Polyunsaturated fatty acid regulation of gene transcription: A molecular mechanism to improve the metabolic syndrome

Journal of Nutrition

Volumn 131, Issue 4, 2001, Pages 1129-1132

  Clarke, Steven D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Diabetes; Fatty acids; Sterol regulatory element binding protein; Transcription

Indexed keywords

NUCLEAR FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; POLYUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

DNA BINDING; DOWN REGULATION; FATTY ACID OXIDATION; GENE EXPRESSION; GLYCOLYSIS; LIPID OXIDATION; LIPOGENESIS; METABOLIC DISORDER; REVIEW; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0035066651     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.4.1129     Document Type: Review

References (38)

1. The fatty acid composition of skeletal muscle membrane phospholipid: Its relationship with the type of feeding and plasma glucose levels in young children
2. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
3. Polyunsaturated fatty acid regulation of gene transcription: A mechanism to improve energy balance and insulin resistance
4. Regulation of gene expression by dietary fat
5. Fatty acid regulation of gene transcription
6. Polyunsaturated fatty acid regulation of gene expression
7. Peroxisome proliferator-activated receptors: A family of lipid-activated transcription factors
8. The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)
9. Regulation of delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice
10. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults
11. Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle
12. Dietary intake of α-linolenic acid and risk of fatal ischemic heart disease among women
13. Dietary fish as a major component of a weight-loss diet: Effect on serum lipids, glucose, and insulin metabolism in overweight hypertensive subjects
14. The potency of polyunsaturated and saturated fats as short term inhibitors of hepatic lipogenesis
15. The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function
16. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
17. Fatty acids and eicosanoids regulate genes expression through direct interactions with peroxisome proliferator-activated receptors α and γ
18. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
19. Altered constitutive expression of fatty acid metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
20. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids
21. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
22. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
23. Lipotoxic heart disease in obese rats: Implications for human obesity
24. Cloning, expression, and nutritional regulation of the mammalian delta-6 desaturase
25. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase
26. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator activated receptor α
27. Improved insulin sensitivity by bezafibrate in rats: Relationship to fatty acid composition of skeletal muscle triglycerides
28. Nutritional and insulin regulation of leptin gene expression
29. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element binding protein
30. Sterol response element binding protein 1c (SREBP-1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription
31. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
32. Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
33. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
34. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-292 cells
35. Polyunsaturated fatty acids suppress hepatic sterol regulatory element binding protein-1 expression by acceleration transcript decay
36. Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase
37. Fatty acid CoA esters are ligands of hepatic nuclear factor-4α
38. Glucose regulation of rat liver fatty acid synthase gene transcription: Involvement of a unique carbohydrate responsive factor