Structural insight into function and regulation of carnitine palmitoyltransferase

Cellular and Molecular Life Sciences

Volumn 66, Issue 15, 2009, Pages 2489-2501

  Rufer, Arne C ^a   Thoma, Ralf ^a   Hennig, Michael ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Carnitine palmitoyltransferase; Drug discovery; Enzyme isoforms; Malonyl CoA; Type 2 diabetes mellitus

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 2; CARNITINE PALMITOYLTRANSFERASE I; CARNITINE PALMITOYLTRANSFERASE INHIBITOR; CP 1975; ETOMOXIR; FATTY ACID; GLUCOSE; LIPID; PERHEXILINE; RO 250187; ST 1326; UNCLASSIFIED DRUG;

COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; GLUCONEOGENESIS; GLUCOSE METABOLISM; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE; NEUROTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; REVIEW;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; HUMANS; ISOENZYMES; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 67651003144     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-009-0035-1     Document Type: Review

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