Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2

Drug Metabolism and Disposition

Volumn 35, Issue 6, 2007, Pages 995-1000

  Fisher, Craig D ^a   Augustine, Lisa M ^a   Maher, Jonathan M ^b   Nelson, David M ^c   Slitt, Angela L ^d   Klaassen, Curtis D ^b   Lehman McKeeman, Lois D ^c   Cherrington, Nathan J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL SULFIDE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 2B6; DIALLYL DISULFIDE; DIALLYL TRISULFIDE; DRUG METABOLIZING ENZYME; GARLIC OIL; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; ENZYME ACTIVATION; ENZYME INDUCTION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION;

ALLYL COMPOUNDS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2B1; DISULFIDES; FEMALE; HERB-DRUG INTERACTIONS; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NAD(P)H DEHYDROGENASE (QUINONE); NADPH DEHYDROGENASE; NF-E2-RELATED FACTOR 2; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STEROID HYDROXYLASES; SULFIDES; TRANSCRIPTION FACTORS;

ALLIUM SATIVUM; MUS; RATTUS;

EID: 34249094270     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.014340     Document Type: Article

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