Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients

Obesity

Volumn 15, Issue 1, 2007, Pages 24-31

  Elizondo, Alejandra ^a   Araya, Julia ^a   Rodrigo, Ramón ^a   Poniachik, Jaime ^b   Csendes, Attila ^b   Maluenda, Fernando ^b   Díaz, Juan C ^b   Signorini, Cinzia ^c   Sgherri, Cristiana ^c   Comportai, Mario ^c   Videla, Luis A ^a,d  

^a UNIVERSITY OF CHILE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^c UNIVERSITY OF SIENA   (Italy)

^d UNIVERSITY OF CHILE   (Chile)

Author keywords

Insulin resistance; Liver disease; Oxidative stress; Polyunsaturated fatty acids

Indexed keywords

ISOPROSTANE DERIVATIVE; PHOSPHOLIPID; UNSATURATED FATTY ACID;

ADULT; ARTICLE; BLOOD; CASE CONTROL STUDY; CHEMISTRY; ERYTHROCYTE; FATTY LIVER; HUMAN; LIVER; METABOLISM; MIDDLE AGED; OBESITY; OXIDATIVE STRESS;

ADULT; CASE-CONTROL STUDIES; ERYTHROCYTES; F2-ISOPROSTANES; FATTY ACIDS, UNSATURATED; FATTY LIVER; HUMANS; LIVER; MIDDLE AGED; OBESITY; OXIDATIVE STRESS; PHOSPHOLIPIDS;

EID: 33846868166     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.518     Document Type: Article

References (12)

1. Neuschwander-Tetri BA, Caldwell S. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37:1202-19.
2. Angulo P. Nonalcoholic fatty liver disease. New Engl J Med. 2002;346:1221-31.
3. Videla LA, Rodrigo R, Araya J, Poniachik J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to non-alcoholic fatty liver disease. Free Radic Biol Med. 2004;37:1499-507.
4. Saltiel AR, Khan CR. Insulin signaling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799-806.
5. Araya J, Rodrigo R, Videla LA, et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Land). 2004;106:635-43.
6. Clarke SD. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Am J Physiol Gastrointest Liver Physiol. 2001;281:0865-9.
7. Baylin A, Kabagambe EK, Siles X, Campos H. Adipose tissue biomarkers of fatty acid intake. Am J Clin Nutr. 2002; 76:750-7.
8. Delarue J, Lefoll C, Corporeau C, Lucas D. n-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev. 2004;44:289-99.
9. Das UN. A defect in the activity of Deltao and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins Leukot Essent Fatty Acids. 2005;72:343-50.
10. Videla LA, Rodrigo R, Orellana M, et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Land). 2004;106:261-8.
11. Connor WE, Neuringer M, Lin DS. Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res. 1990;31:237-47.
12. Makrides M, Neumann MA, Byard RW, Simmer K, Gibson RA. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr. 1994;60:189-94.