Garlic in health and disease

Nutrition Research Reviews

Volumn 24, Issue 1, 2011, Pages 60-71

  Rana, S V ^a   Pal, R ^a   Vaiphei, K ^a   Sharma, Sanjeev K ^a   Ola, R P ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Antimicrobials; Antineoplastics; Antioxidants; Garlic; Hepatoprotection

Indexed keywords

ALLICIN; ANTIOXIDANT; GARLIC EXTRACT; GARLIC OIL; ISONIAZID; LIPOPROTEIN; PROSTAGLANDIN SYNTHASE; PROTON PUMP INHIBITOR; RIFAMPICIN; THROMBOXANE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; HEMATOLOGIC AGENT; PLANT EXTRACT;

ANTICOAGULATION; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; BLOATING; CARCINOGENESIS; CARDIOVASCULAR RISK; CELL PROLIFERATION; DIARRHEA; DIZZINESS; ENZYME INHIBITION; FLATULENCE; FLUSHING; GARLIC; HEADACHE; HEART PROTECTION; HEARTBURN; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HYPERLIPIDEMIA; INSOMNIA; LIVER INJURY; LIVER PROTECTION; MACROPHAGE; NAUSEA; NONHUMAN; ORTHOSTATIC HYPOTENSION; REVIEW; SIDE EFFECT; SWEATING; TACHYCARDIA; VOMITING; ANIMAL; CARDIOVASCULAR DISEASES; CHEMISTRY; DRUG-INDUCED LIVER INJURY; HELICOBACTER INFECTIONS; NEOPLASMS; PHYTOTHERAPY;

ALLIUM SATIVUM; ANIMALIA; HELICOBACTER PYLORI;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; DRUG-INDUCED LIVER INJURY; GARLIC; HELICOBACTER INFECTIONS; HEMATOLOGIC AGENTS; HUMANS; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 79958848140     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422410000338     Document Type: Review

References (134)

1. Fenwick GR & Hanley AB (1985) The genus Allium. Part 2. Crit Rev Food Sci Nutr 22, 273-277.
2. Matsuura H, Ushiroguchi T, Itakura T, et al. (1988) A furostanol glycoside from garlic bulbs of Allium sativum L. Chem Pharm Bull 36, 3659-3663.
3. Kaku H, Goldstein IJ, Van Damme EJM, et al. (1992) New mannose-specific lectins from garlic (Allium sativum) and ramsons (Allium ursinum) bulbs. Carbohydr Res 229, 347-353.
4. Amagase H, Petesch LB, Matsuura H, et al. (2001) Intake of garlic and its bioactive compounds. J Nutr 31, 955S-962S.
5. Lawson LD & Gardner CD (2005) Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem 53, 6254-6261. (Pubitemid 41169369)
6. Egen-Schwind C, Eckard R & Kemper FH (1992) Metabolism of garlic constituents in the isolated perfused rat liver. Planta Medica 58, 301-305.
7. Lachmann G, Horenz D, Radeck W, et al. (1994) The pharmacokinetics of the S-35 labeled garlic constituents alliin, allicin and vinyldithiine (article in German). Arzeimitteforschung 44, 734-743. (Pubitemid 24210106)
8. Su CC, Chen GW, Tan TW, et al. (2006) Crude extract of garlic induced caspase-3 gene expression leading to apoptosis in human colon cancer cells. In Vivo 20, 85-90.
9. Manson MM, Ball HW, Barrett MC, et al. (1997) Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Carcinogenesis 18, 1729-1738. (Pubitemid 28134678)
10. Wang BH, Zuzel KA, Rahman K, et al. (1999) Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology 132, 215-225. (Pubitemid 29121959)
11. Singh A & Shukla Y (1998) Antitumor activity of diallyl sulfide in two-stage mouse skin model of carcinogenesis. Biomed Environ Sci 11, 258-263. (Pubitemid 128690777)
12. Hughes MF, Chamulitrat W, Mason RP, et al. (1989) Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene via a hydroperoxide-dependent mechanism catalyzed by lipoxygenases. Carcinogenesis 10, 2075-2080. (Pubitemid 19280488)
13. Roy P & Kulkarni AP (1999) Co-oxidation of acrylonitrile by soybean lipoxygenase and partially purified human lung lipoxygenase. Xenobiotica 29, 511-531. (Pubitemid 29245749)
14. Singh A & Singh SP (1997) Modulatory potential of smokeless tobacco on the garlic, mace or black mustard-altered hepatic detoxication system enzymes, sulfhydryl content and lipid peroxidation in murine system. Cancer Lett 118, 109-114. (Pubitemid 27397231)
15. Hu X, Benson PJ, Srivastava SK, et al. (1997) Induction of glutathione S-transferase p as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model. Int J Cancer 73, 897-902. (Pubitemid 127483048)
16. Morihara N, Nishihama T, Ushijima M, et al. (2007) Garlic as an anti-fatigue agent. Mol Nutr Food Res 51, 1329-1334. (Pubitemid 350195606)
17. Tattelman E (2005) Health effects of garlic. Am Fam Physician 72, 103-106.
18. Ryzhenkov VE & Makarov VG (2003) Biologically active substances in garlic (Allium sativum L.) and their application in nutrition for humans (article in Russian). Vopr Pitam 72, 42-46.
19. Ghazanfar SA (1994) Handbook of Arabian Medicinal Plants. Boca Raton, FL: CRC Press.
20. Kapoor LD (1990) CRC Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press.
21. Peirce A (1999) The ABC Clinical Guide to Herbs: The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: William Morrow and Company, Inc.
22. Barnes J, Anderson LA & Phillipson ID (1996) Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press.
23. Woodward PW (1996) Garlic and Friends: The History, Growth and Use of Edible Alliums. Melbourne: Hyland House Publishing.
24. El Shenawy NS, Soliman MF & Reyad SI (2008) The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo 50, 29-36. (Pubitemid 351416352)
25. Liu HG & Xu LH (2007) Garlic oil prevents tributyltin-induced oxidative damage in vivo and in vitro. J Food Prot 70, 716-721.
26. Ogita A, Nagao Y, Fujita K, et al. (2007) Amplification of vacuole-targeting fungicidal activity of antibacterial antibiotic polymyxin B by allicin, an allylsulfur compound from garlic. J Antibiot (Tokyo) 60, 511-518.
27. Chan KC, Yin MC & Chao WJ (2007) Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Food Chem Toxicol 45, 502-507.
28. Kumaraguruparan R, Chandra Mohan KV & Abraham SK (2005) Attenuation of N-methyl-N′-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination. Life Sci 76, 2247-2255. (Pubitemid 40283649)
29. Prasad K, Haxdal A, Yu M, et al. (1995) Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148, 183-189.
30. Imai J, Ide N, Nagae S, et al. (1994) Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Medica 60, 417-420. (Pubitemid 24330767)
31. Melaleb R (1993) Antioxidant, antitumor and cardiovascular actions of garlic. Herbal Gram 29, 18-72.
32. Torok B, Belaggi J & Reitz B (1994) Effectiveness of garlic on the radical activity in radical generating system. Arzeimittelfrschung 44, 608-611. (Pubitemid 24179884)
33. Chang HS, Yamato O, Yamasaki M, et al. (2005) Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine platelets: possible mechanism for the anti-aggregatory effect. Prostaglandins Leukot Essent Fatty Acids 72, 351-355. (Pubitemid 40585789)
34. Lewin G & Popev I (1994) Antioxidant effect of aqueous garlic extract. 2nd communication: inhibition of the Cu(2 + )-initiated oxidation of low density lipoproteins. Arzneimettelforchung 44, 604-607.
35. Ahmad MS & Ahmed N (2006) Antiglycation properties of aged garlic extract: possible role in prevention of diabetic complications. J Nutr 136, 796S-799S.
36. Park EY, Ki SH, Ko MS, et al. (2005) Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats. Chem Biol Interact 155, 82-96.
37. Sener G, Sehirli O, Ipçi Y, et al. (2005) Aqueous garlic extract alleviates ischaemia-reperfusion-induced oxidative hepatic injury in rats. J Pharm Pharmacol 57, 145-150. (Pubitemid 40030113)
38. Augusti KT (1996) Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J Exp Biol 34, 634-640.
39. Fukao T, Hosono T, Misawa S, et al. (2004) The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol 42, 743-749. (Pubitemid 38376341)
40. Arivazhagan S, Velmurugan B, Bhuvaneswari V, et al. (2004) Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. J Med Food 7, 334-339. (Pubitemid 39299493)
41. Pérez-Severiano S, Rodríguez-Pérez M, Pedraza-Chaverrí J, et al. (2004) S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats. Neurochem Int 45, 1175-1183. (Pubitemid 39222059)
42. Borek C (2006) Garlic reduces dementia and heart-disease risk. J Nutr 136, 810S-812S.
43. Liu Jz, Lin XY & Milner JZ (1992) Dietary garlic powder increase glutathione content and glutathione S-transferase activity in rat liver and mammary tissues. FASEB J 6, A3230-A3231.
44. Wang Z, Peng Z, Keng R, et al. (1998) Effect of allicin in ethanol-induced hepatotoxicity in mice. Wei Sheng Yan Jiu 27, 415-457.
45. Williams MJ, Sutherland WH, McCormick MP, et al. (2005) Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res 19, 314-319. (Pubitemid 41098126)
46. Dhawan V & Jain S (2004) Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem 266, 109-115. (Pubitemid 39562311)
47. Khanum F, Anilakumar KR & Viswanatham KR (2004) Anticarcinogenic properties of garlic: a review. Crit Rev Food Sci Nutr 44, 479-488. (Pubitemid 39597803)
48. Durak I, Aytac B, Atmaca Y, et al. (2004) Effects of garlic extract consumption in plasma and erythrocyte antioxidant parameters in atherosclerotic patients. Life Sci 75, 1957-1966.
49. Zahid AM, Hussain ME & Fahim M (2005) Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: restoration of endothelial function in rats. Life Sci 77, 837-857. (Pubitemid 40827189)
50. Gonen A, Harats D, Rabinkov A, et al. (2005) The antiatherogenic effect of allicin: possible mode of action. Pathobiology 72, 325-334.
51. Gebhardt R & Beck H (1996) Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 31, 1269-1276. (Pubitemid 26425022)
52. Larner AJ (1995) How does garlic exert its hypocholesterolaemic action? The tellurium hypothesis. Med Hypotheses 44, 295-307.
53. Yeh YY & Liu L (2001) Cholesterol lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr 131, 989S-993S.
54. Mathew BC, Daniel RS & Augusti KT (1996) Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil. Indian J Exp Biol 34, 337-340. (Pubitemid 26127759)
55. Chetty KN, Calaham L, Harris KC, et al. (2003) Garlic attenuates hypercholesterolemic risk factors in olive oil fed rats and high cholesterol fed rats. Pathophysiology 9, 127-132. (Pubitemid 37297870)
56. Chowdhury SR, Chowdhury SD & Smith TK (2002) Effects of dietary garlic on cholesterol metabolism in laying hens. Poult Sci 81, 1856-1862. (Pubitemid 41136866)
57. Liu L & Yeh YY (2002) S-alk(en)ylcysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes. J Nutr 132, 1129-1144.
58. Kweon MJ, Song YS, Choi MS, et al. (2003) Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder. Life Sci 72, 2953-2964.
59. Hsu CC, Huang CN, Hung YC, et al. (2004) Five cysteinecontaining compounds have antioxidative activity in Balb/cA mice. J Nutr 134, 149-152.
60. Ahmed RS & Sharma SB (1997) Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc) in albino rats. Indian J Exp Biol 35, 841-843. (Pubitemid 127482959)
61. Silagy C & Neil A (1994) Garlic as a lipid lowering agent - a meta-analysis. J R Coll Physicians Lond 28, 39-45. (Pubitemid 24034204)
62. Jain AK, Varges R, Gotzkowsky S, et al. (1993) Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 94, 632-635. (Pubitemid 23166711)
63. Campbell JH, Efendy JL, Smith NJ, et al. (2001) Molecular basis by which garlic suppresses atherosclerosis. J Nutr 131, 1006S-1009S.
64. Ismail MF, Gad MZ & Handy MA (1999) Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits. Pharmacol Res 39, 157-166. (Pubitemid 29106167)
65. Jung F, Jung EM, Mrowietz C, et al. (1990) Influence of garlic powder on cutaneous microcirculation: a randomized, placebo-controlled, double-blind, crossover study in apparently healthy subjects. Br J Clin Pract 69, 30-35. (Pubitemid 20362174)
66. Siegel G, Walter A, Engel S, et al. (1999) Pleiotropic effects of garlic. Wien Med Wochenschr 149, 217-224. (Pubitemid 29399811)
67. Fisher CD, Augustine LM, Maher JM, et al. (2007) Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos 35, 995-1000. (Pubitemid 46798610)
68. 4-induced acute liver injury in rats. Free Radic Res 41, 489-497.
69. Pal R, Vaiphei K, Sikander A, et al. (2006) Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World J Gastroenterol 12, 636-639. (Pubitemid 43380798)
70. Fancelli SL, Castro GD, de Toranzo FG, et al. (1998) Mechanisms of the preventive properties of some garlic components in the carbon tetrachloride-promoted oxidative stress. Diallyl sulfide; diallyl disulfide; allyl mercaptan and allyl methyl sulfide. Res Commun Mol Pathol Pharmacol 102, 163-174.
71. Senapati SK, Dey S, Dwivedi SK, et al. (2001) Effect of garlic (Allium sativum L.) extract on tissue lead level in rats. J Ethnopharmacol 76, 229-232. (Pubitemid 32633848)
72. Arora A, Seth K & Shukla Y (2004) Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver. Carcinogenesis 25, 941-949. (Pubitemid 38886080)
73. Bergès R, Siess MH, Arnault J, et al. (2004) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats. Carcinogenesis 25, 1953-1959. (Pubitemid 39405915)
74. Kalantari H & Salehi M (2001) The protective effect of garlic oil on hepatotoxicity induced by acetaminophen in mice and comparison with N-acetylcysteine. Saudi Med J 22, 1080-1084. (Pubitemid 34036773)
75. Sheweita SA, Abd El-Gabar M & Bastawy M (2001) Carbon tetrachloride induced changes in the activity of phase II drug metabolizing enzymes in the liver of male rats: role of antioxidants. Toxicology 165, 217-224. (Pubitemid 32778314)
76. Gedik N, Kabasakal L, Sehirli O, et al. (2005) Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci 76, 2593-2606. (Pubitemid 40354261)
77. Caldwell SH, Jeffers LI, Narula OS, et al. (1992) Ancient remedies revisited: does Allium sativum (garlic) palliate the hepatopulmonary syndrome? J Clin Gastroenterol 15, 248-250.
78. Pearson W, Charch A, Brewer D, et al. (2007) Pilot study investigating the ability of an herbal composite to alleviate clinical signs of respiratory dysfunction in horses with recurrent airway obstruction. Can J Vet Res 71, 145-151. (Pubitemid 46730821)
79. Wojcikowski K, Myers S & Brooks L (2007) Effects of garlic oil on platelet aggregation: a double-blind placebocontrolled crossover study. Platelets 18, 29-34.
80. MacDonald JA, Marchand ME & Langler RF (2004) Improving upon the in vitro biological activity of antithrombotic disulfides. Blood Coagul Fibrinolysis 15, 447-450. (Pubitemid 39180228)
81. Ide N, Keller C & Weiss N (2006) Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J Nutr 136, 755S-757S.
82. Chung I, Kwon SH, Shim ST, et al. (2007) Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. J Food Sci 72, M437-M440. (Pubitemid 350150705)
83. Eja ME, Asikong BE, Abriba C, et al. (2007) A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J Trop Med Public Health 38, 343-348.
84. Al-Waili NS, Saloom KY, Akmal M, et al. (2007) Effects of heating, storage, and ultraviolet exposure on antimicrobial activity of garlic juice. J Med Food 10, 208-212. (Pubitemid 46706872)
85. Aydin A, Bostan K, Erkan ME, et al. (2007) The antimicrobial effects of chopped garlic in ground beef and raw meatball (ciǧ köfte). J Med Food 10, 203-207. (Pubitemid 46706871)
86. Groppo FC, Ramacciato JC, Motta RH, et al. (2007) Antimicrobial activity of garlic against oral streptococci. Int J Dent Hyg 5, 109-115.
87. Sallam KI, Ishioroshi M & Samejima K (2007) Antioxidant and antimicrobial effects of garlic in chicken sausage. Lebenson Wiss Technol 37, 849-855.
88. Konaklieva MI & Plotkin BJ (2006) Antimicrobial properties of organosulfur anti-infectives: a review of patent literature 1999-2005. Recent Patents Anti-Infect Drug Disc 1, 177-180.
89. Amin M & Kapadnis BP (2005) Heat stable antimicrobial activity of Allium ascalonicum against bacteria and fungi. Indian J Exp Biol 43, 751-754. (Pubitemid 41127563)
90. Maldonado PD, Chanez CME & Pedraza CJ (2005) Aged garlic extract, garlic-powder extract, S-allylcysteine, diallyl sulfide and diallyl disulfide do not interfere with the antibiotic activity of gentamicin. Phytother Res 19, 252-254. (Pubitemid 40827652)
91. Cañizares P, Gracia I, Gómez LA, et al. (2004) Allylthiosulfinates, the bacteriostatic compounds of garlic against Helicobacter pylori. Biotechnol Prog 20, 397-401. (Pubitemid 38204214)
92. Sivam GP, Lampe JW, Ulness B, et al. (1997) Helicobacter pylori - in vitro susceptibility to garlic (Allium sativum) extract. Nutr Cancer 27, 118-121. (Pubitemid 27089684)
93. Cellini L, Di Campli E, Masulli M, et al. (1996) Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbial 13, 273-277. (Pubitemid 26157931)
94. Chowdhury AK, Ahsam M, Islam SN, et al. (1991) Efficacy of aqueous extract of garlic and allicin in experimental shigellosis in rabbits. Indian J Med Res 93, 33-36.
95. Howard EW, Lee DT, Chiu YT, et al. (2008) Evidence of a novel docetaxel sensitizer, garlic-derived S-allylmercaptocysteine, as a treatment option for hormone refractory prostate cancer. Int J Cancer 122, 1941-1948. (Pubitemid 351441182)
96. Jo HJ, Song JD, Kim KM, et al. (2008) Diallyl disulfide induces reversible G2/M phase arrest on a p53-independent mechanism in human colon cancer HCT-116 cells. Oncol Rep 19, 275-280. (Pubitemid 351176161)
97. Devrim E & Durak I (2007) Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? Mol Nutr Food Res 51, 1319-1323.
98. Nigam N & Shukla Y (2007) Preventive effects of diallyl sulfide on 7,12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin. Mol Nutr Food Res 51, 1324-1328. (Pubitemid 350195605)
99. Kaur P & Singh R (2007) In vivo interactive effect of garlic oil and vitamin E against stavudine induced genotoxicity in Mus musculus. Indian J Exp Biol 45, 807-811.
100. Lu HF, Yang JS, Lin YT, et al. (2007) Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. Cancer Genomics Proteomics 4, 93-97.
101. Zhang ZM, Yang XY, Deng SH, et al. (2007) Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice. Chin Med J (Engl) 120, 1336-1342.
102. Das A, Banik NL & Ray SK (2007) Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells. Cancer 110, 1083-1095. (Pubitemid 47312875)
103. Khan A, Shukla Y, Kalra N, et al. (2007) Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. MolMed 13, 443-451. (Pubitemid 47378146)
104. Iciek M, Marcinek J, Mleczko U, et al. (2007) Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells. Eur J Pharmacol 569, 1-7. (Pubitemid 47175873)
105. Lemar KM, Aon MA, Cortassa S, et al. (2007) Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy. Yeast 24, 695-706. (Pubitemid 47322306)
106. Terrasson J, Xu B, Li M, et al. (2007) Activities of Z-ajoene against tumour and viral spreading in vitro. Fundam Clin Pharmacol 21, 281-289. (Pubitemid 46800471)
107. Agarwal MK, Iqbal M & Athar M (2007) Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention. Food Chem Toxicol 45, 1634-1640. (Pubitemid 47102500)
108. Schulz M, Lahmann PH, Boeing H, et al. (2005) Fruit and vegetable consumption and risk of epithelial ovarian cancer. The European Prospective Investigation into Cancer and Nutrition. Cancer Epidemol Biomarkers Prev 14, 2531-2535.
109. Bose C, Guo J, Zimniak L, et al. (2002) Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic. Carcinogenesis 23, 1661-1665. (Pubitemid 35221303)
110. Hu DJ (1990) Protective effect of diallyl sulfide, a natural extract of garlic, on MNNG-induced damage of rat glandular stomach mucosa. Zhonghua Zhonghua Zhong Liu Za Zhi 12, 429-431.
111. Srivastava SK, Hu X, Xia H, et al. (1997) Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice. Cancer Lett 118, 61-67. (Pubitemid 27397225)
112. Ip C & Disk DJ (1997) Modulation of phase I and phase II xenobiotic-metabolizing enzymes by selenium-enriched garlic in rats. Nutr Cancer 28, 184-188. (Pubitemid 27396208)
113. Augusti KT & Mathew PT (1975) Effect of allicin on certain enzymes of liver after a short term feeding to normal rats. Experientia 31, 148-149.
114. Dixit VP & Joshi S (1982) Effects of chronic administration of garlic (Allium sativum Linn) on testicular function. Indian J Exp Biol 20, 534-566.
115. Egen-Schwind C, Eckard R, Jekat FW, et al. (1992) Pharmacokinetics of vinyldithiins, transformation products of allicin. Planta Med 58, 8-13.
116. Alnaqeeb MA, Thomson M, Bordia T, et al. (1996) Histopathological effects of garlic on liver and lung of rats. Toxicol Lett 85, 157-164. (Pubitemid 26164335)
117. Fehri M, Aiache JM, Korbi S, et al. (1991) Toxic effects induced by the repeat administration of Allium sativum L. J Pharm Belg 46, 363-374.
118. Banerjee SK, Maulik M, Manchanda SC, et al. (2001) Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food Chem Toxicol 39, 793-797. (Pubitemid 32575246)
119. Jocelyn PC (1972) Biochemistry of the SH Group: The Occurrence, Chemical Properties, Metabolism and Biological Functions of Thiols and Disulphides, p. 107. New York: Academic Press.
120. Shashikanth KN, Basappa SC & Sreenivasa Murthy VA (1984) A comparative study of raw garlic extract and tetracycline on caecal microflora and serum proteins of albino rats. Folia Microbial 29, 348-352.
121. Ruffin J & Hunter SA (1983) An evaluation of the side effects of garlic as an antihypertensive agent. Cytobios 37, 85-89. (Pubitemid 13011458)
122. Desai HG, Kalro RH & Choksi AP (1990) Effect of ginger and garlic on DNA content of gastric aspirate. Indian J Med Res 92, 139-141. (Pubitemid 20300398)
123. Yadav RK & Verma NS (2004) Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose dependent study. Indian J Exp Biol 42, 628-631. (Pubitemid 38730102)
124. Das T, Roychoudhury A, Sharma A, et al. (1996) Effects of crude garlic extract on mouse chromosomes in vivo. Food Chem Toxicol 34, 43-47. (Pubitemid 26057848)
125. Nakagawa S, Masamoto K, Sumiyoshi H, et al. (1980) Effect of raw and extracted-aged garlic juice on growth of young rats and their organs after peroral administration (article in Japanese). J Toxicol Sci 5, 91-112. (Pubitemid 12065207)
126. Chen L, Hong JY, So E, et al. (1999) Decrease of hepatic catalase level by treatment with diallyl sulfide and garlic homogenates in rats and mice. J Biochem Mol Toxicol 13, 127-133.
127. Joseph PK, Rao KR & Sundaresh CS (1989) Toxic effects of garlic extract and garlic oil in rats. Indian J Exp Biol 27, 977-979.
128. Sheen LY, Chen HW, Kung YL, et al. (1999) Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets. Nutr Cancer 35, 160-166.
129. Banerjee SK & Maulik SK (2002) Effect of garlic on cardiovascular disorders: a review. Nutr J 1, 4.
130. Scharbert G, Kalb ML, Duris M, et al. (2007) Garlic at dietary doses does not impair platelet function. Anesth Analg 105, 1214-1218. (Pubitemid 350303918)
131. Gadkari JV & Joshi VD (1991) Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med 37, 128-131.
132. Asdaq SM & Inamdar MN (2011) The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats. J Nat Med 65, 81-88.
133. Asdaq SM, Inamdar MN & Asad M (2010) Pharmacodynamic interaction of garlic with propranolol in ischemia-reperfusion induced myocardial damage. Pak J Pharm Sci 23, 42-47.
134. Satitvipawee P, Rawdaree P, Indrabhakti S, et al. (2003) No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects. J Med Assoc Thai 86, 750-757. (Pubitemid 37151209)