메뉴 건너뛰기




Volumn 43, Issue 7, 2011, Pages 981-989

Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect

Author keywords

Glycolysis; Hypoxia; Magnetic resonance; Mass spectroscopy; Metabolomics

Indexed keywords

CARBOHYDRATE; GLUTAMIC ACID; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR 1;

EID: 79958093404     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.08.009     Document Type: Article
Times cited : (103)

References (95)
  • 2
    • 1542344522 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 and oncogenic signalling
    • DOI 10.1002/bies.20002
    • J.I. Bárdos, and M. Ashcroft Hypoxia-inducible factor-1 and oncogenic signalling Bioessays 26 2004 262 269 (Pubitemid 38325667)
    • (2004) BioEssays , vol.26 , Issue.3 , pp. 262-269
    • Bardos, J.I.1    Ashcroft, M.2
  • 3
    • 33847307112 scopus 로고    scopus 로고
    • Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2
    • DOI 10.1074/jbc.M607065200
    • U. Berchner-Pfannschmidt, H. Yamac, B. Trinidad, and J. Fandrey Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2 J Biol Chem 282 2007 1788 1796 (Pubitemid 47076719)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.3 , pp. 1788-1796
    • Berchner-Pfannschmidt, U.1    Yamac, H.2    Trinidad, B.3    Fandrey, J.4
  • 6
    • 34250751339 scopus 로고    scopus 로고
    • Nitric oxide and superoxide: Interference with hypoxic signaling
    • DOI 10.1016/j.cardiores.2007.03.005, PII S0008636307001162
    • B. Brune, and J. Zhou Nitric oxide and superoxide: interference with hypoxic signaling Cardiovasc Res 75 2007 275 282 (Pubitemid 46961919)
    • (2007) Cardiovascular Research , vol.75 , Issue.2 , pp. 275-282
    • Brune, B.1    Zhou, J.2
  • 7
    • 0035399174 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
    • DOI 10.1006/excr.2001.5243
    • M.T. Canning, L.M. Postovit, S.H. Clarke, and C.H. Graham Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells Exp Cell Res 267 2001 88 94 (Pubitemid 32579144)
    • (2001) Experimental Cell Research , vol.267 , Issue.1 , pp. 88-94
    • Canning, M.T.1    Postovit, L.-M.2    Clarke, S.H.3    Graham, C.H.4
  • 8
    • 6344249084 scopus 로고    scopus 로고
    • Tumour cell growth in culture: Dependence on arginine
    • DOI 10.1042/CS20040096
    • G. Caso, M.A. McNurlan, N.D. McMillan, O. Eremin, and P.J. Garlick Tumour cell growth in culture: dependence on arginine Clin Sci (Lond) 107 2004 371 379 (Pubitemid 39389304)
    • (2004) Clinical Science , vol.107 , Issue.4 , pp. 371-379
    • Caso, G.1    McNurlan, M.A.2    McMillan, N.D.3    Eremin, O.4    Garlick, P.J.5
  • 9
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography-mass spectrometry (GC/MS)
    • E.C.Y. Chan Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography-mass spectrometry (GC/MS) J Proteome Res 8 2009 352 361
    • (2009) J Proteome Res , vol.8 , pp. 352-361
    • Chan, E.C.Y.1
  • 10
    • 34249006269 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α correlates with MET and metastasis in node-negative breast cancer
    • DOI 10.1007/s10549-006-9360-3
    • H.H.W. Chen, W.-C. Su, P.-W. Lin, H.-R. Guo, and W.-Y. Lee Hypoxia-inducible factor-1alpha correlates with MET and metastasis in node-negative breast cancer Breast Cancer Res Treat 103 2007 167 175 (Pubitemid 46789135)
    • (2007) Breast Cancer Research and Treatment , vol.103 , Issue.2 , pp. 167-175
    • Chen, H.H.W.1    Su, W.-C.2    Lin, P.-W.3    Guo, H.-R.4    Lee, W.-Y.5
  • 11
    • 69949132016 scopus 로고    scopus 로고
    • The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth
    • D. Corda The developmentally regulated osteoblast phosphodiesterase GDE3 is glycerophosphoinositol-specific and modulates cell growth J Biol Chem 284 2009 24848 24856
    • (2009) J Biol Chem , vol.284 , pp. 24848-24856
    • Corda, D.1
  • 12
    • 26844461245 scopus 로고    scopus 로고
    • 'Why do tumour cells glycolyse?': From glycolysis through citrate to lipogenesis
    • DOI 10.1007/s11010-005-8841-8
    • L.C. Costello, and R.B. Franklin 'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis Mol Cell Biochem 280 2005 1 8 (Pubitemid 41829794)
    • (2005) Molecular and Cellular Biochemistry , vol.280 , Issue.1-2 , pp. 1-8
    • Costello, L.C.1    Franklin, R.B.2
  • 15
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab 7 2008 11 20
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 16
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • N.C. Denko Hypoxia, HIF1 and glucose metabolism in the solid tumour Nat Rev Cancer 8 2008 705 713
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 17
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • DOI 10.1038/nrc2397, PII NRC2397
    • M.W. Dewhirst, Y. Cao, and B. Moeller Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response Nat Rev Cancer 8 2008 425 437 (Pubitemid 351744964)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 20
    • 55949125948 scopus 로고    scopus 로고
    • Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes
    • T.W.M. Fan Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes Mol Cancer 7 2008 79
    • (2008) Mol Cancer , vol.7 , pp. 79
    • Fan, T.W.M.1
  • 21
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • T.W.M. Fan Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM) Mol Cancer 8 2009 41
    • (2009) Mol Cancer , vol.8 , pp. 41
    • Fan, T.W.M.1
  • 22
    • 0028141627 scopus 로고
    • Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: Specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine
    • B.E. Felouati, J.F. Pageaux, J.M. Fayard, M. Lagarde, and C. Laugier Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine Biochem J 301 1994 361 366 (Pubitemid 24231935)
    • (1994) Biochemical Journal , vol.301 , Issue.2 , pp. 361-366
    • Felouati, B.-E.1    Pageaux, J.-F.2    Fayard, J.-M.3    Lagarde, M.4    Laugier, C.5
  • 23
    • 60249085118 scopus 로고    scopus 로고
    • Mitochondria in cancer: Not just innocent bystanders
    • C. Frezza, and E. Gottlieb Mitochondria in cancer: not just innocent bystanders Semin Cancer Biol 19 2009 4 11
    • (2009) Semin Cancer Biol , vol.19 , pp. 4-11
    • Frezza, C.1    Gottlieb, E.2
  • 26
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • DOI 10.1038/nrc1478
    • R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4 2004 891 899 (Pubitemid 39472955)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 27
    • 33847183528 scopus 로고    scopus 로고
    • Biomolecular profiling of metastatic prostate cancer cells in bone marrow tissue using FTIR microspectroscopy: A pilot study
    • E. Gazi Biomolecular profiling of metastatic prostate cancer cells in bone marrow tissue using FTIR microspectroscopy: a pilot study Anal Bioanal Chem 387 2007 1621 1631
    • (2007) Anal Bioanal Chem , vol.387 , pp. 1621-1631
    • Gazi, E.1
  • 30
    • 28544446058 scopus 로고    scopus 로고
    • Mitochondrial tumour suppressors: A genetic and biochemical update
    • DOI 10.1038/nrc1737
    • E. Gottlieb, and I.P. Tomlinson Mitochondrial tumour suppressors: a genetic and biochemical update Nat Rev Cancer 5 2005 857 866 (Pubitemid 41746030)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.11 , pp. 857-866
    • Gottlieb, E.1    Tomlinson, I.P.M.2
  • 31
    • 33847370301 scopus 로고    scopus 로고
    • Tumour metabolomics in animal models of human cancer
    • DOI 10.1021/pr060464h
    • J.L. Griffin, and R.A. Kauppinen Tumour metabolomics in animal models of human cancer J Proteome Res 6 2007 498 505 (Pubitemid 46340153)
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 498-505
    • Griffin, J.L.1    Kauppinen, R.A.2
  • 32
    • 3042823722 scopus 로고    scopus 로고
    • Metabolic profiles of cancer cells
    • J.L. Griffin, and J.P. Shockcor Metabolic profiles of cancer cells Nat Rev Cancer 4 2004 551 561 (Pubitemid 38868624)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.7 , pp. 551-561
    • Griffin, J.L.1    Shockcor, J.P.2
  • 34
    • 0038716692 scopus 로고    scopus 로고
    • Opportunities for studying cancer by metabolomics: Preliminary observations on tumors deficient in hypoxia-inducible factor 1
    • DOI 10.1016/S0065-2571(02)00030-4
    • J.R. Griffiths, and M. Stubbs Opportunities for studying cancer by metabolomics: preliminary observations on tumours deficient in hypoxia-inducible factor 1 Adv Enzyme Regul 43 2003 67 76 (Pubitemid 36872823)
    • (2003) Advances in Enzyme Regulation , vol.43 , pp. 67-76
    • Griffiths, J.R.1    Stubbs, M.2
  • 35
    • 54049123723 scopus 로고    scopus 로고
    • Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma
    • T. Hamaguchi Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma Int J Oncol 33 2008 725 731
    • (2008) Int J Oncol , vol.33 , pp. 725-731
    • Hamaguchi, T.1
  • 36
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat Rev Cancer 2 2002 38 47 (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 37
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • DOI 10.1038/nrc1456
    • C.H. Heldin, K. Rubin, K. Pietras, and A. Ostman High interstitial fluid pressure - an obstacle in cancer therapy Nat Rev Cancer 4 2004 806 813 (Pubitemid 39331152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 38
    • 66349095388 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
    • A. Hirayama Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry Cancer Res 69 2009 4918 4925
    • (2009) Cancer Res , vol.69 , pp. 4918-4925
    • Hirayama, A.1
  • 39
    • 0035984647 scopus 로고    scopus 로고
    • Going malignant: The hypoxia-cancer connection in the prostate
    • DOI 10.1002/bies.10131
    • P.W. Hochachka, J.L. Rupert, L. Goldenberg, M. Gleave, and P. Kozlowski Going malignant: the hypoxia-cancer connection in the prostate Bioessays 24 2002 749 757 (Pubitemid 34850332)
    • (2002) BioEssays , vol.24 , Issue.8 , pp. 749-757
    • Hochachka, P.W.1    Rupert, J.L.2    Goldenberg, L.3    Gleave, M.4    Kozlowski, P.5
  • 40
    • 43449095001 scopus 로고    scopus 로고
    • Increased chemosensitivity and elevated reactive oxygen species are mediated by glutathione reduction in glutamine deprived neuroblastoma cells
    • S. Izaki, H. Goto, and S. Yokota Increased chemosensitivity and elevated reactive oxygen species are mediated by glutathione reduction in glutamine deprived neuroblastoma cells J Cancer Res Clin Oncol 134 2008 761 768
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 761-768
    • Izaki, S.1    Goto, H.2    Yokota, S.3
  • 41
    • 27844601569 scopus 로고    scopus 로고
    • Metabolite changes in HT-29 xenograft tumors following HIF-1α inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo
    • DOI 10.1002/nbm.977
    • B.F. Jordan, K. Black, I.F. Robey, M. Runquist, G. Powis, and R.J. Gillies Metabolite changes in HT-29 xenograft tumours following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo NMR Biomed 18 2005 430 439 (Pubitemid 41646184)
    • (2005) NMR in Biomedicine , vol.18 , Issue.7 , pp. 430-439
    • Jordan, B.F.1    Black, K.2    Robey, I.F.3    Runquist, M.4    Powis, G.5    Gillies, R.J.6
  • 42
    • 40749118374 scopus 로고    scopus 로고
    • Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants-Hakomori's concepts revisited
    • DOI 10.1016/j.bbagen.2007.10.007, PII S0304416507002395
    • R. Kannagi, J. Yin, K. Miyazaki, and M. Izawa Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants - Hakomori's concepts revisited Biochim Biophys Acta 1780 2008 525 531 (Pubitemid 351381253)
    • (2008) Biochimica et Biophysica Acta - General Subjects , vol.1780 , Issue.3 , pp. 525-531
    • Kannagi, R.1    Yin, J.2    Miyazaki, K.3    Izawa, M.4
  • 43
    • 46049114875 scopus 로고    scopus 로고
    • DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer
    • Y.I. Kawamura DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer Gastroenterology 135 2008 142-51.e3
    • (2008) Gastroenterology , vol.135
    • Kawamura, Y.I.1
  • 44
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factors, Stem Cells, and Cancer
    • DOI 10.1016/j.cell.2007.04.019, PII S0092867407005259
    • B. Keith, and M.C. Simon Hypoxia-inducible factors, stem cells, and cancer Cell 129 2007 465 472 (Pubitemid 46660978)
    • (2007) Cell , vol.129 , Issue.3 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 45
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • J. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab 3 2006 177 185
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 46
    • 0035107731 scopus 로고    scopus 로고
    • Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells
    • DOI 10.1046/j.1471-4159.2001.00214.x
    • S. Kobayashi, and D.E. Millhorn Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells J Neurochem 76 2001 1935 1948 (Pubitemid 32221134)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.6 , pp. 1935-1948
    • Kobayashi, S.1    Millhorn, D.E.2
  • 48
    • 77953230908 scopus 로고    scopus 로고
    • 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells
    • S. Krishnamoorthy 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells Exp Cell Res 316 2010 1706 1715
    • (2010) Exp Cell Res , vol.316 , pp. 1706-1715
    • Krishnamoorthy, S.1
  • 51
    • 27644477840 scopus 로고    scopus 로고
    • Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1α in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells
    • DOI 10.1158/1078-0432.CCR-04-2530
    • S.J. Kwon, and Y.J. Lee Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells Clin Cancer Res 11 2005 4694 4700 (Pubitemid 41557187)
    • (2005) Clinical Cancer Research , vol.11 , Issue.13 , pp. 4694-4700
    • Kwon, S.J.1    Lee, Y.J.2
  • 52
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • DOI 10.1128/MCB.21.12.3995-4004.2001
    • E. Laughner, P. Taghavi, K. Chiles, P.C. Mahon, and G.L. Semenza HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol 21 2001 3995 4004 (Pubitemid 32476461)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.12 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 53
    • 40549137783 scopus 로고    scopus 로고
    • Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways
    • DOI 10.1111/j.1365-2184.2008.00516.x
    • S.H. Lee, M.Y. Lee, and H.J. Han Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways Cell Prolif 41 2008 230 247 (Pubitemid 351367492)
    • (2008) Cell Proliferation , vol.41 , Issue.2 , pp. 230-247
    • Lee, S.H.1    Lee, M.Y.2    Han, H.J.3
  • 54
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • DOI 10.1074/jbc.M202487200
    • H. Lu, R.A. Forbes, and A. Verma Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis J Biol Chem 277 2002 23111 23115 (Pubitemid 34952134)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.26 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 55
    • 0442313668 scopus 로고    scopus 로고
    • Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
    • DOI 10.1007/s00280-003-0724-7
    • J.C. Maher, A. Krishan, and T.J. Lampidis Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumour cells treated under hypoxic vs aerobic conditions Cancer Chemother Pharmacol 53 2004 116 122 (Pubitemid 38186989)
    • (2004) Cancer Chemotherapy and Pharmacology , vol.53 , Issue.2 , pp. 116-122
    • Maher, J.C.1    Krishan, A.2    Lampidis, T.J.3
  • 59
    • 60249083822 scopus 로고    scopus 로고
    • Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "warburg effect" and a pivotal target for effective therapy
    • S.P. Mathupala, Y.H. Ko, and P.L. Pedersen Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg effect" and a pivotal target for effective therapy Semin Cancer Biol 19 2009 17 24
    • (2009) Semin Cancer Biol , vol.19 , pp. 17-24
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 60
    • 33646856626 scopus 로고    scopus 로고
    • Differential expression proteomics of human colon cancer
    • R. Mazzanti Differential expression proteomics of human colon cancer Am J Physiol Gastrointest Liver Physiol 290 2006 G1329-1338
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. 1329-1338
    • Mazzanti, R.1
  • 61
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • G. Medes, A. Thomas, and S. Weinhouse Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro Cancer Res 13 1953 27 29
    • (1953) Cancer Res , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 62
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • DOI 10.1038/nrc2222, PII NRC2222
    • J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat Rev Cancer 7 2007 763 777 (Pubitemid 47469806)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 63
    • 34247860855 scopus 로고    scopus 로고
    • Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    • K. Mikuriya Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry Int J Oncol 30 2007 849 855
    • (2007) Int J Oncol , vol.30 , pp. 849-855
    • Mikuriya, K.1
  • 64
    • 0037086084 scopus 로고    scopus 로고
    • Melanoma tumors acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumor samples
    • D. Morvan, A. Demidem, J. Papon, M. De Latour, and J.C. Madelmont Melanoma tumours acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumour samples Cancer Res 62 2002 1890 1897 (Pubitemid 34408518)
    • (2002) Cancer Research , vol.62 , Issue.6 , pp. 1890-1897
    • Morvan, D.1    Demidem, A.2    Papon, J.3    De Latour, M.4    Claude Madelmont, J.5
  • 65
    • 33646153307 scopus 로고    scopus 로고
    • Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation
    • U.M. Muñoz-Nájar, K.M. Neurath, F. Vumbaca, and Claffey KP Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation Oncogene 25 2006 2379 2392
    • (2006) Oncogene , vol.25 , pp. 2379-2392
    • Muñoz-Nájar, U.M.1    Neurath, K.M.2    Vumbaca, F.3    Claffey, K.P.4
  • 66
    • 66449130218 scopus 로고    scopus 로고
    • Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
    • S. Nanni Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer J Clin Invest 119 2009 1093 1108
    • (2009) J Clin Invest , vol.119 , pp. 1093-1108
    • Nanni, S.1
  • 67
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • DOI 10.1074/jbc.R200006200
    • O.E. Owen, S.C. Kalhan, and R.W. Hanson The key role of anaplerosis and cataplerosis for citric acid cycle function J Biol Chem 277 2002 30409 30412 (Pubitemid 34970728)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 68
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • I. Papandreou, R.A. Cairns, L. Fontana, A.L. Lim, and Denko NC HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab 3 2006 187 197
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 69
    • 33846345278 scopus 로고    scopus 로고
    • Exploiting hypoxia in solid tumors to achieve oncolysis
    • DOI 10.1016/j.mehy.2006.09.013, PII S030698770600644X
    • A.G. Payne Exploiting hypoxia in solid tumours to achieve oncolysis Med Hypotheses 68 2007 828 831 (Pubitemid 46136784)
    • (2007) Medical Hypotheses , vol.68 , Issue.4 , pp. 828-831
    • Payne, A.G.1
  • 70
    • 33744951504 scopus 로고    scopus 로고
    • Regulation of ornithine decarboxylase
    • DOI 10.1074/jbc.R500031200
    • A.E. Pegg Regulation of ornithine decarboxylase J Biol Chem 281 2006 14529 14532 (Pubitemid 43855154)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 14529-14532
    • Pegg, A.E.1
  • 71
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • DOI 10.1038/sj.onc.1209597, PII 1209597
    • H. Pelicano, D.S. Martin, R. Xu, -H, and P. Huang Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646 (Pubitemid 44187614)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.-H.3    Huang, P.4
  • 73
    • 64849087954 scopus 로고    scopus 로고
    • Cancer: Puzzling patterns of predisposition
    • P.J. Pollard, and Ratcliffe PJ Cancer: puzzling patterns of predisposition Science 324 2009 192 194
    • (2009) Science , vol.324 , pp. 192-194
    • Pollard, P.J.1    Ratcliffe, P.J.2
  • 74
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • DOI 10.1038/nature04871, PII NATURE04871
    • J. Pouysségur, F. Dayan, and Mazure NM Hypoxia signalling in cancer and approaches to enforce tumour regression Nature 441 2006 437 443 (Pubitemid 44050138)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 76
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the "warburg kinase"? - Akt-energy metabolism interactions and oncogenesis
    • R.B. Robey, and N. Hay Is Akt the "Warburg kinase"? - Akt-energy metabolism interactions and oncogenesis Semin Cancer Biol 19 2009 25 31
    • (2009) Semin Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 77
    • 68349135032 scopus 로고    scopus 로고
    • Regulation of autophagy through multiple independent hypoxic signaling pathways
    • K.M.A. Rouschop, and B.G. Wouters Regulation of autophagy through multiple independent hypoxic signaling pathways Curr Mol Med 9 2009 417 424
    • (2009) Curr Mol Med , vol.9 , pp. 417-424
    • Rouschop, K.M.A.1    Wouters, B.G.2
  • 78
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • G.L. Semenza Regulation of cancer cell metabolism by hypoxia-inducible factor 1 Semin Cancer Biol 19 2009 12 16
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 80
    • 0024311955 scopus 로고
    • Modulation of prostaglandin biosynthesis in hypoxic murine mammary adenocarcinoma cells by misonidazole
    • D.R. Shalinsky, D.B. McNamara, and K.C. Agrawal Modulation of prostaglandin biosynthesis in hypoxic murine mammary adenocarcinoma cells by misonidazole Cancer Res 49 1989 3853 3856 (Pubitemid 19197410)
    • (1989) Cancer Research , vol.49 , Issue.14 , pp. 3853-3856
    • Shalinsky, D.R.1    McNamara, D.B.2    Agrawal, K.C.3
  • 81
    • 34247121454 scopus 로고    scopus 로고
    • Hypoxia upregulates amino acid transport in a human neuroblastoma cell line
    • DOI 10.1016/j.jpedsurg.2006.12.010, PII S0022346806009407
    • H. Soh, M. Wasa, and M. Fukuzawa Hypoxia upregulates amino acid transport in a human neuroblastoma cell line J Pediatr Surg 42 2007 608 612 (Pubitemid 46589519)
    • (2007) Journal of Pediatric Surgery , vol.42 , Issue.4 , pp. 608-612
    • Soh, H.1    Wasa, M.2    Fukuzawa, M.3
  • 82
    • 52949145571 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells
    • S. Suzuki, A. Oguro, M. Osada-Oka, Y. Funae, and S. Imaoka Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells J Pharmacol Sci 108 2008 79 88
    • (2008) J Pharmacol Sci , vol.108 , pp. 79-88
    • Suzuki, S.1    Oguro, A.2    Osada-Oka, M.3    Funae, Y.4    Imaoka, S.5
  • 83
    • 60849139085 scopus 로고    scopus 로고
    • Metabolic enzymes as oncogenes or tumour suppressors
    • C.B. Thompson Metabolic enzymes as oncogenes or tumour suppressors N Engl J Med 360 2009 813 815
    • (2009) N Engl J Med , vol.360 , pp. 813-815
    • Thompson, C.B.1
  • 84
    • 67349284054 scopus 로고    scopus 로고
    • Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m
    • V.P. Tissot, and C. Martha Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m Free Radic Biol Med 46 2009 1551 1557
    • (2009) Free Radic Biol Med , vol.46 , pp. 1551-1557
    • Tissot, V.P.1    Martha, C.2
  • 85
    • 38449095968 scopus 로고    scopus 로고
    • Measurement of eicosanoids in cancer tissues
    • D. Wang, and R.N. DuBois Measurement of eicosanoids in cancer tissues Meth Enzymol 433 2007 27 50
    • (2007) Meth Enzymol , vol.433 , pp. 27-50
    • Wang, D.1    Dubois, R.N.2
  • 86
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • D. Wang, and R.N. DuBois Eicosanoids and cancer Nat Rev Cancer 10 2010 181 193
    • (2010) Nat Rev Cancer , vol.10 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 87
    • 47049089532 scopus 로고    scopus 로고
    • Nitric oxide, apoptosis and macrophage polarization during tumour progression
    • A. Weigert, and B. Brune Nitric oxide, apoptosis and macrophage polarization during tumour progression Nitric Oxide 19 2008 95 102
    • (2008) Nitric Oxide , vol.19 , pp. 95-102
    • Weigert, A.1    Brune, B.2
  • 89
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • B.G. Wouters, and M. Koritzinsky Hypoxia signalling through mTOR and the unfolded protein response in cancer Nat Rev Cancer 8 2008 851 864
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 90
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • R.-H. Xu Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia Cancer Res 65 2005 613 621
    • (2005) Cancer Res , vol.65 , pp. 613-621
    • Xu, R.-H.1
  • 91
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis - The seventh hallmark of cancer
    • S.J. Yeung, J. Pan, and M.-H. Lee Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer Cell Mol Life Sci 65 2008 3981 3999
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.-H.3
  • 92
    • 77951887561 scopus 로고    scopus 로고
    • Altered sphingolipid metabolism induced by tumour hypoxia - New vistas in glycolipid tumour markers
    • J. Yin, K. Miyazaki, R.L. Shaner, A.H. Merrill, and R. Kannagi Altered sphingolipid metabolism induced by tumour hypoxia - new vistas in glycolipid tumour markers FEBS Lett 584 2010 1872 1878
    • (2010) FEBS Lett , vol.584 , pp. 1872-1878
    • Yin, J.1    Miyazaki, K.2    Shaner, R.L.3    Merrill, A.H.4    Kannagi, R.5
  • 93
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • S. Zhao Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha Science 324 2009 261 265
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1
  • 94
    • 60249087212 scopus 로고    scopus 로고
    • The Warburg effect returns to the cancer stage
    • B. Zhivotovsky, and S. Orrenius The Warburg effect returns to the cancer stage Semin Cancer Biol 19 2009 1 3
    • (2009) Semin Cancer Biol , vol.19 , pp. 1-3
    • Zhivotovsky, B.1    Orrenius, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.