A synthetic mammalian gene circuit reveals antituberculosis compounds

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 9994-9998

  Weber, Wilfried ^a   Schoenmakers, Ronald ^a   Keller, Bettina ^a   Gitzinger, Marc ^a   Grau, Thomas ^b   Baba, Marie Daoud El ^c   Sander, Peter ^b,d   Fussenegger, Martin ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITÉ DE LYON   (France)

^d National Center for Mycobacteria   (Switzerland)

Author keywords

Antibiotic; Biology; Ethionamide; Genetic engineering; Mycobacterium

Indexed keywords

2 PHENYLETHYLBUTYRATE; BUTYRIC ACID DERIVATIVE; ETHIONAMIDE; PRODRUG; SYNTHETIC DNA; TUBERCULOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE REPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; MAMMALIAN GENETICS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERATOR GENE; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE ANALYSIS; REPORTER GENE; SENSITIVITY ANALYSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BIOPHYSICS; CELL LINE; DNA, BACTERIAL; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; GENE EXPRESSION; GENE FUSION; GENES, BACTERIAL; GENETIC TECHNIQUES; HERPES SIMPLEX VIRUS PROTEIN VMW65; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PHENYLBUTYRATES; REPRESSOR PROTEINS;

MAMMALIA; MUS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 48249141397     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800663105     Document Type: Article

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