Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity

Journal of Medicinal Chemistry

Volumn 39, Issue 3, 1996, Pages 680-685

  Barbachyn, Michael R ^a   Hutchinson, Douglas K ^a   Brickner, Steven J ^a   Cynamon, Michael H ^b   Kilburn, James O ^c   Klemens, Sally P ^b   Glickman, Suzanne E ^c   Grega, Kevin C ^a   Hendges, Susan K ^a   Toops, Dana S ^a   Ford, Charles W ^a   Zurenko, Gary E ^a  

^a PFIZER INC   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; ISONIAZID; N [[3 [3 FLUORO 4 (1 OXOTHIOMORPHOLIN 4 YL)PHENYL] 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; N [[3 [3 FLUORO 4 (4 THIOMORPHOLINYL)PHENYL] 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; N [[3 [4 (1,1 DIOXOTHIOMORPHOLIN 4 YL) 3 FLUOROPHENYL] 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; OXAZOLIDINE DERIVATIVE; U 100480; U 101244; U 101603; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG DESIGN; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIOSIS; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM INTRACELLULARE AVIUM; MYCOBACTERIUM TUBERCULOSIS; ORAL DRUG ADMINISTRATION;

ACETAMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; OXAZOLES; RATS;

EID: 13344284628     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950956y     Document Type: Article

References (21)

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