Modest doses of β-glucan do not reduce concentrations of potentially atherogenic lipoproteins

American Journal of Clinical Nutrition

Volumn 72, Issue 1, 2000, Pages 49-55

  Lovegrove, Julie A ^a   Clohessy, Anna ^b   Milon, Hubert ^b   Williams, Christine M ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b NONE

Author keywords

Atherogenic lipoproteins; Cholesterol; Healthy adults; LDL cholesterol; Oat bran; Postprandial evaluation; Triacylglycerol; Wheat bran; glucan

Indexed keywords

BETA GLUCAN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; ATHEROGENESIS; BRAN; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; OAT; RANDOMIZED CONTROLLED TRIAL; UNITED KINGDOM; WHEAT;

TRITICUM AESTIVUM;

EID: 0033948546     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/72.1.49     Document Type: Article

References (40)

1. De Groot AP, Luyken R, Pikaar NA. Cholesterol lowering effect of rolled oats. Lancet 1963;2:303-4.
2. Welch RW. Can dietary oats promote health? Br J Biomed Sci 1994; 51:260-70.
3. Ripsin CM, Keenan JM, Jacobs DR, et al. Oat products and lipid lowering. A meta-analysis. JAMA 1992;267:3317-25.
4. Food and Drug Administration. Food labeling: health claims: oats and coronary heart disease. Fed Regist 1996;61:296-313.
5. Swain JF, Rouse IL, Curley CB, Sacks FM. Comparison of the effects of oat bran and low-fiber wheat on serum lipoprotein levels and blood pressure. N Engl J Med 1990;322:147-52.
6. Dubois C, Armand M, Senft M, et al. Chronic oat bran intake alters postprandial lipemia and lipoproteins in healthy adults. Am J Clin Nutr 1995;61:325-33.
7. Redard CL, Davis PA, Schneeman BO. Dietary fiber and gender: effect on postprandial lipemia. Am J Clin Nutr 1990;52:837-45.
8. Kirby RW, Anderson JW, Sieling B, et al. Oat-bran intake selectively lowers serum low-density lipoprotein cholesterol concentrations of hypercholesterolemic men. Am J Clin Nutr 1981;34:824-9.
9. Groot PHE, Van Striphout WAHJ, Krauss XH, et al. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler Thromb 1991;11:653-62.
10. Patsch JR. Relation of triglyceride metabolism and coronary artery disease. Arterioscler Thromb 1992;12:1336-45.
11. 2+ high density lipoprotein cholesterol precipitation method for use with previously frozen plasma. Clin Chem 1994;40:233-9.
12. Friedewald WT, Levey RI. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
13. Törrönen R, Kansanen L, Uusitupa M, et al. Effects of an oat bran concentrate on serum lipids in free-living men with mild to moderate hypercholesterolaemia. Eur J Clin Nutr 1992;46:621-7.
14. Beer MU, Arrigoni E, Amadò R. Effects of oat gum on blood cholesterol levels in healthy young men. Eur J Clin Nutr 1995;49:517-22.
15. Leadbetter J, Ball MJ, Mann JI. Effects of increasing quantities of oat bran in hypocholesterolemic people. Am J Clin Nutr 1991;54:841-5.
16. Mackay S, Ball MJ. Do beans and oat bran add to the effectiveness of a low-fat diet? Eur J Clin Nutr 1942;46:641-8.
17. Stewart FH, Neutze JM, Newsome-White R. The addition of oatbran to a low fat diet has no effect on lipid values in hypercholesterolaemic subjects. N Z Med J 1992;105:398-400.
18. Demark-Wahnefreid W, Bowering J, Cohen PS. Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets. J Am Diet Assoc 1990;90:23-9.
19. Van Horn L, Moag-Stahlberg A, Liu K, et al. Effects on serum lipids of adding instant oats to usual American diets. Am J Public Health 1991;81:183-8.
20. Gerhardt AL, Gallo NB. Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. J Nutr 1998;128:865-9.
21. Braaten JT, Wood PJ, Scott FW, et al. Oat β-glucan reduces blood cholesterol concentration in hypercholesterolemic subjects. Eur J Clin Nutr 1994;48:465-74.
22. Spiller GA, Farquhar JW, Gates JE, Nichols SF. Guar gum and plasma cholesterol. Effects of guar gum and oat fiber source on plasma lipoproteins and cholesterol in hypercholesterolemic adults. Arterioscler Thromb 1991;11:1204-8.
23. Poulter N, Chang CL, Cuff A, Poulter C, Sever P, Thom S. Lipid profiles after the daily consumption of an oat-based cereal: a controlled crossover trial. Am J Clin Nutr 1994;59:66-9.
24. Davidson MH, Dugan LD, Burns JH, Bova J, Story K, Drennan KB. The hypocholesterolemic effects of β-glucan in oatmeal and oat bran. JAMA 1991;265:1833-9.
25. Behall KM, Scholfield DJ, Hallfrisch J. Effect of β-glucan level in oat fiber extracts on blood lipids in men and women. J Am Coll Nutr 1997;16:46-51.
26. Anderson JW, Story L, Sieling B, Chen WJL, Petro MS, Story J. Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. Am J Clin Nutr 1984;40:1146-55.
27. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999;69: 30-42.
28. Mazza G, ed. Functional oat products in functional foods. Biochemical and processing aspects. Basel, Switzerland: Technomic Publishing Co, Inc, 1998.
29. Würsch P, Pi-Sunyer FX. The role of viscous soluble fiber in the metabolic control of diabetes. Diabetes Care 1997;20:1774-80.
30. Anderson JW, Gilinsky NH, Deakins DA, et al. Lipid responses of hypercholesterolemic men to oat-bran and wheat-bran intake. Am J Clin Nutr 1991;54:678-83.
31. Ehnholm C, Lukka M, Kuusi T, et al. Apolipoprotein E polymorphism in the Finnish population: gene frequency and the relation to lipoprotein concentrations. J Lipid Res 1986;27:227-35.
32. Jenkins DJA, Hegele RA, Jenkins AL, et al. The apolipoprotein E gene and the serum low-density lipoprotein cholesterol response to dietary fiber. Metabolism 1993;42:585-93.
33. Wolever TMS, Hegele RA, Connelly PW, et al. Long-term effect of soluble-fiber foods on postprandial fat metabolism in dyslipidemic subjects with apo E3 and apo E4 genotypes. Am J Clin Nutr 1997; 66:584-90.
34. Cara L, Dubois C, Borel P, et al. Effects of oat bran, rice bran, wheat fiber, and wheat germ on postprandial lipemia in healthy adults. Am J Clin Nutr 1992;55:81-8.
35. Lia A, Andersson H, Mekki N, Juhel C, Senft M, Lairon D. Postprandial lipemia in relation to sterol and fat excretion in ileostomy subjects given oat-bran and wheat test meals. Am J Clin Nutr 1997; 66:357-65.
36. Braaten JT, Scott FW, Wood PJ, et al. High β-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes. Diabet Med 1994;11:312-8.
37. Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men. Am J Clin Nutr 1990;52:661-6.
38. Noakes M, Clifton PM, Nestel PJ, Le Leu R, McIntosh G. Effect of high-amylose starch and oat bran on metabolic variables and bowel function in subjects with hypertriglyceridemia. Am J Clin Nutr 1996;64:944-51.
39. Pick ME, Hawrysh ZJ, Gee MI, Toth E, Garg ML, Hardin RT. Oat bran concentrate bread products improve long-term control of diabetes: a pilot study. J Am Diet Assoc 1996;96:1254-61.
40. Hallfrisch J, Scholfield DJ, Behall KM. Diets containing soluble oat extracts improve glucose and insulin responses of moderately hypercholesterolemic men and women. Am J Clin Nutr 1995;61:379-84.