PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice

Science

Volumn 330, Issue 6007, 2010, Pages 1104-1107

  Rad, Roland ^a   Rad, Lena ^a   Wang, Wei ^a   Cadinanos, Juan ^a,b   Vassiliou, George ^a   Rice, Stephen ^a   Campos, Lia S ^a   Yusa, Kosuke ^a   Banerjee, Ruby ^a   Li, Meng Amy ^a   De La Rosa, Jorge ^b   Strong, Alexander ^a   Lu, Dong ^a   Ellis, Peter ^a   Conte, Nathalie ^a   Yang, Fang Tang ^a   Liu, Pentao ^a   Bradley, Allan ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b Instituto de Medicina Oncologica y Molecular de Asturias   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE 7; TRANSCRIPTION FACTOR PU 1; TRANSPOSASE;

CANCER; CHROMOSOME; ENZYME ACTIVITY; GENE; GENETIC ANALYSIS; GENETICALLY MODIFIED ORGANISM; GENOME; MUTATION; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENE THERAPY; CELL LINE; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC SCREENING; HEMATOLOGIC MALIGNANCY; LATENT PERIOD; MALE; MOUSE; MUTAGENESIS; NONHUMAN; PIGGYBAC TRANSPOSON; PRIORITY JOURNAL; REGULATORY MECHANISM; SOLID TUMOR; TRANSGENIC MOUSE; TRANSPOSON;

ANIMALS; DNA TRANSPOSABLE ELEMENTS; GENES, NEOPLASM; GENETIC TESTING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; NEOPLASMS; ONCOGENES; PROMOTER REGIONS, GENETIC;

MUS;

EID: 78449294626     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1193004     Document Type: Article

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25. We thank the research support facility team, B.L. Ng, B. Fu, and Y. Hooks for technical assistance; N. Carter and C. Lopez-Otin for experimental resources; L. Wessels, J. ten Hoeve, and J. de Ridder for software used in data analysis; D. Saur for technical advice; and H. Prosser for reagents. The work was supported by the Wellcome Trust. R.R. and J.R. are recipients of a fellowship from the Deutsche Forschungsgemeinschaft and the Fundación Maria Cristina Masaveu Peterson, respectively.