Cholesterol-lowering effects of oat β-glucan

Nutrition Reviews

Volumn 69, Issue 6, 2011, Pages 299-309

  Othman, Rgia A ^a   Moghadasian, Mohammed H ^a   Jones, Peter J H ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Low density lipoprotein cholesterol; Oat; Oat glucan; Total cholesterol

Indexed keywords

BETA GLUCAN; BILE ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SHORT CHAIN FATTY ACID;

ARTICLE; BILLING AND CLAIMS; BLOOD VISCOSITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DIABETES MELLITUS; DIET SUPPLEMENTATION; DIETARY FIBER; DRUG DOSE REDUCTION; EVIDENCE BASED MEDICINE; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; MILK; MOLECULAR WEIGHT; OAT; PHYSICAL CHEMISTRY; RICE; RICE BRAN; UPREGULATION;

ANTICHOLESTEREMIC AGENTS; AVENA SATIVA; BETA-GLUCANS; DIETARY FIBER; HUMANS; HYPERCHOLESTEROLEMIA; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

AVENA;

EID: 79957924224     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2011.00401.x     Document Type: Article

References (72)

1. Sadiq Butt M, Tahir-Nadeem M, Khan MK, Shabir R, Butt MS. Oat: unique among the cereals. Eur J Nutr. 2008;47:68-79.
2. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999;69:30-42.
3. Berg A, Konig D, Deibert P, Grathwohl D, Baumstark MW, Franz IW. Effect of an oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. A controlled randomized lifestyle intervention study. Ann Nutr Metab. 2003;47:306-311.
4. U.S. Food and Drug Administration. FDA final rule for federal labeling: health claims; oats and coronary heart disease. Fed Regist. 1997;62:3584-3681.
5. Joint Health Claims Initiative. Final Report on a Generic Health Claim for Oats and Reduction of Blood Cholesterol 2004:Available at: Accessed 2 May 2011.
6. Chen J, Raymond K. Beta-glucans in the treatment of diabetes and associated cardiovascular risks. Vasc Health Risk Manag. 2008;4:1265-1272.
7. Maki KC, Galant R, Samuel P, etal. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. Eur J Clin Nutr. 2007;61:786-795.
8. Wang SC, Bligh SW, Zhu CL, etal. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity. J Agric Food Chem. 2008;56:2624-2629.
9. Murphy EA, Davis JM, Carmichael MD, Mayer EP, Ghaffar A. Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1188-R1194.
10. Erkkila AT, Lichtenstein AH. Fiber and cardiovascular disease risk: how strong is the evidence? J Cardiovasc Nurs. 2006;21:3-8.
11. Koskinen O, Villanen M, Korponay-Szabo I, Lindfors K, Maki M, Kaukinen K. Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. J Pediatr Gastroenterol Nutr. 2009;48:559-565.
12. Lund EK, Gee JM, Brown JC, Wood PJ, Johnson IT. Effect of oat gum on the physical properties of the gastrointestinal contents and on the uptake of D-galactose and cholesterol by rat small intestine in vitro. Br J Nutr. 1989;62:91-101.
13. Lia A, Hallmans G, Sandberg AS, Sundberg B, Aman P, Andersson H. Oat beta-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am J Clin Nutr. 1995;62:1245-1251.
14. Xiao CW. Health effects of soy protein and isoflavones in humans. J Nutr. 2008;138(Suppl):S1244-S1249.
15. United States Department of Health and Human Services, Food and Drug Administration. Health claims: oats and coronary heart disease - proposed rule. Fed Regist. 1996;61:296-337.
16. Kelly SA, Summerbell CD, Brynes A, Whittaker V, Frost G. Wholegrain cereals for coronary heart disease. Cochrane Database Syst Rev. 2007:CD005051.
17. Jadad AR, Moore RA, Carroll D, etal. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1-12.
18. Uusitupa MI, Miettinen TA, Sarkkinen ES, Ruuskanen E, Kervinen K, Kesaniemi YA. Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran. Eur J Clin Nutr. 1997;51:607-611.
19. Johnston LRH, Hunninghake DB, Schultz K, Westereng B. Cholesterol-lowering benefits of a whole grain oat ready to eat cereal. Nutr Clin Care. 1998;1:6-12.
20. Gerhardt AL, Gallo NB. Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. J Nutr. 1998;128:865-869.
21. Onning G, Wallmark A, Persson M, Akesson B, Elmstahl S, Oste R. Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia. Ann Nutr Metab. 1999;43:301-309.
22. Lovegrove JA, Clohessy A, Milon H, Williams CM. Modest doses of beta-glucan do not reduce concentrations of potentially atherogenic lipoproteins. Am J Clin Nutr. 2000;72:49-55.
23. Van Horn L, Liu K, Gerber J, etal. Oats and soy in lipid-lowering diets for women with hypercholesterolemia: is there synergy? J Am Diet Assoc. 2001;101:1319-1325.
24. Kabir M, Oppert JM, Vidal H, etal. Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metabolism. 2002;51:819-826.
25. Kerckhoffs DA, Hornstra G, Mensink RP. Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies. Am J Clin Nutr. 2003;78:221-227.
26. Maki KC, Shinnick F, Seeley MA, etal. Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults. J Nutr. 2003;133:808-813.
27. Frank J, Sundberg B, Kamal-Eldin A, Vessby B, Aman P. Yeast-leavened oat breads with high or low molecular weight beta-glucan do not differ in their effects on blood concentrations of lipids, insulin, or glucose in humans. J Nutr. 2004;134:1384-1388.
28. Biörklund M, van Rees A, Mensink RP, Onning G. Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with beta-glucans from oats or barley: a randomised dose-controlled trial. Eur J Clin Nutr. 2005;59:1272-1281.
29. Karmally W, Montez MG, Palmas W, etal. Cholesterol-lowering benefits of oat-containing cereal in Hispanic Americans. J Am Diet Assoc. 2005;105:967-970.
30. Chen J, He J, Wildman RP, Reynolds K, Streiffer RH, Whelton PK. A randomized controlled trial of dietary fiber intake on serum lipids. Eur J Clin Nutr. 2006;60:62-68.
31. Naumann E, van Rees AB, Onning G, Oste R, Wydra M, Mensink RP. Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations. Am J Clin Nutr. 2006;83:601-605.
32. Theuwissen E, Mensink RP. Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects. J Nutr. 2007;137:583-588.
33. Queenan KM, Stewart ML, Smith KN, Thomas W, Fulcher RG, Slavin JL. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutr J. 2007;6:6.
34. Anderson JW, Bridges SR. Plant-fibre metabolites alter hepatic glucose and lipid metabolism. Diabetes. 1981;30:133A.
35. Liatis S, Tsapogas P, Chala E, etal. Consumption of bread enriched with beta-glucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes. Diabetes Metab. 2009;35:115-120.
36. Beck EJ, Tapsell LC, Batterham MJ, Tosh SM, Huang XF. Oat beta-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women. Br J Nutr. 2010;103:1212-1222.
37. Cugnet-Anceau C, Nazare JA, Biorklund M, etal. A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects. Br J Nutr. 2010;103:422-428.
38. Kim SY, Song HJ, Lee YY, Cho KH, Roh YK. Biomedical issues of dietary fiber beta-glucan. J Korean Med Sci. 2006;21:781-789.
39. Wolever TM, Tosh SM, Gibbs AL, etal. Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr. 2010;92:723-732.
40. Cubeddu LX, Cubeddu RJ, Heimowitz T, Restrepo B, Lamas GA, Weinberg GB. Comparative lipid-lowering effects of policosanol and atorvastatin: a randomized, parallel, double-blind, placebo-controlled trial. Am Heart J. 2006;152:982.e1-982.e5.
41. Howard BV, Robbins DC, Sievers ML, etal. LDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: the Strong Heart Study. Arterioscler Thromb Vasc Biol. 2000;20:830-835.
42. Gould AL, Rossouw JE, Santanello NC, Heyse JF, Furberg CD. Cholesterol reduction yields clinical benefit: impact of statin trials. Circulation. 1998;97:946-952.
43. Reyna-Villasmil N, Bermudez-Pirela V, Mengual-Moreno E, etal. Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. Am J Ther. 2007;14:203-212.
44. Robitaille J, Fontaine-Bisson B, Couture P, Tchernof A, Vohl MC. Effect of an oat bran-rich supplement on the metabolic profile of overweight premenopausal women. Ann Nutr Metab. 2005;49:141-148.
45. Andersson A, Ruegg N, Aman P. Molecular weight distribution and content of water-extractable β-glucan in rye crisp bread. J Cereal Sci. 2008;47:399-406.
46. Wursch P, Pi-Sunyer FX. The role of viscous soluble fiber in the metabolic control of diabetes. A review with special emphasis on cereals rich in beta-glucan. Diabetes Care. 1997;20:1774-1780.
47. Keogh GF, Cooper GJ, Mulvey TB, etal. Randomized controlled crossover study of the effect of a highly beta-glucan-enriched barley on cardiovascular disease risk factors in mildly hypercholesterolemic men. Am J Clin Nutr. 2003;78:711-718.
48. Juvonen KR, Purhonen AK, Salmenkallio-Marttila M, etal. Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans. J Nutr. 2009;139:461-466.
49. Chang YJ, Lee S, Yoo MA, Lee HG. Structural and biological characterization of sulfated-derivatized oat beta-glucan. J Agric Food Chem. 2006;54:3815-3818.
50. Tosh SM, Brummer Y, Miller SS, etal. Processing affects the physicochemical properties of beta-glucan in oat bran cereal. J Agric Food Chem. 2010;58:7723-7730.
51. Wilson TA, Nicolosi RJ, Delaney B, etal. Reduced and high molecular weight barley beta-glucans decrease plasma total and non-HDL-cholesterol in hypercholesterolemic Syrian golden hamsters. J Nutr. 2004;134:2617-2622.
52. Bae IY, Lee S, Kim SM, Lee HG. Effect of partially hydrolyzed oat beta-glucan on the weight gain and lipid profile of mice. Food Hydrocol. 2009;23:2016-2021.
53. Bae IY, Kim SM, Lee S, Lee HG. Effect of enzymatic hydrolysis on cholesterol-lowering activity of oat beta-glucan. N Biotechnol. 2010;27:85-88.
54. Andersson KE, Immerstrand T, Sward K, etal. Effects of oats on plasma cholesterol and lipoproteins in C57BL/6 mice are substrain specific. Br J Nutr. 2010;103:513-521.
55. Andersson KE, Svedberg KA, Lindholm MW, Oste R, Hellstrand P. Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice. Atherosclerosis. 2010;212:93-99.
56. Immerstrand T, Andersson KE, Wange C, etal. Effects of oat bran, processed to different molecular weights of beta-glucan, on plasma lipids and caecal formation of SCFA in mice. Br J Nutr. 2010;104:364-373.
57. Braaten JT, Wood PJ, Scott FW, etal. Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects. Eur J Clin Nutr. 1994;48:465-474.
58. Biörklund M, Holm J, Onning G. Serum lipids and postprandial glucose and insulin levels in hyperlipidemic subjects after consumption of an oat beta-glucan-containing ready meal. Ann Nutr Metab. 2008;52:83-90.
59. Park SY, Bae IY, Lee S, Lee HG. Physicochemical and hypocholesterolemic characterization of oxidized oat beta-glucan. J Agric Food Chem. 2009;57:439-443.
60. Horton JD, Cuthbert JA, Spady DK. Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster. J Clin Invest. 1994;93:2084-2092.
61. Chen JHX. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol. 2009;3:154-158.
62. Reihner E, Angelin B, Rudling M, Ewerth S, Bjorkhem I, Einarsson K. Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients. J Lipid Res. 1990;31:2219-2226.
63. Fernandez ML. Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium. J Lipid Res. 1995;36:2394-2404.
64. Roy S, Vega-Lopez S, Fernandez ML. Gender and hormonal status affect the hypolipidemic mechanisms of dietary soluble fiber in guinea pigs. J Nutr. 2000;130:600-607.
65. Andersson M, Ellegard L, Andersson H. Oat bran stimulates bile acid synthesis within 8h as measured by 7alpha-hydroxy-4-cholesten-3-one. Am J Clin Nutr. 2002;76:1111-1116.
66. Ellegard L, Andersson H. Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. Eur J Clin Nutr. 2007;61:938-945.
67. Drozdowski LA, Reimer RA, Temelli F, Bell RC, Vasanthan T, Thomson AB. Beta-glucan extracts inhibit the in vitro intestinal uptake of long-chain fatty acids and cholesterol and down-regulate genes involved in lipogenesis and lipid transport in rats. J Nutr Biochem. 2010;21:695-701.
68. Burton-Freeman B. Dietary fiber and energy regulation. J Nutr. 2000;130(Suppl):S272-S275.
69. Beck EJ, Tosh SM, Batterham MJ, Tapsell LC, Huang XF. Oat beta-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects. Mol Nutr Food Res. 2009;53:1343-1351.
70. Lyly M, Ohls N, Lähteenmäki L, etal. The effect of fibre amount, energy level and viscosity of beverages containing oat fibre supplement on perceived satiety. Food Nutr Res. 2010;54. doi: 10.3402/fnr.v54i0.2149.
71. Lyly M, Liukkonen KH, Salmenkallio-Marttila M, Karhunen L, Poutanen K, Lahteenmaki L. Fibre in beverages can enhance perceived satiety. Eur J Nutr. 2009;48:251-258.
72. Maki KC, Beiseigel JM, Jonnalagadda SS, etal. Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. J Am Diet Assoc. 2010;110:205-214.