Nonalcoholic Steatosis and Steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 4 44-4, 2001, Pages

  Clarke, S D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Fatty livers; Nuclear factor Y; Sterol regulatory element binding protein; Transcription

Indexed keywords

HEPATIC NUCLEAR FACTOR 4; NUCLEAR FACTOR; NUCLEAR FACTOR Y; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; POLYUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

DNA BINDING; FATTY ACID OXIDATION; FATTY LIVER; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMAN; LIPID OXIDATION; LIPOGENESIS; LIVER DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEATOSIS; TRANSCRIPTION REGULATION;

EID: 0034791616     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.4.g865     Document Type: Review

References (25)

1. Altered constitutive expression of fatty acid metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
2. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
3. Polyunsaturated fatty acid regulation of gene transcription: A mechanism to improve energy balance and insulin resistance
4. Cloning, expression, and nutritional regulation of the mammalian delta-6 desaturase
5. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase
6. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults
7. Fatty acid regulation of gene transcription
8. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-292 cells
9. Fatty acid CoA esters are ligands of hepatic nuclear factor-4α
10. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
11. Regulation of gene expression by dietary fat
12. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
13. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
14. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
15. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
16. Regulation of delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice
17. Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
18. Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle
19. Glucose regulation of rat liver fatty acid synthase gene transcription: Involvement of a unique carbohydrate responsive factor
20. The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)
21. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y and Sp1-binding sites
22. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids
23. Polyunsaturated fatty acids suppress hepatic sterol regulatory element binding protein-1 expression by accelerating transcript decay
24. The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function
25. Lipotoxic heart disease in obese rats: Implications for human obesity