Application of fragment growing and fragment linking to the discovery of inhibitors of mycobacterium tuberculosis pantothenate synthetase

Angewandte Chemie - International Edition

Volumn 48, Issue 45, 2009, Pages 8452-8456

  Hung, Alvin W ^a   Silvestre, H Leonardo ^a   Wen, Shijun ^a   Ciulli, Alessio ^a   Blundell, Tom L ^a   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drug design; Fragment linking; Inhibitors; Tuberculosis; X ray diffraction

Indexed keywords

DRUG DESIGN; ENZYME ACTIVE SITES; FRAGMENT LINKING; INHIBITORS; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; POTENT INHIBITOR; SYNTHETASES; TUBERCULOSIS;

DIFFRACTION; ENZYMES; SULFUR COMPOUNDS; X RAY DIFFRACTION; X RAY SCREENS;

X RAY CRYSTALLOGRAPHY;

ENZYME INHIBITOR; PANTOTHENATE SYNTHETASE; PEPTIDE SYNTHASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; STEREOISOMERISM;

ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; PROTEIN CONFORMATION; STEREOISOMERISM;

EID: 70350346470     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200903821     Document Type: Article

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