S.T.1
Eiglmeier, K.2
Parkhill, J.3
James, K.D.4
Thomson, N.R.5
Wheeler, P.R.6
Honore, N.7
Garnier, T.8
Churcher, C.9
Harris, D.10
Mungall, K.11
Basham, D.12
Brown, D.13
Chillingworth, T.14
Connor, R.15
Davies, R.M.16
Devlin, K.17
Duthoy, S.18
Feltwell, T.19
Fraser, A.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Lacroix, C.25
Maclean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Quail, M.A.30
Rajandream, M.-A.31
Rutherford, K.M.32
Rutter, S.33
Seeger, K.34
Simon, S.35
Simmonds, M.36
Skelton, J.37
Squares, R.38
Squares, S.39
Stevens, K.40
Taylor, K.41
Whitehead, S.42
Woodward, J.R.43
Barrell, B.G.44
more..
-
104
-
-
0036632847
-
Comparative mycobacterial genomics as a tool for drug target and antigen discovery
-
Cole ST: Comparative mycobacterial genomics as a tool for drug target and antigen discovery. Eur. Respir. J. Suppl. 36, S78-S86 (2002
-
(2002)
Eur. Respir. J. Suppl.
, vol.36
-
-
Cole, S.T.1
-
105
-
-
66349100409
-
Structural genomics approach to drug discovery for mycobacterium tuberculosis
-
Ioerger TR, Sacchettini JC: Structural genomics approach to drug discovery for Mycobacterium tuberculosis. Curr. Opin. Microbiol. 12(3), 318-325 (2009
-
(2009)
Curr. Opin. Microbiol.
, vol.12
, Issue.3
, pp. 318-325
-
-
Ioerger, T.R.1
Sacchettini, J.C.2
-
106
-
-
34548526629
-
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides
-
DOI 10.1016/j.bmc.2007.08.013, PII S0968089607007043
-
He X, Alian A, Ortiz de Montellano PR: Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg. Med. Chem. 15(21), 6649-6658 (2007 (Pubitemid 47385250)
-
(2007)
Bioorganic and Medicinal Chemistry
, vol.15
, Issue.21
, pp. 6649-6658
-
-
He, X.1
Alian, A.2
Ortiz De Montellano, P.R.3
-
107
-
-
61649103348
-
Signalling inhibitors against Mycobacterium tuberculosis - early days of a new therapeutic concept in tuberculosis
-
Hegymegi-Barakonyi B, Szekely R, Varga Z et al.: Signalling inhibitors against Mycobacterium tuberculosis - early days of a new therapeutic concept in tuberculosis. Curr. Med. Chem. 15(26), 2760-2770 (2008
-
(2008)
Curr. Med. Chem.
, vol.15
, Issue.26
, pp. 2760-2770
-
-
Hegymegi-Barakonyi, B.1
Szekely, R.2
Varga, Z.3
-
108
-
-
40149098046
-
A novel drug discovery concept for tuberculosis: Inhibition of bacterial and host cell signalling
-
Szekely R, Waczek F, Szabadkai I et al.: A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling. Immunol. Lett. 116(2), 225-231 (2008
-
(2008)
Immunol. Lett.
, vol.116
, Issue.2
, pp. 225-231
-
-
Szekely, R.1
Waczek, F.2
Szabadkai, I.3
-
109
-
-
37549048176
-
Fragment-based approaches to enzyme inhibition
-
Ciulli A, Abell C: Fragment-based approaches to enzyme inhibition. Curr. Opin. Biotechnol. 18(6), 489-496 (2007
-
(2007)
Curr. Opin. Biotechnol.
, vol.18
, Issue.6
, pp. 489-496
-
-
Ciulli, A.1
Abell, C.2
-
110
-
-
70350346470
-
Application of fragment growing and fragment linking to the discovery of inhibitors of mycobacterium tuberculosis pantothenate synthetase
-
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C: Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew. Chem. Int. Ed. Engl. 48(45), 8452-8456 (2009
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, Issue.45
, pp. 8452-8456
-
-
Hung, A.W.1
Silvestre, H.L.2
Wen, S.3
Ciulli, A.4
Blundell, T.L.5
Abell, C.6
-
111
-
-
71849090071
-
Fragment-based discovery of selective inhibitors of the mycobacterium tuberculosis protein tyrosine phosphatase PtpA
-
Rawls KA, Lang PT, Takeuchi J et al.: Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg. Med. Chem. Lett. 19(24), 6851-6854 (2009
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.24
, pp. 6851-6854
-
-
Rawls, K.A.1
Lang, P.T.2
Takeuchi, J.3
-
112
-
-
34547758886
-
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB
-
DOI 10.1021/ja0727520
-
Soellner MB, Rawls KA, Grundner C, Alber T, Ellman JA: Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB. J. Am. Chem. Soc. 129(31), 9613-9615 (2007 (Pubitemid 47237472)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.31
, pp. 9613-9615
-
-
Soellner, M.B.1
Rawls, K.A.2
Grundner, C.3
Alber, T.4
Ellman, J.A.5
-
113
-
-
78649858286
-
Novel small molecule inhibitors of MDR mycobacterium tuberculosis by NMR fragment screening of antigen 85C
-
Scheich C, Puetter V, Schade M: Novel small molecule inhibitors of MDR Mycobacterium tuberculosis by NMR fragment screening of antigen 85C. J. Med. Chem. (2010
-
(2010)
J. Med. Chem.
-
-
Scheich, C.1
Puetter, V.2
Schade, M.3
-
114
-
-
77955250106
-
Structure-based in silico design of a high-affinity dipeptide inhibitor for novel protein drug target shikimate kinase of mycobacterium tuberculosis
-
Kumar M, Verma S, Sharma S, Srinivasan A, Singh TP, Kaur P: Structure-based in silico design of a high-affinity dipeptide inhibitor for novel protein drug target Shikimate kinase of Mycobacterium tuberculosis. Chem. Biol. Drug Des. 76(3), 277-284 (2010
-
(2010)
Chem. Biol. Drug Des.
, vol.76
, Issue.3
, pp. 277-284
-
-
Kumar, M.1
Verma, S.2
Sharma, S.3
Srinivasan, A.4
Singh, T.P.5
Kaur, P.6
-
115
-
-
78650174960
-
In silico structure-based design of a novel class of potent and selective small peptide inhibitor of mycobacterium tuberculosis dihydrofolate reductase a potential target for anti-TB drug discovery
-
Kumar M, Vijayakrishnan R, Subba Rao G: In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis dihydrofolate reductase, a potential target for anti-TB drug discovery. Mol. Divers. 14(3), 595-604 (2010
-
(2010)
Mol. Divers.
, vol.14
, Issue.3
, pp. 595-604
-
-
Kumar, M.1
Vijayakrishnan, R.2
Subba Rao, G.3
-
116
-
-
37349074787
-
Rational design syn thesis and evaluation of nanomolar type II dehydroquinase inhibitors
-
Payne RJ, Peyrot F, Kerbarh O, Abell AD, Abell C: Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors. ChemMedChem 2(7), 1015-1029 (2007
-
(2007)
Chem. Med. Chem.
, vol.2
, Issue.7
, pp. 1015-1029
-
-
Payne, R.J.1
Peyrot, F.2
Kerbarh, O.3
Abell, A.D.4
Abell, C.5
-
117
-
-
33644777600
-
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis
-
DOI 10.1073/pnas.0510580103
-
Lin TW, Melgar MM, Kurth D et al.: Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 103(9), 3072-3077 (2006 (Pubitemid 43346426)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.9
, pp. 3072-3077
-
-
Lin, T.-W.1
Melgar, M.M.2
Kurth, D.3
Swamidass, S.J.4
Purdon, J.5
Tseng, T.6
Gago, G.7
Baldi, P.8
Gramajo, H.9
Tsai, S.-C.10
-
118
-
-
33750048012
-
High affinity InhA inhibitors with activity against drug-resistant strains of mycobacterium tuberculosis
-
Sullivan TJ, Truglio JJ, Boyne ME et al.: High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. ACS Chem. Biol. 1(1), 43-53 (2006
-
(2006)
ACS Chem. Biol.
, vol.1
, Issue.1
, pp. 43-53
-
-
Sullivan, T.J.1
Truglio, J.J.2
Boyne, M.E.3
-
119
-
-
0038757566
-
Targeting tuberculosis and malaria through inhibition of enoyl reductase. Compound activity and structural data
-
DOI 10.1074/jbc.M211968200
-
Kuo MR, Morbidoni HR, Alland D et al.: Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J. Biol. Chem. 278(23), 20851-20859 (2003 (Pubitemid 36806391)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.23
, pp. 20851-20859
-
-
Kuo, M.R.1
Morbidoni, H.R.2
Alland, D.3
Sneddon, S.F.4
Gourlie, B.B.5
Staveski, M.M.6
Leonard, M.7
Gregory, J.S.8
Janjigian, A.D.9
Yee, C.10
Musser, J.M.11
Kreiswirth, B.12
Iwamoto, H.13
Perozzo, R.14
Jacobs Jr., W.R.15
Sacchettini, J.C.16
Fidock, D.A.17
-
120
-
-
70350048603
-
Structure-based design of DevR inhibitor active against nonreplicating mycobacterium tuberculosis
-
Gupta RK, Thakur TS, Desiraju GR, Tyagi JS: Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. J. Med. Chem. 52(20), 6324-6334 (2009
-
(2009)
J. Med. Chem.
, vol.52
, Issue.20
, pp. 6324-6334
-
-
Gupta, R.K.1
Thakur, T.S.2
Desiraju, G.R.3
Tyagi, J.S.4
-
121
-
-
33646112903
-
Antibacterial drug discovery and structure-based design
-
Barker JJ: Antibacterial drug discovery and structure-based design. Drug Discov. Today 11(9-10), 391-404 (2006
-
(2006)
Drug Discov. Today
, vol.11
, Issue.9-10
, pp. 391-404
-
-
Barker, J.J.1
-
122
-
-
4644371689
-
Structural bioinformatic approaches to the discovery of new antimycobacterial drugs
-
DOI 10.2174/1381612043383205
-
Kantardjieff K, Rupp B: Structural bioinformatic approaches to the discovery of new antimycobacterial drugs. Curr. Pharm. Des. 10(26), 3195-3211 (2004 (Pubitemid 39276609)
-
(2004)
Current Pharmaceutical Design
, vol.10
, Issue.26
, pp. 3195-3211
-
-
Kantardjieff, K.1
Rupp, B.2
-
123
-
-
48249141397
-
A synthetic mammalian gene circuit reveals antituberculosis compounds
-
USA
-
Weber W, Schoenmakers R, Keller B et al.: A synthetic mammalian gene circuit reveals antituberculosis compounds. Proc. Natl Acad. Sci. USA 105(29), 9994-9998 (2008
-
(2008)
Proc. Natl Acad. Sci.
, vol.105
, Issue.29
, pp. 9994-9998
-
-
Weber, W.1
Schoenmakers, R.2
Keller, B.3
-
124
-
-
67349287483
-
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
-
Willand N, Dirie B, Carette X et al.: Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat. Med. 15(5), 537-544 (2009
-
(2009)
Nat. Med.
, vol.15
, Issue.5
, pp. 537-544
-
-
Willand, N.1
Dirie, B.2
Carette, X.3
-
125
-
-
0346964261
-
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator
-
DOI 10.1046/j.1365-2958.2003.03809.x
-
Engohang-Ndong J, Baillat D, Aumercier M et al.: EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator. Mol. Microbiol. 51, 175-188 (2004 (Pubitemid 38031080)
-
(2004)
Molecular Microbiology
, vol.51
, Issue.1
, pp. 175-188
-
-
Engohang-Ndong, J.1
Baillat, D.2
Aumercier, M.3
Bellefontaine, F.4
Besra, G.S.5
Locht, C.6
Baulard, A.R.7
-
126
-
-
0023130443
-
Neurological manifestations and toxicities of the antituberculosis drugs. A review
-
Holdiness MR: Neurological manifestations and toxicities of the antituberculosis drugs. A review. Med. Toxicol. 2(1), 33-51 (1987 (Pubitemid 17001248)
-
(1987)
Medical Toxicology and Adverse Drug Experience
, vol.2
, Issue.1
, pp. 33-51
-
-
Holdiness, M.R.1
-
128
-
-
0030903133
-
Microplate Alamar blue assay versus BACTEC 460 system for high- throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
-
Collins L, Franzblau SG: Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob. Agents Chemother. 41(5), 1004-1009 (1997) (Pubitemid 27194176)
-
(1997)
Antimicrobial Agents and Chemotherapy
, vol.41
, Issue.5
, pp. 1004-1009
-
-
Collins, L.A.1
Franzblau, S.G.2
|