Targeting tuberculosis and malaria through inhibition of enoyl reductase. Compound activity and structural data

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20851-20859

  Kuo, Mack R ^a   Morbidoni, Hector R ^b   Alland, David ^d   Sneddon, Scott F ^e   Gourlie, Brian B ^e   Staveski, Mark M ^e   Leonard, Marina ^e   Gregory, Jill S ^e   Janjigian, Andrew D ^e   Yee, Christopher ^e   Musser, James M ^f   Kreiswirth, Barry ^g   Iwamoto, Hiroyuki ^a   Perozzo, Remo ^a   Jacobs Jr , William R ^b,c   Sacchettini, James C ^a   Fidock, David A ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Dept of Microbiol and Immunology ^*  (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^e GENZYME CORPORATION   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CHEMICAL BONDS; ENZYMES; MALARIA CONTROL;

TUBERCULOSIS;

BIOCHEMISTRY;

ANTIINFECTIVE AGENT; CARRIER PROTEIN; CHLOROQUINE; CYCLOGUANIL; ENOYL ACYL CARRIER PROTEIN REDUCTASE; ENOYL REDUCTASE INHIBITOR; ENZYME INHIBITOR; FATTY ACID SYNTHASE; GENZ 10850; GENZ 8575; ISONIAZID; PROTEIN INHA; PYRIMETHAMINE; QUININE; SULFADOXINE; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; MALARIA; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STOICHIOMETRY; STRUCTURE ANALYSIS; TUBERCULOSIS;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL PROTEINS; DINITROBENZENES; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; HUMANS; INDOLES; MALARIA; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PIPERAZINES; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRICLOSAN; TUBERCULOSIS, PULMONARY;

BACTERIA (MICROORGANISMS); CINCHONA PUBESCENS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0038757566     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211968200     Document Type: Article

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