Yeast-leavened oat breads with high or low molecular weight β-glucan do not differ in their effects on blood concentrations of lipids, insulin, or glucose in humans

Journal of Nutrition

Volumn 134, Issue 6, 2004, Pages 1384-1388

  Frank, Jan ^a   Sundberg, Birgitta ^a   Kamal Eldin, Afaf ^a   Vessby, Bengt ^b   Åman, Per ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood lipids; Humans; Oat bran bread; Soluble fiber; glucan

Indexed keywords

ALPHA TOCOPHEROL; BETA GLUCAN; GAMMA TOCOPHEROL; GLUCOSE; INSULIN; LIPID;

ADULT; ARTICLE; BRAN; BREAD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY FIBER; DOUBLE BLIND PROCEDURE; FEMALE; FOOD COMPOSITION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; MOLECULAR WEIGHT; NORMAL HUMAN; OAT; RANDOMIZED CONTROLLED TRIAL;

EID: 2642572723     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.6.1384     Document Type: Article

References (25)

1. De Groot, A. P., Luyken, R. & Pikaar, N. A. (1963) Cholesterol lowering effect of rolled oats. Lancet 2: 291-300.
2. U.S. Food and Drug Administration (1997) FDA final rule for federal labeling: health claims; oats and coronary heart disease. Fed. Regist. 62: 3584-3681.
3. Brown, L., Rosner, B., Willett, W. W. & Sacks, F. M. (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am. J. Clin. Nutr. 69: 30-42.
4. Truswell, A. S. (2002) Cereal grains and coronary heart disease. Eur. J. Clin. Nutr. 56: 1-14.
5. Lia, A., Andersson, H., Mekki, N., Juhel, C., Senft, M. & Lairon, D. (1997) Postprandial lipemia in relation to sterol and fat excretion in ileostomy subjects given oat-bran and wheat test meals. Am. J. Clin. Nutr. 66: 357-365.
6. Lia, A., Hallmans, G., Sandberg, A. S., Sundberg, B., Aman, P. & Andersson, H. (1995) Oat beta-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am. J. Clin. Nutr. 62: 1245-1251.
7. Andersson, M., Ellegard, L. & Andersson, H. (2002) Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one. Am. J. Clin. Nutr. 76: 1111-1116.
8. Tietyen, J. L., Nevins, D. J. & Schneeman, B. O. (1990) Characterization of the hypercholesterolemic potential of oat bran. FASEB J. 4: A527 (abs.).
9. Bengtsson, S., Aman, P., Graham, H., Newman, C. W. & Newman, R. K. (1990) Chemical studies on mixed-linked beta-glucans in hull-less barley cultivars giving different hypocholesterolaemic responses in chickens. J. Sci. Food Agric. 52: 435-445.
10. Bach Knudsen, K. E., Hansen, I., Borg Jensen, B. & Østergård, K. (1990) Physiological implications of wheat and oat dietary fiber. In: New Developments in Dietary Fiber (Furda, I. & Brine, C. J., eds.), pp. 135-150. Plenum Press, New York, NY.
11. Åman, P., Rimsten, L. & Andersson, R. (2004) Molecular weight distribution of β-glucan in oat based foods. Cereal Chem. 81: 356-360.
12. Rimsten, L., Stenberg, T., Andersson, R., Andersson, A. & Åman, P. (2003) Determination of beta-glucan molecular weight using SEC with calcofluor detection in cereal extracts. Cereal Chem. 80: 485-490.
13. Seigler, L. & Wu, W. T. (1981) Separation of serum high-density lipoprotein for cholesterol determination: ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride. Clin. Chem. 27: 838-841.
14. Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502.
15. Jones, B. & Kenward, M. G. (1989) Monographs on Statistics and Applied Probability 34: Design and Analysis of Cross-over Trials. Chapman & Hall, London.
16. Amundsen, A. L., Haugum, B. & Andersson, H. (2003) Changes in serum cholesterol and sterol metabolites after intake of products enriched with an oat bran concentrate within a controlled diet. Scand. J. Nutr. 47: 60-74.
17. Kerckhoffs, D. A., Hornstra, G. & Mensink, R. P. (2003) Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies. Am. J. Clin. Nutr. 78: 221-227.
18. Behall, K. M., Scholfield, D. J. & Hallfrisch, J. (1997) Effect of beta-glucan level in oat fiber extracts on blood lipids in men and women. J. Am. Coll. Nutr. 16: 46-51.
19. Braaten, J. T., Wood, P. J., Scott, F. W., Wolynetz, M. S., Lowe, M. K., Bradley-White, P. & Collins, M. W. (1994) Oat beta-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects. Eur. J. Clin. Nutr. 48: 465-474.
20. Davidson, M. H., Dugan, L. D., Burns, J. H., Bova, J., Story, K. & Drennan, K. B. (1991) The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study. J. Am. Med. Assoc. 265: 1833-1839.
21. Kirby, R. W., Anderson, J. W., Sieling, B., Rees, E. D., Chen, W. J., Miller, R. E. & Kay, R. M. (1981) Oat-bran intake selectively lowers serum low-density lipoprotein cholesterol concentrations of hypercholesterolemic men. Am. J. Clin. Nutr. 34: 824-829.
22. Onning, G., Wallmark, A., Persson, M., Akesson, B., Elmstahl, S. & Oste, R. (1999) Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia. Ann. Nutr. Metab. 43: 301-309.
23. Uusitupa, M. I., Ruuskanen, E., Makinen, E., Laitinen, J., Toskala, E., Kervinen, K. & Kesaniemi, Y. A. (1992) A controlled study on the effect of beta-glucan-rich oat bran on serum lipids in hypercholesterolemic subjects: relation to apolipoprotein E phenotype. J. Am. Coll. Nutr. 11: 651-659.
24. Anderson, J. W. (1995) Dietary fibre, complex carbohydrate and coronary artery disease. Can. J. Cardiol. 11(Suppl G): 55G-62G.
25. Ripsin, C. M., Keenan, J. M., Jacobs, D. R., Jr., Elmer, P. J., Welch, R. R., Van Horn, L., Liu, K., Turnbull, W. H., Thye, F. W., Kestin, M. & et al. (1992) Oat products and lipid lowering. A meta-analysis. J. Am. Med. Assoc. 267: 3317-3325.