A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Nature

Volumn 405, Issue 6789, 2000, Pages 962-966

  Stover, C Kendall ^a   Warrener, Paul ^a   VanDevanter, Donald R ^a   Sherman, David R ^b   Arain, Taraq M ^a   Langhorne, Michael H ^a   Anderson, Scott W ^a   Towell, J Andrew ^a   Yuan, Ying ^a   McMurray, David N ^c   Kreiswirth, Barry N ^d   Barry, Clifton E ^e   Baker, William R ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF WASHINGTON   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^d PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; AMIKACIN; BACTERIAL PROTEIN; ETHAMBUTOL; ISONIAZID; METRONIDAZOLE; MYCOLIC ACID; NITROIMIDAZOLE DERIVATIVE; PYRAN DERIVATIVE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG MECHANISM; EPIDEMIC; GUINEA PIG; MOUSE; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; GUINEA PIGS; LIPIDS; METRONIDAZOLE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; NITROIMIDAZOLES; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA PORCELLUS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; SUS SCROFA; UNCULTURED ACTINOMYCETE;

EID: 0034702247     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35016103     Document Type: Article

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