-
1
-
-
8344237449
-
Hydroxylation of HIF-1: oxygen sensing at the molecular level
-
Semenza G.L. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19 (2004) 176-182
-
(2004)
Physiology (Bethesda)
, vol.19
, pp. 176-182
-
-
Semenza, G.L.1
-
2
-
-
0037098081
-
How oxygen makes its presence felt
-
Kaelin Jr. W.G. How oxygen makes its presence felt. Genes Dev. 16 (2002) 1441-1445
-
(2002)
Genes Dev.
, vol.16
, pp. 1441-1445
-
-
Kaelin Jr., W.G.1
-
3
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: role of the HIF system
-
Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
4
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
-
5
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
-
Ivan M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 (2001) 464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
-
6
-
-
17944375360
-
EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., et al. EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107 (2001) 43-54
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
-
7
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R.K., and McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 (2001) 1337-1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
8
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
9
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
-
Salceda S., and Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J. Biol. Chem. 272 (1997) 22642-22647
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
10
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang L.E., Gu J., Schau M., and Bunn H.F. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA 95 (1998) 7987-7992
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
11
-
-
0029038392
-
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes
-
Roach P.L., Clifton I.J., Fulop V., Harlos K., Barton G.J., Hajdu J., et al. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature 375 (1995) 700-704
-
(1995)
Nature
, vol.375
, pp. 700-704
-
-
Roach, P.L.1
Clifton, I.J.2
Fulop, V.3
Harlos, K.4
Barton, G.J.5
Hajdu, J.6
-
12
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M., Koivunen P., Gunzler V., Kivirikko K.I., and Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278 (2003) 30772-30780
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
13
-
-
4544346656
-
JunD reduces tumor angiogenesis by protecting cells from oxidative stress
-
Gerald D., Berra E., Frapart Y.M., Chan D.A., Giaccia A.J., Mansuy D., et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118 (2004) 781-794
-
(2004)
Cell
, vol.118
, pp. 781-794
-
-
Gerald, D.1
Berra, E.2
Frapart, Y.M.3
Chan, D.A.4
Giaccia, A.J.5
Mansuy, D.6
-
14
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch
-
Lando D., Peet D.J., Whelan D.A., Gorman J.J., and Whitelaw M.L. Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295 (2002) 858-861
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
15
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
16
-
-
4944246547
-
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
-
Greijer A.E., and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J. Clin. Pathol. 57 (2004) 1009-1014
-
(2004)
J. Clin. Pathol.
, vol.57
, pp. 1009-1014
-
-
Greijer, A.E.1
van der Wall, E.2
-
17
-
-
0029944122
-
Angiostatin induces and sustains dormancy of human primary tumors in mice
-
O'Reilly M.S., Holmgren L., Chen C., and Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2 (1996) 689-692
-
(1996)
Nat. Med.
, vol.2
, pp. 689-692
-
-
O'Reilly, M.S.1
Holmgren, L.2
Chen, C.3
Folkman, J.4
-
18
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., and Neckers L.M. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392 (1998) 405-408
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
19
-
-
0032535077
-
Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction
-
Wenger R.H., Camenisch G., Desbaillets I., Chilov D., and Gassmann M. Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction. Cancer Res. 58 (1998) 5678-5680
-
(1998)
Cancer Res.
, vol.58
, pp. 5678-5680
-
-
Wenger, R.H.1
Camenisch, G.2
Desbaillets, I.3
Chilov, D.4
Gassmann, M.5
-
20
-
-
0035140981
-
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
-
Koumenis C., Alarcon R., Hammond E., Sutphin P., Hoffman W., Murphy M., et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol. Cell. Biol. 21 (2001) 1297-1310
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1297-1310
-
-
Koumenis, C.1
Alarcon, R.2
Hammond, E.3
Sutphin, P.4
Hoffman, W.5
Murphy, M.6
-
21
-
-
0038795317
-
Hypoxia attenuates the p53 response to cellular damage
-
Achison M., and Hupp T.R. Hypoxia attenuates the p53 response to cellular damage. Oncogene 22 (2003) 3431-3440
-
(2003)
Oncogene
, vol.22
, pp. 3431-3440
-
-
Achison, M.1
Hupp, T.R.2
-
22
-
-
3042779529
-
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
-
Pan Y., Oprysko P.R., Asham A.M., Koch C.J., and Simon M.C. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 23 (2004) 4975-4983
-
(2004)
Oncogene
, vol.23
, pp. 4975-4983
-
-
Pan, Y.1
Oprysko, P.R.2
Asham, A.M.3
Koch, C.J.4
Simon, M.C.5
-
23
-
-
0036678830
-
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53
-
Hansson L.O., Friedler A., Freund S., Rudiger S., and Fersht A.R. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc. Natl Acad. Sci. USA 99 (2002) 10305-10309
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 10305-10309
-
-
Hansson, L.O.1
Friedler, A.2
Freund, S.3
Rudiger, S.4
Fersht, A.R.5
-
24
-
-
0038529602
-
Direct interactions between HIF-1alpha and Mdm2 modulate p53 function
-
Chen D., Li M., Luo J., and Gu W. Direct interactions between HIF-1alpha and Mdm2 modulate p53 function. J. Biol. Chem. 278 (2003) 13595-13598
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13595-13598
-
-
Chen, D.1
Li, M.2
Luo, J.3
Gu, W.4
-
25
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14 (2000) 34-44
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
-
26
-
-
2642574174
-
p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)
-
Schmid T., Zhou J., Kohl R., and Brune B. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem. J. 380 (2004) 289-295
-
(2004)
Biochem. J.
, vol.380
, pp. 289-295
-
-
Schmid, T.1
Zhou, J.2
Kohl, R.3
Brune, B.4
-
27
-
-
0032524285
-
p53 inhibits hypoxia-inducible factor-stimulated transcription
-
Blagosklonny M.V., An W.G., Romanova L.Y., Trepel J., Fojo T., and Neckers L. p53 inhibits hypoxia-inducible factor-stimulated transcription. J. Biol. Chem. 273 (1998) 11995-11998
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11995-11998
-
-
Blagosklonny, M.V.1
An, W.G.2
Romanova, L.Y.3
Trepel, J.4
Fojo, T.5
Neckers, L.6
-
28
-
-
19944371176
-
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
-
Fei P., Wang W., Kim S.H., Wang S., Burns T.F., Sax J.K., et al. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 6 (2004) 597-609
-
(2004)
Cancer Cell
, vol.6
, pp. 597-609
-
-
Fei, P.1
Wang, W.2
Kim, S.H.3
Wang, S.4
Burns, T.F.5
Sax, J.K.6
-
29
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl Acad. Sci. USA 97 (2000) 9082-9087
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
30
-
-
0033942613
-
BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
-
Vande Velde C., Cizeau J., Dubik D., Alimonti J., Brown T., Israels S., et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol. Cell. Biol. 20 (2000) 5454-5468
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5454-5468
-
-
Vande Velde, C.1
Cizeau, J.2
Dubik, D.3
Alimonti, J.4
Brown, T.5
Israels, S.6
-
31
-
-
0043091971
-
BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
-
Kothari S., Cizeau J., McMillan-Ward E., Israels S.J., Bailes M., Ens K., et al. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22 (2003) 4734-4744
-
(2003)
Oncogene
, vol.22
, pp. 4734-4744
-
-
Kothari, S.1
Cizeau, J.2
McMillan-Ward, E.3
Israels, S.J.4
Bailes, M.5
Ens, K.6
-
32
-
-
3442888541
-
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
-
Okami J., Simeone D.M., and Logsdon C.D. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 64 (2004) 5338-5346
-
(2004)
Cancer Res.
, vol.64
, pp. 5338-5346
-
-
Okami, J.1
Simeone, D.M.2
Logsdon, C.D.3
-
33
-
-
0036789917
-
Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
-
Kubasiak L.A., Hernandez O.M., Bishopric N.H., and Webster K.A. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc. Natl Acad. Sci. USA 99 (2002) 12825-12830
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 12825-12830
-
-
Kubasiak, L.A.1
Hernandez, O.M.2
Bishopric, N.H.3
Webster, K.A.4
-
34
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., and Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61 (2001) 6669-6673
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
35
-
-
0346655211
-
BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
-
Kim J.Y., Ahn H.J., Ryu J.H., Suk K., and Park J.H. BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J. Exp. Med. 199 (2004) 113-124
-
(2004)
J. Exp. Med.
, vol.199
, pp. 113-124
-
-
Kim, J.Y.1
Ahn, H.J.2
Ryu, J.H.3
Suk, K.4
Park, J.H.5
-
36
-
-
17144416875
-
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment
-
Papandreou I., Krishna C., Kaper F., Cai D., Giaccia A.J., and Denko N.C. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res. 65 (2005) 3171-3178
-
(2005)
Cancer Res.
, vol.65
, pp. 3171-3178
-
-
Papandreou, I.1
Krishna, C.2
Kaper, F.3
Cai, D.4
Giaccia, A.J.5
Denko, N.C.6
-
37
-
-
0025994345
-
Protons in ischemia: where do they come from; where do they go to?
-
Dennis S.C., Gevers W., and Opie L.H. Protons in ischemia: where do they come from; where do they go to?. J. Mol. Cell. Cardiol. 23 (1991) 1077-1086
-
(1991)
J. Mol. Cell. Cardiol.
, vol.23
, pp. 1077-1086
-
-
Dennis, S.C.1
Gevers, W.2
Opie, L.H.3
-
38
-
-
0021111735
-
Protons and anaerobiosis
-
Hochachka P.W., and Mommsen T.P. Protons and anaerobiosis. Science 219 (1983) 1391-1397
-
(1983)
Science
, vol.219
, pp. 1391-1397
-
-
Hochachka, P.W.1
Mommsen, T.P.2
-
39
-
-
11244305854
-
Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury
-
Zheng M., Reynolds C., Jo S.H., Wersto R., Han Q., and Xiao R.P. Intracellular acidosis-activated p38 MAPK signaling and its essential role in cardiomyocyte hypoxic injury. FASEB J. 19 (2005) 109-111
-
(2005)
FASEB J.
, vol.19
, pp. 109-111
-
-
Zheng, M.1
Reynolds, C.2
Jo, S.H.3
Wersto, R.4
Han, Q.5
Xiao, R.P.6
-
40
-
-
0032728077
-
Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
-
Webster K.A., Discher D.J., Kaiser S., Hernandez O., Sato B., and Bishopric N.H. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. J. Clin. Invest. 104 (1999) 239-252
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 239-252
-
-
Webster, K.A.1
Discher, D.J.2
Kaiser, S.3
Hernandez, O.4
Sato, B.5
Bishopric, N.H.6
-
41
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell P.H., Dachs G.U., Gleadle J.M., Nicholls L.G., Harris A.L., Stratford I.J., et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94 (1997) 8104-8109
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
-
42
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression
-
Jiang B.H., Agani F., Passaniti A., and Semenza G.L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 57 (1997) 5328-5335
-
(1997)
Cancer Res.
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
43
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan H.E., Lo J., and Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17 (1998) 3005-3015
-
(1998)
EMBO J.
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
44
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 (1998) 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
-
45
-
-
8544229943
-
Enhancement of hypoxia-induced tumor cell death In vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
-
Zhang X., Kon T., Wang H., Li F., Huang Q., Rabbani Z.N., et al. Enhancement of hypoxia-induced tumor cell death In vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res. 64 (2004) 8139-8142
-
(2004)
Cancer Res.
, vol.64
, pp. 8139-8142
-
-
Zhang, X.1
Kon, T.2
Wang, H.3
Li, F.4
Huang, Q.5
Rabbani, Z.N.6
-
46
-
-
2942534846
-
Antiapoptotic action of hypoxia-inducible factor-1 alpha in human endothelial cells
-
Yu E.Z., Li Y.Y., Liu X.H., Kagan E., and McCarron R.M. Antiapoptotic action of hypoxia-inducible factor-1 alpha in human endothelial cells. Lab. Invest. 84 (2004) 553-561
-
(2004)
Lab. Invest.
, vol.84
, pp. 553-561
-
-
Yu, E.Z.1
Li, Y.Y.2
Liu, X.H.3
Kagan, E.4
McCarron, R.M.5
-
47
-
-
4143076004
-
Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas
-
Zhang Q., Zhang Z.F., Rao J.Y., Sato J.D., Brown J., Messadi D.V., and Le A.D. Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int. J. Cancer 111 (2004) 849-857
-
(2004)
Int. J. Cancer
, vol.111
, pp. 849-857
-
-
Zhang, Q.1
Zhang, Z.F.2
Rao, J.Y.3
Sato, J.D.4
Brown, J.5
Messadi, D.V.6
Le, A.D.7
-
48
-
-
0035418621
-
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
-
Akakura N., Kobayashi M., Horiuchi I., Suzuki A., Wang J., Chen J., et al. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res. 61 (2001) 6548-6554
-
(2001)
Cancer Res.
, vol.61
, pp. 6548-6554
-
-
Akakura, N.1
Kobayashi, M.2
Horiuchi, I.3
Suzuki, A.4
Wang, J.5
Chen, J.6
-
49
-
-
12144287046
-
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler J.T., Cawthorne C.J., Williams K.J., Koritzinsky M., Wouters B.G., Wilson C., et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol. Cell. Biol. 24 (2004) 2875-2889
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
Koritzinsky, M.4
Wouters, B.G.5
Wilson, C.6
-
50
-
-
0036083168
-
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Park S.Y., Billiar T.R., and Seol D.W. Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochem. Biophys. Res. Commun. 291 (2002) 150-153
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.291
, pp. 150-153
-
-
Park, S.Y.1
Billiar, T.R.2
Seol, D.W.3
-
51
-
-
0035378480
-
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
-
Dong Z., Venkatachalam M.A., Wang J., Patel Y., Saikumar P., Semenza G.L., et al. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J. Biol. Chem. 276 (2001) 18702-18709
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18702-18709
-
-
Dong, Z.1
Venkatachalam, M.A.2
Wang, J.3
Patel, Y.4
Saikumar, P.5
Semenza, G.L.6
-
52
-
-
15744369062
-
Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis
-
Piret J.P., Minet E., Cosse J.P., Ninane N., Debacq C., Raes M., and Michiels C. Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. J. Biol. Chem. 280 (2005) 9336-9344
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9336-9344
-
-
Piret, J.P.1
Minet, E.2
Cosse, J.P.3
Ninane, N.4
Debacq, C.5
Raes, M.6
Michiels, C.7
-
53
-
-
1542305379
-
Hypoxia selection of death-resistant cells. A role for Bcl-X(L)
-
Dong Z., and Wang J. Hypoxia selection of death-resistant cells. A role for Bcl-X(L). J. Biol. Chem. 279 (2004) 9215-9221
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9215-9221
-
-
Dong, Z.1
Wang, J.2
-
54
-
-
0034699326
-
Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
-
Baek J.H., Jang J.E., Kang C.M., Chung H.Y., Kim N.D., and Kim K.W. Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 19 (2000) 4621-4631
-
(2000)
Oncogene
, vol.19
, pp. 4621-4631
-
-
Baek, J.H.1
Jang, J.E.2
Kang, C.M.3
Chung, H.Y.4
Kim, N.D.5
Kim, K.W.6
-
55
-
-
0035313989
-
Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells
-
Liu W., Davis D.W., Ramirez K., McConkey D.J., and Ellis L.M. Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells. Int. J. Cancer 92 (2001) 26-30
-
(2001)
Int. J. Cancer
, vol.92
, pp. 26-30
-
-
Liu, W.1
Davis, D.W.2
Ramirez, K.3
McConkey, D.J.4
Ellis, L.M.5
-
56
-
-
12144287799
-
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
-
Rehman J., Traktuev D., Li J., Merfeld-Clauss S., Temm-Grove C.J., Bovenkerk J.E., et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109 (2004) 1292-1298
-
(2004)
Circulation
, vol.109
, pp. 1292-1298
-
-
Rehman, J.1
Traktuev, D.2
Li, J.3
Merfeld-Clauss, S.4
Temm-Grove, C.J.5
Bovenkerk, J.E.6
-
57
-
-
0141818115
-
Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells
-
Zhang S.X., Gozal D., Sachleben Jr. L.R., Rane M., Klein J.B., and Gozal E. Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells. FASEB J. 17 (2003) 1709-1711
-
(2003)
FASEB J.
, vol.17
, pp. 1709-1711
-
-
Zhang, S.X.1
Gozal, D.2
Sachleben Jr., L.R.3
Rane, M.4
Klein, J.B.5
Gozal, E.6
-
58
-
-
0242694963
-
The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-kappaB-dependent antiapoptotic pathway
-
Qi H., and Ohh M. The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-kappaB-dependent antiapoptotic pathway. Cancer Res. 63 (2003) 7076-7080
-
(2003)
Cancer Res.
, vol.63
, pp. 7076-7080
-
-
Qi, H.1
Ohh, M.2
-
59
-
-
19944432390
-
Hypoxia-induced neutrophil survival is mediated by HIF-1{alpha}-dependent NF-{kappa}B activity
-
Walmsley S.R., Print C., Farahi N., Peyssonnaux C., Johnson R.S., Cramer T., et al. Hypoxia-induced neutrophil survival is mediated by HIF-1{alpha}-dependent NF-{kappa}B activity. J. Exp. Med. 201 (2005) 105-115
-
(2005)
J. Exp. Med.
, vol.201
, pp. 105-115
-
-
Walmsley, S.R.1
Print, C.2
Farahi, N.3
Peyssonnaux, C.4
Johnson, R.S.5
Cramer, T.6
-
60
-
-
0035925098
-
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
-
Hockel M., and Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93 (2001) 266-276
-
(2001)
J. Natl Cancer Inst.
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
61
-
-
0037093946
-
Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells
-
Wang J.H., Wu Q.D., Bouchier-Hayes D., and Redmond H.P. Hypoxia upregulates Bcl-2 expression and suppresses interferon-gamma induced antiangiogenic activity in human tumor derived endothelial cells. Cancer 94 (2002) 2745-2755
-
(2002)
Cancer
, vol.94
, pp. 2745-2755
-
-
Wang, J.H.1
Wu, Q.D.2
Bouchier-Hayes, D.3
Redmond, H.P.4
-
62
-
-
0036882302
-
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
-
Piret J.P., Mottet D., Raes M., and Michiels C. CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann. NY Acad. Sci. 973 (2002) 443-447
-
(2002)
Ann. NY Acad. Sci.
, vol.973
, pp. 443-447
-
-
Piret, J.P.1
Mottet, D.2
Raes, M.3
Michiels, C.4
-
63
-
-
0038282482
-
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
-
Unruh A., Ressel A., Mohamed H.G., Johnson R.S., Nadrowitz R., Richter E., et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 22 (2003) 3213-3220
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
Johnson, R.S.4
Nadrowitz, R.5
Richter, E.6
-
64
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold D.M., Burri P., Beer K.T., Laissue J., Djonov V., Greiner R.H., and Semenza G.L. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61 (2001) 2911-2916
-
(2001)
Cancer Res.
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
Laissue, J.4
Djonov, V.5
Greiner, R.H.6
Semenza, G.L.7
-
65
-
-
0034896068
-
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy
-
Birner P., Schindl M., Obermair A., Breitenecker G., and Oberhuber G. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin. Cancer Res. 7 (2001) 1661-1668
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Breitenecker, G.4
Oberhuber, G.5
-
66
-
-
0035266307
-
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
-
Koukourakis M.I., Giatromanolaki A., Skarlatos J., Corti L., Blandamura S., Piazza M., et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res. 61 (2001) 1830-1832
-
(2001)
Cancer Res.
, vol.61
, pp. 1830-1832
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Skarlatos, J.3
Corti, L.4
Blandamura, S.5
Piazza, M.6
-
67
-
-
0342433777
-
Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
-
Volm M., and Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 20 (2000) 1527-1533
-
(2000)
Anticancer Res.
, vol.20
, pp. 1527-1533
-
-
Volm, M.1
Koomagi, R.2
|