Histopathological effects of garlic on liver and lung of rats

Toxicology Letters

Volumn 85, Issue 3, 1996, Pages 157-164

  Alnaqeeb, M A ^a   Thomson, M ^a   Bordia, T ^a   Ali, M ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Garlic; Liver; Lung; Rats

Indexed keywords

GARLIC EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; GARLIC; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER TOXICITY; LUNG TOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0029943883     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(96)03658-2     Document Type: Article

References (23)

1. 2 during infusion of arachidonic acid and collagen in rabbits. Prostaglandins, Leukotrienes and Essential Fatty Acids 41, 95-99.
2. Ernst, E., Weichmayr, T. and Matari, A. (1985) Garlic and blood lipids. Br. Med. J. 291, 139-143.
3. Jain, R.C. and Sachdev, K.M. (1971) A note on hypoglycemic action of onion in diabetes. Curr. Med. Pract. 15, 901-902.
4. Rashid, A. and Khan, H.H. (1985) The mechanism of hypotensive effect of garlic extract. J. Pak. Med. Assoc. 35, 357-362.
5. Rees, L.P., Minney, S.F., Plummer, N.Y., Slater, J.H. and Skyrme, D.A. (1993) A quantitative assessment of the antimicrobial activity of garlic (Allium sativum). Sch. Pure Appl. Biol. 9, 303-308.
6. Bordia, A., Verma, S.K., Vyas, A.K., Khabya, B.L., Rathore, A.S., Bhu, N. and Bedi, H.K. (1977) Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits. Atherosclerosis 26, 379-386.
7. Bordia, A., Joshi, H.K., Sandhya, Y.K. and Bhu, N. (1978) Effects of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery diseases. Atherosclerosis 28, 155-159.
8. Bordia, A. (1978) Effect of garlic on human platelet aggregation in vitro. Atherosclerosis 29, 355-360.
9. Makheja, A.N., Vanderhock, J.Y. and Bailey, J.M. (1979) Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. Lancet 1, 781.
10. Srivastava, K.C. (1984) Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in blood vascular system. In vitro study. Prostaglandins, Leukotrienes Med. 13, 277-235.
11. Srivastava, K.C. (1986) Evidence for the mechanism by which garlic inhibits platelet aggregation. Prostaglandins, Leukotrienes Med. 22, 313-321.
12. Ali, M. and Mohammad, S.Y. (1986) Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandins, Leukotrienes Med. 25, 139-146.
13. Nakagawa, S., Masamoto, K., Sumiyoshi, H., Kunihiro, K. and Fuwa, T. (1980) Effect of raw and extracted garlic juice on growth of young rats and their organs after peroral administration (Japanese). J. Toxicol. Sci. 5, 91-112.
14. Kanezawa, A., Nakagawa, S., Sumiyoshi, H., Masamoto, K. and Harada, H. (1984) General toxicity testing of a garlic extract preparation containing vitamins (Japanese). Oyo yakuri 27, 909-929.
15. Nakagawa, S., Masamoto, K., Sumiyoshi, H. and Harada, H. (1984) Acute toxicity test of garlic extract (Japanese). J. Toxicol. Sci. 9, 57-60.
16. Ruffin, J. and Hunter, S.A. (1983) An evaluation of the side effects of garlic as an antihypertensive agent. Cytobios 37, 85-89.
17. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
18. Hawkins, D.R. (1988-1992) Biotransformations: A survey of biotransformations of drugs and chemicals in animals, Vols. 1-4, Royal Society of Chemistry, London.
19. Dalvi, R.R. (1992) Alterations in hepatic Phase I and Phase II biotransformation enzymes by garlic oil in rats. Toxicol. Lett. 60, 299-305.
20. Ali, M., Afzal, M., Abdul, Y.S., Saleh, J.A., Gubler, C.J. and Dhami, M.S.I. (1991) Changes in the levels of lactic dehydrogenase and transketolase in liver and red cells of rats after treatment with garlic extracts. J. Environ. Sci. Health A26, 1-12.
21. Lybarger, J.A., Gallagher, J.S., Pulver, D.W., Litwin, A., Brooks, S. and Bernstein, I.L. (1982) Occupational asthma induced by inhalation and ingestion of garlic. J. Allergy Clin. Immunol. 69, 448-454.
22. Stoll, A. and Seeback, E. (1951) Chemical investigations of allicin, the specific principle of garlic. Adv. Enzymol. 11, 377-381.
23. Ali, M. and Thomson, M. (1995) Consumption of a garlic clove a day could be beneficial in preventing thrombosis. Prostaglandins, Leukotrienes and Essential Fatty Acids 53, 211-212.