An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence

Infection and Immunity

Volumn 64, Issue 6, 1996, Pages 2062-2069

  Wayne, Lawrence G ^a,b   Hayes, Ladonna G ^a  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAEROBIC GROWTH; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; COLONY FORMING UNIT; DNA SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

EID: 0029976980     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.6.2062-2069.1996     Document Type: Article

References (16)

1. Cambau, E., W. Sougakoff, and V. Jarlier. 1994. Amplification and nucleotide sequence of the quinolone resistance-determining region in the gyrA gene of mycobacteria. FEMS Microbiol. Lett. 116:49-54.
2. Dhople, A. M., and J. H. Hanks. 1973. Quantitative extraction of adenosine triphosphate from cultivable and host-grown microbes: calculation of adenosine triphosphate pools. Appl. Microbiol. 26:399-403.
3. Dickinson, J. M., and D. A. Mitchison. 1981. Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis. Am. Rev. Respir. Dis. 123:367-371.
4. Edwards, D. I. 1979. Mechanism of antimicrobial action of metronidazole. J. Antimicrob. Chemother. 5:499-502.
5. Goldman, D. S., and M. J. Wagner. 1962. Enzyme systems in the mycobacteria. XIII. Glycine dehydrogenase and the glyoxylic acid cycle. Biochim. Biophys. Acta 65:297-306.
6. Harshey, R. M., and T. Ramakrishnan. 1977. Rate of ribonucleic acid chain growth in M. tuberculosis H37Rv. J. Bacteriol. 129:616-622.
7. 6a. Kaprelyants, A. S., J. C. Gottschal, and D. B. Kell. 1993. Dormancy in nonsporulating bacteria. FEMS Microbiol. Rev. 104:271-286.
8. Shoeb, H. A., B. U. Bowman, Jr., A. C. Ottolenghi, and A. J. Merola. 1985. Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra. Antimicrob. Agents Chemother. 27:404-407.
9. Takayama, K., L. Wang, and H. L. David. 1972. Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth and viability of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2:29-35.
10. Wayne, L. G. 1976. Dynamics of submerged growth of Mycobacterium tuberculosis under aerobic and microaerophilic conditions. Am. Rev. Respir. Dis. 114:807-811.
11. Wayne, L. G. 1977. Synchronized replication of Mycobacterium tuberculosis. Infect. Immun. 17:528-530.
12. Wayne, L. G. 1994. Dormancy of Mycobacterium tuberculosis and latency of disease. Eur. J. Clin. Microbiol. Infect. Dis. 13:908-914.
13. Wayne, L. G. 1994. Cultivation of Mycobacterium tuberculosis for research purposes, p. 73-84. In B. R. Bloom (ed.), Tuberculosis: pathogenesis, protection, and control. ASM Press, Washington, D.C.
14. Wayne, L. G., and K.-Y. Lin. 1982. Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect. Immun. 37:1042-1049.
15. Wayne, L. G., and H. A. Sramek. 1979. Antigenic differences between extracts of actively replicating and synchronized resting cells of Mycobacterium tuberculosis. Infect. Immun. 24:363-370.
16. Wayne, L. G., and H. A. Sramek. 1994. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38:2054-2058.