Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 2, 2006, Pages 431-436

  Manjunatha, Ujjini H ^a   Boshoff, Helena ^a   Dowd, Cynthia S ^a   Zhang, Liang ^a   Albert, Thomas J ^b   Norton, Jason E ^b   Daniels, Lacy ^c,e   Dick, Thomas ^d   Pang, Siew Siew ^d   Barry III, Clifton E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Roche NimbleGen Inc   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^e TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Comparative genome sequencing; F420; Nitroimidazole

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; BACTERIAL PROTEIN; CGI 17341; CGI 71341; CGP 70520; COENZYME F420; DEAZAFLAVIN; F420 DEPENDENT GLUCOSE 6 PHOSPHATE DEHYDROGENASE; NITROIMIDAZOLE DERIVATIVE; OXAZINE DERIVATIVE; PA 647; PRODRUG; PROTEIN RV3547; RIBOFLAVIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVATION; DRUG METABOLISM; DRUG SENSITIVITY; DRUG STRUCTURE; ELECTRON; ENZYME ACTIVITY; FEMALE; GENE SEQUENCE; GENETIC COMPLEMENTATION; MICROARRAY ANALYSIS; MOUSE; MOUSE STRAIN; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

BACTERIAL PROTEINS; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; GLUCOSEPHOSPHATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NITROIMIDAZOLES; OXAZINES; PHENOTYPE;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 31044452898     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508392103     Document Type: Article

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