Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 21, 2007, Pages 6649-6658

  He, Xin ^a   Alian, Akram ^b   Ortiz de Montellano, Paul R ^b  

^a Experimental Station   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enoyl Co A reductase inhibition; High throughput screening; InhA inhibition; Mycobacterium tuberculosis; Parallel synthesis

Indexed keywords

4 (9H FLUOREN 9 YL)PIPERAZIN 1 YL (4 METHYLBENZYL)METHANONE; 4 (9H FLUOREN 9 YL)PIPERAZIN 1 YL BENZYLMETHANONE; 4 [BIS(4 FLUOROPHENYL)METHYL]PIPERAZIN 1 YL (1H INDOLE 5 CARBONYL); 4 [BIS(4 FLUOROPHENYL)METHYL]PIPERAZIN 1 YL (4 METHYLBENZYL)METHANONE; 4 [BIS(4 FLUORPHENYL)METHYL)PIPERAZIN 1 YL BENZYLMETHANONE; ANTIINFECTIVE AGENT; AROMATIC AMIDE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); ETHAMBUTOL; ISONIAZID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN CONFORMATION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34548526629     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.013     Document Type: Article

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